EP2109767A2 - Capteur pour dispositif médical implantable - Google Patents

Capteur pour dispositif médical implantable

Info

Publication number
EP2109767A2
EP2109767A2 EP07871092A EP07871092A EP2109767A2 EP 2109767 A2 EP2109767 A2 EP 2109767A2 EP 07871092 A EP07871092 A EP 07871092A EP 07871092 A EP07871092 A EP 07871092A EP 2109767 A2 EP2109767 A2 EP 2109767A2
Authority
EP
European Patent Office
Prior art keywords
fluorinated
implantable medical
crown
electrical lead
sensor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07871092A
Other languages
German (de)
English (en)
Inventor
Zhengrong Zhou
Qingshan Ye
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Inc
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc filed Critical Medtronic Inc
Publication of EP2109767A2 publication Critical patent/EP2109767A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/333—Ion-selective electrodes or membranes
    • G01N27/3335—Ion-selective electrodes or membranes the membrane containing at least one organic component

Definitions

  • the present invention relates to medical devices and, more particularly, to ion sensors on implantable medical leads.
  • IMDs Implantable medical devices detect and deliver therapy for a variety of medical conditions in patients.
  • IMDs include implantable pulse generators (IPGs) or implantable cardioverter-defibrillators (ICDs) that deliver electrical stimuli to tissue of a patient.
  • ICDs typically comprise, inter alia, a control module, a capacitor, and a battery that are housed in a hermetically sealed container.
  • the control module signals the battery to charge the capacitor, which in turn discharges electrical stimuli to tissue of a patient through a medical electrical lead.
  • Leads deliver pacing, cardioversion or defibrillation pulses via electrodes disposed on the leads, e.g., typically near distal ends of the leads. In that case, the leads may position the electrodes with respect to various cardiac locations so that the pacemaker can deliver pulses to the appropriate locations. Leads are also used for sensing purposes and/or delivery of an agent (e.g. drug, gene etc.).
  • an agent e.g. drug, gene etc.
  • FIG. 1 is a schematic view of a medical device system
  • FIG. 2 is a schematic view of a medical electrical lead that includes ion- selective electrodes
  • FIG. 3 is a schematic view of a medical electrical lead that includes ion- selective electrodes
  • FIG. 4 is a schematic view of a sensor structure
  • FIG. 5 depicts a chemical reaction for synthesis of a representative fluorinated bis-crown ether-based sodium ionophore
  • FIG. 6 depicts a chemical reaction for synthesis of a representative fluorinated bis-crown ether potassium ionophore
  • FIG. 7 depicts chemical reactions for synthesis of three representative fluorinated crown ether-based potassium ionophores.
  • the present invention is directed to ion sensors on implantable medical leads.
  • Ion sensors include ion-selective electrodes (ISEs) such as a working electrode and a reference electrode.
  • ISEs ion-selective electrodes
  • Each electrode includes an ion-sensing membrane component.
  • the ion-sensing membrane component comprises organic compounds (e.g. polymers such as polyurethane, silicone rubber, ionophores, additives etc.) that are partially, not fully, fluorinated.
  • An organic compound is fully fluorinated when all the hydrogens on the carbon are replaced by fluorine (e.g., - ionophores, additives R- CF 2 CF 2 CF 2 CF 2 CF 2 CF 3 ).
  • Partial fluorination of one or more organic compounds occurs through fluorination of about less than 5% by weight of the polymer.
  • organic compounds undergo fluorination by about 1 % to about 5% by weight of the polymer.
  • Partially fluorinated organic compounds in an ion-sensing membrane component increases the fluorophilic interaction in sensor chemistry. Increased fluorophilic interaction (i.e. hydrophobic interaction and fluorophilic interaction) prevents leaching of any sensing components from a sensor membrane, which enhances biostability and extends the useful life of an ISE.
  • FIG. 1 depicts a medical device system 100.
  • a medical device system 100.
  • a medical device system 100 includes a medical device housing 102 having a connector module 104 that electrically couples various internal electrical components of medical device housing 102 to a proximal end 105 of a medical lead 106.
  • a medical device system 100 may include any of a wide variety of medical devices that include one or more medical lead(s) 106 and circuitry coupled to the medical lead(s) 106.
  • medical device system 100 may take the form of an implantable cardiac pacemaker that provides therapeutic stimulation to the heart.
  • medical device system 100 may take the form of an implantable cardioverter, an implantable defibrillator, or an implantable cardiac pacemaker-cardioverter-defibrillator (PCD).
  • Medical device system 100 may deliver electrical stimuli to a patient via electrodes 108 disposed on distal ends 107 of one or more lead(s) 106.
  • lead 106 includes a lead shaft 132 that has a symmetric sensor pair carrying a primary ISE 138 (i.e. the working electrode) for measuring an ion (e.g. potassium (K + ) ion etc.) and a secondary ISE 134 (i.e. the reference electrode) for measuring an ion (e.g. sodium (Na + ) ion).
