EP2021499A4 - Funktionelle arrays zur kennzeichnung von elementen zur genexpressionsregulierung mit hohem durchsatz - Google Patents
Funktionelle arrays zur kennzeichnung von elementen zur genexpressionsregulierung mit hohem durchsatzInfo
- Publication number
- EP2021499A4 EP2021499A4 EP06849046A EP06849046A EP2021499A4 EP 2021499 A4 EP2021499 A4 EP 2021499A4 EP 06849046 A EP06849046 A EP 06849046A EP 06849046 A EP06849046 A EP 06849046A EP 2021499 A4 EP2021499 A4 EP 2021499A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- gene expression
- regulating gene
- functional networks
- elements regulating
- frequency characterization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000012512 characterization method Methods 0.000 title 1
- 230000014509 gene expression Effects 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75092905P | 2005-12-16 | 2005-12-16 | |
| US76205606P | 2006-01-24 | 2006-01-24 | |
| US11/636,385 US20070161031A1 (en) | 2005-12-16 | 2006-12-07 | Functional arrays for high throughput characterization of gene expression regulatory elements |
| PCT/US2006/046920 WO2007078599A2 (en) | 2005-12-16 | 2006-12-08 | Functional arrays for high throughput characterization of gene expression regulatory elements |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP2021499A2 EP2021499A2 (de) | 2009-02-11 |
| EP2021499A4 true EP2021499A4 (de) | 2010-02-17 |
Family
ID=38228711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP06849046A Ceased EP2021499A4 (de) | 2005-12-16 | 2006-12-08 | Funktionelle arrays zur kennzeichnung von elementen zur genexpressionsregulierung mit hohem durchsatz |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2021499A4 (de) |
| JP (1) | JP2009519710A (de) |
| WO (1) | WO2007078599A2 (de) |
Families Citing this family (57)
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| DK2432881T3 (en) | 2009-05-18 | 2018-02-26 | Curna Inc | TREATMENT OF REPROGRAMMING FACTOR-RELATED DISEASES BY INHIBITING NATURAL ANTISENSE TRANSCRIPTS TO A REPROGRAMMING FACTOR |
| CN102575250B (zh) * | 2009-07-15 | 2014-05-28 | 朱正仑 | 治疗和诊断免疫系统疾病的药物和制剂及其用途 |
| SG10201800541SA (en) | 2010-04-23 | 2018-03-28 | Univ Florida | Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1) |
| WO2011146411A1 (en) * | 2010-05-17 | 2011-11-24 | University Of Southern California | Grp78 gene polymorphism rs391957 is associated with tumor recurrence and survival in gastrointestinal cancer patients |
| CN103608455B (zh) * | 2011-01-07 | 2019-01-15 | 应用遗传科技公司 | 用于治疗色盲和其它疾病的启动子、表达盒、载体、药盒和方法 |
| WO2013151058A1 (ja) * | 2012-04-03 | 2013-10-10 | 独立行政法人国立成育医療研究センター | miR-140の発現を制御するDNA及び該DNAを利用した薬剤のスクリーニング方法 |
| US9163259B2 (en) | 2012-05-04 | 2015-10-20 | Novartis Ag | Viral vectors for the treatment of retinal dystrophy |
| WO2014031079A1 (en) * | 2012-08-21 | 2014-02-27 | Singapore Health Services Pte Ltd | Method and/or probe for determining glaucoma susceptibility |
| KR102495527B1 (ko) * | 2013-03-14 | 2023-02-06 | 몬산토 테크놀로지 엘엘씨 | 식물 조절 성분 및 이의 용도 |
