EP2022794A4 - Composé fluorescent et agent de marquage comprenant ledit composé - Google Patents

Composé fluorescent et agent de marquage comprenant ledit composé

Info

Publication number
EP2022794A4
EP2022794A4 EP07742603A EP07742603A EP2022794A4 EP 2022794 A4 EP2022794 A4 EP 2022794A4 EP 07742603 A EP07742603 A EP 07742603A EP 07742603 A EP07742603 A EP 07742603A EP 2022794 A4 EP2022794 A4 EP 2022794A4
Authority
EP
European Patent Office
Prior art keywords
compound
marking agent
fluorescent
fluorescent compound
marking
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP07742603A
Other languages
German (de)
English (en)
Other versions
EP2022794A1 (fr
EP2022794B1 (fr
Inventor
Koji Suzuki
Keitaro Umezawa
Hiroshi Makino
Daniel Citterio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Keio University
Original Assignee
Keio University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Keio University filed Critical Keio University
Publication of EP2022794A1 publication Critical patent/EP2022794A1/fr
Publication of EP2022794A4 publication Critical patent/EP2022794A4/fr
Application granted granted Critical
Publication of EP2022794B1 publication Critical patent/EP2022794B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1003—Carbocyclic compounds
    • C09K2211/1007—Non-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1003—Carbocyclic compounds
    • C09K2211/1011—Condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1003—Carbocyclic compounds
    • C09K2211/1014—Carbocyclic compounds bridged by heteroatoms, e.g. N, P, Si or B
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1018—Heterocyclic compounds
    • C09K2211/1025—Heterocyclic compounds characterised by ligands
    • C09K2211/1029—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1018—Heterocyclic compounds
    • C09K2211/1025—Heterocyclic compounds characterised by ligands
    • C09K2211/1088—Heterocyclic compounds characterised by ligands containing oxygen as the only heteroatom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1018—Heterocyclic compounds
    • C09K2211/1025—Heterocyclic compounds characterised by ligands
    • C09K2211/1092—Heterocyclic compounds characterised by ligands containing sulfur as the only heteroatom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP07742603.9A 2006-04-28 2007-04-27 Composé fluorescent et agent de marquage comprenant ledit composé Not-in-force EP2022794B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006126208 2006-04-28
PCT/JP2007/059168 WO2007126052A1 (fr) 2006-04-28 2007-04-27 Composé fluorescent et agent de marquage comprenant ledit composé

Publications (3)

Publication Number Publication Date
EP2022794A1 EP2022794A1 (fr) 2009-02-11
EP2022794A4 true EP2022794A4 (fr) 2011-05-25
EP2022794B1 EP2022794B1 (fr) 2017-08-23

Family

ID=38655573

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07742603.9A Not-in-force EP2022794B1 (fr) 2006-04-28 2007-04-27 Composé fluorescent et agent de marquage comprenant ledit composé

Country Status (4)

