EP2519322B1 - Ultraschall-kopplungsvorrichtung - Google Patents

Ultraschall-kopplungsvorrichtung Download PDF

Info

Publication number
EP2519322B1
EP2519322B1 EP11728550.2A EP11728550A EP2519322B1 EP 2519322 B1 EP2519322 B1 EP 2519322B1 EP 11728550 A EP11728550 A EP 11728550A EP 2519322 B1 EP2519322 B1 EP 2519322B1
Authority
EP
European Patent Office
Prior art keywords
ultrasound
coupling device
transducer
low
profile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP11728550.2A
Other languages
English (en)
French (fr)
Other versions
EP2519322A2 (de
EP2519322A4 (de
Inventor
George K. Lewis Jr.
Bryant Guffey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zetroz Systems LLC
Original Assignee
Zetroz Systems LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zetroz Systems LLC filed Critical Zetroz Systems LLC
Publication of EP2519322A2 publication Critical patent/EP2519322A2/de
Publication of EP2519322A4 publication Critical patent/EP2519322A4/de
Application granted granted Critical
Publication of EP2519322B1 publication Critical patent/EP2519322B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/42—Details of probe positioning or probe attachment to the patient
    • A61B8/4209—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames
    • A61B8/4227—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames characterised by straps, belts, cuffs or braces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/42—Details of probe positioning or probe attachment to the patient
    • A61B8/4209—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames
    • A61B8/4236—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames characterised by adhesive patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/42—Details of probe positioning or probe attachment to the patient
    • A61B8/4272—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue
    • A61B8/4281—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue characterised by sound-transmitting media or devices for coupling the transducer to the tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A61B17/2251—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves characterised by coupling elements between the apparatus, e.g. shock wave apparatus or locating means, and the patient, e.g. details of bags, pressure control of bag on patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00681—Aspects not otherwise provided for
    • A61B2017/00734—Aspects not otherwise provided for battery operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A61B17/2251—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves characterised by coupling elements between the apparatus, e.g. shock wave apparatus or locating means, and the patient, e.g. details of bags, pressure control of bag on patient
    • A61B2017/2253—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves characterised by coupling elements between the apparatus, e.g. shock wave apparatus or locating means, and the patient, e.g. details of bags, pressure control of bag on patient using a coupling gel or liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • A61B2034/107—Visualisation of planned trajectories or target regions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/30—Surgical robots
    • A61B2034/301—Surgical robots for introducing or steering flexible instruments inserted into the body, e.g. catheters or endoscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/30—Surgical robots
    • A61B2034/303—Surgical robots specifically adapted for manipulations within body lumens, e.g. within lumen of gut, spine, or blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/30—Surgical robots
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4427—Device being portable or laptop-like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0034—Skin treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0056—Beam shaping elements
    • A61N2007/006—Lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0078—Ultrasound therapy with multiple treatment transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A61N2007/0091—Beam steering with moving parts, e.g. transducers, lenses, reflectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A61N2007/0095—Beam steering by modifying an excitation signal
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49002—Electrical device making
    • Y10T29/49005—Acoustic transducer

Definitions

  • the present invention relates to an ultrasound coupling device, ultrasound apparatus, ultrasound kit.
  • Traditional therapeutic ultrasound generation technologies have a number of deficiencies that prohibit their use in portable ultrasound delivery devices.
  • current therapeutic ultrasound generation technologies are generally, at the smallest, shoebox-sized devices that include a user interface, power generation circuitry, and a separate transducer attached via a hand wand.
  • the devices vary in shape and size, but generally are 2.7-9.1 kgs (6-20 pounds).
  • Such devices also require wall power and administer ultrasound energies from 0-4 Watts and at frequencies of from 1-3 MHz. The energy from the transducers of such devices is applied to penetrate into the tissue and administer ultrasound.
  • Traditional ultrasound therapies are for a short duration (e.g., 5-20 minutes).
  • Other purported therapeutic ultrasound technologies purport to be portable, but are capable of producing only surface ultrasound waves.
  • therapeutic ultrasound devices are generally not able to be used for long periods, due to safety concerns, the non-portable size of the devices or the need for external power sources.
  • portable therapeutic ultrasound devices that are able to safely deliver ultrasound energy deep into tissue.
