EP2155212A2 - Pharmazeutische oder kosmetische präparate zur topischen und/oder parenteralen anwendung, verfahren zu ihrer herstellung und ihre anwendung - Google Patents

Pharmazeutische oder kosmetische präparate zur topischen und/oder parenteralen anwendung, verfahren zu ihrer herstellung und ihre anwendung

Info

Publication number: EP2155212A2
Authority: EP; European Patent Office
Prior art keywords: hyaluronic acid; composition; inhibitor; degradation; acid
Prior art date: 2007-05-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP08788212A

Other languages

English (en)

French (fr)

Inventor

Marc Moutet

Jean-Claude Yadan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Galderma Research and Development SNC

Original Assignee

Galderma Research and Development SNC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-05-11

Filing date

2008-04-22

Publication date

2010-02-24

2008-04-22 Application filed by Galderma Research and Development SNC filed Critical Galderma Research and Development SNC

2010-02-24 Publication of EP2155212A2 publication Critical patent/EP2155212A2/de

Status Withdrawn legal-status Critical Current

Links

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239000002537 cosmetic Substances 0.000 title claims description 11
238000002360 preparation method Methods 0.000 title description 4
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 92
229920002674 hyaluronan Polymers 0.000 claims abstract description 91
229960003160 hyaluronic acid Drugs 0.000 claims abstract description 90
230000015556 catabolic process Effects 0.000 claims abstract description 36
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MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims description 20
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MQUQNUAYKLCRME-INIZCTEOSA-N N-tosyl-L-phenylalanyl chloromethyl ketone Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N[C@H](C(=O)CCl)CC1=CC=CC=C1 MQUQNUAYKLCRME-INIZCTEOSA-N 0.000 claims description 3
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HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 2
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102100034367 Putative peptide YY-2 Human genes 0.000 claims description 2
QHOPXUFELLHKAS-UHFFFAOYSA-N Thespesin Natural products CC(C)c1c(O)c(O)c2C(O)Oc3c(c(C)cc1c23)-c1c2OC(O)c3c(O)c(O)c(C(C)C)c(cc1C)c23 QHOPXUFELLHKAS-UHFFFAOYSA-N 0.000 claims description 2
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WPQRDUGBKUNFJW-ZZSHFKPLSA-N [(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-[5-hydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxyoxan-2-yl]methyl (e)-3-(4-hydroxyphenyl)prop-2-enoate Chemical compound C([C@@H]1[C@H]([C@@H]([C@@H](O)[C@H](OC=2C=C3C(C(C=C(O3)C=3C=CC(O)=CC=3)=O)=C(O)C=2)O1)O)O)OC(=O)\C=C\C1=CC=C(O)C=C1 WPQRDUGBKUNFJW-ZZSHFKPLSA-N 0.000 claims description 2
KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 claims description 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
- A61K2800/884—Sequential application
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection

Definitions

compositions for topical and / or parenteral application comprising, in a physiologically acceptable medium, an inhibitor of the degradation of hyaluronic acid, methods of making such compositions, and their uses as a pharmaceutical composition , especially medicine or cosmetics.
Said compositions are intended for the treatment of dermatological conditions, in particular, the filling treatment of wrinkles, fine lines, fibroblastic depletions and any scarring.
the third object is the use of hyaluronic acid and at least one inhibitor of the degradation of hyaluronic acid for the manufacture of a medicament for the treatment and / or prevention of dermatological conditions.
the method of manufacturing a composition according to the invention comprises a step of mixing hyaluronic acid and at least one inhibitor of its degradation with a physiologically acceptable medium.

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Birds (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Gerontology & Geriatric Medicine (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Cosmetics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP08788212A 2007-05-11 2008-04-22 Pharmazeutische oder kosmetische präparate zur topischen und/oder parenteralen anwendung, verfahren zu ihrer herstellung und ihre anwendung Withdrawn EP2155212A2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0755023		2007-05-11
PCT/FR2008/050724 WO2008139122A2 (fr)	2007-05-11	2008-04-22	Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations

Publications (1)

Publication Number	Publication Date
EP2155212A2 true EP2155212A2 (de)	2010-02-24

Family

ID=38777678

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP08788212A Withdrawn EP2155212A2 (de)	2007-05-11	2008-04-22	Pharmazeutische oder kosmetische präparate zur topischen und/oder parenteralen anwendung, verfahren zu ihrer herstellung und ihre anwendung

Country Status (4)

Country	Link
US (1)	US20100323985A1 (de)
EP (1)	EP2155212A2 (de)
CA (1)	CA2686505A1 (de)
WO (1)	WO2008139122A2 (de)

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WO2013185934A1 (en)	2012-06-15	2013-12-19	Merz Pharma Gmbh & Co. Kgaa	Method of preparing a composition based on hyaluronic acid
WO2017001057A1 (en)	2015-06-30	2017-01-05	Merz Pharma Gmbh & Co. Kgaa	Method of preparing a composition based on hyaluronic acid

