EP1749836A3 - Facteur recombinant de croissance de cellules vasculaires - Google Patents
Facteur recombinant de croissance de cellules vasculaires Download PDFInfo
- Publication number
- EP1749836A3 EP1749836A3 EP06121918A EP06121918A EP1749836A3 EP 1749836 A3 EP1749836 A3 EP 1749836A3 EP 06121918 A EP06121918 A EP 06121918A EP 06121918 A EP06121918 A EP 06121918A EP 1749836 A3 EP1749836 A3 EP 1749836A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- vegf
- endothelial cell
- growth factor
- cell growth
- vascular endothelial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 title 1
- 102100031706 Fibroblast growth factor 1 Human genes 0.000 title 1
- 210000003556 vascular endothelial cell Anatomy 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 102000009519 Vascular Endothelial Growth Factor D Human genes 0.000 abstract 1
- 108010073919 Vascular Endothelial Growth Factor D Proteins 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000008728 vascular permeability Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK09162873.5T DK2107109T3 (da) | 1996-08-23 | 1997-08-21 | Rekombinant vaskulær endotelcelle-vækstfaktor D (VEGF-D) |
| EP09162873A EP2107109B1 (fr) | 1996-08-23 | 1997-08-21 | Facteur D recombinant de croissance de cellules vasculaires endotheliales |
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2375196P | 1996-08-23 | 1996-08-23 | |
| AUPO1825A AUPO182596A0 (en) | 1996-08-23 | 1996-08-23 | Growth factor |
| AUPO3554A AUPO355496A0 (en) | 1996-11-11 | 1996-11-11 | Growth factor |
| US3109796P | 1996-11-14 | 1996-11-14 | |
| AUPO4954A AUPO495497A0 (en) | 1997-02-05 | 1997-02-05 | Growth factors |
| US3881497P | 1997-02-10 | 1997-02-10 | |
| AUPO7435A AUPO743597A0 (en) | 1997-06-19 | 1997-06-19 | Growth factor |
| US5142697P | 1997-07-01 | 1997-07-01 | |
| EP97938486A EP0956339B1 (fr) | 1996-08-23 | 1997-08-21 | Facteur d recombinant de croissance des cellules endotheliales vasculaires (vegf-d) |
| EP02018842A EP1283268A3 (fr) | 1996-08-23 | 1997-08-21 | Facteur recombinant de croissance de cellules vascularies endothéliales D (VEGF-D) |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP02018842A Division EP1283268A3 (fr) | 1996-08-23 | 1997-08-21 | Facteur recombinant de croissance de cellules vascularies endothéliales D (VEGF-D) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP09162873A Division EP2107109B1 (fr) | 1996-08-23 | 1997-08-21 | Facteur D recombinant de croissance de cellules vasculaires endotheliales |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP1749836A2 EP1749836A2 (fr) | 2007-02-07 |
| EP1749836A3 true EP1749836A3 (fr) | 2007-08-22 |
| EP1749836B1 EP1749836B1 (fr) | 2009-06-17 |
Family
ID=46149776
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP06121918A Expired - Lifetime EP1749836B1 (fr) | 1996-08-23 | 1997-08-21 | Facteur D recombinant de croissance de cellules vasculaires endothéliales |
| EP97938486A Revoked EP0956339B1 (fr) | 1996-08-23 | 1997-08-21 | Facteur d recombinant de croissance des cellules endotheliales vasculaires (vegf-d) |
| EP09162873A Expired - Lifetime EP2107109B1 (fr) | 1996-08-23 | 1997-08-21 | Facteur D recombinant de croissance de cellules vasculaires endotheliales |
| EP02018842A Withdrawn EP1283268A3 (fr) | 1996-08-23 | 1997-08-21 | Facteur recombinant de croissance de cellules vascularies endothéliales D (VEGF-D) |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP97938486A Revoked EP0956339B1 (fr) | 1996-08-23 | 1997-08-21 | Facteur d recombinant de croissance des cellules endotheliales vasculaires (vegf-d) |
| EP09162873A Expired - Lifetime EP2107109B1 (fr) | 1996-08-23 | 1997-08-21 | Facteur D recombinant de croissance de cellules vasculaires endotheliales |
| EP02018842A Withdrawn EP1283268A3 (fr) | 1996-08-23 | 1997-08-21 | Facteur recombinant de croissance de cellules vascularies endothéliales D (VEGF-D) |
Country Status (10)
| Country | Link |
|---|---|
| US (14) | US6235713B1 (fr) |
| EP (4) | EP1749836B1 (fr) |
| JP (3) | JP2001517075A (fr) |
| AT (2) | ATE306546T1 (fr) |
| AU (1) | AU729880C (fr) |
| CA (1) | CA2263890C (fr) |
| DE (2) | DE69734359T2 (fr) |
| DK (3) | DK1749836T3 (fr) |
| ES (3) | ES2390107T3 (fr) |
| WO (1) | WO1998007832A1 (fr) |
Families Citing this family (128)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6824777B1 (en) | 1992-10-09 | 2004-11-30 | Licentia Ltd. | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
| US6734285B2 (en) | 1994-03-08 | 2004-05-11 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 proteins and compositions |
| US5932540A (en) | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| EP0751992B1 (fr) | 1994-03-08 | 2005-11-09 | Human Genome Sciences, Inc. | Facteur 2 de croissance endotheliale vasculaire |
