EP2040746A4 - Verfahren zur rückgewinnung stabilisierter trimerer formulierungen retroviraler hüllproteine - Google Patents

Verfahren zur rückgewinnung stabilisierter trimerer formulierungen retroviraler hüllproteine

Info

Publication number
EP2040746A4
EP2040746A4 EP07809720A EP07809720A EP2040746A4 EP 2040746 A4 EP2040746 A4 EP 2040746A4 EP 07809720 A EP07809720 A EP 07809720A EP 07809720 A EP07809720 A EP 07809720A EP 2040746 A4 EP2040746 A4 EP 2040746A4
Authority
EP
European Patent Office
Prior art keywords
trimerer
wrapper
retroviral
formulations
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07809720A
Other languages
English (en)
French (fr)
Other versions
EP2040746A1 (de
Inventor
William C Olson
Paul J Maddon
Michael Franti
Sai Prasad N Iyer
Yun Kang
John P Moore
Simon Beddows
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell Research Foundation Inc
Progenics Pharmaceuticals Inc
Original Assignee
Cornell Research Foundation Inc
Progenics Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Research Foundation Inc, Progenics Pharmaceuticals Inc filed Critical Cornell Research Foundation Inc
Publication of EP2040746A1 publication Critical patent/EP2040746A1/de
Publication of EP2040746A4 publication Critical patent/EP2040746A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
EP07809720A 2006-06-19 2007-06-19 Verfahren zur rückgewinnung stabilisierter trimerer formulierungen retroviraler hüllproteine Withdrawn EP2040746A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81511406P 2006-06-19 2006-06-19
PCT/US2007/014388 WO2007149490A1 (en) 2006-06-19 2007-06-19 Processes for recovering stabilized formulations of trimers of retroviral envelope (env) proteins

Publications (2)

Publication Number Publication Date
EP2040746A1 EP2040746A1 (de) 2009-04-01
EP2040746A4 true EP2040746A4 (de) 2009-12-16

Family

ID=38833738

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07809720A Withdrawn EP2040746A4 (de) 2006-06-19 2007-06-19 Verfahren zur rückgewinnung stabilisierter trimerer formulierungen retroviraler hüllproteine

Country Status (3)

Country Link
EP (1) EP2040746A4 (de)
CA (1) CA2655929A1 (de)
WO (1) WO2007149490A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101691574B1 (ko) 2008-12-09 2017-01-02 노바백스, 인코포레이티드 변형 ｒｓｖ ｆ 단백질 및 이들의 사용 방법
US11446374B2 (en) 2008-12-09 2022-09-20 Novavax, Inc. Modified RSV F proteins and methods of their use
US9738688B2 (en) 2012-11-05 2017-08-22 International Aids Vaccine Initiative HIV-1 envelope glycoprotein
WO2015171975A1 (en) * 2014-05-09 2015-11-12 The Regents Of The University Of Michigan Use of modified banana lectin in purification of glycoproteins
IL257800B2 (en) 2015-09-03 2023-11-01 Novavax Inc Immune compositions with improved stability and immunogenicity
US12083228B2 (en) 2017-07-24 2024-09-10 Novavax, Inc. Methods and compositions for treating respiratory disease
AU2019238171B2 (en) 2018-03-19 2026-01-08 Novavax, Inc. Multivalent influenza nanoparticle vaccines
CN114585639A (zh) * 2019-11-07 2022-06-03 扬森疫苗与预防公司 蛋白质纯化

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050089526A1 (en) * 2001-09-06 2005-04-28 Moore John P. Human immunodeficiency virus envelope clycoprotein mutants and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2781676B1 (fr) * 1998-07-31 2004-04-02 Pasteur Merieux Serums Vacc Trimere du produit d'expression du gene env de hiv
EP1610816B1 (de) * 2003-03-28 2013-01-02 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Mva virus, der modifizierte hiv hülle, gag und pol gene exprimiert

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050089526A1 (en) * 2001-09-06 2005-04-28 Moore John P. Human immunodeficiency virus envelope clycoprotein mutants and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SANDERS R W ET AL: "Stabilization of the soluble, cleaved, trimeric form of the envelope glycoprotein complex of human immunodeficiency virus type 1", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 76, no. 17, 1 September 2002 (2002-09-01), pages 8875 - 8889, XP002393505, ISSN: 0022-538X *
See also references of WO2007149490A1 *

Also Published As

Publication number Publication date
EP2040746A1 (de) 2009-04-01
CA2655929A1 (en) 2007-12-27
WO2007149490A1 (en) 2007-12-27

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Legal Events

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Extension state: AL BA HR MK RS

RIN1 Information on inventor provided before grant (corrected)

Inventor name: BEDDOWS, SIMON

Inventor name: MOORE, JOHN P.

Inventor name: KANG, YUN

Inventor name: IYER, SAI PRASAD N.

Inventor name: FRANTI, MICHAEL

Inventor name: MADDON, PAUL J.

Inventor name: OLSON, WILLIAM C.

A4 Supplementary search report drawn up and despatched

Effective date: 20091118

17Q First examination report despatched

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