  • US 2003/171700 discloses a medical instrument that uses solid tapered cones mounted to a preferably concave, spherically curved, piezoelectric ultrasound transducer.
  • US 5394877 discloses a contact medium structure attachable to externally-applied medical diagnostic devices for providing self-adherence of the medical device to the skin of a patient.
  • US 2002/055693 discloses systems and methods for applying ultrasound energy to a body region.
  • WO 2008/137944 discloses a system for coupling acoustic energy using an encapsulated coupler member.
  • US 2008/200810 discloses an ultrasound coupling device for transmitting ultrasound waves from an ultrasound transducer to a test specimen.
  • US 2009/198157 discloses a device and methods for the use of ultrasonic energy for providing therapeutic effects by heating and stimulating bioactive points (BAPs) in the body of a patient.
  • US 2003/229331 A1 discloses a wide beam ultrasound delivery system providing a uniform exposure field.
  • GB 2 435 614 A discloses a transducer holder comprising a base adherently attachable to a patient's skin.
  • the present invention is directed to overcoming these and other deficiencies in the art.
  • the present disclosure relates to an ultrasound coupling device for use with various ultrasound transducers, systems, and applications.
  • the ultrasound coupling device includes a coupling compartment, which in turn includes a chamber having a continuous side wall and an opening on a first end of the chamber.
  • the continuous side wall is configured to hold a low-profile ultrasound transducer within the chamber so that a front ultrasound emitting surface of the low-profile ultrasound transducer faces outward toward the chamber opening.
  • the front ultrasound emitting surface is configured to control the direction and wave pattern of ultrasonic energy emitted from the low-profile ultrasound transducer.
  • the continuous side wall is also configured to hold a quantity of an ultrasound conductive medium within the chamber and is operative to keep the ultrasound conductive medium in simultaneous contact with a surface of a subject and with at least a portion of the front ultrasound emitting surface of the low-profile ultrasound transducer.
  • the present disclosure relates to an ultrasound apparatus for use with various ultrasound applications.
  • the ultrasound apparatus includes at least one low-profile ultrasound transducer and at least one ultrasound coupling device as described herein.
  • the at least one ultrasound coupling device is operatively coupled to the at least one low- profile ultrasound transducer, thereby forming a transducer/coupling device unit.
  • Various energy generating modules e.g., portable power devices
  • the present disclosure relates to a therapeutic ultrasound kit.
  • the therapeutic ultrasound kit includes at least one low-profile ultrasound transducer and at least one ultrasound coupling device as described herein.
  • the at least one ultrasound coupling device is configured to be operatively coupled to the at least one low-profile ultrasound transducer, thereby forming a transducer/coupling device unit.
  • Various energy generating modules e.g., portable power devices
  • the present disclosure relates to a method for performing physiotherapy on a subject.
  • This method involves providing at least one low-profile ultrasound transducer operatively coupled with at least one ultrasound coupling device of the present invention, thereby forming at least one transducer/coupling device unit.
  • the at least one transducer/coupling device unit is used to apply therapeutic ultrasonic energy to a subject, where the therapeutic ultrasonic energy is generated by the at least one low-profile ultrasound transducer.
  • the present disclosure relates to a method for applying ultrasonic energy to a subject.
  • This method involves providing at least one low-profile ultrasound transducer operatively coupled with at least one ultrasound coupling device of the present invention, thereby forming at least one transducer/coupling device unit.
  • the at least one transducer/coupling device unit is used to apply therapeutic ultrasonic energy to a subject, where the therapeutic ultrasonic energy is generated by the at least one low-profile ultrasound transducer.
  • the present disclosure relates to a method of topically delivering a drug to a subject.
  • This method involves providing at least one low-profile ultrasound transducer operatively coupled with at least one ultrasound coupling device of the present invention, thereby forming at least one transducer/coupling device unit, where the coupling device further contains a deliverable component that includes a drug to be delivered to a subject.
  • the at least one transducer/coupling device unit is used to apply ultrasonic energy to a surface of a subject along with the deliverable component, where the ultrasonic energy is generated by the low-profile ultrasound transducer and emitted through the semi-permeable membrane of the coupling device.
  • the ultrasound coupling device is operative to be used with an ultrasound transducer (e.g., a low-profile ultrasound transducer) that is able to emit ultrasonic energy at a frequency and intensity effective to penetrate deep into the tissue of the subject, and that portable and not limited to just providing surface ultrasonic energy.
