EP2021499A4 - Reseaux fonctionnels pour la caracterisation a grande cadence d'elements regulant l'expression genique - Google Patents

Reseaux fonctionnels pour la caracterisation a grande cadence d'elements regulant l'expression genique

Info

Publication number
EP2021499A4
EP2021499A4 EP06849046A EP06849046A EP2021499A4 EP 2021499 A4 EP2021499 A4 EP 2021499A4 EP 06849046 A EP06849046 A EP 06849046A EP 06849046 A EP06849046 A EP 06849046A EP 2021499 A4 EP2021499 A4 EP 2021499A4
Authority
EP
European Patent Office
Prior art keywords
gene expression
regulating gene
functional networks
elements regulating
frequency characterization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP06849046A
Other languages
German (de)
English (en)
Other versions
EP2021499A2 (fr
Inventor
Nathan D Trinklein
Shelley F Aldred
Sara J Cooper
Richard M Myers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/636,385 external-priority patent/US20070161031A1/en
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of EP2021499A2 publication Critical patent/EP2021499A2/fr
Publication of EP2021499A4 publication Critical patent/EP2021499A4/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP06849046A 2005-12-16 2006-12-08 Reseaux fonctionnels pour la caracterisation a grande cadence d'elements regulant l'expression genique Ceased EP2021499A4 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75092905P 2005-12-16 2005-12-16
US76205606P 2006-01-24 2006-01-24
US11/636,385 US20070161031A1 (en) 2005-12-16 2006-12-07 Functional arrays for high throughput characterization of gene expression regulatory elements
PCT/US2006/046920 WO2007078599A2 (fr) 2005-12-16 2006-12-08 Réseaux fonctionnels pour la caractérisation à grande cadence d'éléments régulant l'expression génique

Publications (2)

Publication Number Publication Date
EP2021499A2 EP2021499A2 (fr) 2009-02-11
EP2021499A4 true EP2021499A4 (fr) 2010-02-17

Family

ID=38228711

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06849046A Ceased EP2021499A4 (fr) 2005-12-16 2006-12-08 Reseaux fonctionnels pour la caracterisation a grande cadence d'elements regulant l'expression genique

Country Status (3)