| WO2014197586A1 (en) | 2013-06-04 | 2014-12-11 | Virginia Commonwealth University | Mda-9/syntenin promoter to image and treat metastatic cancer cells |
| PL3097197T3 (pl) * | 2014-01-21 | 2021-06-28 | Vrije Universiteit Brussel | Mięśniowo-specyficzne elementy regulatorowe kwasów nukleinowych oraz sposoby i ich zastosowanie |
| US20150276767A1 (en) * | 2014-03-12 | 2015-10-01 | The University Of Sydney | Systems and methods for identifying cancers having activated progesterone receptors |
| ES2719122T3 (es) * | 2014-03-21 | 2019-07-08 | Life Technologies Corp | Ensayo de referencia multi-copia |
| CN103981185B (zh) * | 2014-04-14 | 2016-04-27 | 浙江理工大学 | 肝癌特异性gp73核心启动子及其筛选构建方法 |
| KR101791296B1 (ko) * | 2014-04-17 | 2017-10-27 | 제주대학교 산학협력단 | 알츠하이머병 관련 돌연변이 유전자를 포함하는 발현 카세트, 벡터, 및 이를 이용하여 형질전환된 세포주 |
| RU2017112748A (ru) | 2014-11-17 | 2018-12-19 | Арно Терапьютикс, Инк. | Композиции онапристона пролонгированного действия и способы |
| CN104673797B (zh) * | 2015-02-09 | 2018-02-02 | 苏州大学 | 参与人体细胞电离辐射应激反应的长链非编码rna及其应用 |
| WO2016149455A2 (en) * | 2015-03-17 | 2016-09-22 | The General Hospital Corporation | The rna interactome of polycomb repressive complex 1 (prc1) |
| EP3307888A1 (de) * | 2015-06-12 | 2018-04-18 | Erasmus University Medical Center Rotterdam | Neue crispr-tests |
| CA2998924A1 (en) | 2015-09-25 | 2017-03-30 | Context Biopharma Inc. | Methods of making onapristone intermediates |
| CA3008422A1 (en) | 2015-12-15 | 2017-06-22 | Context Biopharma Inc. | Amorphous onapristone compositions and methods of making the same |
| MX2018009542A (es) | 2016-02-04 | 2018-11-09 | Zhu Zhenglun | Tratamiento y diagnostico de trastornos inflamatorios. |
| WO2023150553A1 (en) * | 2022-02-01 | 2023-08-10 | University Of Rochester | Gpr17 promoter-based targeting and transduction of glial progenitor cells |
| MX2018012537A (es) | 2016-04-15 | 2019-02-25 | Univ Pennsylvania | Terapia de genes para tratar hemofilia a. |
| US20180148471A1 (en) | 2016-11-30 | 2018-05-31 | Arno Therapeutics, Inc. | Methods for onapristone synthesis dehydration and deprotection |
| WO2018111104A1 (en) * | 2016-12-14 | 2018-06-21 | Erasmus University Medical Center Rotterdam | Use of human crispr sequences in diagnostics |
| WO2018178067A1 (en) * | 2017-03-27 | 2018-10-04 | Vrije Universiteit Brussel | Diaphragm-specific nucleic acid regulatory elements and methods and use thereof |
| MX2019011772A (es) * | 2017-04-03 | 2020-01-09 | Encoded Therapeutics Inc | Expresion transgenica selectiva de tejidos. |
| JP7119009B2 (ja) | 2017-05-31 | 2022-08-16 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 最適化されたヒト凝固第ix因子遺伝子発現カセットおよびそれらの使用 |
| RU2671156C1 (ru) * | 2017-08-21 | 2018-10-29 | Общество с ограниченной ответственностью "Центр Генетики и Репродуктивной Медицины "ГЕНЕТИКО" | Способ преимплантационной генетической диагностики спинальной мышечной атрофии типа 1 |
| WO2019097122A1 (en) * | 2017-11-20 | 2019-05-23 | Turun Yliopisto | A novel cip2a variant and uses thereof |
| EP3717505A4 (de) | 2017-12-01 | 2021-12-01 | Encoded Therapeutics, Inc. | Gentechnisch veränderte dna-bindende proteine |
