ATE509928T1 - 8-azabicycloä3.2.1üoktan-verbindungen als mu- opioid-rezeptorantagonisten - Google Patents

8-azabicycloä3.2.1üoktan-verbindungen als mu- opioid-rezeptorantagonisten

Info

Publication number
ATE509928T1
ATE509928T1 AT07752111T AT07752111T ATE509928T1 AT E509928 T1 ATE509928 T1 AT E509928T1 AT 07752111 T AT07752111 T AT 07752111T AT 07752111 T AT07752111 T AT 07752111T AT E509928 T1 ATE509928 T1 AT E509928T1
Authority
AT
Austria
Prior art keywords
compounds
receptor antagonists
opioid receptor
opioid
antagonists
Prior art date
Application number
AT07752111T
Other languages
English (en)
Inventor
Daniel Long
Timothy J Church
John R Jacobsen
Lan Jiang
Daisuke Roland Saito
Ioanna Stergiades
Dyke Priscilla Van
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38436795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE509928(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Theravance Inc filed Critical Theravance Inc
Application granted granted Critical
Publication of ATE509928T1 publication Critical patent/ATE509928T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT07752111T 2006-03-01 2007-02-28 8-azabicycloä3.2.1üoktan-verbindungen als mu- opioid-rezeptorantagonisten ATE509928T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77796206P 2006-03-01 2006-03-01
US84102806P 2006-08-30 2006-08-30
PCT/US2007/005388 WO2007103187A2 (en) 2006-03-01 2007-02-28 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

Publications (1)

Publication Number Publication Date
ATE509928T1 true ATE509928T1 (de) 2011-06-15

Family

ID=38436795

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07752111T ATE509928T1 (de) 2006-03-01 2007-02-28 8-azabicycloä3.2.1üoktan-verbindungen als mu- opioid-rezeptorantagonisten

Country Status (24)

Country Link
US (11) US7622508B2 (de)
EP (1) EP2001876B1 (de)
JP (2) JP5086280B2 (de)
KR (1) KR101376479B1 (de)
AR (1) AR059690A1 (de)
AT (1) ATE509928T1 (de)
AU (1) AU2007224213B2 (de)
BR (1) BRPI0708490B8 (de)
CA (1) CA2646409C (de)
CY (1) CY1111747T1 (de)
DK (1) DK2001876T3 (de)
HR (1) HRP20110590T1 (de)
IL (1) IL193690A (de)
MA (1) MA30284B1 (de)
MX (1) MX2008011165A (de)
MY (1) MY145633A (de)
NZ (1) NZ570764A (de)
PE (1) PE20071311A1 (de)
PL (1) PL2001876T3 (de)
PT (1) PT2001876E (de)
RU (1) RU2423362C2 (de)
SI (1) SI2001876T1 (de)
TW (1) TWI379832B (de)
WO (1) WO2007103187A2 (de)

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MY145633A (en) * 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI409067B (zh) 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
US7947710B2 (en) * 2007-08-27 2011-05-24 Theravance, Inc. Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
US7902221B2 (en) * 2007-08-27 2011-03-08 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
ES2465621T3 (es) * 2007-08-27 2014-06-06 Theravance, Inc. Compuestos de heteroarilalquil-8-azabiciclo[3.2.1]octano, como antagonistas de los receptores opiodes mu
US20110071163A1 (en) * 2009-09-18 2011-03-24 Adolor Corporation Use of an opioid receptor antagonist for the treatment or prevention of gastrointestinal tract disorders
US20120122928A1 (en) 2010-08-11 2012-05-17 Bayer Cropscience Ag Heteroarylpiperidine and -Piperazine Derivatives as Fungicides
EP2423210A1 (de) 2010-08-25 2012-02-29 Bayer CropScience AG Heteroarylpiperidin- und -piperazinderivate als Fungizide
US8759527B2 (en) 2010-08-25 2014-06-24 Bayer Cropscience Ag Heteroarylpiperidine and -piperazine derivatives as fungicides
EP2632922B1 (de) 2010-10-27 2019-02-27 Bayer CropScience Aktiengesellschaft Heteroarylpiperidin und -piperazinderivate als fungizide
JP5703009B2 (ja) * 2010-12-16 2015-04-15 住友精化株式会社 スルホン化合物、スルホン化合物の製造方法、および電気化学デバイス用電解液
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US10004232B2 (en) 2011-09-15 2018-06-26 Bayer Intellectual Property Gmbh Piperidine pyrazoles as fungicides
ES2695233T3 (es) 2011-12-27 2019-01-02 Bayer Cropscience Ag Derivados de isoxazol
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US20160287573A1 (en) 2015-04-02 2016-10-06 Theravance Biopharma R&D Ip, Llc Combination dosage form of a mu opioid receptor antagonist and an opioid agent
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KR20230154789A (ko) * 2020-11-06 2023-11-09 액티노젠 메디컬 리미티드 헤테로고리 메탄온 화합물 및 그의 아자-비시클로 중간체의 제조 공정