| US7186688B1 (en) | 1994-03-08 | 2007-03-06 | Human Genome Sciences, Inc. | Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2 |
| US6608182B1 (en) | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
| US6040157A (en) * | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| US7153827B1 (en) | 1994-03-08 | 2006-12-26 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 and methods of use |
| US7109308B1 (en) | 1994-03-08 | 2006-09-19 | Human Genome Sciences, Inc. | Antibodies to human vascular endothelial growth factor 2 |
| US7597886B2 (en) | 1994-11-07 | 2009-10-06 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
| US7429646B1 (en) | 1995-06-05 | 2008-09-30 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like 2 |
| US7423125B2 (en) * | 1995-08-01 | 2008-09-09 | Vegenics Limited | Antibodies to VEGF-C |
| ES2202469T5 (es) | 1995-09-08 | 2011-06-06 | Genentech, Inc. | Proteína relacionada con el vegf. |
| WO1997012972A2 (fr) | 1995-09-29 | 1997-04-10 | Universita'degli Studi Di Siena | Genes regules et leurs utilisations |
| WO1997033904A1 (fr) | 1996-03-12 | 1997-09-18 | Human Genome Sciences, Inc. | Recepteurs contenant un domaine de mort cellulaire |
| US6713061B1 (en) | 1996-03-12 | 2004-03-30 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US7357927B2 (en) | 1996-03-12 | 2008-04-15 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US6635743B1 (en) | 1996-03-22 | 2003-10-21 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II and methods of use |
| US7964190B2 (en) | 1996-03-22 | 2011-06-21 | Human Genome Sciences, Inc. | Methods and compositions for decreasing T-cell activity |
| AU733322B2 (en) * | 1996-07-15 | 2001-05-10 | Chugai Seiyaku Kabushiki Kaisha | Novel VEGF-like factor |
| CA2263890C (fr) * | 1996-08-23 | 2013-05-14 | Ludwig Institute For Cancer Research | Facteur d recombinant de croissance des cellules endotheliales vasculaires (vegf-d) |
| US7125714B2 (en) | 1997-02-05 | 2006-10-24 | Licentia Ltd. | Progenitor cell materials and methods |
| US20020137890A1 (en) * | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6391311B1 (en) | 1998-03-17 | 2002-05-21 | Genentech, Inc. | Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1 |
| KR100628697B1 (ko) * | 1997-12-24 | 2006-09-28 | 루드빅 인스티튜트 포 캔서 리서치 | 맥관 내피 성장인자 d를 발현하는 발현 벡터와 셀라인,및 흑색종을 치료하는 방법 |
| AU765888B2 (en) * | 1997-12-24 | 2003-10-02 | Vegenics Limited | Expression vectors and cell lines expressing vascular endothelial growth factor D, and method of treating melanomas |
| ES2389387T3 (es) | 1998-03-17 | 2012-10-25 | Genentech, Inc. | Polipéptidos homólogos de VEGF y de BMP1 |
| EP0984063A3 (fr) * | 1998-08-31 | 2000-08-16 | Eli Lilly And Company | Gene et proteine apparentee au vegf |
| US20030082670A1 (en) * | 1998-09-30 | 2003-05-01 | Ulf Eriksson | Platelet-derived growth factor C, DNA coding therefor, and uses thereof |
| US20040053837A1 (en) * | 1998-09-30 | 2004-03-18 | Ludwig Institute For Cancer Research | Composition and method for modulating vasculogenesis or angiogenesis |
| US20030211994A1 (en) * | 1998-09-30 | 2003-11-13 | Ludwig Institute For Cancer Research | Composition and method for modulating vasculogenesis or angiogenesis |
| ATE489108T1 (de) | 1998-10-09 | 2010-12-15 | Vegenics Ltd | Flt4 (vegfr-3) als ziel für tumornachweis (imaging) und antitumortherapie |
| US6958147B1 (en) | 1998-10-26 | 2005-10-25 | Licentia Ltd | Use of VEGF-C to prevent restenosis |
| ES2229788T3 (es) * | 1998-10-26 | 2005-04-16 | Ludwig Institute For Cancer Research | Uso del gen o proteina vegf-c o vegf-d para prevenir la restenosis. |
| EP1568375A1 (fr) * | 1998-10-26 | 2005-08-31 | Ludwig Institute For Cancer Research | Utilisation des protéines VEGF-C ou VEGF-D pour la prévention de la resténose |
| JP2002534061A (ja) | 1998-11-10 | 2002-10-15 | ルードヴィッヒ・インスティテュート・フォア・キャンサー・リサーチ | 血小板由来増殖因子d、それをコードするdna、及びその利用法 |
| CA2354325C (fr) * | 1998-12-07 | 2011-08-16 | Zymogenetics, Inc. | Zvegf3 homologue du facteur de croissance |
| CA2355896A1 (fr) | 1998-12-21 | 2000-06-29 | Ludwig Institute For Cancer Research | Anticorps antifacteur de croissance endotheliale vasculaire tronque et leur utilisation |
| US6783953B1 (en) | 1998-12-22 | 2004-08-31 | Janssen Pharmaceutica N.V. | Vascular endothelial growth factor-X |
| AU778412B2 (en) * | 1998-12-22 | 2004-12-02 | Janssen Pharmaceutica N.V. | Vascular endothelial growth factor-X |
| US7223724B1 (en) | 1999-02-08 | 2007-05-29 | Human Genome Sciences, Inc. | Use of vascular endothelial growth factor to treat photoreceptor cells |
| EP2357192A1 (fr) | 1999-02-26 | 2011-08-17 | Human Genome Sciences, Inc. | Endokine alpha humain et methodes d'utilisation |
| WO2000058511A1 (fr) | 1999-03-26 | 2000-10-05 | Ludwig Institute For Cancer Research | Dosage et therapie pour les troubles lymphatiques impliquant la tyrosine kinase flt4 (vegfr-3) |