| AU2019227910B2 (en) | 2018-02-28 | 2025-07-17 | The Regents Of The University Of California | A modular system for gene and protein delivery based on AAV |
| US12274733B2 (en) | 2018-09-28 | 2025-04-15 | President And Fellows Of Harvard College | Cellular reprogramming to reverse aging and promote organ and tissue regeneration |
| IL281470B2 (en) | 2018-09-28 | 2025-08-01 | Harvard College | Cellular reprogramming to reverse aging and promote organ and tissue regeneration |
| KR20210086644A (ko) * | 2018-10-31 | 2021-07-08 | 럿거스, 더 스테이트 유니버시티 오브 뉴 저지 | Gramc: cis 조절 모듈에 대한 게놈 스케일 리포터 분석방법 |
| FR3088194B1 (fr) * | 2018-11-09 | 2021-02-19 | Univ Paris Sud | Utilisation du microrna mir-27a-5p pour traiter l'inflammation intestinale induite par clostridium difficile |
| US20220073905A1 (en) * | 2018-12-28 | 2022-03-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods and materials for single cell transcriptome-based development of aav vectors and promoters |
| EP3947700A4 (de) | 2019-04-01 | 2023-01-04 | Tenaya Therapeutics, Inc. | Adeno-assoziiertes virus mit manipuliertem kapsid |
| KR102192455B1 (ko) * | 2019-04-05 | 2020-12-17 | 한국과학기술원 | 개인의 전이효소-접근가능한 염색질 시퀀싱 정보를 이용한 암 진단 마커 및 이의 용도 |
| WO2020204297A1 (ko) * | 2019-04-05 | 2020-10-08 | 한국과학기술원 | 개인의 전이효소-접근가능한 염색질 시퀀싱 정보를 이용한 암 진단 마커 및 이의 용도 |
| PL3976798T3 (pl) | 2019-05-29 | 2026-04-07 | Encoded Therapeutics, Inc. | Kompozycje i sposoby selektywnej regulacji genów |
| CN110117659B (zh) * | 2019-06-18 | 2022-10-11 | 上海奕谱生物科技有限公司 | 一种新型的肿瘤标记物stamp-ep10及其应用 |
| JP2023525969A (ja) * | 2020-05-19 | 2023-06-20 | イグザカ フランス | インビトロおよびインビボでのcd3+細胞における遺伝子治療産物の発現のためのプロモータ配列 |
| CN115243705A (zh) | 2020-05-27 | 2022-10-25 | 苏黎世大学 | 新颖的转导增强剂及其用途 |
| CA3190092A1 (en) * | 2020-08-21 | 2022-02-24 | Felix MUERDTER | Methods and systems for sequence generation and prediction |
| JP2023540553A (ja) * | 2020-09-07 | 2023-09-25 | サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、(セーエヌエルエス) | 真核生物dna複製起点、及びそれを含むベクター |
| US11781156B2 (en) | 2020-10-09 | 2023-10-10 | Tenaya Therapeutics, Inc. | Plakophillin-2 gene therapy methods and compositions |
| BR112023006305A2 (pt) | 2020-10-09 | 2023-05-09 | Tenaya Therapeutics Inc | Métodos e composições de terapia gênica com placofilina-2 |
| US11464872B2 (en) * | 2020-12-07 | 2022-10-11 | Noga Therapeutics Ltd. | Lentiviral vectors for therapeutic expression of BTK in haematopoietic cells |
| WO2022212766A2 (en) * | 2021-03-31 | 2022-10-06 | Hunterian Medicine Llc | Compact promoters for gene expression |
| CN113265428B (zh) * | 2021-06-11 | 2023-03-14 | 东北林业大学 | 一种利用金属硫蛋白构建活细胞内铜变化的检测系统及应用 |
| CN119654412A (zh) * | 2022-06-27 | 2025-03-18 | 中美瑞康核酸技术(南通)研究院有限公司 | 激活补体因子h表达的寡核苷酸调节剂 |
| WO2024110770A1 (en) * | 2022-11-22 | 2024-05-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A new promoter for retinal pigment epithelium (rpe) targeted gene therapy |
| US12252518B2 (en) | 2023-01-06 | 2025-03-18 | Life Biosciences, Inc. | Methods of treating non-arteritic anterior ischemic optic neuropathy |
