EP2329257A4 - Vorrichtung und verfahren zur reinigung, isolierung, entsalzung oder zum puffer-/lösungsmittelaustausch von substanzen - Google Patents

Vorrichtung und verfahren zur reinigung, isolierung, entsalzung oder zum puffer-/lösungsmittelaustausch von substanzen

Info

Publication number
EP2329257A4
EP2329257A4 EP09803694.0A EP09803694A EP2329257A4 EP 2329257 A4 EP2329257 A4 EP 2329257A4 EP 09803694 A EP09803694 A EP 09803694A EP 2329257 A4 EP2329257 A4 EP 2329257A4
Authority
EP
European Patent Office
Prior art keywords
desaling
purification
insulation
substances
buffer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP09803694.0A
Other languages
English (en)
French (fr)
Other versions
EP2329257B1 (de
EP2329257A1 (de
Inventor
Elliott P Dawson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BioVentures Inc
Original Assignee
BioVentures Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BioVentures Inc filed Critical BioVentures Inc
Priority to EP15002788.6A priority Critical patent/EP3006934B1/de
Publication of EP2329257A1 publication Critical patent/EP2329257A1/de
Publication of EP2329257A4 publication Critical patent/EP2329257A4/de
Application granted granted Critical
Publication of EP2329257B1 publication Critical patent/EP2329257B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6091—Cartridges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • B01J20/267—Cross-linked polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/283—Porous sorbents based on silica
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/291—Gel sorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/58—Use in a single column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N2030/381—Flow patterns centrifugal chromatography
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP09803694.0A 2008-08-01 2009-07-31 Vorrichtung und verfahren zur reinigung, isolierung, entsalzung oder zum puffer-/lösungsmittelaustausch von substanzen Active EP2329257B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP15002788.6A EP3006934B1 (de) 2008-08-01 2009-07-31 Vorrichtung zur reinigung, isolierung, entsalzung oder zum puffer-/lösungsmittelaustausch von substanzen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8559108P 2008-08-01 2008-08-01
PCT/US2009/052517 WO2010014970A1 (en) 2008-08-01 2009-07-31 Devices and methods for the purification, isolation, desalting or buffer/solvent exchange of substances

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP15002788.6A Division EP3006934B1 (de) 2008-08-01 2009-07-31 Vorrichtung zur reinigung, isolierung, entsalzung oder zum puffer-/lösungsmittelaustausch von substanzen
EP15002788.6A Division-Into EP3006934B1 (de) 2008-08-01 2009-07-31 Vorrichtung zur reinigung, isolierung, entsalzung oder zum puffer-/lösungsmittelaustausch von substanzen

Publications (3)

Publication Number Publication Date
EP2329257A1 EP2329257A1 (de) 2011-06-08
EP2329257A4 true EP2329257A4 (de) 2014-03-05
EP2329257B1 EP2329257B1 (de) 2018-03-07

Family

ID=41610765

Family Applications (2)

Application Number Title Priority Date Filing Date
EP09803694.0A Active EP2329257B1 (de) 2008-08-01 2009-07-31 Vorrichtung und verfahren zur reinigung, isolierung, entsalzung oder zum puffer-/lösungsmittelaustausch von substanzen
EP15002788.6A Active EP3006934B1 (de) 2008-08-01 2009-07-31 Vorrichtung zur reinigung, isolierung, entsalzung oder zum puffer-/lösungsmittelaustausch von substanzen

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP15002788.6A Active EP3006934B1 (de) 2008-08-01 2009-07-31 Vorrichtung zur reinigung, isolierung, entsalzung oder zum puffer-/lösungsmittelaustausch von substanzen

Country Status (5)

