EP1996937A4 - Materiels génétiques et utilisations correspondantes - Google Patents
Materiels génétiques et utilisations correspondantesInfo
- Publication number
- EP1996937A4 EP1996937A4 EP07752549A EP07752549A EP1996937A4 EP 1996937 A4 EP1996937 A4 EP 1996937A4 EP 07752549 A EP07752549 A EP 07752549A EP 07752549 A EP07752549 A EP 07752549A EP 1996937 A4 EP1996937 A4 EP 1996937A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- genetic packages
- packages
- genetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74341006P | 2006-03-06 | 2006-03-06 | |
| US74362206P | 2006-03-21 | 2006-03-21 | |
| US11/528,927 US20070191272A1 (en) | 2005-09-27 | 2006-09-27 | Proteinaceous pharmaceuticals and uses thereof |
| US11/528,950 US20070212703A1 (en) | 2005-09-27 | 2006-09-27 | Proteinaceous pharmaceuticals and uses thereof |
| PCT/US2007/005857 WO2007103455A2 (fr) | 2006-03-06 | 2007-03-06 | Materiels génétiques et utilisations correspondantes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1996937A2 EP1996937A2 (fr) | 2008-12-03 |
| EP1996937A4 true EP1996937A4 (fr) | 2009-04-08 |
Family
ID=38475542
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP07752549A Withdrawn EP1996937A4 (fr) | 2006-03-06 | 2007-03-06 | Materiels génétiques et utilisations correspondantes |
| EP07752636.6A Active EP1996220B2 (fr) | 2005-09-27 | 2007-03-06 | Polymères recombinés non structurés et utilisations correspondantes |
| EP20140189047 Ceased EP2863222A1 (fr) | 2006-03-06 | 2007-03-06 | Polymères recombinants non structurés et leurs utilisations |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP07752636.6A Active EP1996220B2 (fr) | 2005-09-27 | 2007-03-06 | Polymères recombinés non structurés et utilisations correspondantes |
| EP20140189047 Ceased EP2863222A1 (fr) | 2006-03-06 | 2007-03-06 | Polymères recombinants non structurés et leurs utilisations |
Country Status (6)
| Country | Link |
|---|---|
| EP (3) | EP1996937A4 (fr) |
| AU (2) | AU2007223855B2 (fr) |
| CA (1) | CA2644712C (fr) |
| DK (1) | DK2402754T4 (fr) |
| SI (1) | SI2402754T2 (fr) |
| WO (2) | WO2007103515A2 (fr) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE512674T1 (de) | 2003-01-06 | 2011-07-15 | Angiochem Inc | Angiopep-1, verwandte verbindungen, und deren verwnedungen |
| US7846445B2 (en) | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
| US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
| US8841255B2 (en) | 2005-12-20 | 2014-09-23 | Duke University | Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides |
| EP1971355B1 (fr) | 2005-12-20 | 2020-03-11 | Duke University | Procedes et compositions pour l'administration d'agents actifs a proprietes pharmacologiques ameliorees |
| US20130172274A1 (en) | 2005-12-20 | 2013-07-04 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
| CA2644712C (fr) | 2006-03-06 | 2016-09-13 | Amunix, Inc. | Polymeres recombines non structures et utilisations correspondantes |
| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| US8563521B2 (en) | 2007-06-21 | 2013-10-22 | Technische Universitat Munchen | Biological active proteins having increased in vivo and/or in vitro stability |
| CA2695374A1 (fr) * | 2007-08-15 | 2009-02-19 | Amunix, Inc. | Compositions et procedes d'amelioration de la production de polypeptides recombines |