  • a primary ISE 138 i.e. the working electrode
  • a secondary ISE 134 i.e. the reference electrode
  • An ion has a charge due to gaining (i.e. negatively charged) or losing (positively charged) one or more electrons.
  • An ion is a conductive element that electrically becomes either positive or negative due to its surrounding conductive system. In the heart, the conductive system is the electrolyte of the blood and the heart tissue.
  • Ionic charge is simply a measurement of a voltage or difference in potential.
  • the voltage difference that is measured is between the relatively neutral charge of the blood electrolyte and the charge created within the heart's electrical system traveling down the P0026312.01 PATENT
  • Conductors 136 and 140 carry the differential electrical signal from shaft 132 to be measured as indicated at 142.
  • FIG. 3 illustrates another symmetric ISE pair 150 including a first planar ISE
  • ISEs are typically used for blood electrolyte analysis. ISEs include a polymeric sensing membrane that is configured with several functional layers. The sensing membrane is in direct contact with physiological fluid of the body (e.g., blood, subcutaneous (subQ fluid) etc.). Typically, the membrane includes one or more layers of hydrogel, lipophilic ionophore and additive, working electrolyte etc.) and one or more layers of ionophore/additive incorporated polymer.
  • physiological fluid of the body e.g., blood, subcutaneous (subQ fluid) etc.
  • the membrane includes one or more layers of hydrogel, lipophilic ionophore and additive, working electrolyte etc.
  • Hydrogel is a network of polymer chains that are water-soluble, sometimes found as a colloidal gel in which water is the dispersion medium.
  • Hydrogels are natural and/or synthetic polymers that are superabsorbent (i.e. may contain over 99% water) and possess a degree of flexibility very similar to natural tissue, due to their significant water content.
  • Exemplary hydrogels include silicone hydrogels, polyacrylamides, cross linked polymers (polyethylene oxide, polyAMPS polyvinylpyrrolidone, polyHEMA) and other suitable compounds.
  • the hydrogel layer that is in direct contact with a solid-state Ag/AgCI electrode contains a fixed amount of electrolytes (e.g.
  • Electrolytes NaCI and KCI, both of which contain a common ion, Cl " , that Ag/AgCI has
  • Electrolytes in the hydrogel can also be completely replaced by fluoride-containing inorganic salts such as AgPF 6 , and eliminate the need of a hydrogel layer, with the electrode being Ag instead of AgCI. This can potentially increase the mobility as well as the compatibility of the electrolytes within the fluorinated hydrogel.
  • Hydrophobic polymers e.g. polyurethane, silicone etc.
  • a matrix is the bulk part of the membrane, film, coating that contain all the additives/ingredients.
  • ionophores ion- selectors
  • additives e.g. tetraphenylborate-type of salts as ion exchangers etc.
  • Ion-sensor membrane component(s) such as polymers, ionophore and lipophilic additives are structurally modified by attaching a fluorinated aliphatic side chain or a fluorinated aromatic functional group onto available functional groups of molecules.
  • Exemplary partially fluorinated ionophores/additives are presented below:
  • a fluoride atom may affect the function of an ionophore; consequently, spacing or placement of a fluoride atom is a possible criteria to be considered when designing a fluorinated ionophore.
  • the degree of fluorination can be adjusted during the molecular design and synthesis of fluorinated organic compounds. Fluorinated side chains with various degrees or percentages of fluorination can be used or attached to the parent ionophore structure by varying the number of fluorinated groups attached or by tuning the fluoride content of the attached group for different purposes.
  • An exemplary partially fluorinated fluorosilicones, as depicted below, are selected as matrices for partial flourination of the above fluorinated lipophilic molecules.
  • fluorosilicone is not only limited to the chemical structure presented above.
  • Partially fluorinated fluorosilicones provide silicones that are used to prepare ion sensors due to its desired hydrophobicity, flexibility, processibility and excellent biocompatibility characteristics. Additionally, matrices with fluoropolymers (e.g. polytetrafluorethylene (PTFE) etc.) are widely used in the biomedical device area due to its excellent biocompatibility.
  • fluoropolymers e.g. polytetrafluorethylene (PTFE) etc.
  • a partially fluorinated hydrogel replaces conventional non-fluorinated hydrogel
  • PVA polyvinyl alcohol
  • pHEMA polyhydroxyethyl methacrylate
  • the degree of modification can be modulated by the amount of perfluorooctanoyl chloride used. Such modification is not limited to only such fluorinated agent, a large variety of similar agent can be chosen to tailor the hydrogel's property. For example, a bifunctional, fluorinated crosslinker can be used to crosslink PVA chains. Such new hydrogels may exhibit other desired, tunable properties for sensor applications (such as small volume change before/after soaking thereby minimizing sensor drifting). P0026312.01 PATENT
  • a two-layer sensor structure is reduced to a single-layer sensor structure by completely eliminating a hydrogel layer.
