EP1670422A4 - Identification d'inhibiteurs de kinase - Google Patents

Identification d'inhibiteurs de kinase

Info

Publication number
EP1670422A4
EP1670422A4 EP03752561A EP03752561A EP1670422A4 EP 1670422 A4 EP1670422 A4 EP 1670422A4 EP 03752561 A EP03752561 A EP 03752561A EP 03752561 A EP03752561 A EP 03752561A EP 1670422 A4 EP1670422 A4 EP 1670422A4
Authority
EP
European Patent Office
Prior art keywords
identification
kinase inhibitors
kinase
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03752561A
Other languages
German (de)
English (en)
Other versions
EP1670422A2 (fr
Inventor
John C Prescott
Andrew Braisted
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viracta Therapeutics Inc
Original Assignee
Sunesis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunesis Pharmaceuticals Inc filed Critical Sunesis Pharmaceuticals Inc
Publication of EP1670422A2 publication Critical patent/EP1670422A2/fr
Publication of EP1670422A4 publication Critical patent/EP1670422A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806Determination of free amino acids
    • G01N33/6812Assays for specific amino acids
    • G01N33/6815Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP03752561A 2003-09-17 2003-09-17 Identification d'inhibiteurs de kinase Withdrawn EP1670422A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2003/029870 WO2005034840A2 (fr) 2003-09-17 2003-09-17 Identification d'inhibiteurs de kinase

Publications (2)

Publication Number Publication Date
EP1670422A2 EP1670422A2 (fr) 2006-06-21
EP1670422A4 true EP1670422A4 (fr) 2007-08-01

Family

ID=34434214

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03752561A Withdrawn EP1670422A4 (fr) 2003-09-17 2003-09-17 Identification d'inhibiteurs de kinase

Country Status (4)

Country Link
EP (1) EP1670422A4 (fr)
AU (1) AU2003270848A1 (fr)
CA (1) CA2539064A1 (fr)
WO (1) WO2005034840A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1694686A1 (fr) 2003-12-19 2006-08-30 Takeda San Diego, Inc. Inhibiteurs de kinase
WO2006023931A2 (fr) 2004-08-18 2006-03-02 Takeda San Diego, Inc. Inhibiteurs de kinase
EP1812439B2 (fr) 2004-10-15 2017-12-06 Takeda Pharmaceutical Company Limited Inhibiteurs de kinase
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
SG158147A1 (en) 2006-10-09 2010-01-29 Takeda Pharmaceutical Kinase inhibitors
US9556426B2 (en) * 2009-09-16 2017-01-31 Celgene Avilomics Research, Inc. Protein kinase conjugates and inhibitors
JP2013516422A (ja) 2009-12-30 2013-05-13 アビラ セラピューティクス, インコーポレイテッド タンパク質のリガンド−指向性共有的修飾
PT2580322T (pt) 2010-06-09 2018-03-01 Dana Farber Cancer Inst Inc Uma mutação em mek1 que confere resistência aos inibidores de raf e mek
GB201614152D0 (en) 2016-08-18 2016-10-05 Imp Innovations Ltd Assay
WO2020176501A1 (fr) * 2019-02-25 2020-09-03 Albert Einstein College Of Medicine Composés utiles pour l'inhibition de dimères de raf
CN116434828B (zh) * 2023-04-17 2024-03-26 深圳新锐基因科技有限公司 基于计算结构生物学的蛋白分子动态二硫键的引入方法及装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002042773A2 (fr) * 2000-11-21 2002-05-30 Sunesis Pharmaceuticals, Inc. Methode de fixation etendue pour l'identification rapide de ligands
WO2003014308A2 (fr) * 2001-08-07 2003-02-20 Sunesis Pharmaceuticals, Inc. Mutants de cysteine et procedes de detection de liaison de ligands a des molecules biologiques
WO2003081210A2 (fr) * 2002-03-21 2003-10-02 Sunesis Pharmaceuticals, Inc. Identification d'inhibiteurs de kinase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002042773A2 (fr) * 2000-11-21 2002-05-30 Sunesis Pharmaceuticals, Inc. Methode de fixation etendue pour l'identification rapide de ligands
WO2003014308A2 (fr) * 2001-08-07 2003-02-20 Sunesis Pharmaceuticals, Inc. Mutants de cysteine et procedes de detection de liaison de ligands a des molecules biologiques
WO2003081210A2 (fr) * 2002-03-21 2003-10-02 Sunesis Pharmaceuticals, Inc. Identification d'inhibiteurs de kinase

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ERLANSON DANIEL A ET AL: "MAKING DRUGS ON PROTEINS: SITE-DIRECTED LIGAND DISCOVERY FOR FRAGMENT-BASED LEAD ASSEMBLY", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, vol. 8, no. 4, August 2004 (2004-08-01), pages 399 - 406, XP009072514, ISSN: 1367-5931 *
MALY D J ET AL: "Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 14 MAR 2000 UNITED STATES, vol. 97, no. 6, 14 March 2000 (2000-03-14), pages 2419 - 2424, XP002199108, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2005034840A8 (fr) 2006-04-20
CA2539064A1 (fr) 2005-04-21
WO2005034840A3 (fr) 2006-10-05
WO2005034840A2 (fr) 2005-04-21
AU2003270848A1 (en) 2005-04-27
EP1670422A2 (fr) 2006-06-21

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