EP2291210A1 - Système de perfusion optimisé à usage universel - Google Patents

Système de perfusion optimisé à usage universel

Info

Publication number
EP2291210A1
EP2291210A1 EP09749639A EP09749639A EP2291210A1 EP 2291210 A1 EP2291210 A1 EP 2291210A1 EP 09749639 A EP09749639 A EP 09749639A EP 09749639 A EP09749639 A EP 09749639A EP 2291210 A1 EP2291210 A1 EP 2291210A1
Authority
EP
European Patent Office
Prior art keywords
blood
patient
pump
blood flow
devices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09749639A
Other languages
German (de)
English (en)
Inventor
Oliver MÖLLENBERG
Frank Stickel
Rudolf Kober
Ulrich Haag
Mathias Nakel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maquet Cardiopulmonary GmbH
Original Assignee
Maquet Cardiopulmonary GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maquet Cardiopulmonary GmbH filed Critical Maquet Cardiopulmonary GmbH
Publication of EP2291210A1 publication Critical patent/EP2291210A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/369—Temperature treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/367—Circuit parts not covered by the preceding subgroups of group A61M1/3621
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/845—Constructional details other than related to driving of extracorporeal blood pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0415—Plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow

Definitions

  • the present invention relates to a method in a perfusion system at least two independently controllable circuits, which are connected to each other via at least two freely selectable nodes and which contain substantially the same fluid, in particular blood, blood plasma or Elektolytroughen to establish with two independently controllable pumps and to optimize.
  • These two circuits are the patient circulation with the patient's blood base, that is, the blood flow that is withdrawn from the patient and returned to the patient, and the treatment circuit with the treatment blood flow that has the blood flow through the blood-treating assembly of devices.
  • the perfusion system can all common devices such. B. for conveying, forwarding, flow or pressure control, filtering, bubble separation, mass and energy exchange or measurement of physico-chemical parameters of these fluids.
  • the present invention relates to devices which have at least one perfusion system according to the invention.
  • Open system In a closed system, the venous blood taken from the patient is supplied via a soft bag reservoir to the further devices for extracorporeal treatment.
  • the extracorporeal system can be closed to the atmosphere.
  • a hard shell reservoir In the open system, however, a hard shell reservoir is used, wherein for pressure equalization always an open connection between the interior of the reservoir and
  • valves or terminals controllable arterio-venous shunt in addition to a z. B. by valves or terminals controllable arterio-venous shunt.
  • a partial decoupling of the patient's blood flow can be achieved by the 25 treatment blood flow, but the self-adjusting flow conditions can be influenced only in the context of the present A / V pressure conditions and the flow resistance. In this way, the patient's blood flow and the treatment blood flow can not be controlled stably, and depending on the prevailing pressure conditions, the patient flow can come to a halt or even change its direction.
  • EP 1 522 323 A1 discloses a device which consists of an oxygenator with a downstream dialyzer integrated in a housing.
  • EP 1522 323 A1, EP 1 524 000 A8 and EP 1 698 362 and also WO 2005/075007 A1 disclose the use of such a device in a combined hemodialysis and CO2 elimination system.
  • WO 2005/075007 A1 discloses a second controllable by a controllable pump circuit, which leads via two nodes ultrafiltrate from Ultrafiltratauslass back to the blood inlet of the oxygenator and thus offers the possibility of diluting the blood flowing through the oxygenator.
  • this cycle is neither independent of the patient's blood flow because the ultrafiltrate can only represent a maximum of a fraction of the blood passed, nor is there essentially the same fluid (blood or ultrafiltrate) in the patient circuit and in the treatment circuit.
  • US Pat. No. 5,411,706 A (Hubbard et al.) Describes a system consisting of a pump and an oxygenator, wherein an internal circuit reducible by more or less clamping of the recirculation line can be effected via the outlet of the oxygenator and a recirculation line to the inlet of the pump , Through this partial recirculation and the resulting more than one passage of the oxygenator better oxygenator performance is to be achieved.
  • the patient's blood flow is not regulated independently of the treatment blood flow, the maximum patient blood flow is achieved with complete closure of the recirculation line and then equal to the treatment blood flow. In all other opening states of the recirculation line, the patient's blood flow is smaller than the treatment blood flow.