Country Link
US (3) US8062533B2 (de)
EP (2) EP2329257B1 (de)
CN (2) CN102132156B (de)
CA (1) CA2730312C (de)
WO (1) WO2010014970A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8357296B2 (en) 2007-09-24 2013-01-22 Emd Millipore Corporation Centrifugal filter
CN102132156B (zh) 2008-08-01 2014-11-26 生物风险公司 用于物质的纯化、分离、脱盐或缓冲液/溶剂交换的装置和方法
CA2773428A1 (en) * 2009-09-10 2011-03-17 Lonza Biologics Plc Method and system for polypeptide purification
CN103038624A (zh) * 2010-07-14 2013-04-10 恰根有限公司 一种新型的贮存、收集或分离用装置
WO2012016720A1 (en) * 2010-08-05 2012-02-09 Vibod Gmbh New columns for incubation and isolation of chemical and/or biological samples
WO2012062753A1 (de) * 2010-11-09 2012-05-18 Qiagen Gmbh Verfahren und vorrichtung zur isolierung und reinigung von doppelsträngigen nukleinsäuren
AU2011343813B2 (en) 2010-12-15 2015-05-21 Takeda Pharmaceutical Company Limited Eluate collection using conductivity gradient
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
CN103649298A (zh) 2011-05-12 2014-03-19 精密科学公司 核酸的分离
US8980107B2 (en) 2011-05-12 2015-03-17 Exact Sciences Corporation Spin filter
US9304070B2 (en) 2011-07-13 2016-04-05 Emd Millipore Corporation All-in-one sample preparation device and method
WO2013101741A1 (en) * 2011-12-30 2013-07-04 Abbott Molecular, Inc. Channels with cross-sectional thermal gradients
WO2013147515A1 (ko) * 2012-03-30 2013-10-03 (주)어핀텍 원심분리 키트 및 이를 이용한 원심분리 방법
CA2877827A1 (en) * 2012-06-27 2014-01-03 Wake Forest University Health Sciences Cell pathology tubes and associated cell processing methods
JP6118570B2 (ja) * 2013-02-01 2017-04-19 株式会社ブリヂストン 生タイヤ支持装置及び生タイヤからのドラムの取り外し方法
CN103131628A (zh) * 2013-02-04 2013-06-05 上海交通大学 植物基因组dna快速提取装置及其检测方法
US9670479B2 (en) 2013-03-15 2017-06-06 F Cubed, LLC Sample preparation device and methods of use
CN103320319B (zh) * 2013-07-05 2015-06-24 博奥生物集团有限公司 一种可选择性高通量电穿孔装置
CN103604684B (zh) * 2013-11-22 2016-03-02 北京纳晶生物科技有限公司 样品分离装置及方法
WO2015135575A1 (de) * 2014-03-11 2015-09-17 ChiPro GmbH Chromatographiekartusche und chromatographievorrichtung
WO2015138850A1 (en) * 2014-03-13 2015-09-17 Halaka Folim G Purification columns and methods
US20170029810A1 (en) * 2014-04-11 2017-02-02 Wako Pure Chemical Industries, Inc. Nucleic acid purification method
EP3137603B1 (de) 2014-04-29 2026-02-18 Accudx Corporation Neuartige affinitätsmatrix und vorrichtungen zur isolierung und reinigung von rna und dna für molekulare vorrichtungen am behandlungsort
US9976993B2 (en) 2014-05-20 2018-05-22 Tecan Sp, Inc. Sample extraction apparatus with micro elution bed design
JP6632610B2 (ja) * 2014-05-20 2020-01-22 テカン・エスピー・インコーポレイテッドＴｅｃａｎ ＳＰ，Ｉｎｃ． 微細溶出のベッドの設計によるサンプル抽出装置
CN107709984A (zh) * 2015-06-10 2018-02-16 恩姆菲舍尔科技公司 提取柱
US9696284B2 (en) 2015-06-10 2017-07-04 Thermo Fisher Scientific Oy Extraction column
CN106317166A (zh) * 2015-07-02 2017-01-11 北京中原领先科技有限公司 高效过滤层析混合机制分离蛋白装置
DK3532186T3 (da) * 2016-10-26 2021-01-04 Emd Millipore Corp Reduktion af udvaskelige beta-glucanniveauer fra celluloseholdige filtermaterialer
CN107029452B (zh) * 2017-03-29 2020-05-19 广西科技大学 一种从样品中移除平面刚性结构物质的方法
GB201706680D0 (en) * 2017-04-27 2017-06-14 Ge Healthcare Uk Ltd Device and method for sample isolation
USD852375S1 (en) 2017-10-25 2019-06-25 Wake Forest University Health Sciences Cell collection and centrifuge tube assembly
EP3717630A4 (de) * 2017-11-30 2021-06-23 Yantai AusBio Laboratories Co., Ltd. Verfahren, system und filtrationseinheit zur isolierung von partikeln aus biologischen proben
CN109142600A (zh) * 2018-10-18 2019-01-04 云南中烟工业有限责任公司 一种测定吸烟者尿液中4种巯基尿酸的方法
CN110127888B (zh) * 2019-06-18 2023-12-29 大连地拓环境科技有限公司 一种用于矿山修复选择性渗透排水系统
CN110433552B (zh) * 2019-08-09 2024-10-22 天津药明康德新药开发有限公司 用于分离设备的自动高压在线过滤装置及其使用方法
CN110917659B (zh) * 2019-12-11 2021-07-02 福建师范大学福清分校 一种分散固相萃取装置
CN115552215A (zh) 2020-05-08 2022-12-30 沃特世科技公司 用于热辅助酶消化的方法
US12411064B2 (en) 2020-05-08 2025-09-09 Waters Technologies Corporation Methods for heat-assisted enzyme digestion
EP4323114A1 (de) * 2021-04-14 2024-02-21 Quantoom Biosciences France SAS Rohrförmige reaktionseinheit
CN113798735B (zh) * 2021-10-25 2023-04-25 浙江亚通新材料股份有限公司 一种焊片/焊环表面涂覆助焊剂的方法
CN115200967B (zh) * 2022-07-11 2026-02-03 中国食品药品检定研究院 一种样品提取液快速过滤净化装置
KR102836558B1 (ko) * 2022-12-29 2025-07-21 경북대학교병원 수율 상승과 불순물 제거 범위를 조절할 수 있는 나노입자 분리장치

