EP2019277A2 - Dispositif de charge et de décharge d'une plaque réglable d'une installation de lyophilisation et un procédé correspondant - Google Patents

Dispositif de charge et de décharge d'une plaque réglable d'une installation de lyophilisation et un procédé correspondant Download PDF

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Publication number
EP2019277A2
EP2019277A2 EP08011967A EP08011967A EP2019277A2 EP 2019277 A2 EP2019277 A2 EP 2019277A2 EP 08011967 A EP08011967 A EP 08011967A EP 08011967 A EP08011967 A EP 08011967A EP 2019277 A2 EP2019277 A2 EP 2019277A2
Authority
EP
European Patent Office
Prior art keywords
vials
transport carriage
freeze
transfer table
loading
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP08011967A
Other languages
German (de)
English (en)
Other versions
EP2019277B1 (fr
EP2019277A3 (fr
Inventor
Alexander Wagner
Ralf Battenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HOF Sonderanlagenbau GmbH
Original Assignee
Accurro GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Accurro GmbH filed Critical Accurro GmbH
Publication of EP2019277A2 publication Critical patent/EP2019277A2/fr
Publication of EP2019277A3 publication Critical patent/EP2019277A3/fr
Application granted granted Critical
Publication of EP2019277B1 publication Critical patent/EP2019277B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
    • F26B25/001—Handling, e.g. loading or unloading arrangements
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Definitions

