EP1982718A4 - Composition pharmaceutique anticancereuse - Google Patents

Composition pharmaceutique anticancereuse

Info

Publication number
EP1982718A4
EP1982718A4 EP07708202A EP07708202A EP1982718A4 EP 1982718 A4 EP1982718 A4 EP 1982718A4 EP 07708202 A EP07708202 A EP 07708202A EP 07708202 A EP07708202 A EP 07708202A EP 1982718 A4 EP1982718 A4 EP 1982718A4
Authority
EP
European Patent Office
Prior art keywords
pharmaceutical composition
anticancer pharmaceutical
anticancer
composition
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07708202A
Other languages
German (de)
English (en)
Other versions
EP1982718A1 (fr
Inventor
Kosaku Fujiwara
Naomi Shimazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of EP1982718A1 publication Critical patent/EP1982718A1/fr
Publication of EP1982718A4 publication Critical patent/EP1982718A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP07708202A 2006-02-09 2007-02-08 Composition pharmaceutique anticancereuse Withdrawn EP1982718A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006031791 2006-02-09
PCT/JP2007/052178 WO2007091622A1 (fr) 2006-02-09 2007-02-08 Composition pharmaceutique anticancereuse

Publications (2)

Publication Number Publication Date
EP1982718A1 EP1982718A1 (fr) 2008-10-22
EP1982718A4 true EP1982718A4 (fr) 2010-05-12

Family

ID=38345216

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07708202A Withdrawn EP1982718A4 (fr) 2006-02-09 2007-02-08 Composition pharmaceutique anticancereuse

Country Status (15)

Country Link
US (4) US8263631B2 (fr)
EP (1) EP1982718A4 (fr)
JP (2) JP5133071B2 (fr)
KR (1) KR20080101888A (fr)
CN (1) CN101415422B (fr)
AU (1) AU2007213028C1 (fr)
BR (1) BRPI0707671A2 (fr)
CA (1) CA2642665C (fr)
IL (1) IL193243A0 (fr)
NO (1) NO20083822L (fr)
NZ (1) NZ570381A (fr)
RU (1) RU2419430C2 (fr)
TW (1) TW200800181A (fr)
WO (1) WO2007091622A1 (fr)
ZA (1) ZA200807721B (fr)

Families Citing this family (31)