Country Link
EP (1) EP2021499A4 (fr)
JP (1) JP2009519710A (fr)
WO (1) WO2007078599A2 (fr)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2432881T3 (en) 2009-05-18 2018-02-26 Curna Inc TREATMENT OF REPROGRAMMING FACTOR-RELATED DISEASES BY INHIBITING NATURAL ANTISENSE TRANSCRIPTS TO A REPROGRAMMING FACTOR
CN102575250B (zh) * 2009-07-15 2014-05-28 朱正仑 治疗和诊断免疫系统疾病的药物和制剂及其用途
SG10201800541SA (en) 2010-04-23 2018-03-28 Univ Florida Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1)
WO2011146411A1 (fr) * 2010-05-17 2011-11-24 University Of Southern California Le polymorphisme du gène grp78 rs391957 est associé à une récurrence de tumeur et à la survie chez des patients atteints de cancer gastro-intestinal
CN103608455B (zh) * 2011-01-07 2019-01-15 应用遗传科技公司 用于治疗色盲和其它疾病的启动子、表达盒、载体、药盒和方法
WO2013151058A1 (fr) * 2012-04-03 2013-10-10 独立行政法人国立成育医療研究センター ADN COMMANDANT L'EXPRESSION DE miR -140, ET PROCÉDÉ DE CRIBLAGE DE MÉDICAMENTS UTILISANT LEDIT ADN
US9163259B2 (en) 2012-05-04 2015-10-20 Novartis Ag Viral vectors for the treatment of retinal dystrophy
WO2014031079A1 (fr) * 2012-08-21 2014-02-27 Singapore Health Services Pte Ltd Méthode et/ou sonde pour déterminer une sensibilité au glaucome
KR102495527B1 (ko) * 2013-03-14 2023-02-06 몬산토 테크놀로지 엘엘씨 식물 조절 성분 및 이의 용도
WO2014197586A1 (fr) 2013-06-04 2014-12-11 Virginia Commonwealth University Promoteur du gène de la synténine (mda-9) utilisé pour la prise d'image et le traitement de cellules cancéreuses métastatiques
PL3097197T3 (pl) * 2014-01-21 2021-06-28 Vrije Universiteit Brussel Mięśniowo-specyficzne elementy regulatorowe kwasów nukleinowych oraz sposoby i ich zastosowanie
US20150276767A1 (en) * 2014-03-12 2015-10-01 The University Of Sydney Systems and methods for identifying cancers having activated progesterone receptors
ES2719122T3 (es) * 2014-03-21 2019-07-08 Life Technologies Corp Ensayo de referencia multi-copia
CN103981185B (zh) * 2014-04-14 2016-04-27 浙江理工大学 肝癌特异性gp73核心启动子及其筛选构建方法
KR101791296B1 (ko) * 2014-04-17 2017-10-27 제주대학교 산학협력단 알츠하이머병 관련 돌연변이 유전자를 포함하는 발현 카세트, 벡터, 및 이를 이용하여 형질전환된 세포주
RU2017112748A (ru) 2014-11-17 2018-12-19 Арно Терапьютикс, Инк. Композиции онапристона пролонгированного действия и способы
CN104673797B (zh) * 2015-02-09 2018-02-02 苏州大学 参与人体细胞电离辐射应激反应的长链非编码rna及其应用
WO2016149455A2 (fr) * 2015-03-17 2016-09-22 The General Hospital Corporation Interactome arn de complexe répressif polycomb 1 (prc1)
EP3307888A1 (fr) * 2015-06-12 2018-04-18 Erasmus University Medical Center Rotterdam Nouveaux dosages crispr
CA2998924A1 (fr) 2015-09-25 2017-03-30 Context Biopharma Inc. Procedes de fabrication d'intermediaires d'onapristone
CA3008422A1 (fr) 2015-12-15 2017-06-22 Context Biopharma Inc. Compositions a base d'onapristone amorphe et leurs procedes de fabrication
MX2018009542A (es) 2016-02-04 2018-11-09 Zhu Zhenglun Tratamiento y diagnostico de trastornos inflamatorios.
WO2023150553A1 (fr) * 2022-02-01 2023-08-10 University Of Rochester Ciblage et transduction basés sur un promoteur rcpg17 de cellules progénitrices gliales
MX2018012537A (es) 2016-04-15 2019-02-25 Univ Pennsylvania Terapia de genes para tratar hemofilia a.
US20180148471A1 (en) 2016-11-30 2018-05-31 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection
WO2018111104A1 (fr) * 2016-12-14 2018-06-21 Erasmus University Medical Center Rotterdam Utilisation de séquences crispr humaines dans des diagnostics
WO2018178067A1 (fr) * 2017-03-27 2018-10-04 Vrije Universiteit Brussel Éléments régulateurs d'acides nucléiques spécifiques au diaphragme et méthodes et utilisation associées
MX2019011772A (es) * 2017-04-03 2020-01-09 Encoded Therapeutics Inc Expresion transgenica selectiva de tejidos.
