EP1883697A4 - Polypeptides et voies de synthese biologique destines a produire des stereoisomeres de monatine et leurs precurseurs - Google Patents

Polypeptides et voies de synthese biologique destines a produire des stereoisomeres de monatine et leurs precurseurs

Info

Publication number: EP1883697A4
Authority: EP; European Patent Office
Prior art keywords: monatin; stereoisomers; polypeptides; precursors; production
Prior art date: 2005-04-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP06751574A

Other languages

German (de)

English (en)

Other versions

EP1883697A2 (fr

Inventor

Brian J Brazeau

Ellen Burke

Souza Mervyn De

Steven J Gort

Paula M Hicks

Sherry R Kollman

Peter Luginbuhl

Sara C Mcfarlan

Toby Richardson

Fernando A Sanchez-Riera

Christopher Solheid

David Weiner

Lishan Zhao

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Cargill Inc

Original Assignee

Cargill Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-04-26

Filing date

2006-04-26

Publication date

2010-05-05

2006-04-26 Application filed by Cargill Inc filed Critical Cargill Inc

2006-04-26 Priority to EP16001105.2A priority Critical patent/EP3168299A3/fr

2006-04-26 Priority to EP11000670.7A priority patent/EP2361976B1/fr

2008-02-06 Publication of EP1883697A2 publication Critical patent/EP1883697A2/fr

2010-05-05 Publication of EP1883697A4 publication Critical patent/EP1883697A4/fr

Status Withdrawn legal-status Critical Current

Links

RMLYXMMBIZLGAQ-UHFFFAOYSA-N (-)-monatin Natural products C1=CC=C2C(CC(O)(CC(N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-UHFFFAOYSA-N 0.000 title 1
RMLYXMMBIZLGAQ-HZMBPMFUSA-N (2s,4s)-4-amino-2-hydroxy-2-(1h-indol-3-ylmethyl)pentanedioic acid Chemical compound C1=CC=C2C(C[C@](O)(C[C@H](N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-HZMBPMFUSA-N 0.000 title 1
230000006696 biosynthetic metabolic pathway Effects 0.000 title 1
229920001184 polypeptide Polymers 0.000 title 1
239000002243 precursor Substances 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Indole Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

EP06751574A 2005-04-26 2006-04-26 Polypeptides et voies de synthese biologique destines a produire des stereoisomeres de monatine et leurs precurseurs Withdrawn EP1883697A4 (fr)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
EP16001105.2A EP3168299A3 (fr)	2005-04-26	2006-04-26	Polypeptides et voies biosynthetiques pour la production de stereoisomeres de monatine et leurs precurseurs
EP11000670.7A EP2361976B1 (fr)	2005-04-26	2006-04-26	Polypeptides et voies biosynthétiques pour la production de stéréoisomères de monatine et leurs précurseurs

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US67493205P	2005-04-26	2005-04-26
PCT/US2006/015930 WO2007133184A2 (fr)	2005-04-26	2006-04-26	Polypeptides et voies de synthèse biologique destinés à produire des stéréoisomères de monatine et leurs précurseurs

Related Child Applications (2)

Application Number	Title	Priority Date	Filing Date
EP11000670.7A Division EP2361976B1 (fr)	2005-04-26	2006-04-26	Polypeptides et voies biosynthétiques pour la production de stéréoisomères de monatine et leurs précurseurs
EP16001105.2A Division EP3168299A3 (fr)	2005-04-26	2006-04-26	Polypeptides et voies biosynthetiques pour la production de stereoisomeres de monatine et leurs precurseurs

Publications (2)

Publication Number	Publication Date
EP1883697A2 EP1883697A2 (fr)	2008-02-06
EP1883697A4 true EP1883697A4 (fr)	2010-05-05

Family

ID=38694337

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
EP11000670.7A Expired - Lifetime EP2361976B1 (fr)	2005-04-26	2006-04-26	Polypeptides et voies biosynthétiques pour la production de stéréoisomères de monatine et leurs précurseurs
EP16001105.2A Withdrawn EP3168299A3 (fr)	2005-04-26	2006-04-26	Polypeptides et voies biosynthetiques pour la production de stereoisomeres de monatine et leurs precurseurs
EP06751574A Withdrawn EP1883697A4 (fr)	2005-04-26	2006-04-26	Polypeptides et voies de synthese biologique destines a produire des stereoisomeres de monatine et leurs precurseurs