| CN105727261A (zh) | 2008-06-27 | 2016-07-06 | 杜克大学 | 包含弹性蛋白样肽的治疗剂 |
| WO2010043047A1 (fr) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Conjugués d'agonistes de glp-1 et leurs utilisations |
| WO2010063122A1 (fr) | 2008-12-05 | 2010-06-10 | Angiochem Inc. | Conjugués de neurotensine ou d'analogues de neurotensine et leurs applications |
| US8703717B2 (en) | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| AU2014206217B2 (en) * | 2009-02-03 | 2015-09-17 | Amunix Pharmaceuticals, Inc. | Extended recombinant polypeptides and compositions comprising same |
| AU2015218510B2 (en) * | 2009-02-03 | 2016-11-10 | Amunix Pharmaceuticals, Inc. | Extended recombinant polypeptides and compositions comprising same |
| DK3178835T3 (da) | 2009-02-03 | 2019-06-24 | Amunix Pharmaceuticals Inc | Forlængede rekombinante polypeptider og sammensætninger omfattende samme |
| US8680050B2 (en) | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
| RU2011146654A (ru) | 2009-04-20 | 2013-05-27 | Ангиокем Инк. | Способы лечения рака яичников с применением конъюгированного средства |
| US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| PE20121539A1 (es) * | 2009-06-08 | 2012-12-06 | Amunix Operating Inc | Polipeptidos de la hormona de crecimiento y metodos de preparacion |
| WO2010144508A1 (fr) * | 2009-06-08 | 2010-12-16 | Amunix Operating Inc. | Polypeptides de régulation du glucose et leurs procédés de production et d'utilisation |
| WO2011000095A1 (fr) * | 2009-07-02 | 2011-01-06 | Angiochem Inc. | Conjugués peptidiques multimères et leurs utilisations |
| CA2771999A1 (fr) * | 2009-08-24 | 2011-03-10 | Amunix Operating Inc. | Compositions de facteurs de coagulation vii et procedes de preparation et d'utilisation de celles-ci |
| WO2011060583A1 (fr) * | 2009-11-19 | 2011-05-26 | 浙江大学 | Protéine non naturelle de type collagène et son utilisation |
| EP4382170A3 (fr) | 2009-12-06 | 2024-09-04 | Bioverativ Therapeutics Inc. | Polypeptides chimériques et hybrides de facteur viii-fc, et leurs procédés d'utilisation |
| EP4450523A3 (fr) * | 2010-04-02 | 2025-03-12 | Amunix Pharmaceuticals, Inc. | Protéines de fusion de liaison, conjugués protéine de fusion-médicament de liaison, conjugués xten-médicament et leurs procédés de fabrication et d'utilisation |
| WO2011123830A2 (fr) | 2010-04-02 | 2011-10-06 | Amunix Operating Inc. | Compositions d'alpha 1-antitrypsine, leurs procédés de préparation et d'utilisation |
| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制vegf-a受體交互作用的經修飾結合性蛋白質 |
| DK2571510T3 (en) | 2010-05-21 | 2018-11-19 | Xl Protein Gmbh | BIOSYNTHETIC PROLIN / ALANIN-RANDOM COIL POLYPEPTIDES AND THEIR APPLICATIONS |
| WO2011157819A2 (fr) | 2010-06-18 | 2011-12-22 | Xiberscience Gmbh | Peptides en tant qu'agents actifs pour stabiliser des barrières biologiques |
| MX375112B (es) | 2010-07-09 | 2025-03-06 | Biogen Hemophilia Inc | Polipéptidos de factor ix y métodos para usarlos. |
| EP3514169B1 (fr) | 2010-11-26 | 2024-03-06 | Molecular Partners AG | Liaison de protéines de répétition conçues à l'albumine sérique |
| CA2838833A1 (fr) | 2011-06-10 | 2012-12-13 | Biogen Idec Ma Inc. | Composes pro-coagulants et leurs procedes d'utilisation |
| EP4169525A1 (fr) | 2011-07-08 | 2023-04-26 | Bioverativ Therapeutics Inc. | Polypeptides chimériques et hybrides de facteur viii et leurs procédés d'utilisation |
