EP1614468A1 - Pipette évitant la formation de goutte et son mode de fonctionnement - Google Patents

Pipette évitant la formation de goutte et son mode de fonctionnement Download PDF

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Publication number
EP1614468A1
EP1614468A1 EP04015682A EP04015682A EP1614468A1 EP 1614468 A1 EP1614468 A1 EP 1614468A1 EP 04015682 A EP04015682 A EP 04015682A EP 04015682 A EP04015682 A EP 04015682A EP 1614468 A1 EP1614468 A1 EP 1614468A1
Authority
EP
European Patent Office
Prior art keywords
liquid
gas pressure
vessel
gas
drive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP04015682A
Other languages
German (de)
English (en)
Other versions
EP1614468B1 (fr
Inventor
Renato Nay
Markus Bentz
René Ackermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hamilton Bonaduz AG
Original Assignee
Hamilton Bonaduz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hamilton Bonaduz AG filed Critical Hamilton Bonaduz AG
Priority to DE502004002377T priority Critical patent/DE502004002377D1/de
Priority to ES04015682T priority patent/ES2274349T3/es
Priority to AT04015682T priority patent/ATE348659T1/de
Priority to EP04015682A priority patent/EP1614468B1/fr
Publication of EP1614468A1 publication Critical patent/EP1614468A1/fr
Application granted granted Critical
Publication of EP1614468B1 publication Critical patent/EP1614468B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0227—Details of motor drive means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0615—Loss of fluid by dripping
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/146—Employing pressure sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/148—Specific details about calibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/024—Storing results with means integrated into the container

