EP1993733B1 - Vorrichtung, verwendung und verfahren zum entziehen einer flüssigkeit - Google Patents

Vorrichtung, verwendung und verfahren zum entziehen einer flüssigkeit Download PDF

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Publication number
EP1993733B1
EP1993733B1 EP07731725A EP07731725A EP1993733B1 EP 1993733 B1 EP1993733 B1 EP 1993733B1 EP 07731725 A EP07731725 A EP 07731725A EP 07731725 A EP07731725 A EP 07731725A EP 1993733 B1 EP1993733 B1 EP 1993733B1
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EP
European Patent Office
Prior art keywords
container
needle
liquid
millimeters
blowing means
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP07731725A
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English (en)
French (fr)
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EP1993733A1 (de
Inventor
Michel Rapaud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomerieux SA
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Biomerieux SA
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Filing date
Publication date
Application filed by Biomerieux SA filed Critical Biomerieux SA
Publication of EP1993733A1 publication Critical patent/EP1993733A1/de
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Publication of EP1993733B1 publication Critical patent/EP1993733B1/de
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics

Definitions

  • the present invention relates to a device for sampling a liquid in a container, for concentrating the drops of liquid present on the inner wall (s) of the container in the lower part of said container.
  • the present invention also relates to a method of sampling a liquid present in a container using the above device.
  • the present invention finally relates to the use of the above sampling device to control the level of the liquid present in the container.
  • this kind of sampling device simply allows, by contact with the liquid to be taken, either the supply of a liquid of interest that it contains or the withdrawal of another liquid of interest present in a container.
  • Such devices are generally constituted by pipettes or hollow needles associated with pumps. Some more sophisticated allow the cleaning of the outer walls of said pipettes or needles that have been soaked in the liquid taken or having added an additional liquid. This is the case for example in the patent application WO-A-99/27973 filed under priority of November 27, 1997 by the plaintiff.
  • This relates to a method for decontaminating a hollow metal needle for sampling and / or dispensing a contaminating liquid, the needle cooperating with electrical connection means making it possible to establish an electric current in the needle. to decontaminate and preserve the integrity of said needle for reuse. Others are equipped with means avoiding contaminating these outer walls of the sampling elements, as is the case with the patent application.
  • WO-A-99/50674 filed under priority 1 April and 22 June 1998 by the applicant.
  • This application relates to a method of sampling a biological sample via a suction-discharge device, such as a pipette, manual or automatic, incorporated or not to an automaton. But it also relates to a method for detecting the free surface of a biological sample, a sample collection apparatus, such as a pipette, and an apparatus for detecting the free surface of a biological sample.
  • Another problem is the determination of a volume of liquid present in a container. Some checks are sometimes necessary to know exactly the volume of liquid dispensed in a container or series of containers. In this case, it is necessary to know precisely said volume. As a result, the presence of unrecovered or recoverable drop (s) can lead to erroneous values and affect the final result.
  • the present invention proposes to provide a solution to these problems in order to meet the expectations of users.
  • the sampling needle consists of a tube open at both ends; the container for containing the liquid to be taken up consists of a tube of diameter greater than that of the lower end of the needle, open only at its upper end.
  • the blowing means comprise at least one lateral opening to the needle; this / these opening (s) allows (s) sending a flow of air on the inner wall (s) (s) of the container.
  • the sampling needle is in a vertical position.
  • the air flow leaving the lateral openings is oblique and directed from top to bottom.
  • This air flow has an angle relative to the horizontal which is between 10 ° and 80 °, preferably between 20 and 50 °, preferably between 25 and 40 ° and even more preferably 30 °.
  • the blowing means comprise three to twenty, preferably five to twelve and even more preferably eight lateral openings.
  • these lateral openings are radially distributed, positioned in the same plane, preferably horizontally.
  • the sampling device is characterized in that the blowing means comprise a closed sleeve comprising at least one pulsed gas inlet, preferably air.
  • the device is characterized in that the sleeve is a closed tube which wholly or partially surrounds the sampling needle.
  • the three steps of introduction, activation of the blowing means (8) and aspiration are sequential.
  • the introduction step and the activation step of the blowing means are performed simultaneously.
  • the first introduction step and the second activation step are sequential but with a recovery period, the introduction ending when the activation has already begun.