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US20070087005A1 (en) 2005-10-14 2007-04-19 Lazar Gregory A Anti-glypican-3 antibody
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
NZ570381A (en) 2006-02-09 2011-02-25 Daiichi Sankyo Co Ltd Anti-cancer pharmaceutical composition
TW201336497A (zh) * 2007-02-08 2013-09-16 Daiichi Sankyo Co Ltd 噻唑啶二酮化合物之結晶型及其製法
JP5294419B2 (ja) * 2007-04-05 2013-09-18 第一三共株式会社 縮合二環式ヘテロアリール誘導体
US8722710B2 (en) 2007-09-26 2014-05-13 Deuterx, Llc Deuterium-enriched pioglitazone
US8497355B2 (en) 2007-09-28 2013-07-30 Chugai Seiyaku Kabushiki Kaisha Anti-glypican-3 antibody having improved kinetics in plasma
CL2009000647A1 (es) * 2008-04-04 2010-06-04 Chugai Pharmaceutical Co Ltd Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto.
JPWO2010013768A1 (ja) * 2008-07-31 2012-01-12 第一三共株式会社 チアゾリジンジオン化合物の結晶及びその製造方法
TW201008936A (en) 2008-07-31 2010-03-01 Daiichi Sankyo Co Ltd Crystalline forms of thiazolidinedione compound and its manufacturing method
SG190568A1 (en) 2008-09-26 2013-06-28 Oncomed Pharm Inc Frizzled-binding agents and uses thereof
WO2010070379A1 (fr) * 2008-12-17 2010-06-24 Centre National De La Recherche Scientifique Traitement combiné d'agoniste rxr-ppargamma/d'inhibiteur de facteur de croissance, servant à l'induction de l'apoptose et au traitement du cancer
CA2754446A1 (fr) 2009-03-05 2010-09-10 Daiichi Sankyo Company, Limited Derive de pyridine
WO2011065420A1 (fr) 2009-11-26 2011-06-03 第一三共株式会社 Procédé de fabrication d'un dérivé de 1-méthyl-1h-benzimidazole substitué en 6 et intermédiaire de fabrication issu de ce procédé
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
EP2788378A4 (fr) * 2011-12-09 2015-09-09 Oncomed Pharm Inc Thérapie d'association pour le traitement du cancer
AU2013243097A1 (en) * 2012-04-03 2014-10-09 Novartis Ag Combination products with tyrosine kinase inhibitors and their use
US20140221369A1 (en) * 2013-02-01 2014-08-07 Deuterx, Llc 5-deutero-2,4-thiazolidinedione and 5-deutero-2,4-oxazolidinedione derivatives and compositions comprising and methods of using the same
AU2014212081A1 (en) 2013-02-04 2015-08-13 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a Wnt pathway inhibitor
WO2014152843A1 (fr) 2013-03-14 2014-09-25 Deuterx, Llc 2,4-thiazolidinediones enrichies en deutérium et méthodes de traitement
AU2014233363B2 (en) * 2013-03-15 2017-06-29 EyePoint, Inc. Compositions, formulations and methods for treating ocular diseases
GB201400034D0 (en) * 2014-01-02 2014-02-19 Astrazeneca Ab Pharmaceutical Compositions comprising AZD9291
EP3094328B1 (fr) 2014-01-15 2020-08-19 Poxel SA Méthodes de traitement de troubles neurologiques, métaboliques et autres à l'aide de pioglitazone énantiopure enrichie en deutérium
JP2016062874A (ja) * 2014-09-22 2016-04-25 株式会社ジャパンディスプレイ 画像表示装置及びその製造方法、並びに画像表示装置の検査方法
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
CN109312157A (zh) * 2016-04-04 2019-02-05 加利福尼亚大学董事会 治疗癌症的lls化合物
KR102399254B1 (ko) * 2016-09-28 2022-05-17 아이거 바이오파마슈티컬스 인코포레이티드 비-알코올성 지방간염의 치료를 위한 방법 및 약제학적 조성물
RU2692129C1 (ru) * 2018-03-19 2019-06-21 Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) Способ прогнозирования лимфогенного метастазирования у больных при аденокарциноме прямой кишки
US11767317B1 (en) 2020-06-30 2023-09-26 Poxel Sa Methods of synthesizing enantiopure deuterium-enriched pioglitazone
US11319313B2 (en) 2020-06-30 2022-05-03 Poxel Sa Crystalline forms of deuterium-enriched pioglitazone
CN113262306A (zh) * 2021-07-21 2021-08-17 北京大学第三医院（北京大学第三临床医学院） Pparg拮抗剂在肿瘤治疗药物中的应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003053440A1 (fr) * 2001-12-11 2003-07-03 Sankyo Company, Limited Composition medicinale
WO2004000356A1 (fr) * 2002-06-25 2003-12-31 Sankyo Company, Limited Composition medicale contenant un diuretique et un activateur du recepteur $g(g) active par la proliferation des peroxisomes (ppar)
EP1424080A1 (fr) * 2001-08-10 2004-06-02 Takeda Chemical Industries, Ltd. Medicaments combines d'agoniste de la gnrh
JP2004315404A (ja) * 2003-04-15 2004-11-11 Sankyo Co Ltd ベンゾイミダゾール誘導体を含有する医薬
WO2005046665A1 (fr) * 2003-11-13 2005-05-26 Warner-Lambert Company Llc Polychimiotherapie comportant un inhibiteur de mek et un inhibiteur du recepteur erbb1/2
WO2005117877A1 (fr) * 2004-06-03 2005-12-15 F.Hoffmann-La Roche Ag Traitement avec de l'irinotecan (cpt-11) et un inhibiteur egfr

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DE10133394A1 (de) 2001-07-13 2003-01-30 Merck Patent Gmbh Flüssige Formulierung enthaltend Cetuximab
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US20050043409A1 (en) * 2001-10-25 2005-02-24 Chen Ying-Nan Pan Combinations comprising a selective cyclooxygenase-2 inhibitor
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WO2003082272A1 (fr) 2002-03-29 2003-10-09 Chiron Corporation Benzazoles substitues et leur utilisation en tant qu'inhibiteurs de la kinase raf
WO2003082865A1 (fr) 2002-04-01 2003-10-09 Sankyo Company, Limited Composition médicinale antitumorale
JP2004083558A (ja) 2002-04-01 2004-03-18 Sankyo Co Ltd 抗腫瘍医薬組成物
ATE356804T1 (de) * 2002-06-14 2007-04-15 Merck & Co Inc Inhibitoren von mitotischem kinesin
JP2004083574A (ja) * 2002-06-25 2004-03-18 Sankyo Co Ltd 利尿剤及びペルオキシソーム増殖因子活性化受容体（ＰＰＡＲ）γ活性化剤を含有する医薬組成物
JP2005162727A (ja) * 2003-03-18 2005-06-23 Sankyo Co Ltd スルファミド誘導体及びその医薬組成物
TW200505834A (en) 2003-03-18 2005-02-16 Sankyo Co Sulfamide derivative and the pharmaceutical composition thereof
NZ570381A (en) 2006-02-09 2011-02-25 Daiichi Sankyo Co Ltd Anti-cancer pharmaceutical composition