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TWI409067B (zh) * 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
US7947710B2 (en) 2007-08-27 2011-05-24 Theravance, Inc. Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
US7902221B2 (en) 2007-08-27 2011-03-08 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
ES2465621T3 (es) 2007-08-27 2014-06-06 Theravance, Inc. Compuestos de heteroarilalquil-8-azabiciclo[3.2.1]octano, como antagonistas de los receptores opiodes mu

Also Published As

Publication number Publication date
US20160176863A1 (en) 2016-06-23
MX2008011165A (es) 2008-09-15
IL193690A (en) 2013-02-28
WO2007103187A2 (en) 2007-09-13
NZ570764A (en) 2011-08-26
US10745394B2 (en) 2020-08-18
HK1125935A1 (en) 2009-08-21
CA2646409A1 (en) 2007-09-13
US10377751B2 (en) 2019-08-13
MA30284B1 (fr) 2009-03-02
US20210024515A1 (en) 2021-01-28
CA2646409C (en) 2015-11-10
US20140288112A1 (en) 2014-09-25
EP2001876B1 (de) 2011-05-18
RU2008138875A (ru) 2010-04-10
US8664242B2 (en) 2014-03-04
US9663509B2 (en) 2017-05-30
RU2423362C2 (ru) 2011-07-10
IL193690A0 (en) 2009-08-03
DK2001876T3 (da) 2011-08-29
TWI379832B (en) 2012-12-21
BRPI0708490A2 (pt) 2011-05-31
US11548887B2 (en) 2023-01-10
US20170349578A1 (en) 2017-12-07
US20130158060A1 (en) 2013-06-20
MY145633A (en) 2012-03-15
US10081626B2 (en) 2018-09-25
AR059690A1 (es) 2008-04-23
PE20071311A1 (es) 2007-12-29
HRP20110590T1 (hr) 2011-09-30
JP5086280B2 (ja) 2012-11-28
JP2012211193A (ja) 2012-11-01
US20150291579A1 (en) 2015-10-15
US20070219278A1 (en) 2007-09-20
US8927573B2 (en) 2015-01-06
CY1111747T1 (el) 2015-10-07
KR20080100282A (ko) 2008-11-14
PT2001876E (pt) 2011-08-18
US20230183232A1 (en) 2023-06-15
AU2007224213A1 (en) 2007-09-13
TW200800981A (en) 2008-01-01
US9206172B2 (en) 2015-12-08
BRPI0708490B8 (pt) 2021-05-25
JP2009528371A (ja) 2009-08-06
WO2007103187A3 (en) 2007-11-01
US7622508B2 (en) 2009-11-24
PL2001876T3 (pl) 2011-10-31
BRPI0708490B1 (pt) 2019-07-30
US20190308966A1 (en) 2019-10-10
US20100035921A1 (en) 2010-02-11
KR101376479B1 (ko) 2014-03-27
AU2007224213B2 (en) 2012-06-14
US20190119267A1 (en) 2019-04-25
SI2001876T1 (sl) 2011-09-30
EP2001876A2 (de) 2008-12-17
US8263618B2 (en) 2012-09-11

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