Definitions

  • the present invention relates to a method for preventing drop losses in remplisstechniksdosiervortechniken.
  • a device of the type mentioned is known from DE 44 21 303 A1.
  • a pipetting device which sucks in or expels an amount of liquid into a portion of a pipetting tip. This is done by changing the gas pressure of a gas trapped between a piston, cylinder walls and the liquid.
  • the pressure of the trapped gas and the prevailing ambient pressure are measured. From the measured values is under Taking into account the geometric shape of the cylinder and the pipette tip calculates a correction value in order to obtain as accurately as possible the distance to be traveled by the piston as a setpoint for the control of the Koblen Gay. The controller then initiates movement of the piston based on the corrected setpoint.
  • DE 44 21 303 A1 be thought to monitor the pressure of the gas between the piston and the amount of liquid between the termination of the fluid intake and the beginning of the liquid delivery to determine leaks on the pipette or the like.
  • WO 97/02893 A1 discloses a method and a device for correcting a temperature-dependent error during the metering of a liquid from a pipette.
  • the known device comprises two chambers connected in series to one another by a gas passage, namely a first chamber in the pipetting tip and a second chamber in the piston-cylinder system to which the pipetting tip is connected.
  • the pipetting tip which is provided with an opening, is immersed in it to absorb liquid.
  • a vessel wall of the second chamber is formed by a movable piston.
  • the second chamber is complete, the first chamber at least partially filled with a gas. The amount of gas is trapped between the piston and liquid in the two chambers.
  • WO 97/02893 A1 proposes to measure the change in temperature of the gas flowing from the first to the second chamber when the liquid is taken up by the piston movement and the change in volume caused by the piston movement in the second chamber to correct based on the measured temperature change during the liquid acquisition process. This is provided at least one temperature sensor.
  • the method known from WO 97/02893 A1 merely serves to correct the piston movement during fluid intake.
  • EP 0 747 689 B1 shows an apparatus and a method for withdrawing a liquid from a tightly closed container.
  • the tightly closed container contains a quantity of gas.
  • the gas pressure inside the container is monitored by a pressure sensor. Before that, the gas pressure inside the sealed vessel is brought to ambient pressure by piercing the seal with a hollow needle.
  • the present application is based on the following problem:
  • the liquid In vessels in which an amount of liquid is delivered or received by varying the pressure of a gas trapped by vessel walls and the liquid, the liquid is kept in the vessel for a considerable time between a liquid receiving operation and a liquid discharging operation, such as to overcome transport routes. During this time, the pressure difference between the ambient pressure and the pressure of the trapped gas as well as frictional and adhesive forces acting between the liquid and the wetted wall maintain the liquid in the vessel. In this case, the pressure difference between the ambient pressure and the gas pressure in the interior of the vessel has the largest share of the force holding the liquid in the vessel.
  • the pressure of the gas trapped in the vessel may change due to evaporation or due to temperature compensation processes.
  • Evaporates for example, absorbed liquid, so the increases Gas pressure in the vessel.
  • the gas pressure usually increases more than the weight of the not yet evaporated liquid decreases.
  • the described processes can lead to the unwanted increased gas pressure, a part of the liquid absorbed amount is undesirably ejected from the vessel. The ejected liquid then drips off the vessel. As a result, undesirably erroneous amounts of liquid can be dispensed despite first correctly taken in liquid quantities.
  • long transport distances can be covered or the liquid metering device can be stopped without loss of metered liquid after receiving the liquid for important short-term required interventions.
  • control device is a control device which is adapted to control at least during a control period between liquid intake and liquid delivery, the gas pressure changing device in response to the detected state variable such that the actual gas pressure in Vessel is held during the control period substantially at a predetermined target gas pressure.
  • the gas pressure is maintained at a predetermined target gas pressure in a control period, which control period comprises a time period in the first half, preferably in the first quarter, between the end time of the liquid receiving device and the start time of the liquid dispensing operation.
  • control period comprises a time period in the first half, preferably in the first quarter, between the end time of the liquid receiving device and the start time of the liquid dispensing operation.
  • the evaporation and temperature compensation processes are fastest and cause a faster change in gas pressure compared to a later period between fluid intake and fluid delivery. It is therefore further advantageous for the reliable prevention of dripping when the control period comprises the first quarter or particularly advantageously the first half of the period lying between the end time of the liquid receiving operation and the start time of the liquid dispensing operation.
  • control period covers the entire time between the end time of the liquid intake operation and the start time of the liquid discharge operation Period covers.
