PL3299356T3 - Sposób wytwarzania pleuromutylin - Google Patents

Sposób wytwarzania pleuromutylin

Info

Publication number
PL3299356T3
PL3299356T3 PL17197350T PL17197350T PL3299356T3 PL 3299356 T3 PL3299356 T3 PL 3299356T3 PL 17197350 T PL17197350 T PL 17197350T PL 17197350 T PL17197350 T PL 17197350T PL 3299356 T3 PL3299356 T3 PL 3299356T3
Authority
PL
Poland
Prior art keywords
pleuromutylin
making
making pleuromutylin
Prior art date
Application number
PL17197350T
Other languages
English (en)
Inventor
Rosemarie Riedl
Lee Spence
Werner Heilmayer
Original Assignee
Nabriva Therapeutics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nabriva Therapeutics GmbH filed Critical Nabriva Therapeutics GmbH
Publication of PL3299356T3 publication Critical patent/PL3299356T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/08—Acetic acid
    • C07C53/10—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/08—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/80—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings
    • C07C2603/82—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings having three condensed rings with in total fourteen carbon atoms and having a having a [5.4.3.0(1,8)] ring structure, e.g. pleuromutiline
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL17197350T 2010-05-26 2011-05-23 Sposób wytwarzania pleuromutylin PL3299356T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP20100450092 EP2399904A1 (en) 2010-05-26 2010-05-26 Process for the preparation of pleuromutilins
PCT/AT2011/000237 WO2011146954A1 (en) 2010-05-26 2011-05-23 Process for the preparation of pleuromutilins
EP17197350.6A EP3299356B1 (en) 2010-05-26 2011-05-23 Process for the preparation of pleuromutilins
EP11724938.3A EP2576505B1 (en) 2010-05-26 2011-05-23 Crystalline form of a pleuromutilin

Publications (1)

Publication Number Publication Date
PL3299356T3 true PL3299356T3 (pl) 2022-04-04

Family

ID=42937801

Family Applications (2)

Application Number Title Priority Date Filing Date
PL17197350T PL3299356T3 (pl) 2010-05-26 2011-05-23 Sposób wytwarzania pleuromutylin
PL11724938T PL2576505T3 (pl) 2010-05-26 2011-05-23 Postać krystaliczna pleuromutyliny

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL11724938T PL2576505T3 (pl) 2010-05-26 2011-05-23 Postać krystaliczna pleuromutyliny

Country Status (29)