| US6764820B2 (en) | 1999-03-26 | 2004-07-20 | Ludwig Institute For Cancer Research | Screening for lymphatic disorders involving the FLT4 receptor tyrosine kinase (VEGFR-3) |
| CA2368670C (fr) * | 1999-03-26 | 2012-06-05 | Chitra Suri | Modulation de la permeabilite vasculaire au moyen d'activateurs de recepteurs tie2 |
| US6372494B1 (en) | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
| WO2001012669A1 (fr) * | 1999-08-16 | 2001-02-22 | Universita' Degli Studi Di Siena | Vegf-d et utilisation angiogenique de celui-ci |
| US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| US7045133B2 (en) | 2000-01-18 | 2006-05-16 | Ludwig Institute For Cancer Research | VEGF-D/VEGF-C/VEGF peptidomimetic inhibitor |
| US6930089B2 (en) | 2000-02-04 | 2005-08-16 | D. Collen Research Foundation Vzw | Use of vascular endothelial growth factor, placenta growth factor or both for preventing or treating ischemic disease or stroke |
| AU4643501A (en) * | 2000-02-04 | 2001-08-14 | Flanders Interuniversity Institute For Biotechnology (Vib) | Use of vascular endothelial growth factor, placenta growth factor or both for preventing or treating ischemic diseases or stroke |
| US7727971B2 (en) | 2000-02-04 | 2010-06-01 | Life Sciences Research Partners Vzw | Use of placental growth factor for treating ischemic muscle disease |
| US7105168B1 (en) | 2002-06-04 | 2006-09-12 | D. Collen Research Foundation Vzw | Method of improving ischemic muscle function by administering placental growth factor |
| WO2001057008A1 (fr) | 2000-02-07 | 2001-08-09 | Abbott Gesellschaft Mit Beschrankter Haftung & Company Kommanditgesellschaft | Derives de 2-benzothiazolyle uree et leur utilisation en tant qu'inhibiteurs de proteine kinase |
| AU2001239884B2 (en) * | 2000-02-25 | 2006-08-10 | Vegenics Limited | Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins and screening methods for modulators |
| DK1259248T3 (da) * | 2000-03-02 | 2005-04-11 | Ludwig Inst Cancer Res | Fremgangsmåde til behandling af cancere, der udtrykker vaskulær endotelvækstfaktor D |
| US20020102260A1 (en) * | 2000-03-02 | 2002-08-01 | Marc Achen | Methods for treating neoplastic disease characterized by vascular endothelial growth factor D expression, for screening for neoplastic disease or metastatic risk, and for maintaining vascularization of tissue |
| CA2401665A1 (fr) * | 2000-03-02 | 2001-09-07 | Ludwig Institute For Cancer Research | Procedes de traitement, d'examen et de detection de cancers exprimant le facteur d de croissance endotheliale vasculaire |
| AU2006201128B2 (en) * | 2000-03-02 | 2009-05-28 | Vegenics Limited | Methods for treating, screening for, and detecting cancers expressing vascular endothelial growth factor D |
| EP1274720A4 (fr) | 2000-04-12 | 2004-08-18 | Human Genome Sciences Inc | Proteines fusionnees a l'albumine |
| AU2001264565B2 (en) * | 2000-05-03 | 2006-12-07 | Vegenics Limited | A method for activating only the vascular endothelial growth factor receptor-3 and uses thereof |
| US7273751B2 (en) | 2000-08-04 | 2007-09-25 | Human Genome Science, Inc. | Vascular endothelial growth factor-2 |
| JP2004527462A (ja) * | 2000-11-01 | 2004-09-09 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | 血管新生活性のinvivo刺激 |
| AU2884102A (en) | 2000-12-07 | 2002-06-18 | Sangamo Biosciences Inc | Regulation of angiogenesis with zinc finger proteins |
| US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| US7611711B2 (en) | 2001-01-17 | 2009-11-03 | Vegenics Limited | VEGFR-3 inhibitor materials and methods |
| CA2435503C (fr) | 2001-01-19 | 2011-02-22 | Ludwig Institute For Cancer Research | Flt4 (vegfr-3) utilise comme cible pour l'imagerie des tumeurs et le traitement antitumoral |
| US20020164624A1 (en) * | 2001-02-12 | 2002-11-07 | Waldemar Debinski | VEGF-D expression in brain cancer |
| MXPA03008560A (es) | 2001-03-22 | 2004-06-30 | Abbot Gmbh & Co Kg | Pirazolopirimidinas como agentes terapeuticos. |
| DE60236646D1 (de) | 2001-04-13 | 2010-07-22 | Human Genome Sciences Inc | Anti-VEGF-2 Antikörper |
| US7402312B2 (en) | 2001-04-13 | 2008-07-22 | Human Genome Sciences, Inc. | Antibodies to vascular endothelial growth factor 2 (VEGF-2) |
| CA2452865A1 (fr) * | 2001-06-07 | 2002-12-12 | Skinmedica, Inc. | Milieu de culture cellulaire conditionne et utilisations de ce milieu |
| CN1555488A (zh) * | 2001-07-12 | 2004-12-15 | 路德维格癌症研究院 | 淋巴管内皮细胞物质及方法 |
| US7514261B2 (en) * | 2001-08-09 | 2009-04-07 | Cornell Research Foundation, Inc. | Platelet-derived growth factor protection of cardiac myocardium |
| US20040214766A1 (en) * | 2001-10-01 | 2004-10-28 | Kari Alitalo | VEGF-C or VEGF-D materials and methods for treatment of neuropathologies |
| US20030113324A1 (en) | 2001-10-01 | 2003-06-19 | Kari Alitalo | Neuropilin/VEGF-C/VEGFR-3 materials and methods |
