EP2274443A4 - Fängermittel sowie verfahren und systeme in verbindung damit zum nachweis und/oder sortieren von zielen - Google Patents

Fängermittel sowie verfahren und systeme in verbindung damit zum nachweis und/oder sortieren von zielen

Info

Publication number
EP2274443A4
EP2274443A4 EP09729900A EP09729900A EP2274443A4 EP 2274443 A4 EP2274443 A4 EP 2274443A4 EP 09729900 A EP09729900 A EP 09729900A EP 09729900 A EP09729900 A EP 09729900A EP 2274443 A4 EP2274443 A4 EP 2274443A4
Authority
EP
European Patent Office
Prior art keywords
detecting
methods
systems related
capturing agents
sorting targets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09729900A
Other languages
English (en)
French (fr)
Other versions
EP2274443A2 (de
Inventor
Gabriel A Kwong
Caius G Radu
Antoni Ribas
Owen Witte
James R Heath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology
University of California Berkeley
University of California San Diego UCSD
Original Assignee
California Institute of Technology
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology, University of California Berkeley, University of California San Diego UCSD filed Critical California Institute of Technology
Publication of EP2274443A2 publication Critical patent/EP2274443A2/de
Publication of EP2274443A4 publication Critical patent/EP2274443A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
EP09729900A 2008-04-09 2009-04-09 Fängermittel sowie verfahren und systeme in verbindung damit zum nachweis und/oder sortieren von zielen Withdrawn EP2274443A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12347808P 2008-04-09 2008-04-09
PCT/US2009/040106 WO2009126828A2 (en) 2008-04-09 2009-04-09 Capture agents and related methods and systems for detecting and/or sorting targets

Publications (2)

Publication Number Publication Date
EP2274443A2 EP2274443A2 (de) 2011-01-19
EP2274443A4 true EP2274443A4 (de) 2012-03-28

Family

ID=41162620

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09729900A Withdrawn EP2274443A4 (de) 2008-04-09 2009-04-09 Fängermittel sowie verfahren und systeme in verbindung damit zum nachweis und/oder sortieren von zielen

Country Status (6)

Country Link
EP (1) EP2274443A4 (de)
JP (1) JP2011518553A (de)
CN (1) CN102112626A (de)
AU (1) AU2009234162A1 (de)
CA (1) CA2721085A1 (de)
WO (1) WO2009126828A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2361930A3 (de) 2007-03-26 2011-10-26 Dako Denmark A/S Multimere von peptide-mhc komplexen und deren verwendung in borrelia infektionskrankheiten
EP3620465B1 (de) * 2007-07-03 2025-02-19 Dako Denmark A/S Verbesserte verfahren zur herstellung, markierung und verwendung von mhc-multimeren
US10611818B2 (en) 2007-09-27 2020-04-07 Agilent Technologies, Inc. MHC multimers in tuberculosis diagnostics, vaccine and therapeutics
DK2254592T3 (da) 2008-02-28 2019-09-09 Dako Denmark As MHC-multimerer til Borrelia-diagnostik og sygdom
US10722562B2 (en) 2008-07-23 2020-07-28 Immudex Aps Combinatorial analysis and repair
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
WO2010037402A1 (en) 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
US20100261292A1 (en) * 2009-04-10 2010-10-14 Meso Scale Technologies, Llc Methods for Conducting Assays
WO2012051386A2 (en) * 2010-10-14 2012-04-19 Meso Scale Technologies, Llc Reagent storage in an assay device
HK1221013A1 (zh) 2013-03-15 2017-05-19 普罗格诺西斯生物科学公司 用於检测肽/mhc/tcr结合的方法
EP3628684B1 (de) * 2014-06-06 2024-09-18 Herlev Hospital Bestimmung von antigenerkennung durch barcoding von mhc-multimeren
EP3155426B1 (de) 2014-06-13 2023-07-19 Immudex ApS Allgemeiner nachweis und isolierung spezifischer zellen durch binden markierter moleküle
CN104165990B (zh) * 2014-07-24 2016-11-09 广州万联生物科技有限公司 氯霉素的化学发光酶联免疫检测试剂盒及使用方法
JP6752231B2 (ja) * 2015-06-01 2020-09-09 カリフォルニア インスティテュート オブ テクノロジー 抗原を用いて特異的集団に関してｔ細胞をスクリーニングするための組成物および方法
CN107847544B (zh) * 2015-07-20 2021-10-15 小利兰·斯坦福大学董事会 用多聚体结合试剂检测细胞表型和定量
GB201516568D0 (en) * 2015-09-18 2015-11-04 Univ Birmingham Apparatus and method for improved molecular detection
WO2018183969A1 (en) * 2017-03-30 2018-10-04 California Institute Of Technology Barcoded rapid assay platform for efficient analysis of candidate molecules and methods of making and using the platform
JP6886854B2 (ja) * 2017-04-13 2021-06-16 シスメックス株式会社 被検物質の情報取得方法
US12258373B2 (en) 2018-12-17 2025-03-25 Immudex Aps Panel comprising Borrelia MHC multimers
CN114450402A (zh) * 2019-09-24 2022-05-06 恰根有限公司 稳定化的含细胞体液样品的多模式分析
CA3193812A1 (en) * 2020-09-24 2022-03-31 University Of Cincinnati Highly chemically stable aptamer sensors
WO2022195089A1 (en) * 2021-03-19 2022-09-22 Paris Sciences Et Lettres Methods for the selective analysis of cells or organelles
WO2025081196A1 (en) * 2023-10-12 2025-04-17 Georgia Tech Research Corporation Scarless isolation of antigen-specific t cells for car t cells for car t cell manufacturing via dnagated sorting