Country Link
US (1) US9120727B2 (pl)
EP (3) EP2399904A1 (pl)
JP (2) JP6038021B2 (pl)
KR (1) KR101935333B1 (pl)
CN (2) CN105111117A (pl)
AU (1) AU2011257938B2 (pl)
BR (1) BR112012029982A2 (pl)
CA (1) CA2799029C (pl)
DK (2) DK3299356T3 (pl)
EA (1) EA023273B1 (pl)
ES (2) ES2909198T3 (pl)
HR (1) HRP20220201T1 (pl)
HU (2) HUE035861T2 (pl)
IL (1) IL222999A (pl)
MA (1) MA34332B1 (pl)
MX (1) MX347176B (pl)
MY (1) MY164666A (pl)
NZ (1) NZ603804A (pl)
PH (1) PH12012502321A1 (pl)
PL (2) PL3299356T3 (pl)
PT (2) PT2576505T (pl)
SG (1) SG185104A1 (pl)
SI (1) SI3299356T1 (pl)
TN (1) TN2012000506A1 (pl)
TR (1) TR201802636T4 (pl)
TW (1) TWI585073B (pl)
UA (1) UA108378C2 (pl)
WO (1) WO2011146954A1 (pl)
ZA (1) ZA201208056B (pl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104447294A (zh) * 2014-11-24 2015-03-25 苏州乔纳森新材料科技有限公司 一种3-环己烯-1-甲酸的手性拆分方法
KR102656841B1 (ko) * 2015-06-17 2024-04-12 나브리바 테라퓨틱스 게엠베하 레파뮬린의 주사가능한 약제학적 제형
RS57328B1 (sr) 2015-06-18 2018-08-31 Mithra Pharmaceuticals S A Orodisperzibilna dozna jedinica koja sadrži estetrolsku komponentu
NZ737945A (en) 2015-06-18 2023-06-30 Estetra Sprl Orodispersible dosage unit containing an estetrol component
TWI762573B (zh) * 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 截短側耳素之純化
CN107417586A (zh) * 2017-06-21 2017-12-01 华南农业大学 一种截短侧耳素类抗生素及其制备方法和应用
CR20200486A (es) 2018-04-19 2021-01-27 Estetra Sprl Compuestos y sus usos para aliviar los síntomas asociados a la menopausa
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
TWI755055B (zh) * 2019-09-18 2022-02-11 台灣神隆股份有限公司 用於製備惡拉戈利鈉及其中間體的方法
CN111170893B (zh) * 2020-01-19 2022-04-26 郑州依米花手性药物研究有限公司 Lefamulin的中间体化合物及其在Lefamulin制备中的应用
TWI893101B (zh) 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物
JP2023522644A (ja) * 2020-04-17 2023-05-31 ナブリバ セラピューティクス ゲーエムベーハー プレウロムチリンの治療的使用
EP4135681B1 (en) 2020-04-17 2025-06-25 Nabriva Therapeutics GMBH Antiviral use of pleuromutilins
EP4475834A1 (en) 2022-02-09 2024-12-18 Nabriva Therapeutics GMBH Lefamulin and its derivatives for use in the treatment of a spiral shaped bacteria
EP4338732A1 (en) 2022-09-16 2024-03-20 Nabriva Therapeutics GMBH Lefamulin and its derivatives for use in the treatment of tularemia
CN118894800A (zh) * 2024-06-27 2024-11-05 福建省微生物研究所 一种Lefamulin中间体化合物的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61207370A (ja) * 1985-03-11 1986-09-13 Seitetsu Kagaku Co Ltd 4−(メタンスルホニルオキシ)チオフエノ−ルの製法
GB0017031D0 (en) * 2000-07-11 2000-08-30 Biochemie Gmbh Antimicrobials
ES2295657T3 (es) * 2002-07-24 2008-04-16 Nabriva Therapeutics Forschungs Gmbh Derivados de pleuromutilina como antimicrobianos.
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
MXPA06000955A (es) * 2003-08-04 2006-03-30 Grindeks Jsc Sales de meldonio, metodo para su preparacion y composiciones farmaceuticas basadas en ellas.
PL1658277T3 (pl) * 2003-08-18 2012-10-31 H Lundbeck As Sól bursztynianowa i malonianowa trans-4-((1R,3S)-6-chloro-3-fenyloindan-1-ylo)-1,2,2-tri-metylopiperazyny i zastosowanie jako lek
EP2181995A3 (en) * 2003-09-03 2010-06-16 Glaxo Group Limited Salts and crystalline form of mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl-sufanyl)-acetate
US9697672B2 (en) 2006-07-20 2017-07-04 Bally Gaming, Inc. Wagering game with special-event eligibility feature based on passive game play
EP1908750A1 (en) * 2006-10-05 2008-04-09 Nabriva Therapeutics Forschungs GmbH Process for the preparation of pleuromutilins
ATE449062T1 (de) * 2007-02-22 2009-12-15 Indena Spa Verfahren zur herstellung von (2r,3s)-3- phenylisoserin-methylester-acetatsalz
EP1972618A1 (en) 2007-03-20 2008-09-24 Nabriva Therapeutics AG Pleuromutilin derivatives for the treatment of diseases mediated by microbes
EP2014645A1 (en) * 2007-07-13 2009-01-14 Nabriva Therapeutics AG Pleuromutilin derivatives and their use as antimicrobials
EP2159220A1 (en) * 2008-09-02 2010-03-03 Nabriva Therapeutics AG Organic compounds

Also Published As

Publication number Publication date
EA023273B1 (ru) 2016-05-31
CA2799029A1 (en) 2011-12-01
CN105111117A (zh) 2015-12-02
TN2012000506A1 (en) 2014-04-01
WO2011146954A1 (en) 2011-12-01
ZA201208056B (en) 2014-01-29
EP2576505B1 (en) 2017-11-29
IL222999A0 (en) 2013-02-03
IL222999A (en) 2016-02-29
MA34332B1 (fr) 2013-06-01
PT3299356T (pt) 2022-02-21
HUE035861T2 (hu) 2018-06-28
AU2011257938B2 (en) 2016-06-23
PL2576505T3 (pl) 2018-05-30
HRP20220201T1 (hr) 2022-04-29
BR112012029982A2 (pt) 2020-09-01
TWI585073B (zh) 2017-06-01
DK3299356T3 (da) 2022-01-31
EP3299356A1 (en) 2018-03-28
UA108378C2 (uk) 2015-04-27
KR101935333B1 (ko) 2019-01-04
MX347176B (es) 2017-04-17
EP2399904A1 (en) 2011-12-28
KR20130079406A (ko) 2013-07-10
ES2659729T3 (es) 2018-03-19
EP3299356B1 (en) 2021-11-24
HK1253006A1 (en) 2019-06-06
DK2576505T3 (en) 2018-03-05
HUE057587T2 (hu) 2022-05-28
CN103080083A (zh) 2013-05-01
CN103080083B (zh) 2016-03-02
US9120727B2 (en) 2015-09-01
TR201802636T4 (tr) 2018-03-21
MX2012013645A (es) 2013-05-01
MY164666A (en) 2018-01-30
US20130079400A1 (en) 2013-03-28
NZ603804A (en) 2014-03-28
SG185104A1 (en) 2012-12-28
PH12012502321A1 (en) 2013-02-11
TW201209026A (en) 2012-03-01
JP6038021B2 (ja) 2016-12-07
ES2909198T3 (es) 2022-05-05
PT2576505T (pt) 2018-03-05
SI3299356T1 (sl) 2022-05-31
EP2576505A1 (en) 2013-04-10
JP2016210804A (ja) 2016-12-15
EA201291370A1 (ru) 2013-09-30
JP6501742B2 (ja) 2019-04-17
JP2013528162A (ja) 2013-07-08
CA2799029C (en) 2019-01-29

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