  • the single- layer sensor structure comprises a hydrophobic silver ionophore with a fluorinated side- chain or a fluoro- functional group can be added together with partially fluorinated ionophore in the fluorosilicone, and deposit this sensing material directly on the AgCI substrate.
  • a representative silver ionophore is depicted below.
  • a fluorophilic interaction is utilized to prevent leaching of any key sensing components from the sensor membrane therefore to enhance biostability and use-life of implantable biochemical sensors.
  • the claimed invention uses partially fluorinated approach to add a stronger fluorophilic interaction on the existing hydrophobic interaction in the sensor chemistry.
  • Table 1 presents exemplary partially fluorinated ionophores, plasticizers and fluorinated polymers used in combination with ionophores.
  • Table 1 includes a chemical class in the first column; the chemical structure of a generic fluorinated ionophore in the second column; an exemplary commercially available chemical structure of a generic fluorinated ionophore in the third column; and in the fourth column, notes related to chemical structures for that particular row.
  • Table 1 List of exemplary fluorinated ionophores, plasticizers and fluorinated polymers used in combination with ionophores
  • FIG. 5 depicts a chemical reaction for synthesis of a representative fluorinated bis-crown ether-based sodium ionophore. Synthesis of a representative fluorinated bis-crown ether-based sodium ionophore includes the following operations:
  • Henicosafluoro-12-iodododecane to form the final fluorinated bis-crown ether as sodium ionophore.
  • FIG. 6 depicts a chemical reaction for synthesis of a representative fluorinated bis-crown ether potassium ionophore. Synthesis of a representative fluorinated bis- crown ether potassium ionophore includes the following operations: P0026312.01 PATENT
  • FIG. 7 depicts a chemical reaction for synthesis of three representative fluorinated crown ether-based potassium ionophores.
  • Synthesis of three representative fluorinated crown ether-based potassium ionophores. includes the following operations:
  • An optical chemical sensor is typically made by depositing a very thin polymer layer (1 -5 micrometer) on an optical waveguide or on the tip of a optical fiber, or in some cases, by using a micro to nanopolymer bead capable of optical chemical sensing.
  • a micro to nanopolymer bead capable of optical chemical sensing.
  • one or two sensing chemicals are incorporated inside the polymer membrane, i.e., to detect the interest analyte and to transducer this detection event into an optical signal.
  • an optical sensing polymer formulation related to potassium sensing is described below.
  • carboxylated PVC based potassium selective optode membrane mixture 1.4wt% of partially fluorinated potassium ion- P0026312.01 PATENT
  • Still yet another embodiment relates to depositing the mixture inside a flow-through optical cell.
  • Micro-bead based micro or nano optical sensor can be prepared by dispensing this mixture directly into an aqueous saline solution and be used in flow-cytometry or other suitable operations.
  • the present invention is not limited for use in pacemakers, cardioverters of defibrillators.
  • Other uses of the leads described herein may include uses in patient monitoring devices, or devices that integrate monitoring and stimulation features.
  • the leads may include sensors disposed on distal ends of the respective lead for sensing patient conditions.
  • the leads described herein may be used with a neurological device such as a deep-brain stimulation device or a spinal cord stimulation device. In those cases, the leads may be stereotactically probed into the brain to position electrodes for deep brain stimulation, or into the spine for spinal stimulation. In other applications, the leads described herein may provide muscular stimulation therapy, gastric system stimulation, nerve stimulation, lower colon stimulation, drug or beneficial agent dispensing, recording or monitoring, gene therapy, or the like. In short, the leads described herein may find useful applications in a wide variety of medical devices that implement leads and circuitry coupled to the leads.
  • the present invention applies to a wide range of medical uses.
  • the sensor applies to all types of ISEs.
  • An exemplary optical sensor may be seen with respect to U.S. Patent No. 6,165,796 issued December 26, 2000, to Bell et al., the disclosure of which is incorporated by reference in its entirety herein.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Electrochemistry (AREA)
  • Electrotherapy Devices (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne des capteurs ioniques sur un fil de dispositif médical. Un capteur ionique comprend une électrode de travail sélective des ions et une électrode de référence sélective des ions. Au moins une des électrodes comprend un composé organique partiellement fluoré. Le composé organique n'est pas complètement fluoré.
EP07871092A 2006-09-21 2007-09-21 Capteur pour dispositif médical implantable Withdrawn EP2109767A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82649306P 2006-09-21 2006-09-21
PCT/US2007/079248 WO2008076491A2 (fr) 2006-09-21 2007-09-21 Capteur pour dispositif médical implantable