  • each gas pressure can serve as the target gas pressure which is present in the vessel in the first 10 seconds from the end time of the liquid intake process.
  • a pressure sensor arrangement is understood to mean a device for measuring the pressure with at least one pressure sensor.
  • the vessel may comprise a piston-cylinder arrangement and a pipetting tip arranged thereon, the pressure sensor arrangement then being provided on the piston-cylinder arrangement for cost reasons. Otherwise, each pipetting tip would have to be provided with a pressure sensor arrangement, and the respective pressure sensor arrangement should be coupled to the control device after the pipetting tip has been received. This represents a considerable effort.
  • the gas pressure varying device is a mechanical device having a drive and a driven by the component which forms part of the vessel wall, so that movement of the component to an increase or decrease of the gas volume in the vessel and thus to a pressure drop or Pressure increase of the gas pressure in the vessel leads.
  • a direction of change of the gas pressure i. rising or falling, assigned a direction of movement of the component.
  • a movement play must be overcome.
  • the mentioned play of motion can be the cause of inaccuracies in the amount of fluid taken or delivered, such as when the amount of fluid dispensed or received is calculated from the movement of the drive or other sensed quantities related to the drive. Because of the play of motion, namely, there are driving activities that actually do not change the gas pressure and therefore do not change the one present in the vessel Effect amount of liquid.
  • control device is designed to determine the movement play that they follow the drive in a first drive direction in the opposite second drive direction drives until the state quantity detection device detects a change in the at least one state variable.
  • control device may be designed to control the drive in the determination of the movement play step by step. This makes it possible to decay dynamic effects before detection of the gas pressure inside the vessel.
  • each liquid metering device can individually determine its system-inherent movement play.
  • the posstechniksdosiervorraum comprises a memory device, so that the individually determined movement play can be stored therein and retrieved when needed. If the liquid metering device is intended for use under changing environmental conditions, motion games can be determined together with further variables, so that movement games determined in the storage device are stored as a function of further variables. Thus, the movement play depending on different ambient temperatures and / or ambient pressures and / or operating periods and / or component positions, etc. may be stored.
  • the aforementioned drive-movable component may be a movable piston forming a vessel wall section. However, it may also be a wall of a bellows connected to the vessel.
  • the gas pressure can advantageously be regulated in a time period which comprises a time range in the first half, preferably in the first quarter of the period lying between the end time of the fluid intake operation and the start time of the fluid delivery operation. The greatest possible security is obtained when the detection step and the control step are carried out during the entire period of time between said points in time.
  • the control step in a specific embodiment advantageously comprises activating the drive in dependence from the detected state variable.
  • a movement described above can be determined with the aid of the method according to the invention by following the drive in the opposite second drive direction following a first drive direction until the state variable detection device detects a change in the at least one state variable.
  • the driving of the drive in the second drive direction can take place step by step, wherein each activation step is associated with a detection of the at least one state variable, preferably the detection of the at least one state variable after the activation of the drive ,
  • the highest possible accuracy in the determination of the movement play can be achieved by detecting further variables during the determination of the movement play, such as the position of the component relative to the vessel or / and a temperature, in particular Ambient temperature or / and the ambient pressure.
  • the at least one determined movement play is stored, possibly together with the previously mentioned further variables assigned to the respective movement play to be stored. If necessary, then the movement play, possibly depending on currently available operating parameters, retrieved from the memory and taken into account in the control of the drive.
  • a liquid metering device according to the invention is designated generally by 10.
  • the liquid metering device 10 comprises a piston-cylinder system 12 with a piston 14, which is movably guided in a cylinder 16 in the direction of the double arrow K.
  • a replaceable pipette tip 18 is received, in which a liquid 20 is present.
  • the pipette tip 18 forms, together with the cylinder 16 and the piston 14, a vessel 20 receiving the liquid.
  • the pipette tip 18 has an opening 22, through which the liquid 20 has been received in the pipetting tip 20 and can be discharged therefrom.
  • the piston 14 is substantially gas-tight against the inner wall 16 a of the cylinder 16.
  • the piston surface 14a facing the pipette tip 18 forms a vessel boundary wall.
  • a gas 24, such as air is enclosed.