  • the present invention relates to a device for loading and unloading an adjusting plate of a freeze-drying plant according to the preamble of claims 1 and 2, and a method for this purpose according to the preamble of claims 16 and 17.
  • the material to be dried in a freeze-drying plant is filled into small vials, and transported with the aid of these vials. Lids are provided on these vials, which are closed after completion of the freeze-drying process.
  • the filled with the freeze-drying material and provided with an open lid vials are placed on a transfer table and transported from there with a pusher on an adjusting plate in the interior of the freeze-drying plant.
  • a plurality of shelves is provided, wherein the loading plates of the freeze-drying plant are taken from a stack, are offset to the height of the transfer table and loaded with the vials. After the shelf is filled, this is moved together with the previously filled panels up and it is the next shelf from the stack fetched and brought to the level of the transfer table, etc ..
  • the panels are merged so that the above Vials located on the lids of vials to the plant and pushes these lids in the vials, so that the vials are now closed. Then the panels are pulled apart again so far that the height of the transfer plate located plate can be unloaded. Once this plate is unloaded, it is brought to the bottom of the freeze dryer and stacked there, while the next shelf is moved to the level of the transfer table to unload it, and so on.
  • the pusher comprises a pivoting up and down beams, which is held on a right and left on the transfer table and on the control plate guided slide.
  • the carriages are guided on special rails, which are mounted on the right and left edges of the transfer plate and the adjusting plate.
  • the rails are designed as a right-angled upwardly projecting web and at the same time form a side boundary for the vials located on the transfer table or the control plate.
  • the metal bands pull the carriages and thus the bar back to the starting position, before the bar is swung upwards via a pivoting mechanism mounted on the carriage, so that the next vials under the bar pass on top Transfer table can be turned off.
  • the now filled tray is moved up and the next, empty shelf is provided. If there are enough vials on the transfer table, this process repeats and the pusher pushes the next group of vials onto the next set plate.
  • the pusher After completion of the freeze-drying operation, the pusher is moved by means of guided on the rails carriage to the rear edge of the adjusting plate. It often happens that the slide has to move a little bit to the side near the rail to get to the rear end of the shelf. Again, the vials are further messed up and it can fall over individual vials.
  • Freeze-drying plants often process food or medicines. Consequently, very strict hygiene requirements apply here. This has the consequence that once fallen over vials can not be further processed and thus represent committee.
  • the present invention the object of the invention to provide a device and a method of the type mentioned, in which the vials low friction and safely transferred to the control plate and back.
  • a trained according to this technical teaching device for loading and unloading a control plate of a freeze-drying plant and executed according to this technical teaching method for loading and unloading a shelf of a freeze dryer have the advantage that by positioning the transport carriage on the right and left edge of the transfer table or the adjusting plate is provided a side boundary, which prevents falling of the vials. It is particularly advantageous to place the transport carriage so that the vials located on the edge lie directly against a transport carriage during the loading and unloading process.
  • the vials are moved into or out of the freeze dryer along with the transport carriages, the vials can be well spaced from the transport carriages be guided. Taking into account that the transport carriages and the vials move in the same direction, it can be seen that this arrangement reduces the relative speed between the transport carriages and the vials to a minimum.
  • the vials move at the same speed as the transport carriages so that the relative velocity is reduced to zero. This has the advantage that there is no friction between the peripheral vials and the transport carriages, thus preventing accidental tipping over, which improves the rejects and thus the effectiveness of the lyophilization process.
  • this ensures that the vials remain in the order once set up so that each vial is in a well-defined position before and after unloading.
  • This specific positioning of the vials makes it possible to better control the freeze-drying process as it is only by the quality of the products in the vials that conclusions about the freeze-drying process can be made. For example, if it is found that always the vials at a certain position have insufficient freeze-drying quality, then the freeze-drying method can be improved on this point with the aim of reducing the rejects.
  • Yet another advantage is that for quality control, only those vials that were at critical locations on the shelf to examine the overall quality of the freeze-drying process must be examined. Consequently, the number of samples can be reduced while improving the examination result.
  • the invention provides a device for loading and unloading a shelf of a freeze dryer with the features of claim 2 and a method for loading and unloading a freeze-drying plant with the features of claim 17 proposed.
  • Advantageous developments of this device can be found in the respective subclaims.
