EP2326764A2 - Utilisation de fibres lyocell et articles contenant des fibres lyocell - Google Patents
Utilisation de fibres lyocell et articles contenant des fibres lyocellInfo
- Publication number
- EP2326764A2 EP2326764A2 EP09783225A EP09783225A EP2326764A2 EP 2326764 A2 EP2326764 A2 EP 2326764A2 EP 09783225 A EP09783225 A EP 09783225A EP 09783225 A EP09783225 A EP 09783225A EP 2326764 A2 EP2326764 A2 EP 2326764A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- wound
- lyocell fibers
- fibers
- textile
- unmodified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229920000433 Lyocell Polymers 0.000 title claims abstract description 45
- 206010052428 Wound Diseases 0.000 claims abstract description 53
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 53
- 239000004753 textile Substances 0.000 claims abstract description 19
- 239000000835 fiber Substances 0.000 claims description 20
- 239000004744 fabric Substances 0.000 claims description 12
- 238000007906 compression Methods 0.000 claims description 4
- 230000006835 compression Effects 0.000 claims description 4
- 208000010668 atopic eczema Diseases 0.000 claims description 2
- 239000010440 gypsum Substances 0.000 claims description 2
- 229910052602 gypsum Inorganic materials 0.000 claims description 2
- 230000000399 orthopedic effect Effects 0.000 claims description 2
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 230000029663 wound healing Effects 0.000 description 20
- 239000000047 product Substances 0.000 description 17
- 229920000742 Cotton Polymers 0.000 description 11
- 229920000728 polyester Polymers 0.000 description 5
- 229920001661 Chitosan Polymers 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 229920003043 Cellulose fiber Polymers 0.000 description 2
- 241000195493 Cryptophyta Species 0.000 description 2
- 206010012438 Dermatitis atopic Diseases 0.000 description 2
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
- LFTLOKWAGJYHHR-UHFFFAOYSA-N N-methylmorpholine N-oxide Chemical compound CN1(=O)CCOCC1 LFTLOKWAGJYHHR-UHFFFAOYSA-N 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 201000008937 atopic dermatitis Diseases 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000004745 nonwoven fabric Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 150000003512 tertiary amines Chemical class 0.000 description 2
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 206010048629 Wound secretion Diseases 0.000 description 1
- 206010048222 Xerosis Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012595 freezing medium Substances 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 238000007490 hematoxylin and eosin (H&E) staining Methods 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000016507 interphase Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000002803 maceration Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010972 statistical evaluation Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003357 wound healing promoting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
Definitions
- the invention relates to the use of lyocell fibers, a yarn containing lyocell fibers, a textile fabric containing lyocell fibers, and a textile article containing lyocell fibers.
- lyocell has been assigned by BISFA (The International Bureau for the Standardization of Man Made Fibers) and stands for cellulose fibers which are produced from solutions of cellulose in an organic solvent, tertiary amine oxides, in particular N-methyl Morpholine N-oxide (NMMO) is used, for example, a process for producing lyocell fibers is described in US-A 4,246,221.
- BISFA The International Bureau for the Standardization of Man Made Fibers
- NMMO N-methyl Morpholine N-oxide
- the present invention relates to the use of lyocell fibers in wound treatment products.
- the expert generally distinguishes three phases of physiological wound healing:
- the primary goal of the treatment is the elimination of cell debris and microorganisms as well as the formation of a provisional matrix
- the primary target is to form granulation tissue and reepithelialize to form a temporary barrier
- the present invention is a dry wound treatment product which is currently primarily cotton
- essentially untreated products such as bleached cotton
- the quickest way to heal wounds would be theoretically (in a germ-free, moist environment) without any support from a bandage, etc.
- WO 2005/026424 A1 describes the use of lyocell fibers for the treatment of textile contact sensitivity or skin diseases, in particular xerosis, atopic eczema or psoriasis.
- Austrian Patent Application A 1471/2008 describes chitosan-modified cellulose fibers and their use as wound-healing products.
- significantly more proliferative cells were wound on the wound edge and tendentially more proliferative cells in the regenerating epidermis of chitosan-treated lyocell fibers than untreated lyocell fiber and cotton.
- DE 100 07 794 A1, DE 100 37 983 A1 and EP 1 354 914 describe polymer compositions which each comprise a biodegradable polymer and various modifying agents, e.g. Including algae, alkaloids and herbs.
