Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
  • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
  • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
  • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
  • B65D81/3205—Separate rigid or semi-rigid containers joined to each other at their external surfaces
  • B65D81/3211—Separate rigid or semi-rigid containers joined to each other at their external surfaces coaxially and provided with means facilitating admixture
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
  • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
  • A61J1/14—Details; Accessories therefor
  • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
  • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
  • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
  • A61J1/14—Details; Accessories therefor
  • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
  • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
  • A61J1/202—Separating means
  • A61J1/2044—Separating means having slits
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
  • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
  • A61J1/14—Details; Accessories therefor
  • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
  • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
  • A61J1/2048—Connecting means
  • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
  • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
  • A61J1/14—Details; Accessories therefor
  • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
  • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
  • A61J1/2048—Connecting means
  • A61J1/2055—Connecting means having gripping means

Definitions

• the invention relates to a socket intended for the extemporaneous preparation of a suspension or of a solution formed by a mixture of a first product and a second product, allowing the placing in communication of a first bottle containing initially the first product and a second bottle initially containing the second product.
• the invention also relates to a packaging comprising such a socket and a kit comprising such a socket.
• the present invention relates to improvements in packaging assemblies for the extemporaneous preparation of suspensions or solutions of an active product.
• Figures 1 and 2 show a known set of the state of the art.
• Such a set consists of two main parts.
• the set comprises two hermetic bottles A and B.
• the first of these bottles A is intended to contain a first active product, generally in the form of a dry powder.
• the second bottle B is intended to contain a second product, usually a liquid in which the active product must be dissolved or suspended at the time of its administration.
• the assembly comprises connecting means for placing the two bottles A and B in communication with one another in order, in the first instance, to introduce the liquid into the first bottle, and then, in a second step, to aspirate, in the second bottle, the solution or the suspension thus formed.
• the second bottle B made of flexible material, is turned over and screwed into a socket 1 of the first bottle A.
• This socket 1 comprises an upper portion 2, having an internal thread 4, and a lower portion 3 having a shoulder. interior 5.
• the bottle B ends with a dropper 6, connected to the body 7 of the bottle by a shoulder 8 externally threaded.
• the bottle A usually glass, is closed by a plug 9 of elastomeric material, through which a hole 10 is sealed by a sealing membrane 11 perforable.
• the membrane is for example made of aluminum.
• the dropper 6 perforates the membrane 11 and opens into the hole 10, bringing into communication the two bottles.
• the connection between the two bottles is made by means of the single piece 1, this piece being secured to the bottle A by snapping of the shoulder 5 on a neck of the bottle A.
• the neck of the bottle A generally comprises two snap-fastening flanges.
• the neck of the bottle has two collars 12, which can interfere with the attachment of the sleeve 1 to the bottle A.
• the two collars and the ribs are not optimal in terms of the amount of material used for the manufacture of the bottle.
• the plug 9 of elastomeric material and the perforable sealing membrane 11 are not optimal either, because they represent separate parts with respect to each other and with respect to the socket. Fastening the plug, diaphragm and socket requires a delicate centering.
• the invention aims a new embodiment, including a socket, eliminating all of these disadvantages, through a simplification of the previous elements.
• a sleeve for the extemporaneous preparation of a suspension or of a solution formed by a mixture of a first product and a second product, allowing the communication of a first bottle initially containing the first product and a second bottle initially containing the second product, the second bottle being provided with a dropper neck, the communication between the first bottle and the second bottle being carried out for the purpose, initially , to introduce the second product in the first bottle and then, in a second step, to suck in the second bottle the suspension or the solution thus formed by the dropper neck, characterized in that the sleeve has internally a receptacle for receiving of the dropper neck, the receptacle having a shape complementary to the stillicer neck.
• the bushing comprises a body having an upper portion adapted to cooperate with a portion of the dropper neck of the second bottle and a lower portion adapted to cap a neck of the first bottle; - A section of the receptacle varies decreasing from the upper portion to the lower portion to cooperate in a complementary manner with the stilliley neck;
• the sleeve further comprises a plug complementary shape of the receptacle, the shape of the plug thus being similar to the shape of the dropper neck;
• the cap is removable from the body;
• the upper portion of the bushing comprises an internal thread for the purpose of coupling by screwing with a thread of a base of the dropper neck or a thread of a base of a stopper;
• the lower portion of the sleeve has an inner shoulder intended to snap by hooking on a circular collar at a neck of the first bottle;
• the sleeve further comprises a lid adapted to cooperate with an outer portion of the body;
• the lid is further adapted to cooperate with an inner portion of the plug
• the lid is removable from the body and / or a plug
• the bushing is molded in plastic material.
• the invention also relates to a packaging comprising such a socket and a kit comprising such a socket.
• the invention has many advantages.
• Fixing the socket on the glass bottle is easier. Less glass is used for the manufacture of the bottle, which generates a lower cost.