  • a trained according to this technical teaching device for loading and unloading a shelf of a freeze-drying plant and a running according to this technical teaching method for loading and unloading a shelf of a freeze dryer have the advantage that by moving the transport carriage transversely to the direction of movement a distance between the Transport sled and the vials can be created. This results in the advantage that the transport carriages, for example, during direct loading or unloading, ie during a slide travel, can be brought close to the vials located at the edge of the transfer table or at the edge of the set plate in order to achieve good guidance of the vials.
  • a guide element is arranged on the right and left edges of the transfer table and / or the setting plate, on which the transport carriage rests.
  • this guide element is placed so that the transport carriage resting thereon acts as a lateral boundary of the transfer table and / or the adjusting plate. It has proven to be advantageous to let the guide element reach to the rear edge of the control plate, so that the transport carriage, especially the push chain, is guided correctly over the entire length and not accidentally slips or falls off partially.
  • a guide groove is formed on the guide element into which a guide pin attached to the underside of the transport carriage and extending downwards extends.
  • the guide element is held laterally by approximately 1 mm to 10 mm, preferably 4 mm, displaceably on the transfer table and / or on the setting plate. This has the advantage that these guide elements can be moved in a simple and cost-effective manner, for example pneumatically, electrically or hydraulically.
  • an inner groove and an outer groove is formed in the guide element, wherein on the underside of the transport carriage, a downwardly extending guide pin is formed, which engages depending on the situation in the inner or in the outer groove. It has proven to be advantageous to arrange the inner groove and the outer groove in parallel.
  • Such a trained guide member has the advantage that the resting on the guide element transport carriage is positively secured by the guided in the inner or outer groove guide pin against lateral slipping.
  • the transport carriage can be freely moved back and forth in the direction of movement, since the aligned also in the direction of movement inner and outer grooves in this direction are not an obstacle, but well across the direction of movement, so that the transport carriage is secured against lateral slipping.
  • At least two connecting grooves are provided between the inner groove and the outer groove.
  • At least two, preferably eight, guide pins are provided on the underside of the transport carriage in order to reliably prevent unintentional, lateral displacement of the transport carriage over the entire length.
  • the connecting grooves are arranged such that the guide pins are in the extended transport carriage in the region of the connecting grooves. In this way, then the transport carriage can be moved in a simple manner, for example, from the inner groove on the respective connecting grooves in the outer groove and vice versa.
  • the transport carriage can be designed either as a rod or push chain.
  • a centering device is arranged in the freeze-drying plant behind the loading table to be loaded, with which the tip of a transport carriage can be grasped.
  • the transport carriage or at least one part thereof, can be reliably transferred into the respective other groove.
  • the centering device moves only the tip of the push chain and some adjoining chain links.
  • On the opposite side of the push chain, including some adjoining chain links from the drive of the push chain is moved, with a more or less large area in the middle more or less remains in the exit groove. If the push chain is now moved out of the freeze-drying system, the push chain pulls straight by itself.
  • FIG. 1a to 1f is a schematic representation of an inventive device for loading and unloading an adjusting plate of a freeze-drying plant and such a freeze-drying plant 10 is shown.
  • This freeze dryer 10 comprises a large chamber 12 which is provided on one side with an opening 14 for loading and unloading. This opening 14 can be closed with a door, not shown here.
  • a number of adjusting plates 16 are provided, which are vertically movable by a mechanism, not shown here.
  • the device shown in the drawing for loading and unloading an adjusting plate and the associated freeze-drying system are shown only schematically. Many details have been omitted in order to more clearly illustrate the basic principle of the device and the freeze dryer.
  • the product to be dried is usually filled in small vials 18, the vials 18 being provided with an open lid before the freeze-drying process, while the vials 18 have a closed lid after the freeze-drying process so as not to pollute the freeze-dried product.
  • a device for loading and unloading a shelf of a freeze-drying plant and the freeze-drying system itself are usually placed in high-purity rooms, so that the drugs located in the vials are not contaminated. But this also means that the entire loading and unloading process must be fully automatic.
  • the apparatus for loading and unloading a positioning plate 16 of a freeze dryer 10 with a number of vials 18 includes a transfer table 20 on which the usually individually or batch incoming vials 18 are collected until a sufficient number of vials 18 on the Transfer table 20 is available.
  • the transfer table 20 is formed as a flat flat surface and is bounded on the right and left by a respective guide element 22.
  • the guide element 22 is connected directly to the transfer table 20, wherein the top of the guide element 22 is flush with the top of the transfer table 20.