JP7119009B2 (ja) 2017-05-31 2022-08-16 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 最適化されたヒト凝固第ｉｘ因子遺伝子発現カセットおよびそれらの使用
RU2671156C1 (ru) * 2017-08-21 2018-10-29 Общество с ограниченной ответственностью "Центр Генетики и Репродуктивной Медицины "ГЕНЕТИКО" Способ преимплантационной генетической диагностики спинальной мышечной атрофии типа 1
WO2019097122A1 (fr) * 2017-11-20 2019-05-23 Turun Yliopisto Nouveau variant de cip2a et ses utilisations
EP3717505A4 (fr) 2017-12-01 2021-12-01 Encoded Therapeutics, Inc. Protéines de liaison à l'adn modifiées
AU2019227910B2 (en) 2018-02-28 2025-07-17 The Regents Of The University Of California A modular system for gene and protein delivery based on AAV
US12274733B2 (en) 2018-09-28 2025-04-15 President And Fellows Of Harvard College Cellular reprogramming to reverse aging and promote organ and tissue regeneration
IL281470B2 (en) 2018-09-28 2025-08-01 Harvard College Cellular reprogramming to reverse aging and promote organ and tissue regeneration
KR20210086644A (ko) * 2018-10-31 2021-07-08 럿거스, 더 스테이트 유니버시티 오브 뉴 저지 Gramc: cis 조절 모듈에 대한 게놈 스케일 리포터 분석방법
FR3088194B1 (fr) * 2018-11-09 2021-02-19 Univ Paris Sud Utilisation du microrna mir-27a-5p pour traiter l'inflammation intestinale induite par clostridium difficile
US20220073905A1 (en) * 2018-12-28 2022-03-10 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and materials for single cell transcriptome-based development of aav vectors and promoters
EP3947700A4 (fr) 2019-04-01 2023-01-04 Tenaya Therapeutics, Inc. Virus adéno-associé comprenant une capside modifiée
KR102192455B1 (ko) * 2019-04-05 2020-12-17 한국과학기술원 개인의 전이효소-접근가능한 염색질 시퀀싱 정보를 이용한 암 진단 마커 및 이의 용도
WO2020204297A1 (fr) * 2019-04-05 2020-10-08 한국과학기술원 Marqueur de diagnostic du cancer utilisant des informations de séquençage de la chromatine accessible par transposase concernant un individu, et son utilisation
PL3976798T3 (pl) 2019-05-29 2026-04-07 Encoded Therapeutics, Inc. Kompozycje i sposoby selektywnej regulacji genów
CN110117659B (zh) * 2019-06-18 2022-10-11 上海奕谱生物科技有限公司 一种新型的肿瘤标记物stamp-ep10及其应用
JP2023525969A (ja) * 2020-05-19 2023-06-20 イグザカ フランス インビトロおよびインビボでのｃｄ３＋細胞における遺伝子治療産物の発現のためのプロモータ配列
CN115243705A (zh) 2020-05-27 2022-10-25 苏黎世大学 新颖的转导增强剂及其用途
CA3190092A1 (fr) * 2020-08-21 2022-02-24 Felix MUERDTER Methodes et systemes de generation et de prediction de sequences
JP2023540553A (ja) * 2020-09-07 2023-09-25 サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、（セーエヌエルエス） 真核生物ｄｎａ複製起点、及びそれを含むベクター
US11781156B2 (en) 2020-10-09 2023-10-10 Tenaya Therapeutics, Inc. Plakophillin-2 gene therapy methods and compositions
BR112023006305A2 (pt) 2020-10-09 2023-05-09 Tenaya Therapeutics Inc Métodos e composições de terapia gênica com placofilina-2
US11464872B2 (en) * 2020-12-07 2022-10-11 Noga Therapeutics Ltd. Lentiviral vectors for therapeutic expression of BTK in haematopoietic cells
WO2022212766A2 (fr) * 2021-03-31 2022-10-06 Hunterian Medicine Llc Promoteurs compacts pour l'expression génique
CN113265428B (zh) * 2021-06-11 2023-03-14 东北林业大学 一种利用金属硫蛋白构建活细胞内铜变化的检测系统及应用
CN119654412A (zh) * 2022-06-27 2025-03-18 中美瑞康核酸技术(南通)研究院有限公司 激活补体因子h表达的寡核苷酸调节剂
WO2024110770A1 (fr) * 2022-11-22 2024-05-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Nouveau promoteur pour thérapie génique ciblée sur l'épithélium pigmentaire rétinien (epr)
US12252518B2 (en) 2023-01-06 2025-03-18 Life Biosciences, Inc. Methods of treating non-arteritic anterior ischemic optic neuropathy
WO2025171086A1 (fr) * 2024-02-07 2025-08-14 Asimov Inc. Promoteurs et leurs utilisations
WO2026030244A1 (fr) * 2024-07-30 2026-02-05 Kate Therapeutics, Inc. Compositions de virus adéno-associés pour le traitement de la dystrophie musculaire des ceintures de type 2a