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US8114898B2 (en)	2007-11-16	2012-02-14	Allergan, Inc.	Compositions and methods for treating purpura
US8394782B2 (en)	2007-11-30	2013-03-12	Allergan, Inc.	Polysaccharide gel formulation having increased longevity
US8357795B2 (en)	2008-08-04	2013-01-22	Allergan, Inc.	Hyaluronic acid-based gels including lidocaine
AU2009288118B2 (en)	2008-09-02	2014-12-11	Allergan, Inc.	Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
FR2948286B1 (fr)	2009-07-27	2011-08-26	Jean-Noel Thorel	Composition injectable associant un agent de comblement et un milieu de croissance des fibroblastes
US9114188B2 (en)	2010-01-13	2015-08-25	Allergan, Industrie, S.A.S.	Stable hydrogel compositions including additives
US20110172180A1 (en)	2010-01-13	2011-07-14	Allergan Industrie. Sas	Heat stable hyaluronic acid compositions for dermatological use
CN102905677A (zh)	2010-03-12	2013-01-30	阿勒根工业有限公司	用于改善皮肤状况的包含透明质烷聚合物和甘露糖醇的流体组合物
ES2585388T5 (es)	2010-03-22	2019-08-08	Allergan Inc	Hidrogeles reticulados de polisacárido y proteína-polisacárido para aumento de tejido blando
US9005605B2 (en)	2010-08-19	2015-04-14	Allergan, Inc.	Compositions and soft tissue replacement methods
US8889123B2 (en)	2010-08-19	2014-11-18	Allergan, Inc.	Compositions and soft tissue replacement methods
US8883139B2 (en)	2010-08-19	2014-11-11	Allergan Inc.	Compositions and soft tissue replacement methods
US9408797B2 (en)	2011-06-03	2016-08-09	Allergan, Inc.	Dermal filler compositions for fine line treatment
KR102312056B1 (ko)	2011-06-03	2021-10-12	알러간 인더스트리 에스에이에스	항산화제를 포함하는 피부 충전제 조성물
US20130096081A1 (en)	2011-06-03	2013-04-18	Allergan, Inc.	Dermal filler compositions
US9393263B2 (en)	2011-06-03	2016-07-19	Allergan, Inc.	Dermal filler compositions including antioxidants
US9662422B2 (en)	2011-09-06	2017-05-30	Allergan, Inc.	Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20130244943A1 (en)	2011-09-06	2013-09-19	Allergan, Inc.	Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US10111904B2 (en) *	2013-01-09	2018-10-30	Berlock Aps	Micron-sized gold, kit comprising said gold and its use as a non-toxic immune suppressor
WO2016051219A1 (en)	2014-09-30	2016-04-07	Allergan Industrie, Sas	Stable hydrogel compositions including additives
WO2016128783A1 (en)	2015-02-09	2016-08-18	Allergan Industrie Sas	Compositions and methods for improving skin appearance
PL3256179T3 (pl)	2015-02-13	2020-05-18	Allergan Industrie, Sas	Implanty do kształtowania, uwydatniania lub korygowania cech twarzy takich jak broda
DE102016208567A1 (de) *	2016-05-19	2017-11-23	Heraeus Medical Gmbh	Polymerlösung zur Viscosupplementation
WO2019238954A1 (en) *	2018-06-15	2019-12-19	Croma-Pharma Gmbh	Hydrogel composition comprising a crosslinked polymer
PL245399B1 (pl)	2018-11-29	2024-07-15	Univ Warszawski Medyczny	Kompozycja farmaceutyczna zawierająca urolitynę A lub jej pochodną do zastosowania zewnętrznego miejscowego w leczeniu, hamowaniu i zapobieganiu chorobom skóry i błon śluzowych o podłożu zapalnym
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2008
- 2008-04-22 EP EP08788212A patent/EP2155212A2/de not_active Withdrawn
- 2008-04-22 CA CA002686505A patent/CA2686505A1/fr not_active Abandoned
- 2008-04-22 WO PCT/FR2008/050724 patent/WO2008139122A2/fr not_active Ceased
- 2008-04-22 US US12/599,674 patent/US20100323985A1/en not_active Abandoned

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See references of WO2008139122A2 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2013185934A1 (en)	2012-06-15	2013-12-19	Merz Pharma Gmbh & Co. Kgaa	Method of preparing a composition based on hyaluronic acid
WO2017001057A1 (en)	2015-06-30	2017-01-05	Merz Pharma Gmbh & Co. Kgaa	Method of preparing a composition based on hyaluronic acid

Also Published As

Publication number	Publication date
US20100323985A1 (en)	2010-12-23
WO2008139122A3 (fr)	2009-02-05
WO2008139122A2 (fr)	2008-11-20
CA2686505A1 (fr)	2008-11-20

