EP2487181A4 - Paire de bases artificielles capable de former une paire de bases spécifiques - Google Patents
Paire de bases artificielles capable de former une paire de bases spécifiquesInfo
- Publication number
- EP2487181A4 EP2487181A4 EP10822055.9A EP10822055A EP2487181A4 EP 2487181 A4 EP2487181 A4 EP 2487181A4 EP 10822055 A EP10822055 A EP 10822055A EP 2487181 A4 EP2487181 A4 EP 2487181A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- pair
- bases
- forming
- artificial
- specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6832—Enhancement of hybridisation reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009232851 | 2009-10-06 | ||
| PCT/JP2010/067560 WO2011043385A1 (fr) | 2009-10-06 | 2010-10-06 | Paire de bases artificielles capable de former une paire de bases spécifiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP2487181A1 EP2487181A1 (fr) | 2012-08-15 |
| EP2487181A4 true EP2487181A4 (fr) | 2013-08-28 |
Family
ID=43856836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP10822055.9A Withdrawn EP2487181A4 (fr) | 2009-10-06 | 2010-10-06 | Paire de bases artificielles capable de former une paire de bases spécifiques |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8895712B2 (fr) |
| EP (1) | EP2487181A4 (fr) |
| JP (1) | JPWO2011043385A1 (fr) |
| CN (1) | CN102741266A (fr) |
| WO (1) | WO2011043385A1 (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2562255A4 (fr) | 2010-04-21 | 2013-10-30 | Riken | Analogue de base d'acide nucléique à caractéristiques de refroidissement et fluorescence et application associées |
| KR101468585B1 (ko) * | 2012-12-13 | 2014-12-03 | 한국 한의학 연구원 | 하나의 핵산상에서 서로 떨어져 있는 복수의 염기서열 요소들의 pcr 증폭 방법 |
| AU2014306271A1 (en) | 2013-08-08 | 2016-03-24 | The Scripps Research Institute | A method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides |
| JP6460626B2 (ja) * | 2013-11-11 | 2019-01-30 | 学校法人慶應義塾 | プローブ作製方法、プローブセット、及び表現型決定遺伝子検出方法 |
| EP3129493B1 (fr) | 2014-04-09 | 2021-07-07 | The Scripps Research Institute | Importation de triphosphates de nucléosides non naturels ou modifiés dans des cellules par l'intermédiaire de transporteurs de triphosphates d'acide nucléique |
| WO2016115168A1 (fr) * | 2015-01-12 | 2016-07-21 | Synthorx, Inc. | Incorporation de nucléotides non naturels et procédés associés |
| WO2017106767A1 (fr) * | 2015-12-18 | 2017-06-22 | The Scripps Research Institute | Production de nucléotides non naturels par l'utilisation d'un système crispr/cas9 |
| EP3475295B1 (fr) | 2016-06-24 | 2022-08-10 | The Scripps Research Institute | Nouveau transporteur de nucléoside triphosphate et ses utilisations |
| TWI821192B (zh) | 2017-07-11 | 2023-11-11 | 美商新索思股份有限公司 | 非天然核苷酸之導入及其方法 |
| WO2019014262A1 (fr) | 2017-07-11 | 2019-01-17 | The Scripps Research Institute | Incorporation de nucléotides non naturels et procédés d'utilisation in vivo de ceux-ci |
| CN107298680A (zh) * | 2017-07-12 | 2017-10-27 | 海门华祥医药科技有限公司 | 一种4‑氯‑7‑氮杂吲哚的生产工艺 |
| IL321812A (en) | 2017-08-03 | 2025-08-01 | Synthorx Inc | Cytokine complexes for the treatment of autoimmune diseases |
| JP7429642B2 (ja) | 2017-12-29 | 2024-02-08 | ザ スクリプス リサーチ インスティテュート | 非天然塩基対組成物および使用の方法 |
| AU2019224159B2 (en) | 2018-02-26 | 2025-05-29 | Sanofi | IL-15 conjugates and uses thereof |
| US20190292596A1 (en) * | 2018-03-21 | 2019-09-26 | Roche Molecular Systems, Inc. | Modified nucleoside phosphates with high thermal stability |
| TW202031284A (zh) | 2018-11-08 | 2020-09-01 | 美商新索思股份有限公司 | 介白素10結合物及其用途 |
| MA54952A (fr) | 2019-02-06 | 2022-05-11 | Synthorx Inc | Conjugués d'il-2 et méthodes d'utilisation de ceux-ci |
| WO2020252262A1 (fr) | 2019-06-14 | 2020-12-17 | The Scripps Research Institute | Réactifs et procédés de réplication, de transcription et de traduction dans des organismes semi-synthétiques |
| CA3148135A1 (fr) | 2019-08-23 | 2021-03-04 | Carolina E. CAFFARO | Conjugues d'il-15 et leurs utilisations |