• Figure 3 shows a first bottle according to one embodiment of the invention
• FIGS. 4a and 4b show a front view in axial section of a socket according to a first embodiment of the invention, the socket comprising a plug according to the invention;
• Figure 5 shows, in axial section and on the left side, a socket according to a first embodiment of the invention, the sleeve cooperating with a dropper neck, also shown on the right side of the figure;
• - Figure 6 shows, in axial section, a plug according to the invention;
• FIG. 7 represents a view in axial section of a socket according to a second embodiment of the invention, the socket comprising a plug and a cover according to the invention; - Figures 8a and 8b show a front view in axial section of a lid according to the invention; and - Figure 9 is a bottom view of a socket according to a second embodiment of the invention.
• DETAILED DESCRIPTION FIGS. 4a, 4b, 5, 7 and 9 schematically show a bushing 190 intended for the extemporaneous preparation of a suspension or a solution formed by a mixture of a first product and a second product.
• the socket 190 allows the communication of a first bottle A visible in Figure 3 and a second bottle B visible in Figure 5 and identical to the bottle B of Figures 1 and 2.
• the first bottle A initially contains the first product.
• the first product is preferably a solid active product in the form of a lyophilized dry powder.
• the second bottle B initially contains the second product.
• the second product is preferably a liquid product.
• the second bottle B is provided with a dropper neck 6.
• the communication of the first bottle A and the second bottle B by the sleeve 190 is carried out conventionally with a view first of introducing the second product into the first bottle.
• bottle A then, in a second step, to suck in the second bottle B the suspension or the solution thus formed.
• the introduction and aspiration is effected by the dropper neck 6.
• FIG. 5 shows that the dropper neck 6 has at its distal end an orifice 600 allowing the passage of products.
• the sleeve 190 internally comprises a receptacle 16 for receiving the dropper neck 6.
• the receptacle 16 has a complementary shape of the dropper neck 6. The reception of the dropper neck 6 in the receptacle 16 of complementary shape allows a good cooperation of the dropper neck 6 with the receptacle, which avoids a leakage of the first product or the second product during the introduction or aspiration, and a compliance with aseptic conditions.
• a hole 100 made in a bottom wall 27 of the receptacle 16 is adapted to cooperate with the orifice 600 when the dropper neck is in position in the receptacle 16. Due to the shape cooperation between the dropper neck 6 and the receptacle 16 , the orifice 600 is found in front of the hole 100, and it avoids a leakage of the first product or the second product during the introduction or suction, as well as a compliance with the aseptic conditions.
• the bushing 190 mainly comprises a body 191.
• the body 191 has an upper portion 2 intended to cooperate with a portion of the dropper neck 6 of the second bottle B.
• the body 191 has a lower portion 3 adapted to cap a neck of the first bottle A.
• a section of the receptacle 16 varies by decreasing from the upper portion 2 to the lower portion 3 to cooperate in a complementary manner with the dropper neck 6.
• FIGS. 4b, 5 and 7 show in particular that the receptacle 16 comprises straight cylindrical sections 160 for cooperating in a complementary manner with straight cylindrical sections 610 of the dropper neck 6.
• the receptacle 16 comprises conical cylindrical sections 161 to cooperate in a complementary manner with conical cylindrical sections 611 of the dropper neck 6.
• the succession of the straight cylindrical 160 and conical sections 161 is such that the section of the receptacle 16 decreases from the upper portion 2 to the lower portion 3.
• the sleeve 190 further comprises a plug 110 of complementary shape of the receptacle 16.
• the shape of the plug is similar to the shape of the dropper neck 6.
• the cooperation of the plug 110 with the receptacle 16 is such that when the plug 110 is in place in the receptacle 16, the hole 100 of the receptacle is completely plugged by the bottom wall 26 of the plug 110.
• reception of the plug 110 in the receptacle 16 of complementary shape allows a good cooperation of the plug 110 with the receptacle 16, which makes it possible to avoid a leakage of the first product, as well as a respect of the asepsis conditions.
• the plug 110 is removable from the receptacle 16, and preferably from the body 191.
• the upper portion 2 of the bushing 190 has an internal thread 4 for the purpose of screw coupling with a thread 8 of a base of the dropper neck 6.
• the thread 4 can also mate by screwing with a thread 18 of a base of the plug 110.
• the lower portion 3 of the sleeve 190 has an inner shoulder 5 for snap-fastening on a flange 12 circular to a neck of the first bottle A.
• the first bottle A has only one flange 12.
• the amount of glass used is therefore less than the amount of glass used for the flasks of the prior art.
• the shoulder may not be continuous and have notches 15.
• the notches 15 allow to further save material, this time on the sleeve 190, while facilitating the mounting of the sleeve 190 on the bottle A.
• Figure 7 shows that the sleeve 190 may have recesses 29 to save the material used for the manufacture of the socket.
• the plug 110 is preferably hollow, with the portion 28, opposite to the bottom wall 26, opened. This saves even more material for the manufacture of the cap 110.
• FIGS. 8a and 8b show that the bushing 190 may then further comprise a cover 14 adapted to cooperate with an external part 17 of the body 191.
• the upper part 2 of the body 191 may comprise patterns, in the form of pin or saw teeth 24, able to cooperate with complementary shoulders 19 on the cover 14.
• the cover 14 may also be adapted to cooperate with an inner portion 21 of the plug 110.
• an upper part of the plug 25 is housed in a recess 20 between an inner wall 22 and an outer wall 23 of the cover 14.
• the lid 14 is of course removable from the body 191 and / or the cap 110.
• Figure 4a shows that the upper part 25 of the plug 110 has a gripping pattern to facilitate the screwing and unscrewing of the plug 110 in the socket.
• the body 191, the cap 110 and the lid 14 are molded of plastic, each in one piece. This saves material and assembly time.
• the invention also relates to a packaging comprising a bottle of type A comprising a socket according to the invention, and a kit comprising a packaging according to the invention and a bottle of type B.