  • sampling device can be used to control the level of the liquid present in a container.
  • figure 11 represents the lower end of the sampling needle according to a second embodiment.
  • the present invention relates to a device for sampling a liquid in a container represented on all Figures 1 to 6 .
  • the Figures 1 to 3 represent the sampling device 1 in the absence of any liquid to be taken.
  • This sampling device 1 is well represented on the Figures 1 and 2 and consists essentially of a sampling needle 4 having a lower free end 5 and an upper end 6, said needle 4 being in a vertical position.
  • a container 3 itself consisting of a tube of diameter greater than that of the lower end 5 of the needle 4, and open at its end upper 11 and closed at its lower end 17, this tube being capable of containing a liquid to be taken.
  • the figure 2 is a sampling device 1 after its introduction along a vertical axis in the container 3, said container 3 of conventional shape having an inner wall 10 and an outer wall, not referenced.
  • the upper end 6 of the sampling needle 4 is connected to suction-discharge means 7 via a hose 13.
  • These means 7, known to those skilled in the art, will not be exposed more before. They may just be constituted by a peristaltic pump, or any other equivalent means, such as time-pressure-depression systems, which are based on the principle of a main reservoir in pressure (or in depression depending on the need of the application whose outlet has a hose provided with a solenoid valve controlled by an electronic device using a time base to perform its switching opening - closing.
  • the initial gas flow therefore comes from the blowing means by the inlet 16, said inlet 16 being connected to the blowing means 8 by a hose 14.
  • the flow of gas from the inlet 16 to the lateral openings 12 is therefore through the closed sleeve 15.
  • the lateral openings 12 are radially implanted on said sleeve 15, in order to improve the efficiency of the device.
  • the assembly of the blowing means therefore consists of the blowing means 8 themselves, the hose 14, the lateral openings 12 and the sleeve 15.
  • Each opening 12 implanted on the sleeve 15 is represented on the detail C of the figure 10 .
  • the diameter 19 of the opening 12 is between 0.1 and 1 millimeter, preferably between 0.3 and 0.6 millimeter, and even more preferably 0.4 millimeter.
  • the pulsed gas flow, according to F4 coming from the openings 12 is in an oblique position relative to the horizontal, and is directed from top to bottom, which makes it possible to concentrate the drops 9 present on the inner and lateral wall 10 (see the figure 4 ), the drops 9 being in a position remote from the lower end 17 of the container 3, and the air flow along F4 directing them towards this lower end 17 of said container 3 as shown in FIGS. Figures 7 to 9 .
  • the angle between the horizontal 20 and the gas flow (F4) coming from the openings 12 is therefore between 10 ° and 80 °, preferably between 20 ° and 50 °, preferably between 25 and 40 °, and even more preferentially 30 °.
  • the sampling device 1 can thus be used to take a liquid 2 contained in a closed container at its upper end, for example by an external aluminum film.
  • the lower free end 5 of the sampling needle 4 is of rounded shape 18 on the outside of the needle 4 so that when the outer film is perforated during the descent of the needle to the container, according to F5 the perforation is clear; this avoids any tearing or punching effect of the outer film.
  • the lower free end 5 of the sampling needle 4 comprises a series of slots 18 arranged radially or radially, the number may vary from 4 to 12 without impacting the sample. In the embodiment this number is 6.
  • the perforation is even sharper; this avoids any tearing or punching effect of the outer film.
  • the sampling with this embodiment is even more effective, because its shape allows the sampling even in tubes, specimen style, the space at the bottom is difficult to access.
  • its outer radius of curvature is adapted to the inner radius of curvature of the bottom of the container.
  • the external radius of curvature of the sampling needle 4 matches the internal radius of curvature of the bottom of the container, that is to say is of slightly smaller radius to allow complete support between the two inner surfaces and external.
  • the diameter of said needle 4 is in the presented embodiment of 3.5 millimeters.
  • Said container 3 can also be directed towards the needle 4 in the direction F6 shown in FIG. figure 6 .
  • the activation of the blowing means 8 causes the creation of a flow of gas along F3 which enters through the inlet 16. This flow of gas flows in the sleeve 15 and leaves it from F4 via the lateral openings 12.
  • the projection of the gas towards the inner wall 10 of the container 3 makes it possible to unhook and thus move, according to F7, and to concentrate towards the lower part 17 of the container 3, the drops of liquid 9 present on said wall 10.
  • the present invention also relates to a sampling method represented on all the Figures 7 to 10 .
  • the step of introducing the needle 4 and the step of activating the blowing means 8 are simultaneous, the descent along F5 of the needle 4 in the container 3 being done at the same time as the arrival of gas, according to F3, in the sleeve 15.
  • the blowing means 8 being always activated.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)

Claims (18)