Country Link
US (1) US8193350B2 (fr)
EP (1) EP2022794B1 (fr)
JP (1) JP5177427B2 (fr)
WO (1) WO2007126052A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009036307A1 (fr) * 2007-09-13 2009-03-19 Cyalume Technologies, Inc. Système et dispositif d'éclairage infrarouge
US20100231125A1 (en) * 2009-03-12 2010-09-16 Sheng Li Organic light emitting device to emit in near infrared
EP2399962B1 (fr) 2010-06-28 2013-02-13 Kemira Germany GmbH Colorants fluorescents comme colorants à papier
US10005793B2 (en) 2012-10-01 2018-06-26 The General Hospital Corporation Bodipy dyes for biological imaging
CN102993763B (zh) * 2012-12-09 2014-08-27 大连理工大学 一类单电荷氟化硼络合二吡咯甲川荧光染料及其应用
US10156521B2 (en) 2013-02-21 2018-12-18 The Johns Hopkins University Red fluorescent aldehyde dehydrogenase (ALDH) substrate
DE102013106639B4 (de) * 2013-06-25 2024-09-26 Heliatek Gmbh Organisches, halbleitendes Bauelement
JP5904685B2 (ja) * 2013-08-13 2016-04-20 Dic株式会社 樹脂組成物、成形体、及び樹脂組成物の製造方法
JP5943530B2 (ja) * 2013-10-17 2016-07-05 Dic株式会社 樹脂組成物及び成形体
SG11201703624PA (en) * 2014-11-03 2017-06-29 Agency Science Tech & Res Compounds for the diagnosis or treatment of disorders associated with protein or peptide oligomers
WO2016132597A1 (fr) * 2015-02-18 2016-08-25 Dic株式会社 Composition de résine et corps moulé
CN112384573A (zh) 2018-03-30 2021-02-19 贝克顿·迪金森公司 含侧基发色团的水溶性聚合染料
US20200048469A1 (en) * 2018-08-07 2020-02-13 Becton, Dickinson And Company Polymeric tandem dyes having pendant narrow emission acceptor
EP3617214B1 (fr) 2018-08-30 2023-05-10 Heliatek GmbH Matériau semi-conducteur organique et sa synthèse et composant semi-conducteur organique dotée dudit matériau
WO2020120636A1 (fr) * 2018-12-14 2020-06-18 Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen Colorant fluorescent
DE102019118872A1 (de) 2019-07-11 2021-01-14 Heliatek Gmbh Organische Verbindung, und optoelektronisches Bauelement mit einer solchen organischen Verbindung
AU2021334059A1 (en) 2020-08-31 2023-04-13 Heliatek Gmbh Chemical compound, use of at least one such chemical compound in an optoelectronic component, and optoelectronic component containing at least one such chemical compound
EP4215574A4 (fr) 2020-09-17 2024-10-02 DIC Corporation Composition de résine et objet moulé
CN118434822A (zh) * 2021-12-27 2024-08-02 Dic株式会社 粉末状色素组合物、粉末状色素组合物的制造方法、树脂组合物和成型体
CN118871508A (zh) 2022-03-22 2024-10-29 Dic株式会社 母料、使用其的树脂组合物及成形体的制造方法
DE102022116403A1 (de) * 2022-06-30 2024-01-04 Heliatek Gmbh Optoelektronisches Bauelement mit einer als planar Heterojunction ausgebildeten photoaktiven Schicht
DE102022116410A1 (de) 2022-06-30 2024-01-04 Heliatek Gmbh Organisches elektronisches Bauelement mit einer Akzeptorschicht und einer daran angeordneten Kaskade aus mindestens zwei in direktem Kontakt aufeinanderfolgenden Donorschichten
DE102022125417A1 (de) 2022-09-30 2024-04-04 Heliatek Gmbh Chemische Verbindung, optoelektronisches Bauelement mit mindestens einer solchen chemischen Verbindung, und Verwendung mindestens einer solchen chemischen Verbindung in einem optoelektronischen Bauelement
CN115677744B (zh) * 2022-10-31 2024-11-05 太原工业学院 一种用于检测Ag+的荧光探针及其制备方法
CN115746036B (zh) * 2022-11-07 2024-09-24 淮阴工学院 一种靶向识别Aβ纤维的荧光探针SN-BODIPY化合物及其制备方法
KR102720878B1 (ko) * 2023-01-03 2024-10-24 국립부경대학교 산학협력단 광역학 암치료를 위한 신규한 화합물, 이를 포함하는 조성물 및 광역학 암치료 방법
KR102720874B1 (ko) * 2023-01-03 2024-10-24 국립부경대학교 산학협력단 광역학 암치료 및 형광 이미징을 위한 신규한 화합물 및 이를 포함하는 조성물
CN116535620A (zh) * 2023-04-17 2023-08-04 上海大学 一种基于氟硼荧的多孔有机聚合物及其制备方法与应用
CN118955543A (zh) * 2024-07-04 2024-11-15 安徽中医药大学 一种多吡咯衍生物、制备方法及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002134275A (ja) * 2000-10-20 2002-05-10 Toray Ind Inc 発光素子

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5433896A (en) 1994-05-20 1995-07-18 Molecular Probes, Inc. Dibenzopyrrometheneboron difluoride dyes
US5446157A (en) * 1990-04-23 1995-08-29 Morgan; Lee R. Boron difluoride compounds useful in photodynamic therapy and production of laser light
US5248782A (en) 1990-12-18 1993-09-28 Molecular Probes, Inc. Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes
US6005113A (en) * 1996-05-15 1999-12-21 Molecular Probes, Inc. Long wavelength dyes for infrared tracing
JP2002169275A (ja) * 2000-12-04 2002-06-14 Mitsui Chemicals Inc 光酸発生剤及びそれを用いた可視光感光性樹脂組成物
JP4279065B2 (ja) * 2003-06-30 2009-06-17 哲雄 長野 亜鉛蛍光プローブ
WO2007044866A2 (fr) 2005-10-11 2007-04-19 The Regents Of The University Of California Composes fluorescents hydrosolubles utilises pour la detection des ions potassium

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002134275A (ja) * 2000-10-20 2002-05-10 Toray Ind Inc 発光素子

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KEVIN BURGESS ET AL: "New Chemistry of BODIPY Dyes, and BODIPY Dye Cassettes Featuring Though-Bond Energy Transfer", ADVANCES IN NUCLEIC ACID AND PROTEIN ANALYSES, MANIPULATION, AND SEQUENCING : 26 - 27 JANUARY 2000, SAN JOSE, CALIFORNIA; [SPIE PROCEEDINGS SERIES ; 3926 - PROGRESS IN BIOMEDICAL OPTICS ; VOL. 1, NO. 20], SPIE, BELLINGHAM, WASH, vol. 3926, 26 January 2000 (2000-01-26), pages 95 - 105, XP002580825, ISBN: 978-0-8194-3542-2, [retrieved on 20030702], DOI: 10.1117/12.380500 *
See also references of WO2007126052A1 *
ZHAO W ET AL: "Conformationally restricted aza-BODIPY: Highly fluorescent, stable near-infrared absorbing dyes", CHEMISTRY - A EUROPEAN JOURNAL, WILEY - V C H VERLAG GMBH & CO. KGAA, WEINHEIM, DE, vol. 12, no. 27, 18 September 2006 (2006-09-18), pages 7254 - 7263, XP002549060, ISSN: 0947-6539, [retrieved on 20060719], DOI: 10.1002/CHEM.200600527 *

Also Published As

Publication number Publication date
US20090176313A1 (en) 2009-07-09
JPWO2007126052A1 (ja) 2009-09-10
US8193350B2 (en) 2012-06-05
EP2022794A1 (fr) 2009-02-11
EP2022794B1 (fr) 2017-08-23
JP5177427B2 (ja) 2013-04-03
WO2007126052A1 (fr) 2007-11-08

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