  • An additional disadvantage of this system is that once set by clamping ratio of patient blood flow to treatment inflow does not remain constant, but may change depending on the existing flow resistance in the venous or arterial line. In extreme cases, z. B. at relatively wide open recirculation line and an increasing vascular resistance of the patient, the patient's blood flow can even come to a standstill.
  • US 3,890,969 (Fischel) describes a perfusion system which receives the venous blood in a bag reservoir and from there with an oxygenation pump via a Membrane oxygenator and heat exchanger in a second bag reservoir passes. From the second bag reservoir, the blood is then returned via the main pump arterially to the patient. In this case, there is a recirculation line from the second reservoir to the first reservoir, which allows overflow of excess blood and thus prevents bursting of the second reservoir.
  • the oxygenation pump is regulated in dependence on the main pump via a regulating mechanism of level sensor, amplifier and servomotor.
  • the object of the invention is therefore to avoid the disadvantages seen in the prior art and to provide a method and a device for a universal perfusion system, which allows the independent control of a patient fluid flow and treatment fluid flow.
  • the first pump causes the patient's blood flow, ie the desired venous and arterial flow.
  • the second pump can selectively flow through parts of the perfusion system with a flow (treatment blood flow) or pressure optimized for the respective application.
  • a flow treatment blood flow
  • pressure optimized for the respective application.
  • the treatment blood flow and related parameters can be chosen arbitrarily high and thus higher than the patient's blood flow. Since in the perfusion system according to the invention not necessarily expandable or collapsible fluid treatment devices are included and the venous flow does not have to be purely passive, both flows in liquid-filled system due to the incompressibility of liquids and the tightness of the system even without a control engineering balance the same size. The specified parameters can be safely kept constant by the independent regulation of the pumps.
  • the first pump which effects patient blood flow and which is known in the prior art need not be contained in the perfusion system according to the invention from the outset. Also, by combining a conventional perfusion system with a pump for the patient circuit and the disclosed system with independently controllable pump for the treatment circuit, the perfusion system according to the invention can be composed.
  • the patient's heart can also function as an independently controllable pump.
  • this independence can only be fully exploited if connected via fluid treatment devices and at least one pump life support functions such.
  • B. gas exchange and patient circulation can be partially or completely taken over. Only in this case, the patient's heart can be down-regulated over a longer period, for example, to zero pumping power, without causing the death of the patient.
  • the invention also includes common extracorporeal blood treatment methods such. As included dialysis, which need to function an integrated blood pump. Also, according to the invention coupling of an independently controllable pump and other blood treatment devices, the perfusion system according to the invention with all its advantages can be used and used in such a per se known system.
  • the property profile resulting from such an advantageous combination of different pumps is superior to the known individual pumps, allows new treatment options and is variably adaptable to the respective requirement.
  • Fig. 1 shows the scheme of a minimized closed system on the patient, the simplest conceivable pump-driven perfusion system.
  • the scheme of the minimized extracorporeal bypass on the patient is shown greatly simplified.
  • an oxygenator is shown as a fluid treatment device, but in this arrangement, other fluid treatment devices, such as dialyzers conceivable.
  • the arrangement of the fluid treatment device after the pump is outlined as in the usual practice, which is the following disclosure of the invention but not limited to this case.
  • the pump can transport the fluid back to the patient without any further fluid treatment devices, only through the hose system (support of the heart's pumping function). But usually it is also useful, for.
  • the venous and arterial lines shown in the figure are tubing connections from the patient to the pump and from the oxygenator to the patient.
  • Another possibility is to use the pumping function of the patient's heart or the resulting arterio-venous (AV) pressure difference as the drive of the extracorporeal circulation. In this case, only fluid treatment devices are needed in the extracorporeal circuit, the patient's blood flow is caused by the AV pressure difference.
  • AV arterio-venous
  • FIG. 2 the schematic structure of a known minimized perfusion system is outlined. Based on this, according to the invention, the nodes for inlets and outlets described in FIG. 4 are possible. The arrangement was always considered in the direction of patient flow. It is understood that any inlet can be combined with any outlet.