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EP1424080A1 (fr) * 2001-08-10 2004-06-02 Takeda Chemical Industries, Ltd. Medicaments combines d'agoniste de la gnrh
WO2003053440A1 (fr) * 2001-12-11 2003-07-03 Sankyo Company, Limited Composition medicinale
WO2004000356A1 (fr) * 2002-06-25 2003-12-31 Sankyo Company, Limited Composition medicale contenant un diuretique et un activateur du recepteur $g(g) active par la proliferation des peroxisomes (ppar)
JP2004315404A (ja) * 2003-04-15 2004-11-11 Sankyo Co Ltd ベンゾイミダゾール誘導体を含有する医薬
WO2005046665A1 (fr) * 2003-11-13 2005-05-26 Warner-Lambert Company Llc Polychimiotherapie comportant un inhibiteur de mek et un inhibiteur du recepteur erbb1/2
WO2005117877A1 (fr) * 2004-06-03 2005-12-15 F.Hoffmann-La Roche Ag Traitement avec de l'irinotecan (cpt-11) et un inhibiteur egfr

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"1450 ORAL Clinical synergism from combinatorial VEGF signal transduction inhibition in patients with advanced solid tumors - early results from a phase I study of sorafenib (BAY 43-9006) and bevacizumab", EUROPEAN JOURNAL OF CANCER. SUPPLEMENT, PERGAMON, OXFORD, GB, vol. 3, no. 2, 1 October 2005 (2005-10-01), pages 419 - 420, XP027684484, ISSN: 1359-6349, [retrieved on 20051001] *
"883 POSTER Phase I trial of sorafenib (BAY 43-9006) in combination with interferon alpha-2a in patients with unresectable and/or metastatic renal cell carcinoma and malignant melanoma", EUROPEAN JOURNAL OF CANCER. SUPPLEMENT, PERGAMON, OXFORD, GB, vol. 3, no. 2, 1 October 2005 (2005-10-01), pages 254, XP027683921, ISSN: 1359-6349, [retrieved on 20051001] *
DATABASE WPI Week 200357, Derwent World Patents Index; AN 2003-607888, XP002575455 *
DATABASE WPI Week 200409, Derwent World Patents Index; AN 2004-090925, XP002575456 *
See also references of WO2007091622A1 *
STRUMBERG D: "Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment", DRUGS OF TODAY 200512 ES, vol. 41, no. 12, December 2005 (2005-12-01), pages 773 - 784, XP002575457, ISSN: 0025-7656 *

Also Published As

Publication number Publication date
US20120258991A1 (en) 2012-10-11
US20130183297A1 (en) 2013-07-18
ZA200807721B (en) 2010-02-24
AU2007213028B2 (en) 2010-10-28
IL193243A0 (en) 2009-02-11
US20120263716A1 (en) 2012-10-18
AU2007213028A1 (en) 2007-08-16
RU2419430C2 (ru) 2011-05-27
JP5133071B2 (ja) 2013-01-30
RU2008136188A (ru) 2010-03-20
NO20083822L (no) 2008-11-05
US8263631B2 (en) 2012-09-11
CA2642665A1 (fr) 2007-08-16
AU2007213028C1 (en) 2011-05-19
KR20080101888A (ko) 2008-11-21
WO2007091622A1 (fr) 2007-08-16
JP2012255042A (ja) 2012-12-27
TW200800181A (en) 2008-01-01
CA2642665C (fr) 2013-01-08
EP1982718A1 (fr) 2008-10-22
BRPI0707671A2 (pt) 2011-05-10
NZ570381A (en) 2011-02-25
US20090028868A1 (en) 2009-01-29
JPWO2007091622A1 (ja) 2009-07-02
CN101415422A (zh) 2009-04-22
CN101415422B (zh) 2012-11-07

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