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6103195A (en) * 1997-08-08 2000-08-15 Shukla; Ashok K. Micro-volume spin columns for sample preparation
WO2001007138A1 (en) * 1999-07-26 2001-02-01 Harvard Apparatus, Inc. Filtration/separation container without an in-built filter
US6451260B1 (en) * 1997-08-26 2002-09-17 Dyax Corp. Method for producing microporous elements, the microporous elements thus produced and uses thereof
US6586585B1 (en) * 1994-01-07 2003-07-01 Qiagen Gmbh Method for the size reduction of high-molecular structures
EP1437402A1 (de) * 2001-09-28 2004-07-14 Kabushiki Kaisha Yakult Honsha Vorrichtung zur extraktion von nukleinsäuren
US20080020446A1 (en) * 2006-07-22 2008-01-24 Xiyu Jia Plasmid DNA isolation

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2062539A (en) 1934-05-03 1936-12-01 Girdler Corp Comestible package
US3347247A (en) * 1964-05-14 1967-10-17 Philip Morris Inc Tobacco smoke filter
US3455766A (en) * 1965-10-22 1969-07-15 American Filtrona Corp Apparatus for forming elongated elements
US3635226A (en) * 1969-06-16 1972-01-18 British American Tobacco Co Tobacco-smoke filters
BE790146A (fr) 1971-10-27 1973-02-15 British American Tobacco Co Cigarette ventilee a bout filtre
US4018678A (en) * 1974-08-09 1977-04-19 Peniston Quintin P Method of and apparatus for fluid filtration and the like with the aid of chitosan
US4174719A (en) 1977-06-29 1979-11-20 Olin Corporation Microperforated filter tip cigarette
DE2845342A1 (de) 1978-10-18 1980-04-30 Hauni Werke Koerber & Co Kg Verfahren zum beeinflussen der luftdurchlaessigkeit eines poroesen huellmaterials fuer stabfoermige rauchartikel sowie maschine zum herstellen derartiger rauchartikel
US4270921A (en) * 1979-09-24 1981-06-02 Graas Joseph E Microchromatographic device and method for rapid determination of a desired substance
US4369117A (en) * 1980-05-12 1983-01-18 American Hospital Supply Corporation Serum separating method and apparatus
DE3639949A1 (de) * 1986-11-22 1988-06-09 Diagen Inst Molekularbio Verfahren zur trennung von langkettigen nukleinsaeuren
DE4034036C2 (de) * 1990-10-26 1994-03-03 Diagen Inst Molekularbio Vorrichtung und Verfahren zur Isolierung von Nukleinsäuren aus Zellsuspensionen
US5187083A (en) * 1990-11-13 1993-02-16 Specialty Laboratories, Inc. Rapid purification of DNA
DE4143639C2 (de) * 1991-12-02 2002-10-24 Qiagen Gmbh Verfahren zur Isolierung und Reinigung von Nukleinsäuren
US5242660A (en) * 1992-02-28 1993-09-07 Paul Hsei Sample preparation device
US5419874A (en) * 1992-07-06 1995-05-30 Beckman Instruments, Inc. Synthesis reaction column
AU6360994A (en) * 1993-03-08 1994-09-26 Steven H Boyd Aligned fiber diagnostic chromatography
US5648271A (en) * 1994-03-11 1997-07-15 Barrskogen, Inc. Method for evaporating solvent using filter
DE4420900A1 (de) * 1994-06-15 1995-12-21 Boehringer Mannheim Gmbh Verfahren zur mehrmaligen Entnahme von Flüssigkeiten
US5660984A (en) * 1994-12-09 1997-08-26 Davis; Thomas E. DNA isolating apparatus comprising a non-porous DNA binding, anion exchange resin and methods of use thereof
EP0769316B1 (de) * 1995-10-20 2003-01-15 Institut Français du Pétrole Verteiler zur unabhängigen Ein- und/oder Abführung von Fluiden