| EA028914B1 (ru) | 2011-07-25 | 2018-01-31 | Байоджен Хемофилия Инк. | Исследования для мониторинга нарушений свертываемости крови |
| HRP20191920T1 (hr) * | 2012-01-12 | 2020-01-10 | Bioverativ Therapeutics Inc. | Kimerni polipeptidi faktora viii i njihova uporaba |
| CN111548418A (zh) | 2012-02-15 | 2020-08-18 | 比奥贝拉蒂治疗公司 | 因子viii组合物及其制备和使用方法 |
| WO2013123457A1 (fr) | 2012-02-15 | 2013-08-22 | Biogen Idec Ma Inc. | Protéines de facteur viii de recombinaison |
| CN104302408B (zh) | 2012-02-27 | 2016-12-14 | 阿穆尼克斯运营公司 | Xten缀合组合物和制造其的方法 |
| PT2846836T (pt) | 2012-05-07 | 2019-10-29 | Allergan Inc | Método de tratamento de dmi em doentes refratários à terapia anti-vegf |
| MX349035B (es) | 2012-05-17 | 2017-07-07 | Extend Biosciences Inc | Portadores para el suministro mejorado de farmaco. |
| SG11201408196RA (en) | 2012-06-28 | 2015-03-30 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
| US10023628B2 (en) | 2012-07-06 | 2018-07-17 | Bioverativ Therapeutics Inc. | Cell line expressing single chain factor VIII polypeptides and uses thereof |
| ES2770501T3 (es) | 2012-07-11 | 2020-07-01 | Bioverativ Therapeutics Inc | Complejo del factor VIII con XTEN y proteína del factor de Von Willebrand y sus usos |
| WO2014052490A1 (fr) | 2012-09-25 | 2014-04-03 | Biogen Idec Ma Inc. | Procédés d'utilisation de polypeptides de facteur ix (fix) |
| EP2738180A1 (fr) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Protéines de liaison comportant au moins deux domaines de liaison ciblant HER2 |
| SG11201505926VA (en) | 2013-03-15 | 2015-09-29 | Biogen Ma Inc | Factor ix polypeptide formulations |
| WO2015022326A1 (fr) | 2013-08-12 | 2015-02-19 | Xiber Science Gmbh | Peptides en tant qu'agents actifs pour le traitement d'un dysfonctionnement du greffon primaire |
| US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
| EP3628324A1 (fr) | 2013-11-05 | 2020-04-01 | Allergan, Inc. | Procédé de traitement d'états de santé de l' il par un darpin anti-vegf |
| WO2015070014A1 (fr) | 2013-11-08 | 2015-05-14 | Biogen Idec Ma Inc. | Composé de fusion procoagulant |
| EA201691111A1 (ru) | 2014-01-10 | 2017-01-30 | Байоджен Ма Инк. | Химерные белки фактора viii и их применение |
| JP6652932B2 (ja) | 2014-06-18 | 2020-02-26 | アルバート アインシュタイン カレッジ オブ メディシン | synTacポリペプチド及びその使用 |
| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| WO2016065052A1 (fr) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Conjugués insuline vitamine d |
| US9458211B1 (en) | 2015-04-02 | 2016-10-04 | Molecular Partners Ag | Recombinant proteins that simultaneously bind HGF, VEGF-A and serum albumin, comprising ankyrin repeat domains |
| EP3303380B1 (fr) | 2015-06-02 | 2020-01-15 | Novo Nordisk A/S | Insulines à extensions recombinées polaires |
| EP3307326B9 (fr) | 2015-06-15 | 2021-02-24 | Angiochem Inc. | Procédés de traitement d'une carcinomatose leptoméningée |
| UA126016C2 (uk) | 2015-08-03 | 2022-08-03 | Біовератів Терапеутікс Інк. | Злитий білок фактора іх |
| IL319047A (en) | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
| WO2017055582A1 (fr) | 2015-10-01 | 2017-04-06 | Novo Nordisk A/S | Conjugués de protéines |
| SG11201808552XA (en) | 2016-05-18 | 2018-10-30 | Cue Biopharma Inc | T-cell modulatory multimeric polypeptides and methods of use thereof |