  • air it is also possible to use any other gas, for example nitrogen or a noble gas, if reactions with the liquid 20 to be taken up are to be avoided in any case.
  • the liquid 20 was introduced in a manner known per se by immersing the opening 22 in a liquid reservoir and moving the piston 14 with the opening immersed such that the volume of the enclosed gas 24 is increased, through the opening 22 into the pipette tip 18 sucked.
  • the pipetting tip 18 of Figure 1, as well as of Figure 2a and b, has already completed the liquid intake and is no longer immersed in the liquid supply.
  • a pressure sensor 26 Connected to the interior of the vessel is a pressure sensor 26 for detecting the gas pressure of the enclosed gas 24.
  • a pressure sensor 26 Connected to the interior of the vessel is a pressure sensor 26 for detecting the gas pressure of the enclosed gas 24.
  • the pressure sensor 26 detects the pressure of the gas 24 and supplies a signal representing the gas pressure via the line 28 to a control device 30, which is adapted to a drive 32 for displacement of the piston 14 in the direction of the double arrow K in response to one of the pressure sensor 26th operated signal to operate.
  • the pressure sensor 26 may be an absolute value of the pressure of the gas 24 or may provide a relative value, approximately based on the ambient pressure, to the control device 30.
  • the pressure value detected by the pressure sensor 26 and delivered to the control device 30 is indicated by a pointer 34.
  • FIG. 2 a indicates how liquid particles V evaporate from the surface 20 a into the space occupied by the gas 24.
  • the liquid 20 releases heat W to the gas 24.
  • the pressure of the gas 24 in the vessel 16 of cylinder 16, piston 14 and pipette tip 18 increases. This pressure increase is detected by the pressure sensor 26, as indicated by the changed position of the pointer 34 with respect to FIG. Without control intervention, this pressure increase would lead to a discharge of liquid 20 from the opening 22.
  • the control device 30 moves depending on the pressure sensor via the line 28 delivered pressure value to the piston in the direction of arrow 36 in Figure 2b and increases the volume of the gas 24 in the vessel from the elements 14, 16, 18 to a predetermined, explained below, target gas pressure is reached. This reduces the pressure increase due to evaporation and heat transfer.
  • the pressure of the gas 24 again reaches the value which has prevailed immediately after the reception of the liquid 20 in the pipette tip 18 in the interior of the vessel from the piston 14, cylinder 16 and pipette tip 18. The original location where the piston wall 14a was before correction is indicated at 14a '.
  • gas pressure As desired gas pressure, the pressure prevailing in the vessel at the time of the end of the liquid intake process is ideally used. Since the increase in pressure due to evaporation and / or heat transfer is usually not instantaneous, it is generally possible to use a gas pressure as target gas pressure which prevails in the vessel within a period of 10 seconds after the end of the liquid intake process.
  • the piston may also be displaced toward the opening 22 to increase the pressure of the gas 24, such as after the intake of particularly cold liquids which remove heat from the enclosed gas 24 thereby reducing its pressure.
  • FIGS. 3a and 3b Signal curves are shown in FIGS. 3a and 3b, which the pressure sensor 26 can deliver via the data line 28 to the control device 30 in determining a mechanical clearance of the drive 32 and the piston 14.
  • the relative pressure of the gas 24 is plotted against the relative position of the drive 32 upon movement of the piston 14 in the direction of the double arrow K.
  • the absolute pressure of the gas 24 may be plotted over an absolute position of the actuator 32.
  • the relative pressure may be related to the ambient pressure associated with another sensor is detected.
  • the relative position may be related to any position of the piston, such as an upper or lower dead center position.
  • each representation of Figures 3a and 3b marks the point of reversal of the direction of travel of the piston.
  • the piston is moved over the distance U to the opening 22 of the pipette tip 18 until, at the relative position U 0, an increase in the relative pressure of the gas 24 of the vessel immersed in a liquid or otherwise closed can be detected.
  • a movement of the drive 32 causes a movement of the piston 14 and thus a pressure increase of the gas 24 from the time when the drive has overcome the Stecke U upon movement in the ejection direction after the suction movement of the piston.
  • FIG. 3b the determination of the clearance during an intake movement, ie when the piston 14 is raised, is shown away from the opening 22 of the pipetting tip 18.
  • the drive 32 first has to overcome the play distance H until at a point H 0 the drive movement actually also leads to a piston movement, so that after the play distance H has been exceeded a further actuation of the drive is required a decrease in the pressure of the gas 24 in the submerged or otherwise closed vessel leads.
  • the play paths U and H that can be determined individually for each dosing device 10 can be stored in the memory 34 of the control device 30.
  • the accuracy of the drive control can be further increased by the fact that movement games are determined depending on other variables and stored in memory 34 retrievable. For example, the movement games depending on the direction and / or piston position dependent and / or temperature-dependent and / or pressure-dependent, etc. may be stored in the memory 34.