  • an outer groove 24 is provided on the outer edge, which extends over the entire length of the guide element 22. Immediately adjacent to the outer groove 24 is a little inwardly offset and to the Outer groove 24 parallel inner groove 26 is provided, which also extends over the entire length of the guide member 22.
  • each of the adjusting plates 16 at its right and left edge on a corresponding guide element 22 ', which also each has an outer groove 24 and an inner groove 26.
  • To load the adjusting plate 16 it is moved into the region of the opening 14 by the lifting mechanism, not shown here, so that the guide element 22 and the guide element 22 'abut flush. This causes the outer groove 24 and the inner groove 26 of the guide member 22 passes directly into the outer 24 and the inner groove 26 of the guide element 22 ', as in particular in the Fig. 1d becomes clear.
  • connecting grooves 28 are provided at certain intervals, which connect the outer groove 24 with the inner groove 26.
  • the connecting grooves 28 are many times longer than the diameter of the guide pin 36th
  • guide elements 22 each designed as a push chain 30 transport carriage is arranged.
  • This push chain 30 is stored on a roller 32 and moved by this.
  • the direction of rotation of the roller 32 determines the direction of movement of the push chain 30.
  • the roller chain 32 guides the push chain 30 about a deflection roller 34 to the guide element 22 on the transfer table 20.
  • the push chain 30 itself is composed of a number of individual, mutually movable members together, which has a certain rigidity during a pushing operation and thus can be used similar to a rod.
  • guide pins 36 are arranged at regular intervals, as in particular from Fig. 1f is apparent.
  • the sliding device also includes a loading element designed as a loading slider 38, which can be deposited in a tray 40 above the transfer table 20, if it is not needed.
  • the loading slider 38 is deposited so far up on the tray 40 that under the loading slider 38, the vials 18 can be passed.
  • the tray 40 is provided with a corresponding automated mechanism and can store the loading slider 38 on the right and left push chain 30 and pick it up from there in due course.
  • right and left engage the loading slider 38 provided slots 42 in corresponding pin 54 on one of the members of the push chain 30, so that the loading slider 38 is reliably held on the right and left push chain 30 in this way.
  • the loading slider 38 is taken and pushes the existing on the transfer table 20 vials 18 before him down to the adjusting plate 16th
  • the right and left push chain 30 are so arranged on the transfer table 20, that is, on the guide member 22 that the push chains 30 form a lateral boundary to the transfer tables 20.
  • the vials 18 are placed so close to the transfer table 20 that the respective marginal vials 18 can abut the corresponding pusher chain 30. The same applies to the control plate 16.
  • the device for loading and unloading a setting plate also includes two centering devices 44, which are attached to one of the opening 14 opposite wall of the chamber 12 of the freeze-drying system 10. Each of these centering devices 44 is positioned so that it can receive a tip 46 of the push chain 30 as soon as it has passed the rear edge of the adjusting plate 16. In this case, the centering device 44 is horizontally displaceable in order to transfer the push chain 30 from the inner groove 26 into the outer groove 24 and vice versa. Details of this will be described in detail below under the loading procedure.
  • a support table 47 is provided at this point. This ensures that the tip 46 always finds in the centering device 44.
  • To the device for loading and unloading an adjusting plate 16 of a freeze dryer 10 further includes a holding facial 48 for receiving a discharge slider 50.
  • a holding facial 48 for receiving a discharge slider 50 is attached to one of the opening 14 opposite wall of the chamber 12 of the freeze dryer 10. It is understood that both the centering device 44 and the retaining mimic 48 are mounted together with the discharge slide 50 on the chamber 12 such that the vertical movement of the adjusting plates 16 is not hindered thereby.
  • the retaining mimic 48 carries the unloading slider 50, unless it is required for unloading the adjusting plates 16.
  • the holding mimic 48 is capable of placing in the unloading slide 50 on the push chains 30 extended to the rear edge of the setting plate 16 in such a way that slots 52 of the unloading slide 50 located at the right and left edges engage corresponding pins 54 on the push chain 30, so that the right and left push chains 30 can carry the unloading slider 50.
  • this third embodiment with the in the Fig. 1a to 1f shown and described above first embodiment identical.
  • Fig. 14a to 14f is a fourth embodiment of a device according to the invention shown schematically.
  • This fourth embodiment is different from that in FIGS Fig. 1a to 1f illustrated first embodiment only in that instead of the push chain, a rod 430 is inserted. As with the push chain, this rod 430 is guided over guide pins 436 in the inner 426 or outer groove 424 and has on its upper side pin 454 for receiving the loading and unloading slide 450.
  • this fourth embodiment with the in the Fig. 1a to 1f shown and described above first embodiment identical.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Drying Of Solid Materials (AREA)
EP08011967.0A 2007-07-23 2008-07-03 Dispositif de charge et de décharge d'une plaque réglable d'une installation de lyophilisation et un procédé correspondant Not-in-force EP2019277B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102007034197A DE102007034197B4 (de) 2007-07-23 2007-07-23 Vorrichtung zum Be- und Entladen einer Stellplatte einer Gefriertrocknungsanlage und ein Verfahren hierfür

