EP2178514A2 - Compositions d'enrobage par un film, à base de phosphate de calcium tribasique. - Google Patents

Compositions d'enrobage par un film, à base de phosphate de calcium tribasique.

Info

Publication number
EP2178514A2
EP2178514A2 EP07866686A EP07866686A EP2178514A2 EP 2178514 A2 EP2178514 A2 EP 2178514A2 EP 07866686 A EP07866686 A EP 07866686A EP 07866686 A EP07866686 A EP 07866686A EP 2178514 A2 EP2178514 A2 EP 2178514A2
Authority
EP
European Patent Office
Prior art keywords
coating composition
composition
coating
range
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07866686A
Other languages
German (de)
English (en)
Inventor
Suresh Rukmanand Pareek
Chetan Rajsharad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ideal Cures Pvt Ltd
Original Assignee
Ideal Cures Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ideal Cures Pvt Ltd filed Critical Ideal Cures Pvt Ltd
Publication of EP2178514A2 publication Critical patent/EP2178514A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2813—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B9/00—Preservation of edible seeds, e.g. cereals
    • A23B9/14—Coating with a protective layer; Compositions or apparatus therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/343—Products for covering, coating, finishing, decorating
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A23P20/10—Coating with edible coatings, e.g. with oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A23P20/10—Coating with edible coatings, e.g. with oils or fats
    • A23P20/105—Coating with compositions containing vegetable or microbial fermentation gums, e.g. cellulose or derivatives; Coating with edible polymers, e.g. polyvinyalcohol
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D129/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Coating compositions based on hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Coating compositions based on derivatives of such polymers
    • C09D129/02—Homopolymers or copolymers of unsaturated alcohols
    • C09D129/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D7/00—Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
    • C09D7/40—Additives
    • C09D7/60—Additives non-macromolecular
    • C09D7/61—Additives non-macromolecular inorganic
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D7/00—Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
    • C09D7/40—Additives
    • C09D7/66—Additives characterised by particle size
    • C09D7/69—Particle size larger than 1000 nm
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G2210/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing inorganic compounds or water in high or low amount
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/32—Phosphorus-containing compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C08K5/0016—Plasticisers