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)
  • Loading And Unloading Of Fuel Tanks Or Ships (AREA)
  • Sink And Installation For Waste Water (AREA)
EP04015682A 2004-07-02 2004-07-02 Pipette évitant la formation de goutte et son mode de fonctionnement Expired - Lifetime EP1614468B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE502004002377T DE502004002377D1 (de) 2004-07-02 2004-07-02 Abtropfsichere Pipettiervorrichtung und abtropfsicheres Pipettierverfahren
ES04015682T ES2274349T3 (es) 2004-07-02 2004-07-02 Dispositivo pipeteado seguro contra goteo y procedimiento de pipeteado seguro contra goteo.
AT04015682T ATE348659T1 (de) 2004-07-02 2004-07-02 Abtropfsichere pipettiervorrichtung und abtropfsicheres pipettierverfahren
EP04015682A EP1614468B1 (fr) 2004-07-02 2004-07-02 Pipette évitant la formation de goutte et son mode de fonctionnement

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04015682A EP1614468B1 (fr) 2004-07-02 2004-07-02 Pipette évitant la formation de goutte et son mode de fonctionnement

Publications (2)

Publication Number Publication Date
EP1614468A1 true EP1614468A1 (fr) 2006-01-11
EP1614468B1 EP1614468B1 (fr) 2006-12-20

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ID=34925603

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04015682A Expired - Lifetime EP1614468B1 (fr) 2004-07-02 2004-07-02 Pipette évitant la formation de goutte et son mode de fonctionnement

Country Status (4)

Country Link
EP (1) EP1614468B1 (fr)
AT (1) ATE348659T1 (fr)
DE (1) DE502004002377D1 (fr)
ES (1) ES2274349T3 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2006022A1 (fr) 2007-06-15 2008-12-24 Hamilton Bonaduz AG Agencement de traitement d'échantillons pour un dispositif de dosage des liquides
WO2010060448A1 (fr) * 2008-11-28 2010-06-03 Hamilton Bonaduz Ag Dispositif et procédé de dosage appropriés pour le dosage de très petits volumes de dosage
WO2011107472A1 (fr) 2010-03-01 2011-09-09 Novozymes A/S Dosage de la viscosité-pression
US8096197B2 (en) 2006-03-31 2012-01-17 Artel, Inc. Air displacement liquid delivery system and related method
US8216527B2 (en) 2010-01-22 2012-07-10 Tecan Trading Ag Positive displacement pump with pressure sensor
DE102011081186A1 (de) * 2011-08-18 2013-02-21 Hamilton Bonaduz Ag Verfahren zum Detektieren der Oberfläche einer Flüssigkeitsprobe in einem Probenbehälter
DE102018125196A1 (de) * 2018-10-11 2020-04-16 Hamilton Bonaduz Ag Vorrichtung und Verfahren zur Qualitätsbestimmung einer impulsartigen Flüssigkeitsdispensation nach dem Air-Displacement-Prinzip
DE102019126731A1 (de) * 2019-10-02 2021-04-08 Hamilton Bonaduz Ag Vorrichtung und Verfahren zum exakten flüssigkeitsklassen-unabhängigen Pipettieren
CN112924706A (zh) * 2019-12-06 2021-06-08 豪夫迈·罗氏有限公司 用于封闭液体容器的移液单元和移液方法
EP3651904B1 (fr) * 2017-07-13 2024-12-18 Hamilton Bonaduz AG Cassette de moteur intégrée destinée à être raccordée et utilisée dans un système de pipetage, système de pipetage et procédé de remplacement d'une cassette de moteur intégrée d'un système de pipetage

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11320295B2 (en) * 2019-04-26 2022-05-03 Festo Se & Co. Kg Dosing unit and method for dosing a liquid

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531241A1 (de) * 1985-08-31 1987-03-05 Eppendorf Geraetebau Netheler Vorrichtung zur gesteuerten ausgabe von fluessigkeiten
EP0682258A1 (fr) * 1994-05-09 1995-11-15 Ciba Corning Diagnostics Corp. Circuit pour détecter l'obstruction d'une sonde de prélèvement d'échantillons
US5499545A (en) * 1993-06-18 1996-03-19 Sony Corporation Pipetting device and method therefore
US5895838A (en) * 1995-07-07 1999-04-20 Biohit Oy Method for correcting a liquid dispensing error, and a liquid dispensing device
US20020188410A1 (en) * 2001-04-18 2002-12-12 Gerhard Salje Method for the controlled proportioning of liquids while dislocating a gas cushion

