EP2049110A4 - Diazépans pontés antagonistes du récepteur de l'oréxine - Google Patents
Diazépans pontés antagonistes du récepteur de l'oréxineInfo
- Publication number
- EP2049110A4 EP2049110A4 EP07796851A EP07796851A EP2049110A4 EP 2049110 A4 EP2049110 A4 EP 2049110A4 EP 07796851 A EP07796851 A EP 07796851A EP 07796851 A EP07796851 A EP 07796851A EP 2049110 A4 EP2049110 A4 EP 2049110A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- ortexin
- diazepans
- antagonist
- receptor
- ortexin receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83117806P | 2006-07-14 | 2006-07-14 | |
| PCT/US2007/016037 WO2008008517A2 (fr) | 2006-07-14 | 2007-07-13 | Diazépans pontés antagonistes du récepteur de l'oréxine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP2049110A2 EP2049110A2 (fr) | 2009-04-22 |
| EP2049110A4 true EP2049110A4 (fr) | 2011-08-10 |
| EP2049110B1 EP2049110B1 (fr) | 2014-08-20 |
Family
ID=38923948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP07796851.9A Not-in-force EP2049110B1 (fr) | 2006-07-14 | 2007-07-13 | Diazépans pontés antagonistes du récepteur de l'oréxine |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8618102B2 (fr) |
| EP (1) | EP2049110B1 (fr) |
| JP (1) | JP2009543785A (fr) |
| AU (1) | AU2007272854B2 (fr) |
| CA (1) | CA2657623A1 (fr) |
| WO (1) | WO2008008517A2 (fr) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20081229A1 (es) | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
| CA2688776A1 (en) * | 2007-05-18 | 2008-11-27 | Merck & Co., Inc. | Oxo bridged diazepan orexin receptor antagonists |
| JP4881476B2 (ja) | 2007-05-23 | 2012-02-22 | メルク・シャープ・エンド・ドーム・コーポレイション | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
| EP2025674A1 (fr) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament |
| EP2214676B1 (fr) | 2007-10-29 | 2012-11-21 | Merck Sharp & Dohme Corp. | Antagonistes des récepteurs de l'orexine, de type diazépan substitué |
| WO2010028033A1 (fr) * | 2008-09-05 | 2010-03-11 | Targacept, Inc. | Amides de diazabicyclooctanes et leurs utilisations |
| WO2010028011A1 (fr) * | 2008-09-05 | 2010-03-11 | Targacept, Inc. | Amides de diazabicyclononanes et leurs utilisations |
| WO2011050202A1 (fr) | 2009-10-23 | 2011-04-28 | Janssen Pharmaceutica Nv | Composés hétérocycliques condensés en tant que modulateurs de récepteur d'orexine |
| ES2585806T3 (es) | 2009-10-23 | 2016-10-10 | Janssen Pharmaceutica N.V. | Octahidropirrolo [3,4-c] pirroles disustituidos como moduladores de receptores de orexina |
| WO2011050200A1 (fr) | 2009-10-23 | 2011-04-28 | Janssen Pharmaceutica Nv | Composés hétérocycliques condensés en tant que modulateurs de récepteur d'orexine |
| WO2012058116A1 (fr) * | 2010-10-27 | 2012-05-03 | Merck Sharp & Dohme Corp. | Inhibiteurs du canal potassique de la médullaire externe rénale |
| WO2012085852A1 (fr) | 2010-12-22 | 2012-06-28 | Actelion Pharmaceuticals Ltd | 3,8-diaza-bicyclo[4.2.0]oct-8-ylamides |
| US9586962B2 (en) | 2011-04-20 | 2017-03-07 | Janssen Pharmaceutica Nv | Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators |
| WO2013050938A1 (fr) | 2011-10-04 | 2013-04-11 | Actelion Pharmaceuticals Ltd | Dérivés de 3,7-diazabicyclo[3.3.1]nonane et de 9-oxa-3,7- diazabicyclo[3.3.1]nonane |
| AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| TWI565703B (zh) | 2011-11-08 | 2017-01-11 | 艾克泰聯製藥有限公司 | ２-（１，２，３-三唑-２-基）苯甲醯胺及３-（１，２，３-三唑-２-基）吡啶醯胺衍生物 |
| ES2672732T3 (es) | 2012-02-07 | 2018-06-15 | Eolas Therapeutics Inc. | Prolinas/piperidinas sustituidas como antagonistas del receptor de orexina |
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| KR101689093B1 (ko) | 2012-06-04 | 2016-12-22 | 액테리온 파마슈티칼 리미티드 | 벤즈이미다졸-프롤린 유도체 |
| US9249160B2 (en) | 2012-07-03 | 2016-02-02 | Heptares Therapeutics Limited | Orexin receptor antagonists |
| BR112015007516A2 (pt) | 2012-10-10 | 2017-07-04 | Actelion Pharmaceuticals Ltd | antagonistas do receptor de orexina que são derivados de [orto bi-(hetero-)aril]-[2-(meta bi-(hetero-)aril)- pirrolidin-1-il]-metanona |
| CA2902135A1 (fr) | 2013-03-12 | 2014-09-18 | Actelion Pharmaceuticals Ltd | Derives d'amide d'azetidine en tant qu'antagonistes des recepteurs d'orexine |
| WO2015048091A1 (fr) * | 2013-09-24 | 2015-04-02 | The Board Of Regents Of The University Of Texas System | Régulation de l'ostéogenèse et de la perte de substance osseuse par l'orexine |
| GB201318222D0 (en) * | 2013-10-15 | 2013-11-27 | Takeda Pharmaceutical | Novel compounds |
| HRP20181710T1 (hr) | 2013-12-04 | 2018-12-28 | Idorsia Pharmaceuticals Ltd | Uporaba derivata benzimidazol-prolina |
| US9732077B2 (en) | 2013-12-18 | 2017-08-15 | Merck Sharp & Dohme Corp. | Diazepane orexin receptor antagonists |
| TW201613864A (en) * | 2014-02-20 | 2016-04-16 | Takeda Pharmaceutical | Novel compounds |
| JP6663909B2 (ja) | 2014-08-13 | 2020-03-13 | エオラス セラピューティクス， インコーポレイテッド | オレキシンレセプターモジュレーターとしてのジフルオロピロリジン |
| AU2015314851B2 (en) * | 2014-09-11 | 2020-01-02 | Janssen Pharmaceutica Nv | Substituted 2-azabicycles and their use as orexin receptor modulators |
| WO2016065587A1 (fr) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Composés pyrazoles antagonistes des récepteurs de l'orexine |
| WO2016065583A1 (fr) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Antagonistes du récepteur d'orexine à base d'oxazole |
| WO2016065584A1 (fr) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Antagonistes pipéridine oxadiazole et pipéridine thiadiazole du récepteur de l'orexine |
| WO2016065586A1 (fr) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Pyrazole, triazole et tétrazole antagonistes des récepteurs de l'orexine |
| WO2016065585A1 (fr) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Composés pipéridines isoxazoles et isothiazoles antagonistes des récepteurs de l'orexine |
| WO2016085784A1 (fr) | 2014-11-26 | 2016-06-02 | Merck Sharp & Dohme Corp. | Antagonistes de récepteur d'orexine de type méthyl-diazépane |
| US9994570B2 (en) | 2014-11-26 | 2018-06-12 | Merck Sharp & Dohme Corp. | Bridged diazepane orexin receptor antagonists |
| JP2018012645A (ja) * | 2014-11-26 | 2018-01-25 | 持田製薬株式会社 | 新規ジアザビシクロ誘導体 |
| WO2016086358A1 (fr) | 2014-12-02 | 2016-06-09 | Merck Sharp & Dohme Corp. | Hydroxyméthyl pipéridines antagonistes du récepteur d'orexine |
| WO2016086357A1 (fr) | 2014-12-02 | 2016-06-09 | Merck Sharp & Dohme Corp. | Méthyl oxazoles antagonistes du récepteur d'orexine |