Publications (3)

Publication Number Publication Date
EP2019277A2 true EP2019277A2 (fr) 2009-01-28
EP2019277A3 EP2019277A3 (fr) 2012-05-30
EP2019277B1 EP2019277B1 (fr) 2015-11-18

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP08011967.0A Not-in-force EP2019277B1 (fr) 2007-07-23 2008-07-03 Dispositif de charge et de décharge d'une plaque réglable d'une installation de lyophilisation et un procédé correspondant

Country Status (4)

Country Link
US (1) US8197171B2 (fr)
EP (1) EP2019277B1 (fr)
DE (1) DE102007034197B4 (fr)
DK (1) DK2019277T3 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20121275A1 (it) * 2012-07-23 2014-01-24 I M A Ind Macchine Automatic He S P A Apparato di movimentazione di piani di carico per macchine liofilizzatrici
CN114353488A (zh) * 2022-01-28 2022-04-15 东莞市德瑞精密设备有限公司 锂电池干燥线
CN114633982A (zh) * 2022-05-10 2022-06-17 上海原能细胞生物低温设备有限公司 一种提取操作室及智能化样本存取系统

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DE102008064094A1 (de) * 2008-12-19 2010-07-01 Accurro Gmbh Gefriertrocknungsanlage und Vorrichtung zum Be- und Entladen einer Stellplatte einer Gefriertrocknungsanlage
DE102011117628B4 (de) 2011-11-04 2015-10-22 Martin Christ Gefriertrocknungsanlagen Gmbh Gefriertrockungsanlage mit einer Be- und Entladevorrichtung
WO2014117690A2 (fr) * 2013-01-31 2014-08-07 楚天科技股份有限公司 Machine de lyophilisation
ITMI20131016A1 (it) * 2013-06-19 2014-12-20 I M A Ind Macchine Automatic He S P A Sistema di alimentazione in una macchina liofilizzatrice per il settore farmaceutico
ITMI20131447A1 (it) * 2013-09-04 2015-03-05 I M A Ind Macchine Automatic He S P A Macchina liofilizzatrice comprendente almeno un organo di guida per dispositivi di carico
JP6455664B2 (ja) * 2015-02-26 2019-01-23 澁谷工業株式会社 凍結乾燥製剤製造システム
ITUA20161823A1 (it) * 2016-03-18 2017-09-18 I M A Industria Macch Automatiche S P A In Sigla Ima S P A Apparato per caricare e scaricare un liofilizzatore.
CN110462320B (zh) * 2017-03-24 2020-10-09 阿自倍尔株式会社 存放装置
CN113154807A (zh) * 2020-02-26 2021-07-23 浙江星菜农业科技有限公司 连续加工式冷冻干燥系统和方法
CN112484402B (zh) * 2020-12-01 2022-06-14 江西新海集团粮油有限公司 一种真空冻干装置
DE102021105371B4 (de) 2021-03-05 2024-06-13 Accurro Gmbh Verfahren zum Be- und Entladen einer Stellplatte einer Gefriertrocknungsanlage und Stellplatte hierzu
CN114754557B (zh) * 2022-04-25 2023-12-12 沛县龙固镇中心卫生院 一种旋转式医疗托盘快速干燥装置
DE102023200949A1 (de) * 2023-02-06 2024-08-08 OPTIMA pharma GmbH Transportsystem, System und Verfahren
CN116216152B (zh) * 2023-03-09 2025-12-30 武汉库柏特科技有限公司 一种药剂的发药系统
CN116620797B (zh) * 2023-06-07 2023-10-13 苏州睿新浩电子科技有限公司 一种线性滑道式托盘供料器

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EP1619459A1 (fr) 2004-07-22 2006-01-25 Ima-Telstar S.L. Dispositif de chargement et de déchargement des récipients

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20121275A1 (it) * 2012-07-23 2014-01-24 I M A Ind Macchine Automatic He S P A Apparato di movimentazione di piani di carico per macchine liofilizzatrici
WO2014016659A3 (fr) * 2012-07-23 2014-03-13 I.M.A. Industria Macchine Automatiche S.P.A. Machine de lyophilisation ou de stérilisation à appareil de déplacement pour plans de chargement
US9192689B2 (en) 2012-07-23 2015-11-24 I.M.A. Industria Macchine Automatiche Spa Lyophilizing or sterilizing machine with movement apparatus for loading planes
CN114353488A (zh) * 2022-01-28 2022-04-15 东莞市德瑞精密设备有限公司 锂电池干燥线
CN114633982A (zh) * 2022-05-10 2022-06-17 上海原能细胞生物低温设备有限公司 一种提取操作室及智能化样本存取系统
WO2023216768A1 (fr) * 2022-05-10 2023-11-16 上海原能细胞生物低温设备有限公司 Salle d'opération d'extraction et système d'accès à un échantillon intelligent
US12265095B1 (en) 2022-05-10 2025-04-01 Shanghai Origincell Biological Cryo Equipment Co., Ltd. Extraction operation room and intelligent sample access system

Also Published As

Publication number Publication date
EP2019277B1 (fr) 2015-11-18
US20090025251A1 (en) 2009-01-29
US8197171B2 (en) 2012-06-12
DK2019277T3 (en) 2016-02-01
EP2019277A3 (fr) 2012-05-30
DE102007034197B4 (de) 2013-06-06
DE102007034197A1 (de) 2009-01-29

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