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10539561B1 (en) * 2001-08-30 2020-01-21 Customarray, Inc. Enzyme-amplified redox microarray detection process
CN1296492C (zh) * 2004-11-18 2007-01-24 博奥生物有限公司 一种基于生物芯片检测能结合特异序列的核酸结合蛋白的方法
US20080220982A1 (en) * 2005-07-26 2008-09-11 Vu Tania Q Nanoparticle Probes for Capture, Sorting and Placement of Targets
AU2007281479A1 (en) * 2006-08-02 2008-02-07 California Institute Of Technology Methods and systems for detecting and/or sorting targets
WO2009012340A2 (en) * 2007-07-16 2009-01-22 California Institute Of Technology Microfluidic devices, methods and systems for detecting target molecules

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BAILEY RYAN C ET AL: "DNA-encoded antibody libraries: A unified platform for multiplexed cell sorting and detection of genes and proteins", February 2007, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, VOL. 129, NR. 7, PAGE(S) 1959-1967, ISSN: 0002-7863, XP002667107 *
DEVIREN GOKHAN ET AL: "Detection of antigen-specific T cells on p/MHC microarrays", January 2007, JOURNAL OF MOLECULAR RECOGNITION, VOL. 20, NR. 1, PAGE(S) 32-38, ISSN: 0952-3499, XP002667108 *
JUNZO NORIMINE ET AL: "Quantitation of Anaplasma marginale major surface protein (MSP)1a and MSP2 epitope-specific CD4+ T lymphocytes using bovine DRB3*1101 and DRB3*1201 tetramers", IMMUNOGENETICS, SPRINGER, BERLIN, DE, vol. 58, no. 9, 19 August 2006 (2006-08-19), pages 726 - 739, XP019421864, ISSN: 1432-1211, DOI: 10.1007/S00251-006-0140-3 *
KWONG GABRIEL A ET AL: "Modular Nucleic Acid Assembled p/MHC Microarrays for Multiplexed Sorting of Antigen-Specific T Cells", July 2009, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, VOL. 131, NR. 28, PAGE(S) 9695-9703, ISSN: 0002-7863, XP002667106 *
SANO T ET AL: "A streptavidin mutant containing a cysteine stretch that facilitates production of a variety of specific streptavidin conjugates", BIO/TECHNOLOGY, NATURE PUBLISHING CO. NEW YORK, US, vol. 11, no. 2, 1 February 1993 (1993-02-01), pages 201 - 206, XP001526159, ISSN: 0733-222X *
SOEN YOAV ET AL: "Detection and characterization of cellular immune responses using peptide-MHC microarrays.", December 2003, PLOS BIOLOGY, VOL. 1, NR. 3 CITED DECEMBER 31, 2003, PAGE(S) 429-438 URL, XP002667110 *
YANG JUNBAO ET AL: "In vivo biotinylation of the major histocompatibility complex (MHC) class II/peptide complex by coexpression of B irA enzyme for the generation of MHC class II/tetramers", HUMAN IMMUNOLOGY, NEW YORK, NY, US, vol. 65, no. 7, 1 July 2004 (2004-07-01), pages 692 - 699, XP002455388, ISSN: 0198-8859, DOI: 10.1016/J.HUMIMM.2004.04.001 *
YOKOUCHI HIROSHI ET AL: "Tetramer-blocking assay for defining antigen-specific cytotoxic T lymphocytes using peptide-MHC tetramer", February 2006, CANCER SCIENCE, VOL. 97, NR. 2, PAGE(S) 148-154, ISSN: 1347-9032, XP002667109 *

Also Published As

Publication number Publication date
EP2274443A2 (de) 2011-01-19
CN102112626A (zh) 2011-06-29
WO2009126828A2 (en) 2009-10-15
CA2721085A1 (en) 2009-10-15
AU2009234162A1 (en) 2009-10-15
WO2009126828A3 (en) 2010-03-04
JP2011518553A (ja) 2011-06-30

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: HEATH, JAMES, R.

Inventor name: WITTE, OWEN

Inventor name: RIBAS, ANTONI

Inventor name: RADU, CAIUS G.

Inventor name: KWONG, GABRIEL, A.

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Ipc: C12N 15/10 20060101ALI20120215BHEP

Ipc: G01N 33/68 20060101ALI20120215BHEP

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