EP2150806A4 - Procédés et systèmes d'analyse de matière fluorescente à autofluorescence limitée - Google Patents

Procédés et systèmes d'analyse de matière fluorescente à autofluorescence limitée

Info

Publication number
EP2150806A4
EP2150806A4 EP08767652A EP08767652A EP2150806A4 EP 2150806 A4 EP2150806 A4 EP 2150806A4 EP 08767652 A EP08767652 A EP 08767652A EP 08767652 A EP08767652 A EP 08767652A EP 2150806 A4 EP2150806 A4 EP 2150806A4
Authority
EP
European Patent Office
Prior art keywords
systems
methods
fluorescent materials
analyzing fluorescent
reduced autofluorescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08767652A
Other languages
German (de)
English (en)
Other versions
EP2150806A1 (fr
Inventor
Paul Lundquist
Cheng-Frank Zhong
Denis Zaccarin
Pegian Zhao
Stephen Turner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pacific Biosciences of California Inc
Original Assignee
Pacific Biosciences of California Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/901,273 external-priority patent/US20080277595A1/en
Application filed by Pacific Biosciences of California Inc filed Critical Pacific Biosciences of California Inc
Publication of EP2150806A1 publication Critical patent/EP2150806A1/fr
Publication of EP2150806A4 publication Critical patent/EP2150806A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
EP08767652A 2007-05-10 2008-05-09 Procédés et systèmes d'analyse de matière fluorescente à autofluorescence limitée Withdrawn EP2150806A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92861707P 2007-05-10 2007-05-10
US11/901,273 US20080277595A1 (en) 2007-05-10 2007-09-14 Highly multiplexed confocal detection systems and methods of using same
PCT/US2008/005953 WO2008140758A1 (fr) 2007-05-10 2008-05-09 Procédés et systèmes d'analyse de matière fluorescente à autofluorescence limitée

Publications (2)

Publication Number Publication Date
EP2150806A1 EP2150806A1 (fr) 2010-02-10
EP2150806A4 true EP2150806A4 (fr) 2013-01-02

Family

ID=41382245

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08767652A Withdrawn EP2150806A4 (fr) 2007-05-10 2008-05-09 Procédés et systèmes d'analyse de matière fluorescente à autofluorescence limitée

Country Status (4)

Country Link
EP (1) EP2150806A4 (fr)
AU (1) AU2008251861B2 (fr)
CA (1) CA2687062C (fr)
WO (1) WO2008140758A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080277595A1 (en) * 2007-05-10 2008-11-13 Pacific Biosciences Of California, Inc. Highly multiplexed confocal detection systems and methods of using same
EP2881736B1 (fr) 2008-03-31 2017-06-07 Pacific Biosciences of California, Inc. Procédés de chargement de polymerase unique et compositions
EP2362947B1 (fr) 2008-09-30 2017-05-10 Pacific Biosciences of California, Inc. Systèmes analytiques à multiplexage ultra-élevé et procédés
US8906670B2 (en) 2009-09-11 2014-12-09 Pacific Bioscience Of California, Inc. Zero-mode waveguides with non-reflecting walls
US8367159B2 (en) 2009-09-11 2013-02-05 Pacific Biosciences Of California, Inc. Methods for producing ZMWs with islands of functionality
EP2491370B1 (fr) 2009-10-23 2023-03-01 Koninklijke Philips N.V. Dispositif pour surveiller une pluralité de signaux discrets de fluorescence
EP2564191B1 (fr) 2010-04-28 2017-11-01 Pacific Biosciences Of California, Inc. Ouvertures à l'échelle du nanomètre possédant des îlots de fonctionnalité
JP2013525811A (ja) * 2010-05-03 2013-06-20 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア オンチップの広視野のレンズフリー蛍光画像化
US9581550B2 (en) * 2013-05-31 2017-02-28 Pacific Biosciences Of California Analytical devices having compact lens train arrays
WO2015036732A1 (fr) 2013-09-10 2015-03-19 Bae Systems Plc Mesure d'une rugosité de surface optique
KR102239487B1 (ko) 2018-01-08 2021-04-14 일루미나, 인코포레이티드 반도체-기반 검출을 사용한 고-처리율 서열분석
NL2020621B1 (en) * 2018-01-08 2019-07-15 Illumina Inc Multiplexing of an active sensor detector using structured illumination
US11378544B2 (en) 2018-01-08 2022-07-05 Illumina, Inc. High-throughput sequencing with semiconductor-based detection
CN108181290B (zh) * 2018-03-24 2020-07-10 王碧 一种荧光定量分析仪
WO2021081129A1 (fr) 2019-10-21 2021-04-29 Illumina, Inc. Efficacité de calcul accrue pour la microscopie à éclairage structuré
CN117330542A (zh) * 2022-06-24 2024-01-02 华中科技大学苏州脑空间信息研究院 高对比度各向同性高分辨荧光显微成像方法及成像系统
EP4379355A1 (fr) * 2022-11-29 2024-06-05 Gnothis Holding AG Analyse à haut débit d'événements de molécule unique