  • Fig. 2 shows a standard circuit, wherein the patient's blood flow is equal to the treatment blood flow.
  • the oxygenator shown in the figure is representative of any fluid treatment devices.
  • Fig. 3 shows a standard circuit with the possibility of reducing the patient's blood flow via a controllable shunt. In this case, the patient's blood flow is always less than or equal to the treatment blood flow.
  • Fig. 4 shows the standard circuits of Fig. 2 and Fig. 3 extended with nodes according to the invention, wherein the nodes 1, 3 and 5 represent possible blood inlets and the nodes 2, 4 and 6 possible blood outlets.
  • the patient's blood flow is equal to the treatment blood flow.
  • the fact that only minimized systems have been listed in FIGS. 2 and 4 is only to be understood as a clearer illustration and not as a restriction to minimized systems.
  • any other fluid treatment devices may be included at any position of the conventional perfusion systems.
  • Variant 2 (arrangement of pump and fluid treatment device between nodes 1 and 4)
  • Variant 3 (arrangement of pump and fluid treatment device between nodes 1 and 6)
  • Variant 4 (arrangement of pump and fluid treatment device between nodes 3 and 4)
  • Variant 5 (arrangement of pump and fluid treatment device between nodes 3 and 6)
  • variant 6 (arrangement of pump and fluid treatment device between
  • the known perfusion system should only consist of a pump integrated in the hose system, the diversity of the nodes is naturally reduced to 4, which in this case leads to only 3 different variants.
  • the diversity of the nodes is naturally reduced to 4, which in this case leads to only 3 different variants.
  • only 4 accessible nodes are present, of which two are located before and after the fluid treatment device, which also leads to only 3 different variants.
  • the possible arrangements of the pump and the fluid treatment device according to the invention can be considered.
  • 5 shows the 6 possible different arrangements a) to f) of pump and fluid treatment device and the respective flow direction in the respective arrangement, always viewed in the flow direction (on ⁇ out).
  • any number of further fluid treatment devices can be contained at arbitrary positions in these arrangements.
  • the node shown on the left in the figures is always selected as the blood inlet and the node shown on the right as the blood outlet.
  • the treatment blood flow can be selected independently of the patient's blood flow in all shown arrangements a) to f).
  • the nodes of FIG. 5 correspond to the nodes of FIG. 4.
  • FIG. 6 shows an exemplary embodiment, which results, for example, from coupling the inventive arrangement a to the nodes 5 and 6. It is understood that all arrangements according to the invention are possible and Fig. 6 represents only one of the preferred embodiments.
  • the treatment blood flow can be selected independently of the patient's blood flow.
  • the perfusion system from the functional design and the independent fluid flows the performance of the fluid treatment devices such.
  • the heat or mass transfer or blood conservation can be optimized.
  • - Oxygenator At any time z.
  • patient blood flow may be reduced to zero, such as when heart surgery is completed and cardiac function is checked while the oxygenator is running at, for example, 21 / min. is recirculated. This avoids stagnant blood in the oxygenator, and eliminates clotting in the oxygenator even in the event of difficult weaning from the HLM and associated prolonged patient flow arrest, making the system available for an emergency such as sudden cardiac hypofunction.
  • Oxygenator Especially in the scope of ECMO, the inventive method offers advantages. For example, from complete cardiopulmonary resuscitation of the patient to high patient blood flow and high blood flow through the oxygenator until the patient is completely weaned from the machine with very low patient blood flow and function-maintaining blood flow through the oxygenator, any proportionate intermediate state can be controlled. In this way, with the least risk to the patient, a heart / lung recovery can be realized, maintained for a longer period of time and weaned without risk after the recovery of the patient. In the event of heart / lung failure can be replaced at any time the full heart / lung function.
  • Oxygenator It may be beneficial to choose blood flow through the oxygenator higher than the patient's blood flow. As a result, stable and optimal for the function flow conditions in the oxygenator possible, with a more than one passage of the blood takes place in the oxygenator or only an internal recirculation takes place. This z. B. Microbubbles deposited by multiple passage of the oxygenator particularly effective or the gas exchange, if lo wished to be moved closer towards the equilibrium setting.