| AU2002363369B2 (en) | 2001-10-15 | 2008-08-21 | Janssen Pharmaceutica N.V. | Substituted 4-phenyl-4-(1H-imidazol-2-yl)-piperidine derivatives for reducing ischaemic damage |
| PT1463751E (pt) | 2001-12-21 | 2013-08-26 | Human Genome Sciences Inc | Proteínas de fusão de albumina |
| WO2003104428A2 (fr) | 2002-01-21 | 2003-12-18 | Vaccinex, Inc. | Gene s'exprimant de façon differentielle dans le cancer du sein et de la vessie et polypeptides codes |
| CA2478063A1 (fr) * | 2002-03-07 | 2003-10-02 | Ludwig Institute For Cancer Research | Genes de cellules endotheliales sanguines et lymphatiques |
| US7510714B2 (en) * | 2002-04-01 | 2009-03-31 | Trustees Of Dartmouth College | Methods for modulating angiogenesis |
| US7241446B2 (en) * | 2002-04-01 | 2007-07-10 | Trustees Of Dartmouth College | Methods for modulating angiogenesis via VEGF |
| AU2003228762A1 (en) * | 2002-05-03 | 2003-11-17 | Ludwig Institute For Cancer Research | Preventing secondary lymphedema with vegf-d dna |
| US7479270B2 (en) | 2002-07-23 | 2009-01-20 | Vegenics Limited | Methods and compositions for activating VEGF-D and VEGF-C |
| US20040120950A1 (en) * | 2002-12-20 | 2004-06-24 | Kari Alitalo | Modulation of VEGF-C/VEGFR-3 interactions in the treatment of rheumatoid arthritis |
| EP1594527A2 (fr) * | 2003-02-04 | 2005-11-16 | Ludwig Institute For Cancer Research | Modulation vegf-b et pdgf de cellules souches |
| EP1635860A2 (fr) * | 2003-06-12 | 2006-03-22 | Ludwig Institute For Cancer Research | Utilisation de vegf-c ou de vegf-d en chirurgie reconstructive |
| WO2005016963A2 (fr) * | 2003-06-12 | 2005-02-24 | Ludwig Institute For Cancer Research | Ligands de recepteur 3 du facteur de croissance des cellules endotheliales de liaison a l'heparine |
| US20070110744A1 (en) * | 2003-09-08 | 2007-05-17 | Kari Alitalo | Lymphatic and blood endothelial cell genes |
| US7284505B1 (en) | 2003-11-03 | 2007-10-23 | Paxton Stephen E | Skijor system |
| US7780973B2 (en) * | 2003-12-15 | 2010-08-24 | Ethicon Endo-Surgery, Inc. | Method and device for minimally invasive implantation of biomaterial |
| KR20070006714A (ko) * | 2003-12-29 | 2007-01-11 | 센텔리옹 에스아에스 | 관상 동맥 또는 말초 허혈 치료 |
| US20050142161A1 (en) * | 2003-12-30 | 2005-06-30 | Freeman Lynetta J. | Collagen matrix for soft tissue augmentation |
| WO2005087812A1 (fr) * | 2004-03-05 | 2005-09-22 | Ludwig Institute For Cancer Research | Substances d'anticorps polyvalentes et procedes pour la famille vegf/pdgf des facteurs de croissance |
| WO2005087177A2 (fr) * | 2004-03-05 | 2005-09-22 | Ludwig Institute For Cancer Research | Anticorps chimeriques anti-vegf-d et anticorps humanises anti-vegf-d et leurs procedes d'utilisation |
| WO2005093098A1 (fr) * | 2004-03-12 | 2005-10-06 | Ludwig Institute For Cancer Research | Sensibilité différentielle aux médicaments |
| US7595149B1 (en) | 2004-11-08 | 2009-09-29 | University Of Kentucky Research Foundation | Methods for cancer detection |
| EP1869075B1 (fr) | 2005-02-28 | 2012-04-11 | Sangamo BioSciences, Inc. | Methodes et compostions anti-angiogeniques |
| WO2007022287A2 (fr) | 2005-08-15 | 2007-02-22 | Vegenics Limited | Vegf-a modifié aux propriétés angiogéniques améliorées |
| TW200732347A (en) | 2005-10-06 | 2007-09-01 | Trophogen Inc | VEGF analogs and methods of use |
| ATE476986T1 (de) | 2006-01-18 | 2010-08-15 | Gen Hospital Corp | Verfahren zur steigerung der lymphatischen funktion |
| DK2548578T3 (da) | 2006-05-17 | 2014-10-06 | Ludwig Inst Cancer Res | Målretning af VEGF-B-regulering af fedtsyretransportører til modulering af humane sygdomme |
| EP2125895B1 (fr) | 2007-02-02 | 2015-04-08 | Vegenics Pty Ltd | Antagoniste du recepteur de facteurs de croissance pour l'allo-immunite de greffe d'organe et l'arteriosclerose |
| US20080267924A1 (en) * | 2007-02-07 | 2008-10-30 | Vegenics Limited | Autologous lymph node transfer in combination with vegf-c or vegf-d growth factor therapy to treat secondary lymphedema and to improve reconstructive surgery |
| US7811776B2 (en) | 2007-12-05 | 2010-10-12 | University Of Cincinnati | Use of VEGF-D in the diagnosis of lymphangioleiomyomatosis (LAM) disease |
| JP5690593B2 (ja) | 2007-12-26 | 2015-03-25 | ヴァクシネックス, インコーポレイテッド | 抗c35抗体併用療法および方法 |
| WO2009143584A1 (fr) * | 2008-05-30 | 2009-12-03 | Vegenics Limited | Traitement de l’œdème pulmonaire |
| US20100029491A1 (en) * | 2008-07-11 | 2010-02-04 | Maike Schmidt | Methods and compositions for diagnostic use for tumor treatment |
| US8255807B2 (en) * | 2008-12-23 | 2012-08-28 | Ganz | Item customization and website customization |
| WO2010111746A1 (fr) * | 2009-04-03 | 2010-10-07 | Vegenics Limited | Anticorps anti-vegf-d |
| WO2011056494A1 (fr) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Combinaisons d'antagonistes de la kinase-1 du type récepteur de l'activine et d'antagonistes vegfr3 |