  • an ultrasound transducer e.g., a low-profile ultrasound transducer
  • the ultrasound coupling device of the present invention is suitable for use with various ultrasound transducer systems.
  • the ultrasound coupling device is effective for use with a low-profile therapeutic ultrasound transducer.
  • the ultrasound coupling device can be configured as an ultrasound transmission patch and be used as a means of temporarily holding an ultrasound transducer in place, and efficiently acoustically coupling the ultrasound transducer to another object (e.g., a human).
  • the patch/coupling device can be similar to an adhesive bandage used to cover a cut; however, it may have an internal pouch that securely holds the transducer in place.
  • the pouch in the patch that the transducer is inserted into can have an ultrasound transmission medium (e.g., ultrasound gel), also referred to herein as an ultrasound conductive medium, that acoustically couples the ultrasound transducer from the patch to the body of interest.
  • the patch allows for temporary placement and coupling of ultrasound transducers in a variety of configurations without the direct application of acoustic transmission medium to the body of interest.
  • the ultrasound coupling device may be designed in various embodiments to apply acoustic coupling from the transducer to the object (e.g., a human or animal) without the requirement of securing the transducer in one spot.
  • the object e.g., a human or animal
  • the present invention provides an ultrasound coupling device that is flexible for use with wearable, portable therapeutic ultrasound systems, as well as with standard in-office therapeutic ultrasound systems.
  • the present invention relates to an ultrasound coupling device suitable for use with low-profile ultrasound transducers and systems.
  • the ultrasound coupling device of the present invention is particularly suitable for use with portable ultrasound devices, systems, and methods.
  • the ultrasound coupling device of the present invention can be configured to be either disposable or re-useable, and can be used with ultrasound transducers that are either disposable or re-usable. Therefore, in one aspect, the present invention provides an entirely autonomous ultrasound coupling device for use with portable ultrasound transducers and systems.
  • the ultrasound coupling device of the present invention can be configured so as to enable the generation of ultrasonic energy from an ultrasound transducer or system.
  • the ultrasound coupling device is configured so that ultrasonic energy is only transmitted when the ultrasound transducer is properly coupled with the ultrasound coupling device.
  • the ultrasound coupling device of the present invention provides an enabler component that connects to the transducer to allow the transducer to operate to emit ultrasonic energy.
  • the ultrasound coupling device can be configured so that the connection between the transducer and energy generating module is completed once the transducer is properly placed within the ultrasound coupling device.
  • the ultrasound coupling device of the present invention can be designed to custom fit a particular transducer, so that the ultrasound coupling device guides the proper placement of the transducer into the ultrasound coupling device.
  • the ultrasound coupling device of the present invention provides strain relief to wiring or cables that connect to the transducer when coupled with the ultrasound coupling device of the present invention. This enables the ultrasound coupling device to protect the transducer for safe and re-usable uses.
  • ultrasound coupling device 100 includes coupling compartment 200.
  • Coupling compartment 200 includes chamber 210 having continuous side wall 300 and opening 211a on first end 211 of chamber 210.
  • continuous side wall 300 is configured to hold low-profile ultrasound transducer 50 within chamber 210 so that front ultrasound emitting surface 58 of low-profile ultrasound transducer 50 faces outward toward opening 211a of chamber 210. Front ultrasound emitting surface 58 is configured to control the direction and wave pattern of ultrasonic energy emitted from low-profile ultrasound transducer 50. As shown in FIGS. 2B-2D , continuous side wall 300 is also configured to hold a quantity of ultrasound conductive medium 700 within chamber 210 and operative to keep ultrasound conductive medium 700 in simultaneously contact with surface 111 of subject 110 and with at least a portion of front ultrasound emitting surface 58 of low-profile ultrasound transducer 50. For example, as shown in FIGS.
  • continuous side wall 300 can be configured to include lip portion 300a.
  • lip portion 300a is formed on the inner surface of continuous side wall 300 at a position operative to keep low-profile ultrasound transducer 50 in place within chamber 210.
  • chamber 210 has a second end 212 opposite to the first end 211.
  • Second end 212 provides a barrier effective to form cavity region 213 within chamber 210, so as to assist in keeping low-profile ultrasound transducer 50 securely in place within cavity region 213/chamber 210.
  • continuous side wall 300 can further include opening 300b that is configured to allow cable 51, which is connected to low-profile ultrasound transducer 50 to extend outside of chamber 210.