  • Very particularly advantageous Perfusionssysteme invention can be realized by using integrated products (bubble trap, centrifugal pump, oxygenator, heat exchanger, filter), wherein z. i5 B. the priming volume, the heat loss and the blood damage compared to discrete design can be significantly improved.
  • the blood flow through a blood concentrator or dialyzer can be optimally selected for the purpose.
  • the pressure of the blood and thus the product performance can also be regulated separately for the treatment branch. This ensures optimum product performance
  • Treatment cycle maintain a treatment blood flow, so there is no stagnation and thus the risk of clotting. As a result, the function of the coupled fluid treatment is not affected even in case of failure.
  • the patient blood flow in a dialysis system is in the range of about 100-500 ml / min. If in addition others
  • Fluid handling devices that are optimized for higher flows coupled to this system are at risk of poor product performance or clotting due to the partially stagnant blood in edge zones (the fluid treatment devices).
  • an independently controllable treatment blood flow is maintained by the second independently controllable pump in the treatment cycle, so that there is no stagnation and thus a risk of clotting.
  • the approximation of the treated fluid to an equilibrium state after passage of the treatment device (s) should be achieved as well as possible
  • substantially the same fluid means that the independent sub-circuits are each a similar fluid, but that in physical, chemical, or biological respects certain differences from another sub-circuit due to the devices passed or otherwise manipulated can have.
  • the cell-free liquid (plasma) is filtered off continuously from the blood according to the prior art and then z. B. passed over adsorption columns, which are to adsorb toxic substances. Thereafter, the toxin-free plasma is added back to the blood-enriched blood.
  • the at least two necessary nodes of the at least two circuits for the function of the perfusion system according to the invention represent in practice the limits of a mixing section of patient circuit and treatment circuit. To achieve a treatment effect, at least a very small admixture of treated fluid in the patient circuit is necessary.
  • the resulting mixing of fluid from the patient and treatment circuit is to be regarded as evidence of the presence of these at least two nodes.
  • the position of the nodal points can not be recognized optically or geometrically, or not precisely.
  • the Containing interconnected fluid treatment devices in combination with a pump may, for. B. only an inlet and an outlet be accessible, but internally by means of the pump and at least one fluid treatment device according to the invention an independently controllable treatment circuit is present. If z. B. this integrated product with at least two internal nodes to an independently controllable patient circuit with contained independently controllable pump, in this case in series, the process principle of the two independently controllable circuits is realized in this case, an inventive perfusion system.
  • the perfusion system according to the invention can also contain control and control components such as sensors for parameters to be controlled as well as control circuits and actuators in addition to the disclosed pumps, without departing from the scope of the invention.
  • the invention relates to a method in a perfusion system at least two independently controllable circuits, which are connected to each other via at least two nodes and containing substantially the same fluid, in particular blood, blood plasma or Elektolytroughen to establish with two independently controllable pump and optimize ,
  • the perfusion system can all common devices such. B. for conveying, forwarding, flow or pressure control, filtering, bubble separation, mass and energy exchange or measurement of physico-chemical parameters of these fluids.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Mechanical Engineering (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention concerne un procédé visant à établir et à optimiser au moins au moins deux circuits indépendants l'un de l'autre, connectés mutuellement au moyen d'au moins deux noeuds, et contenant essentiellement le même fluide, notamment du sang, du plasma sanguin ou des solutions électrolytiques, au moyen de deux pompes pouvant être régulées indépendamment l'une de l'autre, dans un système de perfusion. Le système de perfusion peut comporter tous les dispositifs habituels, par ex. pour le transport, le transfert, la régulation de débit ou de pression, le filtrage, la séparation de bulles, l'échange de matière ou d'énergie ou la mesure de paramètres physico-chimiques de ces fluides.
EP09749639A 2008-05-23 2009-05-22 Système de perfusion optimisé à usage universel Withdrawn EP2291210A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008024835A DE102008024835A1 (de) 2008-05-23 2008-05-23 Universell anwendbares optimiertes Perfusionssystem
PCT/EP2009/003625 WO2009141149A1 (fr) 2008-05-23 2009-05-22 Système de perfusion optimisé à usage universel