| IL262606B2 (en) | 2016-05-18 | 2023-04-01 | Albert Einstein College Medicine Inc | pd-l1 variant polypeptides, T-cell modulatory multimeric polypeptides, and methods of using them |
| KR20190090827A (ko) | 2016-12-02 | 2019-08-02 | 바이오버라티브 테라퓨틱스 인크. | 키메라 응고 인자를 사용해 혈우병성 관절증을 치료하는 방법 |
| CN110325205B (zh) | 2016-12-22 | 2023-08-15 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
| US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| KR20240005989A (ko) | 2017-03-15 | 2024-01-12 | 큐 바이오파마, 인크. | 면역 반응을 조절하는 방법 |
| JP2020513019A (ja) | 2017-04-05 | 2020-04-30 | ノヴォ ノルディスク アー/エス | オリゴマー伸長インスリン−Fcコンジュゲート |
| WO2019051127A1 (fr) | 2017-09-07 | 2019-03-14 | Cue Biopharma, Inc. | Polypeptide multimère modulateur de lymphocyte t ayant des sites de conjugaison et procédés d'utilisation associés |
| WO2019139896A1 (fr) | 2018-01-09 | 2019-07-18 | Cue Biopharma, Inc. | Polypeptides multimères modulateurs de lymphocytes t et leurs procédés d'utilisation |
| WO2019201855A1 (fr) * | 2018-04-16 | 2019-10-24 | Swedish Orphan Biovitrum Ab (Publ) | Protéine de fusion lysosomale |
| KR102914074B1 (ko) | 2018-05-18 | 2026-01-16 | 바이오버라티브 테라퓨틱스 인크. | A형 혈우병의 치료 방법 |
| TWI856047B (zh) | 2018-12-19 | 2024-09-21 | 美商信號生物製藥公司 | 多聚體t細胞調節多肽及其使用方法 |
| JP7691927B2 (ja) | 2019-03-06 | 2025-06-12 | キュー バイオファーマ, インコーポレイテッド | T細胞調節抗原提示ポリペプチド及びその使用方法 |
| WO2020181062A1 (fr) | 2019-03-06 | 2020-09-10 | Cue Biopharma, Inc. | Polypeptides multimères modulateurs des lymphocytes t et leurs méthodes d'utilisation |
| KR20220016944A (ko) | 2019-06-04 | 2022-02-10 | 몰리큘라 파트너스 아게 | 개선된 안정성을 갖는 설계된 안키린 반복 도메인 |
| WO2021081232A1 (fr) | 2019-10-23 | 2021-04-29 | Cue Biopharma, Inc. | Lymphocytes t cytoxiques modifiés et leurs procédés d'utilisation |
| WO2021136223A1 (fr) | 2019-12-31 | 2021-07-08 | Beijing Ql Biopharmaceutical Co., Ltd. | Protéines de fusion de glp-1 et de gdf15 et leurs conjugués |
| WO2022032187A1 (fr) | 2020-08-07 | 2022-02-10 | Bristol-Myers Squibb Company | Fgf21 combiné à des antagonistes de ccr2/5 pour le traitement de la fibrose |
| CA3193453A1 (fr) | 2020-09-30 | 2022-04-07 | Beijing Ql Biopharmaceutical Co., Ltd. | Conjugues polypeptidiques et leurs procedes d'utilisation |
| WO2022115597A1 (fr) | 2020-11-25 | 2022-06-02 | Bristol-Myers Squibb Company | Méthodes de traitement de maladies du foie |
| US20240018265A1 (en) | 2020-12-11 | 2024-01-18 | Friedrich Miescher Institute For Biomedical Research | Hdac6 binding proteins and their anti-viral use |
| EP4323413A4 (fr) | 2022-03-30 | 2025-10-15 | Beijing Ql Biopharmaceutical Co Ltd | Compositions pharmaceutiques liquides de conjugués polypeptidiques et leurs procédés d'utilisation |
| CN115083016A (zh) * | 2022-06-09 | 2022-09-20 | 广州紫为云科技有限公司 | 一种基于单目摄像机的面向小目标手部隔空交互方法与装置 |
| US12233115B2 (en) | 2022-09-30 | 2025-02-25 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD257197A1 (de) † | 1987-01-28 | 1988-06-08 | Univ Dresden Tech | Verfahren zur herstellung von immobilisierten, in ihrer biologischen aktivitaet stabilisierten und in ihren pharmakologischen eigenschaften modifizierten insulinpraeparationen |
| FR2647677B1 (fr) * | 1989-05-31 | 1991-09-27 | Roussel Uclaf | Nouvelles micro-proteines, procede de preparation et application a titre de medicaments de ces nouvelles micro-proteines |