Landscapes

• Health & Medical Sciences (AREA)
• Veterinary Medicine (AREA)
• Pharmacology & Pharmacy (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Engineering & Computer Science (AREA)
• Mechanical Engineering (AREA)
• Closures For Containers (AREA)
• Input Circuits Of Receivers And Coupling Of Receivers And Audio Equipment (AREA)
• Details Of Rigid Or Semi-Rigid Containers (AREA)
• Medical Preparation Storing Or Oral Administration Devices (AREA)
• Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
• Fertilizing (AREA)
• Cosmetics (AREA)
• Coating Apparatus (AREA)
• Packages (AREA)

Priority Applications (3)

Applications Claiming Priority (2)

Publications (2)

Family

ID=37027410

Family Applications (1)

Country Status (20)

Families Citing this family (14)

Family Cites Families (14)

• 2005
  • 2005-11-25 FR FR0511943A patent/FR2893926B1/fr not_active Expired - Fee Related
• 2006
  • 2006-11-23 DK DK06819700T patent/DK1959911T3/da active
  • 2006-11-23 CN CN2006800439597A patent/CN101312705B/zh not_active Expired - Fee Related
  • 2006-11-23 BR BRPI0618763-3A patent/BRPI0618763A2/pt not_active IP Right Cessation
  • 2006-11-23 AT AT06819700T patent/ATE468836T1/de active
  • 2006-11-23 JP JP2008541744A patent/JP5122472B2/ja not_active Expired - Fee Related
  • 2006-11-23 AU AU2006316523A patent/AU2006316523B2/en not_active Ceased
  • 2006-11-23 EP EP20060819700 patent/EP1959911B1/de not_active Not-in-force
  • 2006-11-23 WO PCT/EP2006/068806 patent/WO2007060193A1/fr not_active Ceased
  • 2006-11-23 CA CA 2630762 patent/CA2630762C/fr not_active Expired - Fee Related
  • 2006-11-23 US US12/085,634 patent/US20100016826A1/en not_active Abandoned
  • 2006-11-23 SI SI200630759T patent/SI1959911T1/sl unknown
  • 2006-11-23 KR KR1020087015384A patent/KR101322736B1/ko not_active Expired - Fee Related
  • 2006-11-23 PL PL06819700T patent/PL1959911T3/pl unknown
  • 2006-11-23 ES ES06819700T patent/ES2346245T3/es active Active
  • 2006-11-23 RU RU2008125831A patent/RU2411026C2/ru not_active IP Right Cessation
  • 2006-11-23 PT PT06819700T patent/PT1959911E/pt unknown
  • 2006-11-23 DE DE200660014589 patent/DE602006014589D1/de active Active
• 2008
  • 2008-05-22 IL IL191647A patent/IL191647A/en not_active IP Right Cessation
• 2010
  • 2010-08-17 CY CY20101100760T patent/CY1110739T1/el unknown
• 2013
  • 2013-06-28 US US13/929,989 patent/US8800759B2/en not_active Expired - Fee Related

Non-Patent Citations (1)

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