Publications (1)

Publication Number Publication Date
EP2291210A1 true EP2291210A1 (fr) 2011-03-09

Family

ID=41077736

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09749639A Withdrawn EP2291210A1 (fr) 2008-05-23 2009-05-22 Système de perfusion optimisé à usage universel

Country Status (7)

Country Link
US (1) US20110098646A1 (fr)
EP (1) EP2291210A1 (fr)
JP (1) JP2011520584A (fr)
KR (1) KR20110025177A (fr)
CN (1) CN102036701A (fr)
DE (1) DE102008024835A1 (fr)
WO (1) WO2009141149A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2777801B1 (fr) 2013-03-15 2019-08-28 Maquet Cardiopulmonary AG Dispositif d'élimination du CO2 du sang d'un patient
US10508663B2 (en) 2016-01-29 2019-12-17 National Oilwell Varco, L.P. Hydraulic circuit for controlling a movable component
DE102017210134A1 (de) * 2016-12-15 2018-06-21 Fresenius Medical Care Deutschland Gmbh System zur extrakorporalen Blutbehandlung, Behandlungsvorrichtung, Kit und Verfahren zum Betreiben eines Systems zur extrakorporalen Blutbehandlung
JP7288454B2 (ja) 2018-03-02 2023-06-07 スペクトラム メディカル リミテッド 酸素化システム
IT201800006973A1 (it) * 2018-07-05 2020-01-05 Apparecchiatura per il trattamento del sangue e relativo metodo di inizializzazione.
GB2583532B (en) 2019-05-03 2023-04-05 Spectrum Medical Ltd Control system

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3890969A (en) 1974-01-21 1975-06-24 Baxter Laboratories Inc Cardiopulmonary bypass system
US5074838A (en) * 1988-11-07 1991-12-24 Kr Phi Yer Karl K K Extracorporal thermo-therapy device and method for curing diseases using penetrants
JPH0654903A (ja) * 1991-02-13 1994-03-01 Saitetsuku Kk 透析中の生体情報制御限外濾過装置
US5411706A (en) 1994-02-09 1995-05-02 Hubbard; Lloyd C. Pump/oxygenator with blood recirculation
CA2174806A1 (fr) * 1995-04-24 1996-10-25 Frank Sever Jr. Methode et appareil pour le traitement therapeutique extracorporel de tout le systeme sanguin d'un patient pendant un seul intervalle de temps et sans interruption
DE19905937C1 (de) * 1999-02-12 2000-07-13 Karsten Kirchhof Mobile Herz-Lungen-Maschine
EP1171178B1 (fr) * 1999-04-23 2006-11-22 RenaMed Biologics, Inc. Circuit extra-corporel
US6610027B1 (en) * 2000-08-17 2003-08-26 Mohamed Kaled Mohamed El Hatu Hemodialysis
ITTO20030785A1 (it) 2003-10-03 2005-04-04 Mri S R L Societa Unipersonale Unita' di filtraggio del sangue in una macchina per emofiltrazione.
ITFI20030256A1 (it) 2003-10-09 2005-04-10 Angela Caramuta Dispositivo per l'eliminazione dell'anidride carbonica
ITFI20040025A1 (it) 2004-02-05 2004-05-05 Angela Caramuta Dispositivo per l'eliminazione dell'anidride carbonica dal sangue ed un'apparecchiatura equipaggiata con il dispositivo medesimo
JP4337980B2 (ja) * 2004-09-15 2009-09-30 旭化成クラレメディカル株式会社 血液浄化装置
DE202004021624U1 (de) * 2004-11-24 2009-08-06 Lifebridge Medizintechnik Ag Vorrichtung zur Bereitstellung eines extrakorporalen Blutkreislaufs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2009141149A1 *