| JP2018016544A (ja) * | 2014-12-03 | 2018-02-01 | 持田製薬株式会社 | 新規ジアザビシクロ［２．２．２］オクタン誘導体 |
| US10011595B2 (en) | 2014-12-19 | 2018-07-03 | Merck Sharp & Dohme Corp. | Ethyldiamine orexin receptor antagonists |
| WO2016100162A2 (fr) | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | Antagonistes oxazoles 5,5-bicycliques du récepteur d'orexine |
| WO2016095205A1 (fr) | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | Composés hétéroaryle en tant qu'antagonistes du récepteur de l'hypocrétine |
| US9938276B2 (en) | 2014-12-19 | 2018-04-10 | Merck Sharp & Dohme Corp. | 6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists |
| WO2016095204A1 (fr) | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | Composés pyrrolidine en tant qu'antagonistes du récepteur de l'hypocrétine |
| WO2016101119A1 (fr) | 2014-12-23 | 2016-06-30 | Merck Sharp & Dohme Corp. | Dérivés d'hétéroaryles fusionnés en tant qu'antagonistes des récepteurs des oréxines |
| WO2016101118A1 (fr) | 2014-12-23 | 2016-06-30 | Merck Sharp & Dohme Corp. | Antagonistes des récepteurs d'orexine de type amidoéthylazole |
| WO2017012502A1 (fr) | 2015-07-17 | 2017-01-26 | Sunshine Lake Pharma Co., Ltd. | Composés de quinazoline substitués, ainsi que préparation et utilisations de ceux-ci |
| WO2017088759A1 (fr) | 2015-11-23 | 2017-06-01 | Sunshine Lake Pharma Co., Ltd. | Dérivés d'octahydropyrrolo [3, 4-c] pyrrole et leurs utilisations |
| CN106986859B (zh) * | 2016-01-20 | 2020-02-11 | 广东东阳光药业有限公司 | 吲哚衍生物及其用途 |
| MX2018009656A (es) | 2016-02-12 | 2019-02-20 | Astrazeneca Ab | Piperidinas halo-sustituidas como moduladores de los receptores de orexinas. |
| US10828302B2 (en) | 2016-03-10 | 2020-11-10 | Janssen Pharmaceutica Nv | Methods of treating depression using orexin-2 receptor antagonists |
| US20190151304A1 (en) | 2016-05-10 | 2019-05-23 | Inserm (Institut National De La Santé Et De La Rechercjae Médicale | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory |
| CN107759620B (zh) * | 2016-08-16 | 2021-11-12 | 广东东阳光药业有限公司 | 八氢吡咯并[3,4-c]吡咯衍生物及其使用方法和用途 |
| GB201702174D0 (en) | 2017-02-09 | 2017-03-29 | Benevolentai Bio Ltd | Orexin receptor antagonists |
| GB201707499D0 (en) | 2017-05-10 | 2017-06-21 | Benevolentai Bio Ltd | Orexin receptor antagonists |
| GB201707504D0 (en) | 2017-05-10 | 2017-06-21 | Benevolentai Bio Ltd | Orexin receptor antagonists |
| JOP20190284A1 (ar) | 2017-06-14 | 2019-12-11 | Bayer Pharma AG | مركبات إيميدازوبيريميدين مستبدلة بديازا ثنائي الحلقة واستخدامها للمعالجة من اضطرابات التنفس |
| CN107573270B (zh) * | 2017-09-29 | 2019-11-29 | 河南师范大学 | 一种α-甲酰基吡咯烷类化合物的合成方法 |
| GB201716871D0 (en) * | 2017-10-13 | 2017-11-29 | Inst Of Cancer Research: Royal Cancer Hospital | Compounds |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0885888A1 (fr) * | 1996-02-02 | 1998-12-23 | Nippon Shinyaku Company, Limited | Derives de l'isoquinoline et medicaments associes |
| WO2000044755A1 (fr) * | 1999-01-29 | 2000-08-03 | Abbott Laboratories | Derives diazabicycliques utiles en tant que ligands du recepteur nicotinique de l'acetylcholine |
