EP1670422A4 - Identifizierung von kinase-inhibitoren - Google Patents

Identifizierung von kinase-inhibitoren

Info

Publication number
EP1670422A4
EP1670422A4 EP03752561A EP03752561A EP1670422A4 EP 1670422 A4 EP1670422 A4 EP 1670422A4 EP 03752561 A EP03752561 A EP 03752561A EP 03752561 A EP03752561 A EP 03752561A EP 1670422 A4 EP1670422 A4 EP 1670422A4
Authority
EP
European Patent Office
Prior art keywords
identification
kinase inhibitors
kinase
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03752561A
Other languages
English (en)
French (fr)
Other versions
EP1670422A2 (de
Inventor
John C Prescott
Andrew Braisted
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viracta Therapeutics Inc
Original Assignee
Sunesis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunesis Pharmaceuticals Inc filed Critical Sunesis Pharmaceuticals Inc
Publication of EP1670422A2 publication Critical patent/EP1670422A2/de
Publication of EP1670422A4 publication Critical patent/EP1670422A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806Determination of free amino acids
    • G01N33/6812Assays for specific amino acids
    • G01N33/6815Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP03752561A 2003-09-17 2003-09-17 Identifizierung von kinase-inhibitoren Withdrawn EP1670422A4 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2003/029870 WO2005034840A2 (en) 2003-09-17 2003-09-17 Identification of kinase inhibitors

Publications (2)

Publication Number Publication Date
EP1670422A2 EP1670422A2 (de) 2006-06-21
EP1670422A4 true EP1670422A4 (de) 2007-08-01

Family

ID=34434214

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03752561A Withdrawn EP1670422A4 (de) 2003-09-17 2003-09-17 Identifizierung von kinase-inhibitoren

Country Status (4)

Country Link
EP (1) EP1670422A4 (de)
AU (1) AU2003270848A1 (de)
CA (1) CA2539064A1 (de)
WO (1) WO2005034840A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005061519A1 (en) 2003-12-19 2005-07-07 Takeda San Diego, Inc. Kinase inhibitors
EP1778669A2 (de) 2004-08-18 2007-05-02 Takeda San Diego, Inc. Kinase-inhibitoren
ATE479687T1 (de) 2004-10-15 2010-09-15 Takeda Pharmaceutical Kinaseinhibitoren
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
SG158147A1 (en) 2006-10-09 2010-01-29 Takeda Pharmaceutical Kinase inhibitors
NZ620174A (en) 2009-09-16 2016-08-26 Celgene Avilomics Res Inc Protein kinase conjugates and inhibitors
EP2519664A4 (de) 2009-12-30 2014-03-12 Avila Therapeutics Inc Ligandgerichtete kovalente modifizierung eines proteins
JP5908466B2 (ja) 2010-06-09 2016-04-26 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド Raf及びmek阻害剤に対する耐性を与えるmek1変異
GB201614152D0 (en) 2016-08-18 2016-10-05 Imp Innovations Ltd Assay
US12440494B2 (en) * 2019-02-25 2025-10-14 Albert Einstein College Of Medicine Compounds useful for inhibiting RAF dimers
CN116434828B (zh) * 2023-04-17 2024-03-26 深圳新锐基因科技有限公司 基于计算结构生物学的蛋白分子动态二硫键的引入方法及装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002042773A2 (en) * 2000-11-21 2002-05-30 Sunesis Pharmaceuticals, Inc. An extended tethering approach for rapid identification of ligands
WO2003014308A2 (en) * 2001-08-07 2003-02-20 Sunesis Pharmaceuticals, Inc. Cysteine mutants and methods for detecting ligand binding to biological molecules
WO2003081210A2 (en) * 2002-03-21 2003-10-02 Sunesis Pharmaceuticals, Inc. Identification of kinase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002042773A2 (en) * 2000-11-21 2002-05-30 Sunesis Pharmaceuticals, Inc. An extended tethering approach for rapid identification of ligands
WO2003014308A2 (en) * 2001-08-07 2003-02-20 Sunesis Pharmaceuticals, Inc. Cysteine mutants and methods for detecting ligand binding to biological molecules
WO2003081210A2 (en) * 2002-03-21 2003-10-02 Sunesis Pharmaceuticals, Inc. Identification of kinase inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ERLANSON DANIEL A ET AL: "MAKING DRUGS ON PROTEINS: SITE-DIRECTED LIGAND DISCOVERY FOR FRAGMENT-BASED LEAD ASSEMBLY", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, vol. 8, no. 4, August 2004 (2004-08-01), pages 399 - 406, XP009072514, ISSN: 1367-5931 *
MALY D J ET AL: "Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 14 MAR 2000 UNITED STATES, vol. 97, no. 6, 14 March 2000 (2000-03-14), pages 2419 - 2424, XP002199108, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2005034840A2 (en) 2005-04-21
WO2005034840A8 (en) 2006-04-20
CA2539064A1 (en) 2005-04-21
EP1670422A2 (de) 2006-06-21
AU2003270848A1 (en) 2005-04-27
WO2005034840A3 (en) 2006-10-05

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