- the polymer composition may be in the form of fibers, e.g. from a mixture of the modifying agent with a solution of cellulose in a tertiary amine oxide.
- non-modified lyocell fibers ie lyocell fibers that do not have modifying agents such as chitosan, algae, alkaloids carboxymethylated form
- modifying agents such as chitosan, algae, alkaloids carboxymethylated form
- the present invention relates to unmodified lyocell fibers, a yarn containing unmodified lyocell fibers, a fabric containing unmodified lyocell fibers, or a textile article containing unmodified lyocell fibers, each for specific use as a product for wound treatment, in particular for dry wound treatment.
- the present invention relates to a dry wound treatment product characterized in that it contains unmodified lyocell fibers in its intended area to be applied to the wound.
- the present invention therefore generally relates to the use of unmodified lyocell fibers for the manufacture of a wound treatment product.
- Unmodified lyocell fibers have been found to significantly accelerate wound healing compared to other unmodified products heretofore used as a substrate in dry wound treatment (ie, products containing no drugs or wound healing promoting agents), particularly when compared to bleached cotton.
- CMC fibers or fibers modified with chitosan represents a very large cost advantage.
- the yarn used according to the invention, the textile fabric or the textile article are each substantially completely composed of non-modified Lyocell fibers.
- the yarn used according to the invention, the textile fabric or the textile article may contain foreign fibers in an amount of up to 90%, preferably 10 to 50%.
- unmodified lyocell fibers are understood to be various fibers, e.g. Cotton, polyester, viscose and modal fibers or modified lyocell fibers. Unmodified fibers are also preferably used as foreign fibers, ie fibers which are not modified or derivatized with active substances, etc.
- a textile fabric for specific use according to the invention may be present in particular in the form of a woven, knitted, knitted or nonwoven fabric.
- the invention relates to a product for wound treatment, in particular for dry wound treatment, which is characterized in that it contains non-modified Lyocell fibers in its area intended for laying on the wound.
- the product according to the invention may in particular be selected from the group consisting of patches, wound dressings, bandages, bandages, gypsum underlay fabrics, underwear, pajamas for atopic dermatitis, orthopedic support bandages, support bandages, wound gauze, compresses, gauze, compression bandages, compression stockings and tubular bandages.
- the wound treatment product according to the invention is preferably characterized in that the proportion of unmodified lyocell fibers in the area intended to rest on the wound is at least 10%, preferably 50% to 100%, particularly preferably 90% to 100%.
- the remaining fibers in the area intended to rest on the wound can be foreign fibers as above, in particular non-modified foreign fibers.
- the lyocell fiber used according to the invention can be present in a tanning range which is customary for textile products or nonwovens or in a customary cutting length.
- the fiber may have a denier of 1.3 dtex and a cut length of 38 mm.
- the fiber can be used in bleached form. Examples
- Punctures with a diameter of 6 mm were taken from the plicae of washed and sterilized pig ears. From the center of the punches, the epidermis and the upper Dennis were removed in a range of 3 mm. Subsequently, the models were incubated in Air-Liquid Interphase at 37 ° C, 5% CO 2 and saturated humidity in the dermatological clinic. Immediately after generation of the models, 5 ⁇ l of PBS were applied to the control. For the other samples, 4 mm diameter platelets were removed from the knits using Biopsy punches and placed on the wounds.
- the models were after 48 h snap frozen and at -8O 0 C.
- the models were completely embedded in tissue freezing medium (Leica, Nussloch) and made with the cryostat 6 micron thin sections. It was ensured that you were in the middle of each model.
- the sections were placed on Superfrost slides, air-dried 10 min cold acetone fixed and stored at -8O 0 C in -20 0 C.
- HE staining (general morphology): All models were stained with hematoxylin / eosin (HE) (2 sections each). The staining was evaluated on a Leica light microscope DM LS and an Olympus Camedia digital camera. Evaluation parameters: Wound healing progress and morphology - Good / bad preservation of the wound margin (maceration)
- the evaluation of the wound healing progress is based on the PBS control in order to take into account the wound healing potential of the respective pig, which is determined by the values obtained with PBS (physiological phosphate buffer).
- PBS physiological phosphate buffer
- the wound healing progress achieved only with PBS is thus the highest value (ideal wound healing) in the skin organ culture model that can be achieved (100% or value 1).