| WO2021050554A1 (fr) | 2019-09-10 | 2021-03-18 | Synthorx, Inc. | Conjugués d'il-2 et méthodes d'utilisation pour traiter des maladies auto-immunes |
| ES3062662T3 (en) | 2021-10-14 | 2026-04-13 | Borealis Gmbh | A propylene-ethylene random copolymer with highly randomized ethylene distribution |
| CN117050074B (zh) * | 2022-05-05 | 2025-08-12 | 中国药科大学 | 一类吡啶联咪唑并吡啶化合物及其制备方法与用途 |
| CN117264004B (zh) * | 2022-06-15 | 2026-03-31 | 深圳华大生命科学研究院 | 一种化合物及核酸合成方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1114827A1 (fr) * | 1999-07-15 | 2001-07-11 | Japan Science and Technology Corporation | Nouvelle paire de bases d'acide nucleique |
| EP1970445A1 (fr) * | 2005-12-09 | 2008-09-17 | Riken | Procédé pour la réplication d'un acide nucléique et nouvelle paires de bases artificielles |
| US20110087015A1 (en) * | 2003-09-10 | 2011-04-14 | Riken | Nucleoside and nucleotide having an unnatural base and use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| US6140496A (en) | 1990-10-09 | 2000-10-31 | Benner; Steven Albert | Precursors for deoxyribonucleotides containing non-standard nucleosides |
| DE60137649D1 (de) | 2000-10-14 | 2009-03-26 | Eragen Biosciences Inc | Nachweissysteme auf festen trägern und methoden zur verwendung von nicht-standardbasen |
-
2010
- 2010-10-06 EP EP10822055.9A patent/EP2487181A4/fr not_active Withdrawn
- 2010-10-06 JP JP2011535429A patent/JPWO2011043385A1/ja active Pending
- 2010-10-06 WO PCT/JP2010/067560 patent/WO2011043385A1/fr not_active Ceased
- 2010-10-06 CN CN2010800553758A patent/CN102741266A/zh active Pending
- 2010-10-06 US US13/500,635 patent/US8895712B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1114827A1 (fr) * | 1999-07-15 | 2001-07-11 | Japan Science and Technology Corporation | Nouvelle paire de bases d'acide nucleique |
| US20110087015A1 (en) * | 2003-09-10 | 2011-04-14 | Riken | Nucleoside and nucleotide having an unnatural base and use thereof |
| EP1970445A1 (fr) * | 2005-12-09 | 2008-09-17 | Riken | Procédé pour la réplication d'un acide nucléique et nouvelle paires de bases artificielles |
Non-Patent Citations (3)
| Title |
|---|
| HIRAO I ET AL: "Unnatural base pairs between 2- and 6-substituted purines and 2-oxo(1H)pyridine for expansion of the genetic alphabet", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 14, no. 19, 4 October 2004 (2004-10-04), pages 4887 - 4890, XP027213190, ISSN: 0960-894X, [retrieved on 20040901] * |
| MICHIKO KIMOTO ET AL: "A Unique Fluorescent Base Analogue for the Expansion of the Genetic Alphabet", vol. 132, no. 14, 1 January 2010 (2010-01-01), pages 4988 - 4989, XP008159272, ISSN: 0002-7863, Retrieved from the Internet <URL:http://pubs.acs.org/doi/pdf/10.1021/ja100806c> [retrieved on 20100324], DOI: 10.1021/JA910502G * |
| See also references of WO2011043385A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US8895712B2 (en) | 2014-11-25 |
| WO2011043385A1 (fr) | 2011-04-14 |
| US20120231462A1 (en) | 2012-09-13 |
| JPWO2011043385A1 (ja) | 2013-03-04 |
| CN102741266A (zh) | 2012-10-17 |
| EP2487181A1 (fr) | 2012-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20120327 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| DAX | Request for extension of the european patent (deleted) | ||
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20130726 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07H 19/24 20060101ALI20130722BHEP Ipc: C12P 21/02 20060101ALI20130722BHEP Ipc: C12M 1/00 20060101ALI20130722BHEP Ipc: C07H 21/04 20060101ALI20130722BHEP Ipc: C12Q 1/68 20060101ALI20130722BHEP Ipc: C07H 19/23 20060101ALI20130722BHEP Ipc: C07H 21/02 20060101AFI20130722BHEP Ipc: C12N 15/09 20060101ALI20130722BHEP |
|
| 17Q | First examination report despatched |
Effective date: 20151208 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20160621 |