DE19609143C1 (de) * 1996-03-08 1997-11-13 Rhodia Ag Rhone Poulenc Melt-blown-Vlies, Verfahren zu dessen Herstellung und dessen Verwendungen
US6207066B1 (en) * 1996-07-23 2001-03-27 Nuvue Technologies, L.L.C. Method for purification of a blood component
JP2001516731A (ja) * 1997-09-17 2001-10-02 ジエントラ・システムズ・インコーポレーテツド 核酸を単離するための装置および方法
US6221655B1 (en) * 1998-08-01 2001-04-24 Cytosignal Spin filter assembly for isolation and analysis
US6401552B1 (en) * 2000-04-17 2002-06-11 Carlos D. Elkins Centrifuge tube and method for collecting and dispensing mixed concentrated fluid samples
US7749388B2 (en) * 2001-06-15 2010-07-06 Life Technologies Corporation Low volume filtration column devices and methods of filtering therewith
US7556733B2 (en) * 2001-06-15 2009-07-07 Mds Analytical Technologies (Us) Inc. Low volume filtration column devices and methods of filtering therewith
US6761855B1 (en) * 2001-11-05 2004-07-13 Biosearch Technologies, Inc. Column for solid phase processing
US7722820B2 (en) * 2004-11-19 2010-05-25 Phynexus, Inc. Method and device for sample preparation
WO2005021844A2 (en) * 2003-08-21 2005-03-10 Filtrona Richmond, Inc. Polymeric fiber rods for separation applications
US20060118491A1 (en) * 2004-12-03 2006-06-08 Gjerde Douglas T Method and device for desalting an analyte
US7878962B2 (en) * 2005-05-03 2011-02-01 Philip Morris Usa Inc. Cigarettes and filter subassemblies with squeezable flavor capsule and methods of manufacture
JP2007240525A (ja) * 2006-02-10 2007-09-20 Hellermann Tyton Co Ltd カラムキット
WO2008075032A1 (en) * 2006-12-19 2008-06-26 Filtrona International Limited Tobacco smoke filter
CN102132156B (zh) 2008-08-01 2014-11-26 生物风险公司 用于物质的纯化、分离、脱盐或缓冲液/溶剂交换的装置和方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586585B1 (en) * 1994-01-07 2003-07-01 Qiagen Gmbh Method for the size reduction of high-molecular structures
US6103195A (en) * 1997-08-08 2000-08-15 Shukla; Ashok K. Micro-volume spin columns for sample preparation
US6451260B1 (en) * 1997-08-26 2002-09-17 Dyax Corp. Method for producing microporous elements, the microporous elements thus produced and uses thereof
WO2001007138A1 (en) * 1999-07-26 2001-02-01 Harvard Apparatus, Inc. Filtration/separation container without an in-built filter
EP1437402A1 (de) * 2001-09-28 2004-07-14 Kabushiki Kaisha Yakult Honsha Vorrichtung zur extraktion von nukleinsäuren
US20080020446A1 (en) * 2006-07-22 2008-01-24 Xiyu Jia Plasmid DNA isolation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2010014970A1 *

Also Published As

Publication number Publication date
EP3006934A3 (de) 2016-06-08
EP2329257B1 (de) 2018-03-07
CA2730312A1 (en) 2010-02-04
US8062533B2 (en) 2011-11-22
CA2730312C (en) 2016-08-16
CN103657145A (zh) 2014-03-26
US8187476B2 (en) 2012-05-29
US20120214974A1 (en) 2012-08-23
US20120031845A1 (en) 2012-02-09
WO2010014970A1 (en) 2010-02-04
US8562840B2 (en) 2013-10-22
EP3006934B1 (de) 2017-02-01
CN102132156A (zh) 2011-07-20
CN102132156B (zh) 2014-11-26
EP2329257A1 (de) 2011-06-08
US20100216220A1 (en) 2010-08-26
EP3006934A2 (de) 2016-04-13

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