Also Published As

Publication number Publication date
WO2009141149A1 (fr) 2009-11-26
DE102008024835A1 (de) 2009-12-10
CN102036701A (zh) 2011-04-27
KR20110025177A (ko) 2011-03-09
JP2011520584A (ja) 2011-07-21
US20110098646A1 (en) 2011-04-28

Similar Documents

Publication Publication Date Title
EP3554578B1 (fr) Dispositif de conduite de sang destiné à effectuer un traitement de sang extracorporel, système de traitement de sang
DE3851633T2 (de) Blutreinigungsvorrichtung.
EP0115835B1 (fr) Appareil pour éliminer l'eau du sang
DE60126817T2 (de) Verfahren und vorrichtung zur erzeugung eines sterilien infusionsfluids
DE3444671C2 (fr)
DE60037408T3 (de) Vorrichtung zur Hämodialyse
EP2106266B1 (fr) Procédé d'amorçage d'un ensemble de tubes sanguins
DE4240681C2 (de) Vorrichtung zur Hämodialyse ohne Antikoagulation
EP2825250B1 (fr) Adaptateur de tubulure servant à influencer la pression à l'intérieur d'un tronçon de tubulure pendant un traitement médical
DE3881559T2 (de) Vorrichtung zur ausserkoerperlichen sauerstoffanreicherung des blutes und zur blutkreislaufunterstuetzung.
EP2337592B1 (fr) Dispositif pour le traitement extracorporel du sang, en fonctionnement à une seule aiguille
DE102014000678A1 (de) Vorrichtung und Verfahren zur Regelung und Vorgabe der Pumprate von Blutpumpen
EP3041525B1 (fr) Dispositif medical avec un dispositif de commande permettant d'influencer la pression a l'interieur d'une poche chauffante pendant un traitement
EP2291210A1 (fr) Système de perfusion optimisé à usage universel
DE102017000843A1 (de) Extrakorporale Blutpumpe, Herz-Lungen-Maschine, Verfahren zum Betreiben einer extrakorporalen Blutpumpe sowie Verfahren zum Betreiben einer Herz-Lungen-Maschine
DE2754810C3 (de) Hämofiltrationsgerät
WO2018055091A1 (fr) Insert pour un ensemble de tubulures sanguines permettant de faciliter un mélange d'une solution d'infusion avec un autre liquide
DE102016008755B4 (de) Dialysegerät mit einer Steuereinheit zur Durchführung einer Konditionierung der Dialysemembran
DE3834126C1 (fr)
DE102014008546B4 (de) Haemofiltrationsgerät, Schlauchset und dessen Verwendung und Verfahren zum Betrieb eines Haemofiltationsgeräts
EP3996768B1 (fr) Machine de dialyse avec trois chambres d'équilibre
DE202017000613U1 (de) Vorrichtung für eine Extrakorporale Blutbehandlung
DE102010049536A1 (de) Universelles künstliches Blutkreislaufsystem

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20101104

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA RS

DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MAQUET CARDIOPULMONARY AG

17Q First examination report despatched

Effective date: 20130625

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20131106