  • opening 300b can be configured as cable support extension 400 that extends outward from continuous side wall 300 and includes passage way 410 for cable 51.
  • coupling compartment 200 further includes a flange region 500 extending outward from at least a portion of continuous side wall 300 of chamber 210.
  • Flange region 500 can be made of various types of materials, including materials that are non-adhesive or adhesive.
  • adhesive is meant to include any material operative to removeably secure ultrasound coupling device 100 to surface 111 of subject 110.
  • suitable adhesives can include glue or glue-like materials (e.g., used with disposable bandages) suitable for use with humans or animals, as well as materials such as Velcro attachments and materials that are held in place mechanically.
  • the present invention contemplates at least a portion of flange region 500 to include adhesive material 510 effective to keep ultrasound coupling device 100 in place on surface 111 of subject 110.
  • FIG. 4 shows an embodiment of ultrasound coupling device 100 having flange region 500 extending on opposite sides of continuous side wall 300, with cable support extension 400 extending in a direction about 90 degrees from flange regions 500.
  • FIG. 4 shows a front view, a back view, and a side view perspective of this embodiment of ultrasound coupling device 100.
  • low-profile ultrasound transducer 50 is shown disposed in chamber 210 of ultrasound coupling device 100, with low-profile ultrasound transducer 50 not extending above continuous side wall 300.
  • adhesive material 510 is shown deposited on portions of flange regions 500.
  • Other embodiments of the present invention include adhesive material 510 being deposited on flange region 500 at other locations and/or on part of continuous side wall 300 at opening 211a of chamber 210, in a manner sufficient to assist in securing ultrasound coupling device 100/low-profile ultrasound transducer 50 in place on the surface of a subject.
  • flange regions 500 can be made of a flexible material in order to enable it to mold to the surface of a subject (e.g., around a wrist or knee area). Silicone is one example of a suitable material for flange regions 500 and ultrasound coupling device 100.
  • FIG. 5 is similar to the embodiment in FIG. 4 , in that it shows an embodiment of ultrasound coupling device 100 having flange region 500 extending on opposite sides of continuous side wall 300, with cable support extension 400 extending in a direction about 90 degrees from flange regions 500.
  • FIG. 5 shows perspectives of two front views, two back views, and three side views of this embodiment of ultrasound coupling device 100. A magnified side view of a portion of continuous side wall 300 is shown. Also, additional side views show passage way 410 of cable support extension 400.
  • FIG. 6 shows an embodiment of ultrasound coupling device 100 having flange region 500 extending on opposite sides of continuous side wall 300, with cable support extension 400 extending along one of the flange regions 500.
  • FIG. 6 shows perspectives of two front views, two back views, and four side views of this embodiment of ultrasound coupling device 100.
  • ultrasound coupling device 100 can further include semi-permeable membrane 520 configured to cover opening 211a of first end 211 of chamber 210.
  • Semi-permeable membrane 520 is effective to allow ultrasound conductive medium 700 to be released from first end 211 of coupling compartment 200 when pressure is applied to semi-permeable membrane 520.
  • Pressure to semi-permeable membrane 520 can be applied by the subject manually by pressing down on ultrasound coupling device 100, or the pressure can be applied by a garment type of apparatus (e.g., a holder component such as a Neoprene wrap) holding ultrasound coupling device 100 against surface 111 of subject 110.
  • a garment type of apparatus e.g., a holder component such as a Neoprene wrap
  • Ultrasound conductive medium 700 can include any material that is effective as a conductor of ultrasound energy from low-profile ultrasound transducer 50 to surface 111 of subject 110.
  • a suitable ultrasound conductive medium 700 include, without limitation, a gel, a hydrogel, an acoustic gel, saline, a low-viscosity liquid, and the like.
  • the ultrasound conductive medium is a gel.
  • ultrasound coupling device 100 can further include covering sheet 530 attached to flange region 500 and configured to cover semi-permeable membrane 520.
  • Covering sheet 530 can be configured to be manually removable from flange region 500 in order to expose semi-permeable membrane 520 when the subject is ready to use ultrasound coupling device 100.
  • Semi-permeable membrane 520 can also be configured to be optically transparent and/or translucent, thereby allowing light emitted from low-profile ultrasound transducer 50 to penetrate through semi-permeable membrane 520.