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531241A1 (de) * 1985-08-31 1987-03-05 Eppendorf Geraetebau Netheler Vorrichtung zur gesteuerten ausgabe von fluessigkeiten
US5499545A (en) * 1993-06-18 1996-03-19 Sony Corporation Pipetting device and method therefore
EP0682258A1 (fr) * 1994-05-09 1995-11-15 Ciba Corning Diagnostics Corp. Circuit pour détecter l'obstruction d'une sonde de prélèvement d'échantillons
US5895838A (en) * 1995-07-07 1999-04-20 Biohit Oy Method for correcting a liquid dispensing error, and a liquid dispensing device
US20020188410A1 (en) * 2001-04-18 2002-12-12 Gerhard Salje Method for the controlled proportioning of liquids while dislocating a gas cushion

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8096197B2 (en) 2006-03-31 2012-01-17 Artel, Inc. Air displacement liquid delivery system and related method
EP2006020A1 (fr) * 2007-06-15 2008-12-24 Hamilton Bonaduz AG Agencement de traitement d'échantillons pour un dispositif de dosage des liquides
EP2006022A1 (fr) 2007-06-15 2008-12-24 Hamilton Bonaduz AG Agencement de traitement d'échantillons pour un dispositif de dosage des liquides
WO2010060448A1 (fr) * 2008-11-28 2010-06-03 Hamilton Bonaduz Ag Dispositif et procédé de dosage appropriés pour le dosage de très petits volumes de dosage
US8216527B2 (en) 2010-01-22 2012-07-10 Tecan Trading Ag Positive displacement pump with pressure sensor
US8231842B2 (en) 2010-01-22 2012-07-31 Tecan Trading Ag Positive displacement pump with pressure sensor
WO2011107472A1 (fr) 2010-03-01 2011-09-09 Novozymes A/S Dosage de la viscosité-pression
DE102011081186A1 (de) * 2011-08-18 2013-02-21 Hamilton Bonaduz Ag Verfahren zum Detektieren der Oberfläche einer Flüssigkeitsprobe in einem Probenbehälter
EP3651904B1 (fr) * 2017-07-13 2024-12-18 Hamilton Bonaduz AG Cassette de moteur intégrée destinée à être raccordée et utilisée dans un système de pipetage, système de pipetage et procédé de remplacement d'une cassette de moteur intégrée d'un système de pipetage
US12403464B2 (en) 2017-07-13 2025-09-02 Hamilton Bonaduz Ag Integrated motor cassette for connection to and for use in a pipetting system, pipetting system, and method for exchanging an integrated motor cassette of a pipetting system
DE102018125196A1 (de) * 2018-10-11 2020-04-16 Hamilton Bonaduz Ag Vorrichtung und Verfahren zur Qualitätsbestimmung einer impulsartigen Flüssigkeitsdispensation nach dem Air-Displacement-Prinzip
US11938474B2 (en) 2018-10-11 2024-03-26 Hamilton Bonaduz Ag Device and method for determining the quality of pulsed dispensing of liquid according to the air displacement principle
CN114502940A (zh) * 2019-10-02 2022-05-13 哈美顿博纳图斯股份公司 用于精确地与液体类别无关地进行移液的设备和方法
DE102019126731A1 (de) * 2019-10-02 2021-04-08 Hamilton Bonaduz Ag Vorrichtung und Verfahren zum exakten flüssigkeitsklassen-unabhängigen Pipettieren
EP3832315A1 (fr) * 2019-12-06 2021-06-09 F. Hoffmann-La Roche AG Unité de pipette et procédé de pipetage pour récipients de liquide fermés
CN112924706B (zh) * 2019-12-06 2024-11-26 豪夫迈·罗氏有限公司 用于封闭液体容器的移液单元和移液方法
CN112924706A (zh) * 2019-12-06 2021-06-08 豪夫迈·罗氏有限公司 用于封闭液体容器的移液单元和移液方法

Also Published As

Publication number Publication date
DE502004002377D1 (de) 2007-02-01
ATE348659T1 (de) 2007-01-15
ES2274349T3 (es) 2007-05-16
EP1614468B1 (fr) 2006-12-20

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