- Sample 1 Polyester Fiber (Tergal PES)
- Sample 2 Unmodified Lyocell Fiber
- Sample 3 Bleached Cotton
- Sample 4 PBS Control
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Yarns And Mechanical Finishing Of Yarns Or Ropes (AREA)
Abstract
L'invention concerne l'utilisation de fibres lyocell non modifiées, d'un fil contenant des fibres lyocell non modifiées, d'une surface textile contenant des fibres lyocell non modifiées, ou d'un article textile contenant des fibres lyocell non modifiées, en tant que produit destiné notamment au traitement de plaies à sec.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0147108A AT507386A1 (de) | 2008-09-22 | 2008-09-22 | Verfahren zur behandlung cellulosischer formkörper |
| AT0175008A AT507387A1 (de) | 2008-09-22 | 2008-11-11 | Verwendung von lyocellfasern sowie lyocellfasern enthaltenden artikeln |
| PCT/EP2009/062177 WO2010031862A2 (fr) | 2008-09-22 | 2009-09-21 | Utilisation de fibres lyocell et articles contenant des fibres lyocell |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP2326764A2 true EP2326764A2 (fr) | 2011-06-01 |
Family
ID=42039948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP09783225A Withdrawn EP2326764A2 (fr) | 2008-09-22 | 2009-09-21 | Utilisation de fibres lyocell et articles contenant des fibres lyocell |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110172624A1 (fr) |
| EP (1) | EP2326764A2 (fr) |
| JP (1) | JP2012502710A (fr) |
| CN (1) | CN102159764A (fr) |
| AT (1) | AT507387A1 (fr) |
| WO (1) | WO2010031862A2 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2368532A1 (fr) | 2010-03-25 | 2011-09-28 | Ganzoni & Cie AG | Textiles de compression contenant des fibres revêtues de chitosan |
| EP2540263A1 (fr) | 2011-06-29 | 2013-01-02 | Sigvaris Inc. | Vêtements à compression graduée |
| CN104764736B (zh) * | 2015-03-30 | 2018-01-12 | 河北出入境检验检疫局检验检疫技术中心 | 莱赛尔a100的鉴别方法及其应用 |
| CN104764872A (zh) * | 2015-03-30 | 2015-07-08 | 河北出入境检验检疫局检验检疫技术中心 | 莱赛尔纤维的鉴别方法及其应用 |
| CN106436024B (zh) * | 2016-09-21 | 2018-09-07 | 天津工业大学 | 一种远红外面膜基布的制备方法 |
| US20200000640A1 (en) * | 2018-06-29 | 2020-01-02 | Milliken & Company | Multi-Layer Wound Care Device Having Absorption and Fluid Transfer Properties |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4246221A (en) * | 1979-03-02 | 1981-01-20 | Akzona Incorporated | Process for shaped cellulose article prepared from a solution containing cellulose dissolved in a tertiary amine N-oxide solvent |
| US4309534A (en) * | 1979-02-15 | 1982-01-05 | University Of Delaware | Renatured chitosan and process of making same |
| US4946870A (en) * | 1986-06-06 | 1990-08-07 | Union Carbide Chemicals And Plastics Company Inc. | Delivery systems for pharmaceutical or therapeutic actives |
| US4929722A (en) * | 1986-06-06 | 1990-05-29 | Union Carbide Chemicals And Plastics Company Inc. | Acid decrystallization of aminopolysaccharides and derivatives thereof |
| JPH0768648B2 (ja) * | 1991-02-20 | 1995-07-26 | 富士紡績株式会社 | 改質セルロース再生繊維 |
| DE4127604A1 (de) * | 1991-08-21 | 1993-02-25 | Hoechst Ag | Schlauchfoermige nahrungsmittelhuelle mit verbesserten hafteigenschaften gegenueber dem fuellgut |
| ATA53792A (de) * | 1992-03-17 | 1995-02-15 | Chemiefaser Lenzing Ag | Verfahren zur herstellung cellulosischer formkörper, vorrichtung zur durchführung des verfahrens sowie verwendung einer spinnvorrichtung |
| FI924408A0 (fi) * | 1992-09-30 | 1992-09-30 | Novasso Oy | Modifierade viskosfibrer och foerfarande foer dess framstaellning. |