| WO2011106697A1 (fr) | 2010-02-25 | 2011-09-01 | Schepens Eye Research Institute | Compositions thérapeutiques pour le traitement de la maladie de l'œil sec |
| WO2011154308A1 (fr) | 2010-06-08 | 2011-12-15 | Proyecto De Biomedicina Cima, S.L. | Nouvelles compositions et procédés de thérapie cellulaire dans le traitement de la cirrhose |
| WO2012088563A1 (fr) * | 2010-11-24 | 2012-07-05 | Vegenics Pty Limited | Formes spécifiques du vegfr-2 de vegf-d et vegf-c et utilisations associées |
| WO2012154983A2 (fr) | 2011-05-10 | 2012-11-15 | Biocare Medical, Llc | Systèmes et procédés pour des anticorps anti-pax8 |
| US9415090B2 (en) * | 2011-06-01 | 2016-08-16 | Universität Heidelberg | VEGF-D/VEGFR2/3-mediated regulation of dendrites |
| US10316103B1 (en) | 2012-03-30 | 2019-06-11 | Biocare Medical, Llc | Systems and methods for anti-Uroplakin III antibodies |
| US10457713B2 (en) | 2012-07-30 | 2019-10-29 | Trophogen, Inc. | Glycoprotein hormone long-acting superagonists |
| EP3572515B1 (fr) | 2012-07-30 | 2021-07-21 | Trophogen Inc. | Superagonistes à action de longue durée des hormones glycoprotéines |
| ES2682345T3 (es) | 2012-09-27 | 2018-09-20 | Biocare Medical, Llc | Sistemas y procedimientos de anticuerpos antiuroplaquina II |
| WO2014100220A2 (fr) | 2012-12-18 | 2014-06-26 | Biocare Medical, Llc | Systèmes de cocktail d'anticorps et procédés de classification de sous-types histologiques dans le cancer du poumon |
| MY199344A (en) | 2013-02-18 | 2023-10-24 | Vegenics Pty Ltd | Ligand binding molecules and uses thereof |
| EP2962113B1 (fr) | 2013-02-28 | 2019-04-03 | Biocare Medical, LLC | Anticorps anti-p40, systèmes et procédés |
| ES2765423T3 (es) | 2013-10-03 | 2020-06-09 | Biocare Medical Llc | Sistemas y procedimientos de anticuerpos anti-SOX10 |
| CN105873602A (zh) | 2013-11-05 | 2016-08-17 | 特洛佛根股份有限公司 | 糖蛋白激素长效超激动剂 |
| EP3924367A4 (fr) * | 2019-04-04 | 2022-10-12 | Sree Chitra Tirunal Institute for Medical Sciences and Technology | Facteur de croissance endothélial vasculaire (vegf) pour une meilleure cicatrisation de plaie par angiogenèse améliorée |
| US20240150807A1 (en) * | 2021-03-10 | 2024-05-09 | Sumitomo Pharma Co., Ltd. | Method for Producing Cysteine Knot Protein |
| WO2024259161A2 (fr) * | 2023-06-14 | 2024-12-19 | Yale University | Procédés et compositions pour le traitement de troubles de la respiration |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995024473A1 (fr) * | 1994-03-08 | 1995-09-14 | Human Genome Sciences, Inc. | Facteur 2 de croissance endotheliale vasculaire |
| WO1997012972A2 (fr) * | 1995-09-29 | 1997-04-10 | Universita'degli Studi Di Siena | Genes regules et leurs utilisations |
| WO1998002543A1 (fr) * | 1996-07-15 | 1998-01-22 | Chugai Research Institute For Molecular Medicine, Inc. | Nouveaux facteurs analogues au vegf |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968778A (en) | 1989-01-12 | 1999-10-19 | Jurgen Hoppe | PDGF-AB, preparation process and pharmaceuticals containing them |
| US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US6207454B1 (en) * | 1989-10-16 | 2001-03-27 | Amgen Inc. | Method for enhancing the effciency of gene transfer with stem cell factor (SCF) polypeptide |
| US5476839A (en) * | 1990-07-10 | 1995-12-19 | Incyte Pharmaceuticals, Inc. | Basophil granule proteins |
| JP3024311B2 (ja) | 1991-10-03 | 2000-03-21 | 味の素株式会社 | Il−2受容体重鎖に結合するポリペプチド |
| JPH05271294A (ja) | 1992-01-24 | 1993-10-19 | Japan Found Cancer Res | ヒトプロヒビチンおよびそれをコードするdna |
| ATE157672T1 (de) | 1992-07-27 | 1997-09-15 | Pfizer | Calcium-kanal blockierende polypeptide aus agelenopsis aperta |
| US5510239A (en) * | 1993-10-18 | 1996-04-23 | Isis Pharmaceuticals, Inc. | Oligonucleotide modulation of multidrug resistance-associated protein |
| DE4423098A1 (de) | 1994-07-01 | 1996-01-04 | Hoechst Ag | Verwendung von Pyrimidingruppen enthaltenden konjugierten Verbindungen als Elektrolumineszenzmaterialien |
| US5814464A (en) | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
| US6221839B1 (en) * | 1994-11-14 | 2001-04-24 | Helsinki University Licensing Ltd. Oy | FIt4 ligand and methods of use |
| US6645933B1 (en) * | 1995-08-01 | 2003-11-11 | Helsinki University Licensing Ltd. Oy | Receptor ligand VEGF-C |
| JPH08185216A (ja) | 1994-12-28 | 1996-07-16 | Meidensha Corp | 工具姿勢パラメータ設定方法及びロボット制御装置 |
| US5928939A (en) | 1995-03-01 | 1999-07-27 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-b and dna coding therefor |
| JPH11500139A (ja) | 1995-03-02 | 1999-01-06 | アムラド・オペレイションズ・プロプライエタリー・リミテッド | 新規成長因子およびそれをコードする遺伝子配列 |
| EP0873348A4 (fr) | 1995-06-06 | 2000-11-08 | Human Genome Sciences Inc | Facteur de croissance 3 de l'endothelium vasculaire humain |
| ES2202469T5 (es) * | 1995-09-08 | 2011-06-06 | Genentech, Inc. | Proteína relacionada con el vegf. |