Publications (1)

Publication Number Publication Date
EP2109767A2 true EP2109767A2 (fr) 2009-10-21

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP07871092A Withdrawn EP2109767A2 (fr) 2006-09-21 2007-09-21 Capteur pour dispositif médical implantable

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EP (1) EP2109767A2 (fr)
WO (1) WO2008076491A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2992319A1 (fr) * 2013-05-02 2016-03-09 Biochem Technology Inc. Détecteurs à électrode sélective à faible dérive
CN104710380B (zh) * 2015-01-06 2017-08-08 南京工业大学 用于检测铅离子的囊泡探针、制备方法及应用
CN108968976B (zh) * 2017-05-31 2022-09-13 心脏起搏器股份公司 具有化学传感器的植入式医疗设备
WO2019023093A1 (fr) 2017-07-26 2019-01-31 Cardiac Pacemakers, Inc. Systèmes et procédés de désambiguïsation de posture
CN109381195B (zh) 2017-08-10 2023-01-10 心脏起搏器股份公司 包括电解质传感器融合的系统和方法
CN109419515B (zh) 2017-08-23 2023-03-24 心脏起搏器股份公司 具有分级激活的可植入化学传感器
WO2022093786A1 (fr) 2020-10-29 2022-05-05 Cardiac Pacemakers, Inc. Capteur chimique thermo-photonique intégré

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62102149A (ja) * 1985-10-30 1987-05-12 Hitachi Ltd ナトリウムイオン選択性電極
JP2700158B2 (ja) * 1989-03-10 1998-01-19 株式会社ネオス 含フッ素アザクラウンエーテル
JPH09208576A (ja) * 1996-01-27 1997-08-12 Doujin Kagaku Kenkyusho:Kk ナトリウムイオン選択性の優れたクラウン化合 物
US6165796A (en) * 1997-11-26 2000-12-26 Beckman Coulter, Inc. Pipettable ion detector and method

Non-Patent Citations (1)

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Title
See references of WO2008076491A2 *

Also Published As

Publication number Publication date
WO2008076491A2 (fr) 2008-06-26
WO2008076491A3 (fr) 2008-12-31

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