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6200760B1 (en) * 1997-02-24 2001-03-13 Cornell Research Foundation, Inc. Method of screening agents as candidates for drugs or sources of drugs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242211B1 (en) * 1996-04-24 2001-06-05 Terragen Discovery, Inc. Methods for generating and screening novel metabolic pathways
US6504084B1 (en) * 1999-04-23 2003-01-07 Pioneer Hi-Bred International, Inc. Maize NPR1 polynucleotides and methods of use
US20030211481A1 (en) * 2002-05-08 2003-11-13 Erives Albert J. Method for identifying cellular targets

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6200760B1 (en) * 1997-02-24 2001-03-13 Cornell Research Foundation, Inc. Method of screening agents as candidates for drugs or sources of drugs

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
COOPER SARA J ET AL: "Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome.", GENOME RESEARCH JAN 2006, vol. 16, no. 1, 12 December 2005 (2005-12-12), pages 1 - 10, XP009126140, ISSN: 1088-9051 *
ENCODE PROJECT CONSORTIUM: "The ENCODE (ENCyclopedia Of DNA Elements) Project.", SCIENCE (NEW YORK, N.Y.) 22 OCT 2004, vol. 306, no. 5696, 22 October 2004 (2004-10-22), pages 636 - 640, XP009126138, ISSN: 1095-9203 *
KIM TAE HOON ET AL: "Direct isolation and identification of promoters in the human genome.", GENOME RESEARCH JUN 2005, vol. 15, no. 6, June 2005 (2005-06-01), pages 830 - 839, XP002412922, ISSN: 1088-9051 *
TRINKLEIN NATHAN D ET AL: "An abundance of bidirectional promoters in the human genome.", GENOME RESEARCH, vol. 14, no. 1, January 2004 (2004-01-01), pages 62 - 66, XP009126141, ISSN: 1088-9051 *
TRINKLEIN NATHAN D ET AL: "Identification and functional analysis of human transcriptional promoters.", GENOME RESEARCH FEB 2003, vol. 13, no. 2, February 2003 (2003-02-01), pages 308 - 312, XP009126139, ISSN: 1088-9051 *
WILSON V S ET AL: "A NOVEL CELL LINE, MDA-KB2, THAT STABLY EXPRESSES AN ANDROGEN- AND GLUCOCORTICOID-RESPONSIVE REPORTER FOR THE DETECTION OF HORMONE RECEPTOR AGONISTS AND ANTAGONISTS", TOXICOLOGICAL SCIENCES, ACADEMIC PRESS, SAN DIEGO, FL, US, vol. 66, no. 1, 1 March 2002 (2002-03-01), pages 69 - 81, XP009028294, ISSN: 1096-6080 *

Also Published As

Publication number Publication date
WO2007078599A9 (fr) 2007-10-04
JP2009519710A (ja) 2009-05-21
WO2007078599A2 (fr) 2007-07-12
EP2021499A2 (fr) 2009-02-11
WO2007078599A3 (fr) 2008-08-28
WO2007078599A8 (fr) 2008-10-30

Similar Documents

Publication Publication Date Title
EP2021499A4 (fr) Reseaux fonctionnels pour la caracterisation a grande cadence d'elements regulant l'expression genique
ZA200702976B (en) Polymorphic forms of 6-[2-(methylcarbamoyl)phenyl-sulfanyl]-3-E-[2-(pyrldin-2-yl)ethenyl]indazole
IL197420A0 (en) Polymorphic form of 4-[3-(4-cyclopropanecarbonyl-piperazine-1-
ZA200709897B (en) Improved methods controlling gene expression
IL190608A0 (en) 5-(arylsulfonyl)-pyrazolopiperidines
DE602005022650D1 (de) Verbessertes Plattierungsverfahren
ZA200901668B (en) 2-(heterocyclylbenzyl)pyridazinone derivatives
EP1972612A4 (fr) Nouveaux composés polymérisables
EP2081698A4 (fr) Crible pour séparateur vibrant
ZA200703436B (en) Methods for increasing maize yields
PL2035357T3 (pl) Proces wytwarzania 1,2-dichloroetanu
ATE496924T1 (de) Prodrugs von 5-amino-3-(3'-deoxy-beta-d- ribofuranosyl)-thiazolä4,5-düpyrimidin-2,7-dion
IL227950A0 (en) Crystalline and amorphous forms of -5 amino-1-[2,6]-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1-h-pyrazole-3-carbonitrile
FR2931845B1 (fr) Production d'un biofilm sur une electrode pour biopile, electrode et biopile obtenues.
DE602005015204D1 (de) Oxadiazolonderivate als ppar-delta-agonisten
ZA200903981B (en) Processes for the preparation of 3-(4-(2,4-difluorobenzyloxy-3-bromo-6-methyl-2-oxopyridin-1(2h)-yl)-n,4-dimethyl-benzamide
PL1896425T3 (pl) Sposób wytwarzania 5-(metylo-1H-1-ilo)-3-trifluorometylo)-benzenoaminy
IL187735A0 (en) 2-(n-nethyl-propanamine)-3-(2-naphthol)thiophene, an impurity of duloxetine hydrochloride
EP2217721A4 (fr) Thérapie génique pour l'ostéoarthrite
BRPI0717833A2 (pt) Polimorfo b de n-{2-flúor-5-[3-(tiofeno-2-carbonil)-pirazolo[1,5-a]piri midin-7-il]fenil}-n-metil-acetamida
EP1873240A4 (fr) GÈNE DE RÉGULATION DE L'EXPRESSION DU GÈNE hTERT
FR2864891B1 (fr) Compensateur dorsal
FR2917963B3 (fr) Ensemble prothetique pour l'articulation de l'epaule.
EP1805152A4 (fr) Derives insecticides de 3-(dihaloalkenyle) phenyle
IL184639A0 (en) Process for the production of 2-(2-aminophenyl)-bicyclopropane derivatives

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20080715

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR MK RS

A4 Supplementary search report drawn up and despatched

Effective date: 20100115

17Q First examination report despatched

Effective date: 20100421

REG Reference to a national code

Ref country code: DE

Ref legal event code: R003

DAX Request for extension of the european patent (deleted)
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20120618