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
EP11000670.7A Expired - Lifetime EP2361976B1 (fr)	2005-04-26	2006-04-26	Polypeptides et voies biosynthétiques pour la production de stéréoisomères de monatine et leurs précurseurs
EP16001105.2A Withdrawn EP3168299A3 (fr)	2005-04-26	2006-04-26	Polypeptides et voies biosynthetiques pour la production de stereoisomeres de monatine et leurs precurseurs

Country Status (8)

Country	Link
EP (3)	EP2361976B1 (fr)
JP (1)	JP5336182B2 (fr)
CN (1)	CN101365787B (fr)
AU (1)	AU2006341528A1 (fr)
BR (1)	BRPI0609876A2 (fr)
CA (1)	CA2638896C (fr)
ES (1)	ES2587572T3 (fr)
WO (1)	WO2007133184A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8372989B2 (en)	2002-04-23	2013-02-12	Cargill, Incorporated	Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US7572607B2 (en)	2002-04-23	2009-08-11	Cargill, Incorporated	Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US7582455B2 (en) *	2005-04-26	2009-09-01	Cargill, Incorporated	Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
MX2008011477A (es)	2006-03-07	2008-09-23	Cargill Inc	Aldolasas, acidos nucleicos que las codifican y metodos para hacerlas y usarlas.
WO2007140195A2 (fr)	2006-05-24	2007-12-06	Cargill, Incorporated	Procédés et systèmes permettant d'augmenter la production de réactions d'équilibre
US8076107B2 (en) *	2007-10-01	2011-12-13	Cargill, Incorporated	Production of monatin stereoisomers
US8367847B2 (en)	2007-10-01	2013-02-05	Cargill, Incorporated	Production of monatin enantiomers
US8003361B2 (en)	2007-10-01	2011-08-23	Cargill Incorporated	Production of monatin enantiomers
EP2479272A4 (fr)	2010-10-14	2013-11-20	Ajinomoto Kk	Procédé de production de monatine
US8771997B2 (en)	2011-04-20	2014-07-08	Ajinomoto Co., Inc.	Method for producing monatin using an L-amino acid aminotransferase
WO2012147674A1 (fr) *	2011-04-25	2012-11-01	味の素株式会社	Procédé de production de monatine
AU2012273271A1 (en)	2011-06-24	2013-11-14	Merck Sharp & Dohme Corp.	Immobilized transaminases and process for making and using immobilized transaminase
WO2013073679A1 (fr) *	2011-11-17	2013-05-23	味の素株式会社	Procédé de production de cristaux de sel métallique polyvalent de (2r,4r)-monatine
CN105073983B (zh)	2013-02-28	2018-09-18	默沙东公司	固定化转氨酶和制备及使用固定化转氨酶的方法
WO2014150633A1 (fr)	2013-03-15	2014-09-25	Merck Sharp & Dohme Corp.	Cétoréductases immobilisées et procédé de fabrication et d'utilisation de cétoréductase immobilisée
WO2024233705A2 (fr) *	2023-05-08	2024-11-14	Lygos, Inc.	Cellule hôte recombinante pour produire de l'aspartate
CN118109531A (zh) *	2023-07-26	2024-05-31	安阳尼采启合生物科技有限公司	一种利用酶催化体外合成吲哚-3-丙酮酸的方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003091396A2 (fr) *	2002-04-23	2003-11-06	Cargill, Incorporated	Polypeptides et voies de biosynthese
JP2004222657A (ja) *	2003-01-24	2004-08-12	Ajinomoto Co Inc	２ｒ−モナティンの製造方法
WO2005001105A1 (fr) *	2003-06-26	2005-01-06	Ajinomoto Co., Inc.	Procede de production de monatine
WO2005016022A1 (fr) *	2003-08-14	2005-02-24	Cargill, Incorporated	Compositions de gomme a macher contenant de la monatine et procedes de preparation associes
WO2005020721A1 (fr) *	2003-08-25	2005-03-10	Cargill, Incorporated	Compositions de boisson comprenant de la monatine et procedes de production associes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE104961T1 (de)	1990-01-19	1994-05-15	Technology Finance Corp	Verfahren zur herstellung von 3-(1-amino-1,3dicarboxy-3-hydroxy-but-4-yl)-indol.
US5728555A (en)	1996-09-30	1998-03-17	Monsanto Company	Preparation of d-amino acids by direct fermentative means
WO2000067796A1 (fr)	1999-05-07	2000-11-16	Genentech, Inc.	Traitement de maladies auto-immunes au moyen d'antagonistes se liant aux marqueurs de surface de lymphocytes b
JP2002060382A (ja) *	2000-08-22	2002-02-26	Ajinomoto Co Inc	モナティンの立体異性体及びその使用、並びにモナティン類の製造方法及びそのための中間体
JP2003171365A (ja) *	2001-11-30	2003-06-20	Ajinomoto Co Inc	モナティン類及びその製造中間体の製造方法並びに新規中間体
CN100549182C (zh) *	2001-12-27	2009-10-14	味之素株式会社	谷氨酸衍生物的制备方法
JP2003292484A (ja) *	2002-04-01	2003-10-15	Ajinomoto Co Inc	γ−ヒドロキシアミノ酸誘導体及びモナティン類の製造方法
US7572607B2 (en)	2002-04-23	2009-08-11	Cargill, Incorporated	Polypeptides and biosynthetic pathways for the production of monatin and its precursors
EP1678313B1 (fr) *	2003-10-21	2011-02-16	Cargill, Incorporated	Production de monatine et de precurseurs de la monatine
US7582455B2 (en) *	2005-04-26	2009-09-01	Cargill, Incorporated	Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors

