EP2037954A4 - Verfahren zur modulation von pharmakokinetik und metabolismus eines therapeutikums - Google Patents

Verfahren zur modulation von pharmakokinetik und metabolismus eines therapeutikums

Info

Publication number
EP2037954A4
EP2037954A4 EP07812192A EP07812192A EP2037954A4 EP 2037954 A4 EP2037954 A4 EP 2037954A4 EP 07812192 A EP07812192 A EP 07812192A EP 07812192 A EP07812192 A EP 07812192A EP 2037954 A4 EP2037954 A4 EP 2037954A4
Authority
EP
European Patent Office
Prior art keywords
pharmacokinetics
metabolism
modulating
therapeutic agent
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07812192A
Other languages
English (en)
French (fr)
Other versions
EP2037954A2 (de
Inventor
Gary M Eichenbaum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of EP2037954A2 publication Critical patent/EP2037954A2/de
Publication of EP2037954A4 publication Critical patent/EP2037954A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01031—Beta-glucuronidase (3.2.1.31)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP07812192A 2006-06-20 2007-06-19 Verfahren zur modulation von pharmakokinetik und metabolismus eines therapeutikums Withdrawn EP2037954A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81522306P 2006-06-20 2006-06-20
PCT/US2007/071510 WO2007149827A2 (en) 2006-06-20 2007-06-19 Method for modulating the pharmacokinetics and metabolism of a therapeutic agent

Publications (2)

Publication Number Publication Date
EP2037954A2 EP2037954A2 (de) 2009-03-25
EP2037954A4 true EP2037954A4 (de) 2011-09-14

Family

ID=38834295

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07812192A Withdrawn EP2037954A4 (de) 2006-06-20 2007-06-19 Verfahren zur modulation von pharmakokinetik und metabolismus eines therapeutikums

Country Status (2)

Country Link
EP (1) EP2037954A4 (de)
WO (1) WO2007149827A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102097026B (zh) * 2009-12-14 2013-04-10 中国科学院上海药物研究所 一种体外模拟药物代谢动力学特征的装置及其方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5279824A (en) * 1988-04-14 1994-01-18 Merck Patent Gmbh Pharmaceutical formulation containing heparin and endo-beta-glucuronidase, useful for the treatment of thrombosis
US20040071685A1 (en) * 2002-10-09 2004-04-15 Devin Houston Compositions and methods for increasing the bioavailability of plant polyphenols
US20050260186A1 (en) * 2003-03-05 2005-11-24 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
WO2006042056A2 (en) * 2004-10-08 2006-04-20 The Ohio State University Methods and compositions for enzyme-specific activation of carbohydrate-conjugated prodrugs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4236237A1 (de) * 1992-10-27 1994-04-28 Behringwerke Ag Prodrugs, ihre Herstellung und Verwendung als Arzneimittel
DK0648503T3 (da) * 1993-09-22 2000-10-02 Hoechst Ag Pro-prodrugs, deres fremstilling og anvendelse
RU2189251C2 (ru) * 1994-12-23 2002-09-20 Зенека Лимитед Химические соединения
ES2323952T3 (es) * 2002-05-15 2009-07-28 Janssen Pharmaceutica Nv 3-aminopirazol triciclicos sustituidos en n como inhibidores receptores de pdfg.
US7172751B2 (en) * 2003-06-13 2007-02-06 Immunomedics, Inc. D-amino acid peptides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5279824A (en) * 1988-04-14 1994-01-18 Merck Patent Gmbh Pharmaceutical formulation containing heparin and endo-beta-glucuronidase, useful for the treatment of thrombosis
US20040071685A1 (en) * 2002-10-09 2004-04-15 Devin Houston Compositions and methods for increasing the bioavailability of plant polyphenols
US20050260186A1 (en) * 2003-03-05 2005-11-24 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
WO2006042056A2 (en) * 2004-10-08 2006-04-20 The Ohio State University Methods and compositions for enzyme-specific activation of carbohydrate-conjugated prodrugs

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HOUBA P H ET AL: "Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate.", INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER 15 FEB 2001 LNKD- PUBMED:11251980, vol. 91, no. 4, 15 February 2001 (2001-02-15), pages 550 - 554, XP002655272, ISSN: 0020-7136 *
YAN Z ET AL: "N-glucuronidation of the platelet-derived growth factor receptor tyrosine kinase inhibitor 6,7-(dimethoxy-2,4-dihydroindeno[1,2-c]pyra zol-3-yl)-(3-fluoro-phenyl)-amine by human UDP-glucuronosyltransferases", DRUG METABOLISM AND DISPOSITION, vol. 34, no. 5, May 2006 (2006-05-01), pages 748 - 755, XP002655273, ISSN: 0090-9556 *

Also Published As

Publication number Publication date
EP2037954A2 (de) 2009-03-25
WO2007149827A3 (en) 2009-04-23
WO2007149827A2 (en) 2007-12-27

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Ipc: A61K 38/46 20060101ALI20110804BHEP

Ipc: A61K 38/44 20060101ALI20110804BHEP

Ipc: A61K 38/43 20060101AFI20110804BHEP

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