  • Backing panel 540 can also be used to keep low-profile ultrasound transducer 50 in place, and can be configured to be removeable to enable the removal of low-profile ultrasound transducer 50. Backing panel 540 can also be applied after low-profile ultrasound transducer 50 is placed within chamber 210.
  • ultrasound coupling device 100 can be configured so that at least a portion 310 of continuous side wall 300 of chamber 210 is configured to allow low-profile ultrasound transducer 50 to be inserted into chamber 210 through portion 310, rather than through first end 211 or second end 212 of chamber 210.
  • the present invention also relates to an ultrasound apparatus that includes at least one low-profile ultrasound transducer and at least one ultrasound coupling device as disclosed herein.
  • ultrasound apparatus 800 includes at least one ultrasound coupling device 100 operatively coupled to at least one low-profile ultrasound transducer 50, thereby forming transducer/coupling device unit 600. Any of the low-profile ultrasound transducers and any of the ultrasound coupling devices described herein are suitable to be combined into transducer/coupling device unit 600.
  • FIG. 9A shows low-profile ultrasound transducer 50 and ultrasound coupling device 100 as individual components, prior to being combined.
  • FIG. 9B shows low-profile ultrasound transducer 50 and ultrasound coupling device 100 combined into transducer/coupling device unit 600.
  • ultrasound apparatus 800 can further include holder component 900, which is configured to hold transducer/coupling device unit 600 in place on or in operative proximity to surface 111 of subject 110.
  • holder component 900 can be configured to hold one or more transducer/coupling device units 600.
  • Suitable holder components 900 can include any wearable apparatus, including, for example, clothing (see FIG. 14 ), wraps (see FIGS. 1010, 11 , 12 , 13A, and 13B ) such as Neoprene wraps and other athletic wraps (see FIGS.
  • ultrasound apparatus 800 can be used for applying ultrasonic energy or therapy to human and animal subjects at any location, including without limitation, the following areas: ankles, elbows, knees, wrists, hands, feet, arms, fingers, thighs, back area, neck, etc.
  • FIG. 10 shows an embodiment of ultrasound apparatus 800 having holder component 900 configured as a multi-unit holder component 902 for use on and around the knee area of a human subject.
  • Other similar embodiments can include a single-unit holder component 901.
  • FIG. 11 shows two embodiments of ultrasound apparatus 800.
  • One embodiment has holder component 900 configured as a multi-unit holder component 902 for use on and around the thigh area of a human subject.
  • This embodiment also illustrates the use of a separate power pack (e.g., battery pack and/or energy generating module as described herein), showing cable 51 connected to the plurality of transducer/coupling device units 600. Cable 51 is shown in just one configuration, but any other operative configurations of cable 51 connections are covered by the present invention.
  • Another embodiment of ultrasound apparatus 800 shown in FIG. 11 illustrates holder component 900 configured as a single-unit holder component 901 for use on and around the ankle and foot area of a human subject.
  • FIG. 12 shows an embodiment of ultrasound apparatus 800 having holder component 900 configured as a single-unit holder component 901 for use on and around the wrist and hand area of a human subject.
  • Other similar embodiments can include a multi-unit holder component 902.
  • FIGS. 13A-13B show an embodiment of ultrasound apparatus 800 having holder component 900 configured as a multi-unit holder component 902 for use on and around the lower back area of a human subject.
  • ultrasound apparatus 800 can include attachments on the ends (e.g., Velcro or other types of attachments well known in the art).
  • Multi-unit holder component 902 configurations are particularly useful for treating large areas (e.g., the lower back) of subjects.
  • Other similar embodiments can include a single-unit holder component 901.
  • FIG. 14 shows an embodiment of ultrasound apparatus 800 having holder component 900 configured as a single-unit holder component 901, with a garment (e.g., shorts) being used to hold a portion of an ultrasound system (e.g., a power pack/energy generating module connected by cable 51 to transducer/coupling device unit 600).
  • transducer/coupling device unit 600 is configured so that it attaches to the target area of the subject using an adhesive (e.g., hydrogel or other biocompatible adhesive).
  • an adhesive e.g., hydrogel or other biocompatible adhesive
  • Other embodiments can include flange regions 500 to assist in surface attachment to the subject.
  • FIG. 14 shows an embodiment of ultrasound apparatus 800 having holder component 900 configured as a single-unit holder component 901, with a garment (e.g., shorts) being used to hold a portion of an ultrasound system (e.g., a power pack/energy generating module connected by cable 51 to transducer/coupling device unit 600).