  1. Vorrichtung zum Entnehmen (1) einer Flüssigkeit (2) aus einem Behälter (3), Folgendes umfassend:
    - eine Entnahmenadel (4), die ein freies unteres Ende (5) und ein oberes Ende (6) aufweist,
    - Ansaug- Fördermittel (7), die an dem oberen Ende (6) der Nadel (4) verbunden sind, gekennzeichnet durch
    - Blasmittel (8), die von der Nadel (4) getragen werden, die es erlauben, die Tropfen (9) von Flüssigkeit (2), die auf der Innenwand oder den Innenwänden (10) des Behälters (3) in dem unteren Teil des Behälters (3) vorhanden sind, zu konzentrieren.
  2. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass die Nadel (4) aus einer Röhre besteht, die an ihren zwei Enden (5 und 6) offen ist, und dass der Behälter (3) aus einer Röhre mit einem größeren Durchmesser besteht, die nur an ihrem oberen Ende (11) offen ist.
  3. Vorrichtung nach einem der Ansprüche 1 oder 2, dadurch gekennzeichnet, dass die Blasmittel (8) mindestens eine seitliche Öffnung (12) an der Nadel (4) aufweisen, die das Entsenden eines Luftstroms (F4) auf die Innenwand oder die Innenwände (10) des Behälters (3) erlaubt.
  4. Vorrichtung nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, dass die Entnahmenadel (4) in vertikaler Position ist.
  5. Vorrichtung nach einem der Ansprüche 3 oder 4, dadurch gekennzeichnet, dass der Luftstrom (F4) schräg und von oben nach unten gerichtet ist.
  6. Vorrichtung nach einem der Ansprüche 3 bis 5, dadurch gekennzeichnet, dass der Luftstrom (F4) einen Winkel (20) in Bezug zu der Horizontalen hat, der zwischen 10° und 80° liegt, vorzugsweise zwischen 20° und 50°, vorzugsweise zwischen 25° und 40°, noch bevorzugter von 30°.
  7. Vorrichtung nach einem der Ansprüche 3 bis 6, dadurch gekennzeichnet, dass die Blasmittel (8) drei bis zwanzig, vorzugsweise fünf bis zwölf und noch bevorzugter acht seitliche Öffnungen (12) aufweisen.
  8. Vorrichtung nach Anspruch 7, dadurch gekennzeichnet, dass die seitlichen Öffnungen (12) strahlenförmig angeordnet sind.
  9. Vorrichtung nach einem der Ansprüche 7 oder 8, dadurch gekennzeichnet, dass die seitlichen Öffnungen (12) in einer gleichen Ebene, die vorzugsweise horizontal ist, positioniert sind.
  10. Vorrichtung nach einem der Ansprüche 3 bis 9, dadurch gekennzeichnet, dass
    - die Entfernung, die die seitlichen Öffnungen (12) von der Innenwand oder den Innenwänden des Behälters (3) trennt, zwischen 30 und 70 %, vorzugsweise zwischen 40 und 60 % des Durchmessers der Nadel (4) liegt,
    - der Durchmesser (19) jeder Öffnung (12) zwischen 3 und 25 %, vorzugsweise zwischen 5 und 15 % liegt und noch bevorzugter gleich 10 % des Durchmessers der Nadel (4) ist, und/oder
    - die Anordnung jeder Öffnung (12) in Bezug zu dem freien unteren Ende (5) der Nadel (4) zwischen 50 und 150 %, vorzugsweise zwischen 80 und 120 % liegt und noch bevorzugter gleich 100 % des Durchmessers der Nadel (4) ist.
  11. Vorrichtung nach Anspruch 10, dadurch gekennzeichnet, dass:
    - die Entfernung, die die seitlichen Öffnungen (12) von der Innenwand oder den Innenwänden des Behälters (3) trennt, zwischen 1 und 10 Millimeter, vorzugsweise zwischen 2,5 und 4 Millimeter und noch bevorzugter zwischen 2,75 und 3 Millimeter liegt,
    - der Durchmesser (19) jeder Öffnung (12) zwischen 0,1 und 1 Millimeter, vorzugsweise zwischen 0,3 und 0,6 Millimeter liegt und noch bevorzugter 0,4 Millimeter beträgt und/oder
    - die Anordnung jeder Öffnung (12) in Bezug zu dem freien unteren Ende (5) der Nadel (4) zwischen 3 und 25 Millimeter, vorzugsweise zwischen 6 und 15 Millimeter liegt und noch bevorzugter 9 Millimeter beträgt.
  12. Vorrichtung nach einem der Ansprüche 1 bis 11, dadurch gekennzeichnet, dass die Blasmittel (8) einen geschlossenen Stutzen aufweisen, der mindestens einen Einlass von gepulstem Gas, vorzugsweise von Luft aufweist.
  13. Vorrichtung nach Anspruch 12, dadurch gekennzeichnet, dass der Stutzen (15) eine geschlossene Röhre ist, die die Entnahmenadel (4) ganz oder teilweise umgibt.
  14. Verfahren zum Entnehmen einer Flüssigkeit (2) aus einem Behälter (3), das eine Vorrichtung (1) nach einem der Ansprüche 1 bis 13 verwendet und die folgenden Schritte umfasst:
    - Einführen des freien unteren Endes (5) der Entnahmenadel (4) in dem Behälter (3),
    - Betätigen der Blasmittel (8), die es erlauben, die Tropfen (9) von Flüssigkeit (2), die auf der oder den Innenwänden (10) des Behälters (3) vorhanden sind, in dem unteren Teil des Behälters (3) zu konzentrieren, und
    - Ansaugen eines Teils oder der ganzen Flüssigkeit (2), die in dem Behälter (3) vorhanden ist, über das untere Ende (5) der Nadel (4).
  15. Verfahren nach Anspruch 14, dadurch gekennzeichnet, dass die drei Schritte des Einführens, Betätigens der Mittel (8) und Ansaugens sequenziell sind.
  16. Verfahren nach Anspruch 14, dadurch gekennzeichnet, dass der erste Schritt des Einführens und der zweite Schritt des Betätigens der Mittel (8) gleichzeitig sind.
  17. Verfahren nach Anspruch 14, dadurch gekennzeichnet, dass der erste Schritt des Einführens und der zweite Schritt des Betätigens der Mittel (8) sequenziell sind, aber mit einer Überlappungsperiode, wobei das Einführen endet, wenn das Betätigen bereits begonnen hat.
  18. Gebrauch einer Entnahmevorrichtung (1) nach einem der Ansprüche 1 bis 13, einer Flüssigkeit (2) aus einem Behälter (3), um den Stand von Flüssigkeit (2) in dem Behälter (3) zu kontrollieren.
EP07731725A 2006-03-13 2007-03-12 Vorrichtung, verwendung und verfahren zum entziehen einer flüssigkeit Active EP1993733B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0602161A FR2898285B1 (fr) 2006-03-13 2006-03-13 Dispositif, utilisation et procede de prelevement d'un liquide
PCT/FR2007/050909 WO2007104886A1 (fr) 2006-03-13 2007-03-12 Dispositif, utilisation et procédé de prélèvement d'un liquide