| WO2025171086A1 (en) * | 2024-02-07 | 2025-08-14 | Asimov Inc. | Promoters and uses thereof |
| WO2026030244A1 (en) * | 2024-07-30 | 2026-02-05 | Kate Therapeutics, Inc. | Adeno-associated virus compositions for the treatment of limb girdle muscular dystrophy 2a |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6200760B1 (en) * | 1997-02-24 | 2001-03-13 | Cornell Research Foundation, Inc. | Method of screening agents as candidates for drugs or sources of drugs |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6242211B1 (en) * | 1996-04-24 | 2001-06-05 | Terragen Discovery, Inc. | Methods for generating and screening novel metabolic pathways |
| US6504084B1 (en) * | 1999-04-23 | 2003-01-07 | Pioneer Hi-Bred International, Inc. | Maize NPR1 polynucleotides and methods of use |
| US20030211481A1 (en) * | 2002-05-08 | 2003-11-13 | Erives Albert J. | Method for identifying cellular targets |
-
2006
- 2006-12-08 JP JP2008545677A patent/JP2009519710A/ja not_active Withdrawn
- 2006-12-08 WO PCT/US2006/046920 patent/WO2007078599A2/en not_active Ceased
- 2006-12-08 EP EP06849046A patent/EP2021499A4/de not_active Ceased
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6200760B1 (en) * | 1997-02-24 | 2001-03-13 | Cornell Research Foundation, Inc. | Method of screening agents as candidates for drugs or sources of drugs |
Non-Patent Citations (6)
| Title |
|---|
| COOPER SARA J ET AL: "Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome.", GENOME RESEARCH JAN 2006, vol. 16, no. 1, 12 December 2005 (2005-12-12), pages 1 - 10, XP009126140, ISSN: 1088-9051 * |
| ENCODE PROJECT CONSORTIUM: "The ENCODE (ENCyclopedia Of DNA Elements) Project.", SCIENCE (NEW YORK, N.Y.) 22 OCT 2004, vol. 306, no. 5696, 22 October 2004 (2004-10-22), pages 636 - 640, XP009126138, ISSN: 1095-9203 * |
| KIM TAE HOON ET AL: "Direct isolation and identification of promoters in the human genome.", GENOME RESEARCH JUN 2005, vol. 15, no. 6, June 2005 (2005-06-01), pages 830 - 839, XP002412922, ISSN: 1088-9051 * |
| TRINKLEIN NATHAN D ET AL: "An abundance of bidirectional promoters in the human genome.", GENOME RESEARCH, vol. 14, no. 1, January 2004 (2004-01-01), pages 62 - 66, XP009126141, ISSN: 1088-9051 * |
| TRINKLEIN NATHAN D ET AL: "Identification and functional analysis of human transcriptional promoters.", GENOME RESEARCH FEB 2003, vol. 13, no. 2, February 2003 (2003-02-01), pages 308 - 312, XP009126139, ISSN: 1088-9051 * |
| WILSON V S ET AL: "A NOVEL CELL LINE, MDA-KB2, THAT STABLY EXPRESSES AN ANDROGEN- AND GLUCOCORTICOID-RESPONSIVE REPORTER FOR THE DETECTION OF HORMONE RECEPTOR AGONISTS AND ANTAGONISTS", TOXICOLOGICAL SCIENCES, ACADEMIC PRESS, SAN DIEGO, FL, US, vol. 66, no. 1, 1 March 2002 (2002-03-01), pages 69 - 81, XP009028294, ISSN: 1096-6080 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007078599A9 (en) | 2007-10-04 |
| JP2009519710A (ja) | 2009-05-21 |
| WO2007078599A2 (en) | 2007-07-12 |
| EP2021499A2 (de) | 2009-02-11 |
| WO2007078599A3 (en) | 2008-08-28 |
| WO2007078599A8 (en) | 2008-10-30 |
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