Legal Events

Date	Code	Title	Description
2010-01-22	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2010-02-24	17P	Request for examination filed	Effective date: 20091211
2010-02-24	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
2010-02-24	AX	Request for extension of the european patent	Extension state: AL BA MK RS
2012-08-15	DAX	Request for extension of the european patent (deleted)
2013-04-10	17Q	First examination report despatched	Effective date: 20130307
2013-12-13	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2014-01-15	18D	Application deemed to be withdrawn	Effective date: 20130718

Publication	Publication Date	Title
EP2155212A2 (de)	2010-02-24	Pharmazeutische oder kosmetische präparate zur topischen und/oder parenteralen anwendung, verfahren zu ihrer herstellung und ihre anwendung
EP1965808B1 (de)	2012-08-15	Pharmazeutische oder kosmetische zubereitungen für topische und/oder parenterale anwendung, zubereitungsverfahren und verwendung
EP2155149A2 (de)	2010-02-24	Pharmazeutische oder kosmetische präparate zur topischen und/oder parenteralen anwendung, verfahren zu ihrer herstellung und ihre anwendung
EP2882415B1 (de)	2020-03-18	Feuchtigkeitsspendender bestandteil eines kosmetikums oder pharmazeutikums
EP2155154A2 (de)	2010-02-24	Pharmazeutische oder kosmetische präparate zur topischen und/oder parenteralen anwendung, verfahren zu ihrer herstellung und ihre anwendung
FR2715565A1 (fr)	1995-08-04	Composition cosmétique ou dermatologique stabilisée contenant plusieurs précurseurs d'un même actif pour maximaliser sa libération, son utilisation.
EP0818200B1 (de)	2002-04-10	Verwendung eines Polysaccharids in einer Zusammensetzung zur Förderung der Abschuppung der Haut und Zusammensetzung, die ein Polysaccharid enthält.
EP1689356B1 (de)	2008-12-31	Topische zusammensetzun mit natrium hyaluronat fragmente und einen retinoid
EP2148727A2 (de)	2010-02-03	Pharmazeutische oder kosmetische präparate zur topischen und/oder parenteralen anwendung, verfahren zu ihrer herstellung und ihre anwendung
FR3018191A1 (fr)	2015-09-11	Utilisations cosmetiques de la swertiamarine
FR2977494A1 (fr)	2013-01-11	Compositions cosmetiques ou pharmaceutiques contenant des acides hyaluroniques de masses moleculaires differentes
FR2966348A1 (fr)	2012-04-27	Compositions comprenant un produit de comblement des rides et une tetracycline modifiee chimiquement
EP2868313B1 (de)	2019-06-19	Verbindung von Vitamin C und Hyaluronsäure für die Behandlung von Hautalterungseffekten
FR2919999A1 (fr)	2009-02-20	Compositions d'acide hyaluronique
EP2155186A2 (de)	2010-02-24	Pharmazeutische oder kosmetische präparate zur topischen und/oder parenteralen anwendung, verfahren zu ihrer herstellung und ihre anwendung
JP4669228B2 (ja)	2011-04-13	皮膚外用剤組成物
FR2966349A1 (fr)	2012-04-27	Compositions comprenant un produit de comblement des rides et un compose de la famille des tetracyclines utilise a une dose sub-antimicrobienne
FR2932381A1 (fr)	2009-12-18	Composition cosmetique ou pharmaceutique contenant une association de hyaluronane reticule ou non reticule et d'heparine et/ou un ou plusieurs derives heparinoides pour voie topique et injectable
WO2023144487A1 (fr)	2023-08-03	Ingredient protecteur de la peau et/ou des muqueuses contre les facteurs de virulence
EP2965745B1 (de)	2017-08-30	Kosmetische oder pharmazeutische zusammensetzung zur lokalen anwendung, die eine verbindung aus pektin und einem extrakt von centella asiatica enthält, und ihre verwendungen
FR2949968A1 (fr)	2011-03-18	Composition injectable comprenant une dispersion vesiculaire comprenant des ceramides et de l'acide hyaluronique, utilisation et procede
WO2003013464A1 (fr)	2003-02-20	Composition comprenant une association entre l'igf1 et l'acide ascorbique
FR3080537A1 (fr)	2019-11-01	Utilisation cosmetique d'une composition comprenant au moins une charge et au moins un polymere tenseur particuliers pour procurer un effet tenseur a la peau
FR2967063A1 (fr)	2012-05-11	Utilisation d'extrait de grenade comme agent raffermissant de la peau d'un sujet ayant subi une modification de poids ou un acte de chirurgie esthetique

EP2155212A2 - Pharmazeutische oder kosmetische präparate zur topischen und/oder parenteralen anwendung, verfahren zu ihrer herstellung und ihre anwendung - Google Patents

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Definitions

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Applications Claiming Priority (2)

Publications (1)

Family

ID=38777678

Family Applications (1)

Country Status (4)

Cited By (2)

Families Citing this family (27)

Family Cites Families (17)

Non-Patent Citations (1)

Cited By (2)

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