2006
- 2006-04-26 EP EP11000670.7A patent/EP2361976B1/fr not_active Expired - Lifetime
- 2006-04-26 JP JP2008515698A patent/JP5336182B2/ja not_active Expired - Fee Related
- 2006-04-26 CN CN200680022628.5A patent/CN101365787B/zh not_active Expired - Fee Related
- 2006-04-26 BR BRPI0609876-2A patent/BRPI0609876A2/pt not_active Application Discontinuation
- 2006-04-26 CA CA2638896A patent/CA2638896C/fr not_active Expired - Fee Related
- 2006-04-26 EP EP16001105.2A patent/EP3168299A3/fr not_active Withdrawn
- 2006-04-26 EP EP06751574A patent/EP1883697A4/fr not_active Withdrawn
- 2006-04-26 AU AU2006341528A patent/AU2006341528A1/en not_active Abandoned
- 2006-04-26 ES ES11000670.7T patent/ES2587572T3/es not_active Expired - Lifetime
- 2006-04-26 WO PCT/US2006/015930 patent/WO2007133184A2/fr not_active Ceased

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003091396A2 (fr) *	2002-04-23	2003-11-06	Cargill, Incorporated	Polypeptides et voies de biosynthese
JP2004222657A (ja) *	2003-01-24	2004-08-12	Ajinomoto Co Inc	２ｒ−モナティンの製造方法
WO2005001105A1 (fr) *	2003-06-26	2005-01-06	Ajinomoto Co., Inc.	Procede de production de monatine
US20060154343A1 (en) *	2003-06-26	2006-07-13	Ajinomoto Co., Inc.	Method for producing monatin
WO2005016022A1 (fr) *	2003-08-14	2005-02-24	Cargill, Incorporated	Compositions de gomme a macher contenant de la monatine et procedes de preparation associes
WO2005020721A1 (fr) *	2003-08-25	2005-03-10	Cargill, Incorporated	Compositions de boisson comprenant de la monatine et procedes de production associes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"EC 2.6.1.27 - tryptophan transaminase", BRENDA THE COMPREHENSIVE ENZYME INFORMATION SYSTEM, 2009, XP002526345, Retrieved from the Internet <URL:http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.27> [retrieved on 20090429] *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 12 August 2004 (2004-08-12), SUGIYAMA, MASAKAZU ET AL: "2R-monatin manufacture by enzymic resolution", XP002526346, retrieved from STN Database accession no. 141:172983 *
KOSHIBA T ET AL: "L- AND D-TRYPTOPHAN AMINOTRANSFERASES FROM MAIZE COLEOPTILES", JOURNAL OF PLANT RESEARCH, TOKYO, JP, vol. 106, no. 1081, 1 January 1993 (1993-01-01), pages 25 - 29, XP008020474, ISSN: 0918-9440 *