Publications (2)

Publication Number Publication Date
EP1993733A1 EP1993733A1 (de) 2008-11-26
EP1993733B1 true EP1993733B1 (de) 2011-06-29

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EP07731725A Active EP1993733B1 (de) 2006-03-13 2007-03-12 Vorrichtung, verwendung und verfahren zum entziehen einer flüssigkeit

Country Status (7)

Country Link
US (1) US7987736B2 (de)
EP (1) EP1993733B1 (de)
JP (1) JP4896162B2 (de)
AT (1) ATE514486T1 (de)
ES (1) ES2369050T3 (de)
FR (1) FR2898285B1 (de)
WO (1) WO2007104886A1 (de)

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DE102011111186B4 (de) * 2011-08-25 2014-07-10 Institut für Bioprozess- und Analysenmesstechnik e.V. Verfahren zur Entnahme von mit Gasblasen durchsetztem Probenmedium aus einem Probenbehälter
WO2016078340A1 (zh) * 2014-11-17 2016-05-26 中国科学院微生物研究所 微量液体分配/混合装置、系统及方法
US10105708B1 (en) 2015-04-29 2018-10-23 John L. Sternick Aspiration adapter and system
US10799871B1 (en) 2015-04-29 2020-10-13 John L. Sternick Aspiration adapter and system
EP3314269A4 (de) 2015-06-26 2019-01-23 Abbott Laboratories Reaktionsgefässtauschervorrichtung für einen diagnostischen analysator
CN108027280B (zh) 2015-06-26 2021-07-06 雅培实验室 用于使得反应容器在诊断分析仪中从处理轨道运动至旋转装置的反应容器运动部件
US20170297013A1 (en) * 2016-04-14 2017-10-19 Jesse Cohen Universal Transfer Pipette

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Also Published As

Publication number Publication date
JP4896162B2 (ja) 2012-03-14
FR2898285B1 (fr) 2008-04-18
ES2369050T3 (es) 2011-11-24
ATE514486T1 (de) 2011-07-15
US7987736B2 (en) 2011-08-02
JP2009530594A (ja) 2009-08-27
FR2898285A1 (fr) 2007-09-14
EP1993733A1 (de) 2008-11-26
US20090000693A1 (en) 2009-01-01
WO2007104886A1 (fr) 2007-09-20

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