Definitions

  • This invention relates to the field of coating compositions for substrates like pharmaceutical tablets, nutritional supplements, food products, confectionery, agricultural seeds for providing protection to the substrate from environmental conditions like light, humidity, atmospheric gases etc.
  • Film coating is generally, a process of depositing a thin layer of material onto a substrate such as a pharmaceutical tablet to provide a protective barrier covering the outer surface and also to provide an aesthetic appearance to the product.
  • Japanese patent JP H8-59512 provides compositions for film coating based on polyvinyl alcohol as film forming polymers.
  • US 3935326 filed in April 1974 describes the coating of core tablets with polymers selected from the group consisting of polyvinyl alcohol, polyvinyl pyrrolidone and solid polyethylene glycol.
  • US patent no. 5,885,617 filed in June 1995 having the application priority of GB9414045 provides moisture barrier film coating compositions based on polyvinyl alcohol.
  • Yet another US patent no. 5604282 filed in Dec 1994 provides a strippable, rewettable film coating generally comprising polyvinyl polymer, polyvinyl alcohol and other ingredients.
  • all these compositions were found to be fairly sticky in nature, making the film coating process quite difficult.
  • compositions based on polyvinyl alcohol there have been many compositions known in the art of film coating based on various cellulosic polymers.
  • the objective of the invention is to provide dry film coating composition that has a smooth surface, shiny gloss, minimal tackiness, good film strength and adhesion properties and provides excellent protection to the substrate against various environmental conditions like light, moisture and atmospheric gases.
  • the present invention provides cost-effective dry film coating compositions comprising of tribasic calcium phosphate as one of the essential ingredient along with other commonly used polymers, plasticizers, excipients like suspending agents, pigments, lubricants, glidents, opacifiers, flavours, sweetener etc. for use in coating of pharmaceutical tablets, nutritional supplements, food products, confectionery, agricultural seeds and the like.
  • the invention provides a method of coating a substrate using the invented coating composition.
  • polyvinyl alcohol is a very tacky polymer which makes the coating process very difficult for the coating compositions where polyvinyl alcohol has been used as the main film forming polymer.
  • tribasic calcium phosphate in firm coating compositions reduces the tackiness of polyvinyl alcohol very significantly, thus makes the film coating process much simpler and easy. Even after reducing the polymer tackiness, use of tribasic calcium phosphate still provides good film strength and high film adhesion so that the resulting film provides much improved protection to the substrate.
  • the present invention describes dry film coating compositions wherein an inexpensive and commonly used pharmaceutical excipient, tribasic calcium phosphate has been used along with other commonly used polymers to achieve a low cost coating composition.
  • the invented composition has excellent film forming ability and film adhesion to the substrate. It has also been observed that the invented composition provides excellent protection to the substrate against various environmental conditions like light, moisture and atmospheric gases.
  • the tribasic calcium phosphate can be used in the composition in a range of about 2% to about 50% more preferably in a range of about 6% to about 40% by weight of the composition.
  • the present inventors have further experimented the compatibility of tribasic calcium phosphate with other polymers like HPMC, HPC, HEC, methyl cellulose, ethyl cellulose, aqueous dispersion of ethyl cellulose, sodium alginate, alginic acid, sodium carboxy methyl cellulose and found that tribasic calcium phosphate is an excellent excipient and can easily be used with other polymers also with superior results.
  • the polymer system of present inventive formulation may comprise one or more polymers as mentioned above.
  • the polymer system of present invention may present in a range of 10% to 90%; more preferably in a range of about 15% to about 75% by weight of the composition.
  • the film adhesion was found to be higher when the polymer was mixed with tribasic calcium phosphate than when used alone.
  • the use of tribasic calcium phosphate does not increase the viscosity of the coating suspension, hence, the solid content of the coating suspension can also be increased than using the polymer alone thus, making the coating process quite faster. It was further observed that in certain compositions based on tribasic calcium phosphate, the solid content of the coating suspension can be increased upto 25% w/w without having any adverse effect on spray characteristics.
  • Tribasic calcium phosphate was found to be an excellent excipient for film coating as it is compatible with a wide variety of plasticizers without affecting the shelf life of the product and hence the composition may advantageously contain one or more plasticizers.
  • plasticizers which have been used in different compositions are triacetin, propylene glycol, various grades of polyethylene glycol, liquid paraffin, diethyl phthalate, dibutyl phthalate, triethyl citrate, lecithin, fractionated coconut oil, castor oil etc. in different concentrations ranging from 2% to 30% w/w. The more preferable range is about 5% to about 20% by weight of the composition.
  • liquid plasticizers like PEG 200 or PEG 400 or triacetin or castor oil or diethyl phthalate or dibutyl phthalate etc. is much easier in the coating compositions based on tribasic calcium phosphate.
  • the liquid plasticizers get adsorbed onto tribasic calcium phosphate and does not make the whole composition wet. This nature of tribasic calcium phosphate helps in adding higher concentrations of liquid plasticizers (which is not possible in many known compositions in art) and also makes the manufacturing of coating composition much easier.
  • composition of the present invention further includes a pigment / opacifier in an amount of 0% to 30% by weight of the composition.
  • Tribasic calcium phosphate is proved to be a useful excipient in film coating compositions as it was found to be compatible with other commonly used excipients in film coating like talc, fumed silica, kaolin, magnesium stearate, stearic acid, opacifiers like titanium dioxide and calcium carbonate, colours (synthetic dyes, natural colours, iron oxide colours as well as candurin colours), flavours, sweeteners etc.
  • the product performance and shelf life was found to be good when coating composition has tribasic calcium phosphate as one of the ingredient.
  • the invented composition further comprises flow aid selected from talc, filmed silica, kaolin, magnesium stearate, stearic acid or magnesium trisilicate, either alone or in combination of more than one ingredient.
  • the flow aid is present in an amount ranging 0% to 20% by weight of the composition.
  • the dry film coating composition further comprises colouring agent selected from lake colours, soluble colours, iron oxide colours, candurin colours or natural colours either alone or a combination thereof.
  • the amount of colouring agent may present in the range of 0% to 30% by weight of the composition.
  • a sweetener selected from sodium saccharin, sucrose, aspartame, neutrame or dextrose, may also present in the film coating composition either alone or in mixtures thereof.
  • the sweetener may present in a range of about 0% to about 10% by weight of the composition.
  • the film coating composition may further contain a flavouring agent in an amount ranging from 0% to 15% by weight of the composition.
  • the flavouring agent being either encapsulated powder or liquid flavour suitable for pharmaceutical / food applications can be used.
  • the presence of tribasic calcium phosphate in film coating composition makes the product less hygroscopic and thus reduces the caking tendency of various polymers; many of those tend to pick moisture from atmosphere in high humidity conditions and tend to cake.
  • the presence of tribasic calcium phosphate helps in increased shelf life of the coating composition.
  • the invented composition can very easily be manufactured by dry mixing of various ingredients (mixing may need specific order of addition depending on the ingredients used), carrying out the colour matching exercise using spectrophotometric colour scan method.
  • the invention describes a method for coating substrates. Accordingly, a method for coating substrates such as pharmaceutical tablets, nutritional supplements, food, confectionery, agricultural seeds, and the like, with a film coating composition comprising the steps of: a) mixing the coating composition into water or into organic solvents or into a combination of water and alcoholic solvents to form a smooth dispersion; b) applying an effective amount of said coating dispersion onto said substrate to form a film on the said substrate, and c) drying the film coating on said substrate.
  • the dry mix composition can easily be converted into coating suspension by suspending in suitable solvent system using a simple stirring procedure.
  • the suspension becomes ready for coating quite quickly when a propeller stirrer is used for suspension preparation.
  • the invented composition can easily be mixed with various solvent systems like purified water, a mixture of purified water and alcoholic solvents (like ethyl alcohol, isopropyl alcohol, methyl alcohol etc.), a mixture of alcoholic solvents and other organic solvents like methylene dichloride, acetone etc.
  • solvent system was found to be mostly governed by the use of polymer/polymer system and the nature of the substrate to be coated.
  • the invented composition can easily work in fairly wide range of film coating process conditions which can easily be controlled, monitored and reproduced. Once the suspension is ready, it can easily be sprayed onto the substrate using commonly used spray equipments and the coating process can easily be carried out either in conventional (non perforated) coating pan, perforated coating pan (like Acela Cota) or in fluid bed coater.
  • the invention covers the novel film coating compositions and includes coating dispersions, the coated substrates, such as coated pharmaceutical tablets, coated nutritional supplements, coated food products, coated confectionery forms, coated agricultural seeds etc and the method of making the dry film coating compositions and the method of making the coating dispersion of the invention.
  • the dry film coating composition of the invention may be granulated using a planetary mixer. After the dry film coating composition was loaded into the mixer, sufficient water was slowly added during the mixing process until the composition forms slightly adherent granules. These granules were then passed through a 1-2 mm screen and then dried in an oven at 3O 0 C until the moisture content below 5%. The composition was then sieved again through a 1-2 mm screen to make it ready for use in a nondusting, granular form.
  • the composition may optionally be milled such as in a hammer mill, for example. Other methods of granulation, which may also be used, are spray granulation and roller compaction.
  • 100 grams of the resulting film coating composition was dispersed into 400 grams of distilled water to form an inventive coating dispersion (20% solids), and 500 grams of the above dispersion was sprayed onto 3 kilograms of tablets using a coater to form the inventive coating on the tablets having a theoretical weight gain of 3%.
  • the tablets were rotated in the coater at a rotation speed of 12 rpm.
  • the spraying rate of coating dispersion during coating was 15 grams per minute.
  • the tablets Upon completion of the coating process, the tablets showed a smooth surface with excellent logo definition.
  • the film coating on the tablets possesses an excellent long- lasting shinny gloss, minimal tackiness, good film adhesion, and good tensile strength.