| JP3843488B2 (ja) | 1996-06-06 | 2006-11-08 | アイシン・エィ・ダブリュ株式会社 | 自動変速機の制御装置 |
| CA2263890C (fr) | 1996-08-23 | 2013-05-14 | Ludwig Institute For Cancer Research | Facteur d recombinant de croissance des cellules endotheliales vasculaires (vegf-d) |
| WO1998024811A2 (fr) | 1996-12-06 | 1998-06-11 | Zymogenetics, Inc. | Facteur de croissance endotheliale vasculaire |
| US20020165174A1 (en) * | 1997-01-31 | 2002-11-07 | Gill Parkash S. | Methods and compositions for antisense VEGF oligonucleotides |
| KR100628697B1 (ko) | 1997-12-24 | 2006-09-28 | 루드빅 인스티튜트 포 캔서 리서치 | 맥관 내피 성장인자 d를 발현하는 발현 벡터와 셀라인,및 흑색종을 치료하는 방법 |
| DE19817835C2 (de) | 1998-04-22 | 2000-05-18 | Billhofer Maschf Gmbh | Sichtkaschiervorrichtung |
| DE19823359C1 (de) | 1998-05-15 | 1999-10-07 | Francotyp Postalia Gmbh | Vorrichtung zum Bedrucken von Postgut |
| CA2355896A1 (fr) | 1998-12-21 | 2000-06-29 | Ludwig Institute For Cancer Research | Anticorps antifacteur de croissance endotheliale vasculaire tronque et leur utilisation |
| WO2001012669A1 (fr) * | 1999-08-16 | 2001-02-22 | Universita' Degli Studi Di Siena | Vegf-d et utilisation angiogenique de celui-ci |
| EP1635860A2 (fr) | 2003-06-12 | 2006-03-22 | Ludwig Institute For Cancer Research | Utilisation de vegf-c ou de vegf-d en chirurgie reconstructive |
| US20070212390A1 (en) | 2005-09-22 | 2007-09-13 | Ludwig Institute For Cancer Research | Protease-resistant forms of VEGF-D, method of making and method of use |
| FR2987282B1 (fr) | 2012-02-24 | 2017-12-29 | Fonds De L'espci Georges Charpak | Microcanal avec dispositif d'ouverture et/ou fermeture et/ou pompage |
| US9405291B2 (en) | 2012-07-31 | 2016-08-02 | Fisher-Rosemount Systems, Inc. | Systems and methods to monitor an asset in an operating process unit |
| US9516755B2 (en) | 2012-12-28 | 2016-12-06 | Intel Corporation | Multi-channel memory module |
| US9426605B2 (en) | 2013-10-10 | 2016-08-23 | Yahoo! Inc. | Cross device information exchange using gestures and locations |
-
1997
- 1997-08-21 CA CA2263890A patent/CA2263890C/fr not_active Expired - Fee Related
- 1997-08-21 ES ES09162873T patent/ES2390107T3/es not_active Expired - Lifetime
- 1997-08-21 DK DK06121918T patent/DK1749836T3/da active
- 1997-08-21 EP EP06121918A patent/EP1749836B1/fr not_active Expired - Lifetime
- 1997-08-21 AU AU40796/97A patent/AU729880C/en not_active Ceased
- 1997-08-21 AT AT97938486T patent/ATE306546T1/de not_active IP Right Cessation
- 1997-08-21 EP EP97938486A patent/EP0956339B1/fr not_active Revoked
- 1997-08-21 EP EP09162873A patent/EP2107109B1/fr not_active Expired - Lifetime
- 1997-08-21 US US08/915,795 patent/US6235713B1/en not_active Expired - Fee Related
- 1997-08-21 AT AT06121918T patent/ATE434034T1/de not_active IP Right Cessation
- 1997-08-21 DE DE69734359T patent/DE69734359T2/de not_active Expired - Lifetime
- 1997-08-21 EP EP02018842A patent/EP1283268A3/fr not_active Withdrawn
- 1997-08-21 DK DK09162873.5T patent/DK2107109T3/da active
- 1997-08-21 DK DK97938486T patent/DK0956339T3/da active
- 1997-08-21 WO PCT/US1997/014696 patent/WO1998007832A1/fr not_active Ceased
- 1997-08-21 JP JP51095398A patent/JP2001517075A/ja active Pending
- 1997-08-21 ES ES06121918T patent/ES2327440T3/es not_active Expired - Lifetime
- 1997-08-21 ES ES97938486T patent/ES2251740T3/es not_active Expired - Lifetime
- 1997-08-21 DE DE69739469T patent/DE69739469D1/de not_active Expired - Lifetime
-
1999
- 1999-04-22 US US09/296,275 patent/US6689580B1/en not_active Expired - Fee Related
-
2002
- 2002-06-05 US US10/161,694 patent/US7410639B2/en not_active Expired - Fee Related
- 2002-10-22 US US10/274,953 patent/US7122654B2/en not_active Expired - Fee Related
-
2003
- 2003-11-12 US US10/705,476 patent/US20040175730A1/en not_active Abandoned
-
2005
- 2005-12-16 US US11/304,585 patent/US20060177428A1/en not_active Abandoned
-
2007
- 2007-01-24 JP JP2007013569A patent/JP2007167072A/ja active Pending
- 2007-03-28 US US11/692,753 patent/US20080145366A1/en not_active Abandoned
- 2007-06-29 US US11/772,089 patent/US7662932B2/en not_active Expired - Fee Related
- 2007-08-23 US US11/843,867 patent/US7871798B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/929,537 patent/US7785803B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/929,120 patent/US7928061B2/en not_active Expired - Fee Related
-
2009
- 2009-07-10 JP JP2009164162A patent/JP2009291198A/ja active Pending
-
2011
- 2011-03-16 US US13/049,308 patent/US8227410B2/en not_active Expired - Fee Related
-
2012
- 2012-05-17 US US13/474,273 patent/US8445234B2/en not_active Expired - Fee Related
-
2013
- 2013-04-19 US US13/866,266 patent/US8759286B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995024473A1 (fr) * | 1994-03-08 | 1995-09-14 | Human Genome Sciences, Inc. | Facteur 2 de croissance endotheliale vasculaire |