| US6440970B1 (en) * | 2000-05-25 | 2002-08-27 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US20050101602A1 (en) * | 2003-09-19 | 2005-05-12 | Anwer Basha | Substituted diazabicycloalkane derivatives |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2175395A1 (fr) * | 1995-06-02 | 1996-12-03 | Ronald J. Mattson | Indanylpiperazines ou homopiperazines, agents melatonergiques |
| AR016817A1 (es) | 1997-08-14 | 2001-08-01 | Smithkline Beecham Plc | Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento |
| ES2196806T3 (es) | 1998-05-08 | 2003-12-16 | Smithkline Beecham Plc | Derivados de fenilurea y de feniltiourea. |
| US7265115B2 (en) | 1999-01-29 | 2007-09-04 | Abbott Laboratories | Diazabicyclic CNS active agents |
| DE60015927T2 (de) | 1999-02-12 | 2005-04-07 | Smithkline Beecham P.L.C., Brentford | Phenylharnstoff und phenylthioharnstoffderivate |
| WO2000047576A1 (fr) | 1999-02-12 | 2000-08-17 | Smithkline Beecham Plc | Derives de cinnamide utilises en tant qu'antagonistes des recepteurs de l'orexine-1 |
| AU2804400A (en) | 1999-02-12 | 2000-08-29 | Smithkline Beecham Plc | Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists |
| DE60108236T2 (de) | 2000-03-14 | 2005-12-22 | Actelion Pharmaceuticals Ltd. | 1,2,3,4-tetrahydroisochinolin-derivate |
| EP1288202A4 (fr) | 2000-05-11 | 2003-07-02 | Banyu Pharma Co Ltd | Derives n-acyltetrahydroisoquinoline |
| JP2003534344A (ja) * | 2000-05-25 | 2003-11-18 | ターガセプト，インコーポレイテッド | ニコチン性コリン受容体リガンドとしてのヘテロアリールジアザビシクロアルカン |
| US6677354B2 (en) | 2000-06-16 | 2004-01-13 | Smithkline Beecham P.L.C. | Piperdines for use as orexin receptor antagonists |
| JP4246490B2 (ja) | 2000-11-28 | 2009-04-02 | スミスクライン ビーチャム ピー エル シー | オレキシン受容体のアンタゴニストとしてのモルホリン誘導体 |
| WO2002051232A2 (fr) | 2000-12-27 | 2002-07-04 | Actelion Pharmaceuticals Ltd. | Nouvelles benzazepines et derives heterocycliques associes |
| IL158463A0 (en) | 2001-05-05 | 2004-05-12 | Smithkline Beecham Plc | N-aroyl cyclic amines |
| US20040192673A1 (en) | 2001-05-05 | 2004-09-30 | Pascale Gaillard | N-aroyl cyclic amine derivatives as orexin receptor antagonists |
| GB0115862D0 (en) | 2001-06-28 | 2001-08-22 | Smithkline Beecham Plc | Compounds |
| BR0210609A (pt) | 2001-06-28 | 2004-07-20 | Smithkline Beecham Plc | Derivados de amina cìclica n-aroila como antagonistas do receptor da orexina |
| GB0124463D0 (en) | 2001-10-11 | 2001-12-05 | Smithkline Beecham Plc | Compounds |
| GB0126292D0 (en) | 2001-11-01 | 2002-01-02 | Smithkline Beecham Plc | Compounds |
| GB0127145D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Compounds |
| TW200300354A (en) * | 2001-11-12 | 2003-06-01 | Jms Co Ltd | Injection needle retractable injector |
| DE10161864A1 (de) | 2001-12-14 | 2003-07-03 | Basf Ag | Stabilisatorzusammensetzung III |
| GB0130393D0 (en) | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
| US6676630B2 (en) | 2002-06-04 | 2004-01-13 | Bioject Medical Technologies, Inc. | Needle-free injection system |
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| US20060040937A1 (en) | 2002-09-18 | 2006-02-23 | Glaxo Group Limited | N-aroyl cyclic amines as orexin receptor antagonists |