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Public Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Fertilizers (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

L'invention porte sur des compositions d'enrobage par un film sec, comprenant du phosphate de calcium tribasique comme l'un des ingrédients essentiels conjointement avec d'autres polymères, plastifiants, excipients comme agents de mise en suspension, pigments, lubrifiants, agents de glissement, opacifiants, agents de saveur, édulcorants, etc., pour une utilisation dans l'enrobage de comprimés pharmaceutiques, de suppléments nutritionnels, de produits alimentaires, de confiserie, de semences pour agriculture et similaires. L'invention porte également sur un procédé d'enrobage d'un substrat à l'aide de la composition d'enrobage de l'invention.
EP07866686A 2007-08-20 2007-08-20 Compositions d'enrobage par un film, à base de phosphate de calcium tribasique. Withdrawn EP2178514A2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2007/000358 WO2009024992A2 (fr) 2007-08-20 2007-08-20 Compositions d'enrobage par un film, à base de phosphate de calcium tribasique.

Publications (1)

Publication Number Publication Date
EP2178514A2 true EP2178514A2 (fr) 2010-04-28

Family

ID=40378799

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07866686A Withdrawn EP2178514A2 (fr) 2007-08-20 2007-08-20 Compositions d'enrobage par un film, à base de phosphate de calcium tribasique.

Country Status (4)

Country Link
EP (1) EP2178514A2 (fr)
CA (1) CA2697071A1 (fr)
MX (1) MX2010002026A (fr)
WO (1) WO2009024992A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3831895A1 (fr) 2019-12-02 2021-06-09 Tomasz Kiska Utilisation de phosphate de magnésium et d'une composition colorante

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060127479A1 (en) * 2004-10-08 2006-06-15 Natrajan Kumaraperumal Solvent free taste masked pharmaceutical compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2009024992A2 *

Also Published As

Publication number Publication date
WO2009024992A3 (fr) 2009-09-17
WO2009024992A2 (fr) 2009-02-26
CA2697071A1 (fr) 2009-02-26
MX2010002026A (es) 2010-03-15

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