Also Published As

Publication number	Publication date
AU2006341528A8 (en)	2009-01-08
WO2007133184A2 (fr)	2007-11-22
JP2008538932A (ja)	2008-11-13
AU2006341528A1 (en)	2007-12-06
ES2587572T3 (es)	2016-10-25
EP3168299A2 (fr)	2017-05-17
EP1883697A2 (fr)	2008-02-06
EP2361976B1 (fr)	2016-05-25
WO2007133184A3 (fr)	2008-08-28
CN101365787A (zh)	2009-02-11
CA2638896C (fr)	2015-01-27
CN101365787B (zh)	2014-03-05
CA2638896A1 (fr)	2007-11-22
EP2361976A2 (fr)	2011-08-31
EP3168299A3 (fr)	2017-07-05
JP5336182B2 (ja)	2013-11-06
EP2361976A3 (fr)	2012-08-01
BRPI0609876A2 (pt)	2010-05-11

Legal Events

Date	Code	Title	Description
2008-01-04	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2008-02-06	17P	Request for examination filed	Effective date: 20071115
2008-02-06	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
2008-02-06	AX	Request for extension of the european patent	Extension state: AL BA HR MK YU
2008-02-27	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: CARGILL, INCORPORATED
2008-02-27	RIC1	Information provided on ipc code assigned before grant	Ipc: H04L 9/00 20060101AFI20080121BHEP
2008-02-27	RIN1	Information on inventor provided before grant (corrected)	Inventor name: ZHAO, LISHAN Inventor name: WEINER, DAVID Inventor name: SOLHEID, CHRISTOPHER Inventor name: SANCHEZ-RIERA, FERNANDO A. Inventor name: RICHARDSON, TOBY Inventor name: MCFARLAN, SARA, C. Inventor name: LUGINBUHL,PETER Inventor name: KOLLMAN, SHERRY R. Inventor name: HICKS, PAULA M. Inventor name: GORT, STEVEN J. Inventor name: DE SOUZA, MERVYN Inventor name: BURKE, ELLEN Inventor name: BRAZEAU, BRIAN J.
2008-04-16	RIN1	Information on inventor provided before grant (corrected)	Inventor name: ZHAO, LISHAN Inventor name: WEINER, DAVID Inventor name: SOLHEID, CHRISTOPHER Inventor name: SANCHEZ-RIERA, FERNANDO A. Inventor name: RICHARDSON, TOBY Inventor name: MCFARLAN, SARA, C. Inventor name: LUGINBUHL,PETER Inventor name: KOLLMAN, SHERRY R. Inventor name: HICKS, PAULA M. Inventor name: GORT, STEVEN J. Inventor name: DE SOUZA, MERVYN Inventor name: BURKE, ELLEN Inventor name: BRAZEAU, BRIAN J.
2008-07-02	RIC1	Information provided on ipc code assigned before grant	Ipc: C12N 9/10 20060101AFI20080529BHEP
2008-07-30	DAX	Request for extension of the european patent (deleted)
2008-10-08	R17D	Deferred search report published (corrected)	Effective date: 20080828
2008-10-08	RIC1	Information provided on ipc code assigned before grant	Ipc: C12N 1/21 20060101ALI20080904BHEP Ipc: C12P 13/22 20060101ALI20080904BHEP Ipc: C12N 9/10 20060101AFI20080904BHEP
2010-05-05	A4	Supplementary search report drawn up and despatched	Effective date: 20100401
2010-05-05	RIC1	Information provided on ipc code assigned before grant	Ipc: C07H 21/04 20060101ALI20100326BHEP Ipc: C12P 13/22 20060101ALI20100326BHEP Ipc: C12N 9/10 20060101AFI20080904BHEP
2010-08-04	RIN1	Information on inventor provided before grant (corrected)	Inventor name: ZHAO, LISHAN Inventor name: WEINER, DAVID Inventor name: SOLHEID, CHRISTOPHER Inventor name: SANCHEZ-RIERA, FERNANDO A. Inventor name: RICHARDSON, TOBY Inventor name: MCFARLAN, SARA, C. Inventor name: LUGINBUHL, PETER Inventor name: KOLLMAN, SHERRY R. Inventor name: HICKS, PAULA M. Inventor name: GORT, STEVEN J. Inventor name: DE SOUZA, MERVYN Inventor name: BURKE, ELLEN Inventor name: BRAZEAU, BRIAN J.
2010-08-25	17Q	First examination report despatched	Effective date: 20100722
2011-06-24	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2011-07-27	18D	Application deemed to be withdrawn	Effective date: 20110202

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