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| WO2004052876A1 (fr) | 2002-12-12 | 2004-06-24 | Janssen Pharmaceutica, N.V. | 4-phenyl-[1,3]-dioxanes substitues |
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| HUP0304101A3 (en) | 2003-12-22 | 2008-10-28 | Sanofi Aventis | Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates |
| HUP0400405A3 (en) | 2004-02-10 | 2009-03-30 | Sanofi Synthelabo | Pyrimidine derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates |
| PT1751111E (pt) | 2004-03-01 | 2015-04-01 | Actelion Pharmaceuticals Ltd | Derivados de 1,2,3,4-tetrahidroisoquinolina substituída |
| WO2006067224A2 (fr) | 2004-12-23 | 2006-06-29 | Biovitrum Ab (Publ) | Nouveaux composes |
| WO2006110626A1 (fr) | 2005-04-12 | 2006-10-19 | Merck & Co., Inc. | Antagonistes du récepteur de l’orexine de type amidopropoxyphényle |
| WO2006127550A1 (fr) | 2005-05-23 | 2006-11-30 | Merck & Co., Inc. | Antagonistes des recepteurs d'orexine a base de bis-amide de proline |
| JP2009503106A (ja) | 2005-08-04 | 2009-01-29 | メルク エンド カムパニー インコーポレーテッド | アミノエタンスルホンアミドオレキシン受容体アンタゴニスト |
| JP2009506061A (ja) | 2005-08-26 | 2009-02-12 | メルク エンド カムパニー インコーポレーテッド | ジアザスピロデカンオレキシン受容体拮抗薬 |
| EP2001485B1 (fr) | 2006-03-29 | 2015-09-09 | Merck Sharp & Dohme Corp. | Antagonistes des récepteurs de l'orexine sous forme de composés diazépane |
| PL2049529T3 (pl) | 2006-07-14 | 2011-01-31 | Merck Sharp & Dohme | Podstawione związki diazepanowe - antagoniści receptora oreksyny |
| PE20081229A1 (es) | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
| CA2688776A1 (en) | 2007-05-18 | 2008-11-27 | Merck & Co., Inc. | Oxo bridged diazepan orexin receptor antagonists |
-
2007
- 2007-07-13 CA CA002657623A patent/CA2657623A1/fr not_active Abandoned
- 2007-07-13 WO PCT/US2007/016037 patent/WO2008008517A2/fr not_active Ceased
- 2007-07-13 AU AU2007272854A patent/AU2007272854B2/en not_active Expired - Fee Related
- 2007-07-13 EP EP07796851.9A patent/EP2049110B1/fr not_active Not-in-force
- 2007-07-13 US US12/309,243 patent/US8618102B2/en active Active
- 2007-07-13 JP JP2009519551A patent/JP2009543785A/ja not_active Ceased
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0885888A1 (fr) * | 1996-02-02 | 1998-12-23 | Nippon Shinyaku Company, Limited | Derives de l'isoquinoline et medicaments associes |
| WO2000044755A1 (fr) * | 1999-01-29 | 2000-08-03 | Abbott Laboratories | Derives diazabicycliques utiles en tant que ligands du recepteur nicotinique de l'acetylcholine |
| US6440970B1 (en) * | 2000-05-25 | 2002-08-27 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US20050101602A1 (en) * | 2003-09-19 | 2005-05-12 | Anwer Basha | Substituted diazabicycloalkane derivatives |
Non-Patent Citations (1)
| Title |
|---|
| See also references of WO2008008517A2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2049110B1 (fr) | 2014-08-20 |
| AU2007272854A1 (en) | 2008-01-17 |
| US20090239843A1 (en) | 2009-09-24 |
| WO2008008517A3 (fr) | 2008-12-04 |
| JP2009543785A (ja) | 2009-12-10 |
| AU2007272854B2 (en) | 2013-08-01 |
| CA2657623A1 (fr) | 2008-01-17 |
| EP2049110A2 (fr) | 2009-04-22 |
| WO2008008517A2 (fr) | 2008-01-17 |
| US8618102B2 (en) | 2013-12-31 |
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