  • cable 51 can run inside of the garment (or outside), and the power pack/energy generating module can be held in the hand, place on a holding surface, or deposited or attached to the garment (e.g., in a pocket).
  • the garment can also be custom made to hold ultrasound apparatus 800.
  • Other similar embodiments can include a multi-unit holder component 902.
  • FIGS. 15A-15C show an embodiment of ultrasound apparatus 800 having holder component 900 configured as a single-unit holder component 901 for use on and around the lower leg/ankle region of an animal subject (i.e, a horse as shown).
  • holder component 900 configured as a single-unit holder component 901 for use on and around the lower leg/ankle region of an animal subject (i.e, a horse as shown).
  • off-the-shelf bandages e.g., ACE bandages
  • wraps e.g., having end attachments
  • ultrasound apparatus 800 is similar to the one described above for FIG. 14 .
  • ultrasound apparatus 800 can be held in place by wrapping holder component 900 around both ultrasound apparatus 800 and the ankle/leg of the horse, and then securely attached for treatment.
  • ultrasound apparatus 800 in its various configurations of holder component 900 can be used for both humans and animals.
  • the figures provided herein with respect to the application of ultrasound apparatus 800 are not meant to be limiting to the subject or area shown.
  • the ultrasound coupling device of the present invention is configured with an enabler mechanism, which is used to control the operation of the ultrasound transducer.
  • FIGS. 16A-16C show ultrasound coupling device 100 having enabler strap 908, which includes enabler component 910 (e.g., a metal nipple or metal nipple-like shape).
  • enabler component 910 e.g., a metal nipple or metal nipple-like shape.
  • the back portion of low-profile ultrasound transducer 50 includes insert component 910b, which is configured to operatively receive enabler component 910.
  • enabler 910 component When enabler 910 component is contacted with insert component 910b, low-profile ultrasound transducer 50 operates to generate ultrasonic energy, but no such ultrasonic energy is generated when these component are not in contact.
  • Attachments 912 can be used to secure enabler strap 908 in place, with one attachment 912 being on enabler strap 908 and the other attachment 912 on a region of ultrasound coupling device such as a flange region 500.
  • FIGS. 16A-16C illustrate just one such embodiment of an enabler mechanism, but any configuration that generally operates as shown and described is covered by the present invention.
  • the present invention also relates to a therapeutic ultrasound kit that includes at least one low-profile ultrasound transducer and at least one ultrasound coupling device as described herein.
  • the at least one ultrasound coupling device is configured to be operatively coupled to the at least one low-profile ultrasound transducer, thereby forming a transducer/coupling device unit.
  • the kit can further include at least one holder component operative to hold the at least one ultrasound coupling device in place on a surface of a subject, where the at least one ultrasound coupling device is operatively coupled to the at least one low-profile ultrasound transducer.
  • the at least one holder component can be configured to hold one or more transducer/coupling device units in place on the surface of the subj ect.
  • the ultrasound coupling device of the present invention has various attributes, as described more fully herein. Without meaning to limit the present invention to a particular embodiment, provided below are various attributes of the present invention.
  • FIGS. 7 and 8 One embodiment (referred to as Ultrasound Coupling Device Embodiment 1 ) is illustrated in FIGS. 7 and 8 .
  • a material such as a non-woven fabric can be used in combination with a semi-permeable membrane to allow placement of an ultrasound transducer on an object.
  • the transducer can be secured in place internally to the patch, and the semi-permeable membrane window allows efficient coupling of ultrasound energy from the transducer into the object (e.g., a human).
  • This embodiment is generally configured in a "patch" or "bandage” configuration.
  • the patch may be in a pouch that can prevent the gel inside of the pouch from drying out.
  • the front surface of the patch (the side that contacts the body) can have a laminate coating/plastic film that may be removed to expose the adhesive as well as the semi-permeable membrane. This mechanism is similar to how an adhesive bandage is produced.