| WO1992010576A1 (fr) † | 1990-12-13 | 1992-06-25 | The Upjohn Company | Polypeptides de fusion |
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| WO1998022577A1 (fr) † | 1996-11-15 | 1998-05-28 | Maria Grazia Masucci | Proteines de fusion a demi-vie allongee |
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| CA2595695A1 (fr) † | 2005-01-25 | 2006-08-03 | Cell Therapeutics, Inc. | Conjugats de proteine active biologiquement renfermant des repetitions de peptide (nn[s/t]) et ayant une demi-vie de plasma prolongee |
| EP1971355B1 (fr) † | 2005-12-20 | 2020-03-11 | Duke University | Procedes et compositions pour l'administration d'agents actifs a proprietes pharmacologiques ameliorees |
| CA2644712C (fr) | 2006-03-06 | 2016-09-13 | Amunix, Inc. | Polymeres recombines non structures et utilisations correspondantes |
| WO2008049711A1 (fr) † | 2006-10-27 | 2008-05-02 | Novo Nordisk A/S | Insuline à peptide ajouté |
-
2007
- 2007-03-06 CA CA2644712A patent/CA2644712C/fr active Active
- 2007-03-06 WO PCT/US2007/005952 patent/WO2007103515A2/fr not_active Ceased
- 2007-03-06 EP EP07752549A patent/EP1996937A4/fr not_active Withdrawn
- 2007-03-06 AU AU2007223855A patent/AU2007223855B2/en active Active
- 2007-03-06 DK DK11172812.7T patent/DK2402754T4/da active
- 2007-03-06 AU AU2007223888A patent/AU2007223888A1/en not_active Abandoned
- 2007-03-06 WO PCT/US2007/005857 patent/WO2007103455A2/fr not_active Ceased
- 2007-03-06 SI SI200731588T patent/SI2402754T2/sl unknown
- 2007-03-06 EP EP07752636.6A patent/EP1996220B2/fr active Active
- 2007-03-06 EP EP20140189047 patent/EP2863222A1/fr not_active Ceased
Non-Patent Citations (4)
| Title |
|---|
| BULAJ GRZEGORZ ET AL: "Efficient oxidative folding of conotoxins and the radiation of venomous cone snails.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, no. Supplement 2, 25 November 2003 (2003-11-25), pages 14562 - 14568, XP002515375, ISSN: 0027-8424 * |
| CHEN X J ET AL: "Site-directed mutations in a highly conserved region of Bacillus thuringiensis delta-endotoxin affect inhibition of short circuit current across Bombyx mori midguts.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1 OCT 1993, vol. 90, no. 19, 1 October 1993 (1993-10-01), pages 9041 - 9045, XP002515378, ISSN: 0027-8424 * |
| GOMEZ-DUARTE O G ET AL: "Expression of fragment C of tetanus toxin fused to a carboxyl-terminal fragment of diphtheria toxin in Salmonella typhi CVD 908 vaccine strain", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 13, no. 16, 1 November 1995 (1995-11-01), pages 1596 - 1602, XP004057422, ISSN: 0264-410X * |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP1996220A4 (fr) | 2009-04-29 |
| SI2402754T1 (sl) | 2015-02-27 |
| WO2007103515A3 (fr) | 2008-04-03 |
| DK2402754T4 (da) | 2023-08-28 |
| AU2007223855B2 (en) | 2013-05-16 |
| EP1996220B2 (fr) | 2023-08-16 |
| WO2007103455A3 (fr) | 2007-11-29 |
| CA2644712A1 (fr) | 2007-09-13 |
| WO2007103455A2 (fr) | 2007-09-13 |
| AU2007223855A1 (en) | 2007-09-13 |
| CA2644712C (fr) | 2016-09-13 |
| DK2402754T3 (en) | 2015-01-12 |
| WO2007103515A2 (fr) | 2007-09-13 |
| EP1996220A2 (fr) | 2008-12-03 |
| EP2863222A1 (fr) | 2015-04-22 |
| AU2007223888A1 (en) | 2007-09-13 |
| SI2402754T2 (sl) | 2023-09-29 |
| EP1996937A2 (fr) | 2008-12-03 |
| EP1996220B1 (fr) | 2013-05-08 |
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