| WO1997012972A2 (fr) * | 1995-09-29 | 1997-04-10 | Universita'degli Studi Di Siena | Genes regules et leurs utilisations |
| WO1998002543A1 (fr) * | 1996-07-15 | 1998-01-22 | Chugai Research Institute For Molecular Medicine, Inc. | Nouveaux facteurs analogues au vegf |
Non-Patent Citations (1)
| Title |
|---|
| ORLANDINI M ET AL: "IDENTIFICATION OF A C-FOS INDUCED GENE THAT IS RELATED TO THE PLATELET-DERIVED GROWTH FACTOR/VASCULAR ENDOTHELIAL GROWTH FACTOR FAMILY", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 93, no. 21, 15 October 1996 (1996-10-15), pages 11675 - 11680, XP002029340, ISSN: 0027-8424 * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1283268A3 (fr) | Facteur recombinant de croissance de cellules vascularies endothéliales D (VEGF-D) | |
| EP2151454A3 (fr) | Facteur de croissance D d'origine plaquettaire, l'ADN codant pour celui-ci et ses utilisations | |
| CA2095153A1 (fr) | Modification genetique de cellules endotheliales | |
| ATE110108T1 (de) | Genetische modifizierung von endothelialen zellen. | |
| EP1308515A3 (fr) | Facteur VIII porcin | |
| EP0897987A3 (fr) | Sécretion de protéine humaine associée au peptide-signal de l' interferon gamma | |
| AU1096595A (en) | Thrombin mutants | |
| ZA943464B (en) | Vascular endothelial growth factor 2 | |
| HU9402143D0 (en) | Dna sequences encoding novel growth/differentiation factors | |
| WO1995005452A3 (fr) | Compositions et procedes ameliores pour l'administration de molecuiles a activite biologique a l'aide de cellules modifiees genetiquement comprises dans des capsules biocompatibles immuno-isolatrices | |
| CA2005016A1 (fr) | Fragment d'adn contenant un promoteur de site de l'elongation de la chaine de polypeptide humaine de facteur-1.alpha. et plamisde d'expression contenant ce fragment d'adn | |
| PT93910A (pt) | Prodesso para a preparacao de uma proteina heterologa mediante secrecao a partir de uma celula | |
| EP0266190A3 (en) | Expression of protein c | |
| AU2001254624A1 (en) | Human coagulation factor vii variants | |
| AU3192889A (en) | T cell activation markers | |
| IL70776A (en) | Recombinant dna molecule encoding at least one polypeptide displaying the immunogenicity of at least one merozoite antigen or asexual blood stage antigen of p.falciparum,vectors comprising the dna molecule,host cells transformed thereby,immunogenic polypeptides produced by host cells and compositions containing the polypeptides | |
| AU3498189A (en) | Fibronectin binding protein | |
| AU7869487A (en) | Expression of biologically active factor XIII | |
| WO2001025438A3 (fr) | Homologues d'interferons alpha | |
| EP0290948A3 (fr) | Oncostatin M et nouvelles compositions ayant une activité anti-néoplastiquée | |
| EP1080724A4 (fr) | Compositions destinees a diminuer l'activite mtp | |
| IL129139A0 (en) | Vertebrate smoothened proteins | |
| WO2001040257A3 (fr) | Polypeptides cytokines et acides nucleiques | |
| WO2001053324A3 (fr) | Nouveaux peptides haptotactiques | |
| WO2001025437A3 (fr) | Polypeptides agissant comme facteur de croissance et acides nucleiques codant pour ces derniers |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| AC | Divisional application: reference to earlier application |
Ref document number: 0956339 Country of ref document: EP Kind code of ref document: P Ref document number: 1283268 Country of ref document: EP Kind code of ref document: P |
|
| AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| 17P | Request for examination filed |
Effective date: 20070404 |
|
| PUAL | Search report despatched |
Free format text: ORIGINAL CODE: 0009013 |
|
| AK | Designated contracting states |
Kind code of ref document: A3 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07K 14/49 20060101ALI20070718BHEP Ipc: C07K 1/14 20060101ALI20070718BHEP Ipc: C12N 15/18 20060101ALI20070718BHEP Ipc: C12N 5/10 20060101ALI20070718BHEP Ipc: C12N 1/21 20060101AFI20070718BHEP Ipc: C07K 14/475 20060101ALI20070718BHEP Ipc: C07K 14/52 20060101ALI20070718BHEP Ipc: C12N 15/63 20060101ALI20070718BHEP |
|
| AKX | Designation fees paid |
Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| 17Q | First examination report despatched |
Effective date: 20080407 |
|
| RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: VEGENICS LIMITED |
|
| GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
| GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
| GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
| AC | Divisional application: reference to earlier application |
Ref document number: 1283268 Country of ref document: EP Kind code of ref document: P Ref document number: 0956339 Country of ref document: EP Kind code of ref document: P |
|
| AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
| REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D |
|