| US5900479A (en) * | 1995-05-05 | 1999-05-04 | Virginia Tech Intellectual Properties, Inc. | Chitin-based coatings |
| AT403296B (de) * | 1995-08-11 | 1997-12-29 | Chemiefaser Lenzing Ag | Verfahren zur herstellung eines celluloseformkörpers |
| DE19607953A1 (de) * | 1996-03-01 | 1997-09-04 | Kalle Nalo Gmbh | Nach dem Aminoxidverfahren hergestellte Nahrungsmittelhüllen auf Cellulosebasis |
| JP2822174B2 (ja) * | 1996-03-01 | 1998-11-11 | オーミケンシ株式会社 | キチンキトサン繊維及び構造体の製造法 |
| AT2256U1 (de) * | 1997-10-15 | 1998-07-27 | Chemiefaser Lenzing Ag | Verfahren zur behandlung von cellulosischen formkörpern |
| GB9812329D0 (en) * | 1998-06-08 | 1998-08-05 | Courtaulds Plc | Yarns and wound dressings containing the same |
| DE10007794A1 (de) * | 2000-02-21 | 2001-06-28 | Zimmer Ag | Polymerzusammensetzung und daraus hergestellter Formkörper |
| DE10009248C2 (de) * | 2000-02-28 | 2002-06-27 | Freudenberg Carl Kg | Medizinisches Verbandsmaterial |
| US6835678B2 (en) * | 2000-05-04 | 2004-12-28 | Kimberly-Clark Worldwide, Inc. | Ion sensitive, water-dispersible fabrics, a method of making same and items using same |
| US7048771B2 (en) * | 2001-10-22 | 2006-05-23 | University Of California | Dyeing textiles using nanoparticles |
| JP3742027B2 (ja) * | 2002-04-08 | 2006-02-01 | Necビューテクノロジー株式会社 | 投射映像の歪補正方法、歪補正プログラム及び投射型映像表示装置 |
| AT411769B (de) * | 2002-07-12 | 2004-05-25 | Chemiefaser Lenzing Ag | Verfahren zur herstellung cellulosischer formkörper |
| GB0303295D0 (en) * | 2003-02-13 | 2003-03-19 | Lohmann Gmbh & Co Kg | Filamentary nonwoven bandage fabric |
| AT504730A1 (de) * | 2003-09-16 | 2008-07-15 | Chemiefaser Lenzing Ag | Verwendung von lyocellfasern sowie lyocellfasern enthaltenden artikeln |
| US20050102815A1 (en) * | 2003-11-03 | 2005-05-19 | L&L Products, Inc. | Reinforced members formed with absorbent mediums |
| GB0513555D0 (en) * | 2005-07-01 | 2005-08-10 | Bristol Myers Squibb Co | Carboxymethylated cellulosic wound dressing garment |
| DK1759676T3 (da) * | 2005-09-06 | 2014-01-13 | Sigvaris Man Ag | Strikket bandage |
| WO2007066339A1 (fr) * | 2005-12-07 | 2007-06-14 | Ramot At Tel Aviv University Ltd. | Structures composites pour l’administration de médicaments |
| AT503803B1 (de) * | 2006-06-14 | 2008-01-15 | Chemiefaser Lenzing Ag | Lyocell-stapelfaser |
| ES2446246T3 (es) * | 2006-08-04 | 2014-03-06 | Kuraray Co., Ltd. | Material textil no tejido estirable y bandas |
-
2008
- 2008-11-11 AT AT0175008A patent/AT507387A1/de not_active Application Discontinuation
-
2009
- 2009-09-21 EP EP09783225A patent/EP2326764A2/fr not_active Withdrawn
- 2009-09-21 JP JP2011527344A patent/JP2012502710A/ja active Pending
- 2009-09-21 CN CN2009801370836A patent/CN102159764A/zh active Pending
- 2009-09-21 WO PCT/EP2009/062177 patent/WO2010031862A2/fr not_active Ceased
- 2009-09-21 US US13/119,828 patent/US20110172624A1/en not_active Abandoned
Non-Patent Citations (1)
| Title |
|---|
| See references of WO2010031862A2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012502710A (ja) | 2012-02-02 |
| US20110172624A1 (en) | 2011-07-14 |
| WO2010031862A3 (fr) | 2010-11-18 |
| AT507387A1 (de) | 2010-04-15 |
| WO2010031862A9 (fr) | 2010-06-10 |
| WO2010031862A2 (fr) | 2010-03-25 |
| CN102159764A (zh) | 2011-08-17 |
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| 18D | Application deemed to be withdrawn |
Effective date: 20130803 |