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6055106A (en) * 1998-02-03 2000-04-25 Arch Development Corporation Apparatus for applying optical gradient forces
WO2003001178A2 (fr) * 2001-06-20 2003-01-03 Arryx, Inc. Jeu ordonne tridimensionnel dynamique de sondes
US20040126780A1 (en) * 2001-05-29 2004-07-01 Rudolf Rigler Use of optical diffraction elements in detection methods
US20060011859A1 (en) * 2004-07-16 2006-01-19 Ralf Wolleschensky Procedure for the optical acquisition of objects by means of a light raster microscope
US20060214106A1 (en) * 2005-03-01 2006-09-28 Ralf Wolleschensky Point scanning laser scanning microscope and methods for adjustment of a microscope

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001002850A1 (fr) * 1999-07-06 2001-01-11 Caliper Technologies Corp. Systemes et methodes microfluidiques permettant de determiner la cinetique d'un modulateur
US20030031596A1 (en) * 2001-08-09 2003-02-13 Yokogawa Electric Corporation Biochip reader and fluorometric imaging apparatus
CA2579150C (fr) * 2004-09-17 2014-11-25 Pacific Biosciences Of California, Inc. Appareil et procede d'analyse de molecules
WO2006127967A2 (fr) * 2005-05-25 2006-11-30 Massachusetts Institute Of Technology Systemes d'imagerie multifocaux et procedes associes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6055106A (en) * 1998-02-03 2000-04-25 Arch Development Corporation Apparatus for applying optical gradient forces
US20040126780A1 (en) * 2001-05-29 2004-07-01 Rudolf Rigler Use of optical diffraction elements in detection methods
WO2003001178A2 (fr) * 2001-06-20 2003-01-03 Arryx, Inc. Jeu ordonne tridimensionnel dynamique de sondes
US20060011859A1 (en) * 2004-07-16 2006-01-19 Ralf Wolleschensky Procedure for the optical acquisition of objects by means of a light raster microscope
US20060214106A1 (en) * 2005-03-01 2006-09-28 Ralf Wolleschensky Point scanning laser scanning microscope and methods for adjustment of a microscope

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GOSCH M ET AL: "Parallel dual-color fluorescence cross-correlation spectroscopy using diffractive optical elements", JOURNAL OF BIOMEDICAL OPTICS SPIE USA, vol. 10, no. 5, September 2005 (2005-09-01), pages 54008 - 1, XP040213852, ISSN: 1083-3668 *
JOHANSSON M ET AL: "DESIGN, FABRICATION, AND EVALUATION OF A MULTICHANNEL DIFFRACTIVE OPTIC ROTARY JOINT", APPLIED OPTICS, OPTICAL SOCIETY OF AMERICA, WASHINGTON, DC; US, vol. 38, no. 8, 10 March 1999 (1999-03-10), pages 1302 - 1310, XP000823450, ISSN: 0003-6935, DOI: 10.1364/AO.38.001302 *
K SVOBODA ET AL: "Biological Applications of Optical Forces", ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, vol. 23, no. 1, 1 June 1994 (1994-06-01), pages 247 - 285, XP055010743, ISSN: 1056-8700, DOI: 10.1146/annurev.bb.23.060194.001335 *
See also references of WO2008140758A1 *

Also Published As

Publication number Publication date
EP2150806A1 (fr) 2010-02-10
WO2008140758A1 (fr) 2008-11-20
CA2687062C (fr) 2016-04-12
AU2008251861B2 (en) 2014-03-20
AU2008251861A1 (en) 2008-11-20
CA2687062A1 (fr) 2008-11-20

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Inventor name: TURNER, STEPHEN

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Inventor name: ZHONG, CHENG-FRANK

Inventor name: LUNDQUIST, PAUL

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