| REF | Corresponds to: |
Ref document number: 69739469 Country of ref document: DE Date of ref document: 20090730 Kind code of ref document: P |
|
| REG | Reference to a national code |
Ref country code: DK Ref legal event code: T3 |
|
| REG | Reference to a national code |
Ref country code: SE Ref legal event code: TRGR |
|
| REG | Reference to a national code |
Ref country code: ES Ref legal event code: FG2A Ref document number: 2327440 Country of ref document: ES Kind code of ref document: T3 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: AT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20090617 |
|
| NLV1 | Nl: lapsed or annulled due to failure to fulfill the requirements of art. 29p and 29m of the patents act | ||
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: BE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20090617 Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20090617 |
|
| PLBI | Opposition filed |
Free format text: ORIGINAL CODE: 0009260 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091017 Ref country code: MC Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20090831 |
|
| 26 | Opposition filed |
Opponent name: CHUGAI SEIYAKU KABUSHIKI KAISHA Effective date: 20100317 |
|
| PLAX | Notice of opposition and request to file observation + time limit sent |
Free format text: ORIGINAL CODE: EPIDOSNOBS2 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20090918 |
|
| PLAF | Information modified related to communication of a notice of opposition and request to file observations + time limit |
Free format text: ORIGINAL CODE: EPIDOSCOBS2 |
|
| PLAF | Information modified related to communication of a notice of opposition and request to file observations + time limit |
Free format text: ORIGINAL CODE: EPIDOSCOBS2 |
|
| PLBP | Opposition withdrawn |
Free format text: ORIGINAL CODE: 0009264 |
|
| PLBB | Reply of patent proprietor to notice(s) of opposition received |
Free format text: ORIGINAL CODE: EPIDOSNOBS3 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20090617 |
|
| PLBD | Termination of opposition procedure: decision despatched |
Free format text: ORIGINAL CODE: EPIDOSNOPC1 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20090821 |
|
| PLBM | Termination of opposition procedure: date of legal effect published |
Free format text: ORIGINAL CODE: 0009276 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: OPPOSITION PROCEDURE CLOSED |
|
| 27C | Opposition proceedings terminated |
Effective date: 20110506 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 20130823 Year of fee payment: 17 Ref country code: IE Payment date: 20130819 Year of fee payment: 17 Ref country code: CH Payment date: 20130826 Year of fee payment: 17 Ref country code: SE Payment date: 20130822 Year of fee payment: 17 Ref country code: DK Payment date: 20130819 Year of fee payment: 17 Ref country code: ES Payment date: 20130828 Year of fee payment: 17 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GB Payment date: 20130823 Year of fee payment: 17 Ref country code: FR Payment date: 20130820 Year of fee payment: 17 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: IT Payment date: 20130823 Year of fee payment: 17 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 69739469 Country of ref document: DE |
|
| REG | Reference to a national code |
Ref country code: DK Ref legal event code: EBP Effective date: 20140831 |
|
| REG | Reference to a national code |
Ref country code: SE Ref legal event code: EUG Ref country code: CH Ref legal event code: PL |
|
| GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20140821 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20140831 Ref country code: IT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20140821 Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20140831 |
|
| REG | Reference to a national code |
Ref country code: IE Ref legal event code: MM4A |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 69739469 Country of ref document: DE Effective date: 20150303 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20140822 |
|
| REG | Reference to a national code |
Ref country code: FR Ref legal event code: ST Effective date: 20150430 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: DK Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20140831 Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20150303 Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20140821 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20140901 Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20140821 |
|
| REG | Reference to a national code |
Ref country code: ES Ref legal event code: FD2A Effective date: 20150925 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: ES Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20140822 |