  • Ultrasound Coupling Device Embodiment 1 has various attributes ( see FIG. 7 ), including, for example, the following: (i) it can be made from disposable, soft, comfortable, flexible materials; (ii) it can be used in combination with a flat, concave, or convex low-profile transducer; (iii) it can include a semi-permeable membrane that is configured to be "leaky,” thereby allowing the contact surface to become slightly wet, and allowing efficient ultrasound transmission; (iv) it can be made from a soft, non-woven material, similar to a bandage with adhesive on the front surface to secure the device into place; (v) the semi-permeable membrane can be thin for efficient ultrasound energy transfer, and to allow liquid to wet the contact surface of the body of ultrasound transmission (e.g., a human); (vi) the semi-permeable membrane may be wet with saline, gel, or any other aqueous medium that allows efficient ultrasound coupling from the transducer into the body (e
  • Ultrasound Coupling Device Embodiment 1 can be used in combination with an ultrasound transducer.
  • FIG. 8 shows how this embodiment of the coupling device works with an ultrasound transducer.
  • the coupling device e.g., patch
  • Extra gel/acoustic coupling medium may be wiped away after the transducer is inserted.
  • Ultrasound Coupling Device Embodiment 2 One embodiment is further referred to as Ultrasound Coupling Device Embodiment 2 .
  • This embodiment is similar to Ultrasound Coupling Device Embodiment 1 (described herein).
  • the device in Ultrasound Coupling Device Embodiment 2, the device is not in the form of a patch but of a semi-permeable membrane that may be used to effectively transmit ultrasound from an ultrasound transducer into a body (e.g., a human) without the need for applying ultrasound gel or other coupling medium to the surface of the object. Therefore, the invention reduces the aggravation and discomfort of using ultrasound devices.
  • Ultrasound Coupling Device Embodiment 2 has various attributes, including, for example, the following: (i) this device can have a broad impact on improving ultrasound imaging and therapy applications by removing the gel; (ii) the transducer can slip into the device; (iii) the device can be filled with ultrasound gel; (iv) the membrane of the device can be configured to leak fluid to allow the object being touched to get "wet," thereby allowing efficient ultrasound energy transmission; (v) the device may take the form of various shapes to accommodate many types of ultrasound transducers; (vi) once the transducer is inserted, the elastic nature of the device can keep the liquid/gel in place; (vii) the device may be used in any spatial direction; (viii) the device may be disposable; (ix) the device may be refilled with acoustic gel/coupling medium; and (x) the membrane can be optically transparent/translucent to allow light to penetrate it.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Acoustics & Sound (AREA)
  • Surgical Instruments (AREA)
  • Transducers For Ultrasonic Waves (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Apparatuses For Generation Of Mechanical Vibrations (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Electrotherapy Devices (AREA)

Claims (14)

  1. Ultraschallkopplungsvorrichtung (100) für ein tragbares, transportierbares therapeutisches Ultraschallsystem, die Ultraschallkopplungsvorrichtung (100) umfassend:
    ein Kopplungsfach (200), umfassend:
    eine Kammer (210), die eine fortlaufende Seitenwand (300) und eine Öffnung (211a) an einem ersten Ende (211) aufweist, und
    einen flexiblen Flanschbereich (500), der sich von mindestens einem Abschnitt der fortlaufenden Seitenwand (300) der Kammer (210) nach außen erstreckt;
    wobei die Ultraschallkopplungsvorrichtung zum Wirkkoppeln mit einem Niedrigprofilultraschallwandler (50) und einem leitfähigen Ultraschallgel (700) konfiguriert ist, um Ultraschallenergie auf ein Subjekt (110) anzuwenden,
    wobei die Ultraschallkopplungsvorrichtung (100) ferner einen Aktivierungsmechanismus umfasst, der den Betrieb des Niedrigprofilultraschallwandlers nur aktiviert, falls der Aktivierungsmechanismus und der Wandler miteinander in Kontakt stehen;
    wobei die fortlaufende Seitenwand konfiguriert ist, um den Niedrigprofilultraschallwandler vollständig innerhalb der Kammer zu halten, so dass eine vordere Ultraschall emittierende Oberfläche (58) des Niedrigprofilultraschallwandlers nach außen in Richtung der Kammeröffnung zeigt, sich jedoch nicht über ein erstes Ende der fortlaufenden Seitenwand der Kammer hinaus erstreckt, wobei die vordere Ultraschall emittierende Oberfläche konfiguriert ist, um die Richtung und das Wellenmuster der Ultraschallenergie zu steuern, die von dem Niedrigprofilultraschallwandler emittiert wird,
    wobei die fortlaufende Seitenwand konfiguriert ist, um das leitfähige Ultraschallgel innerhalb der Kammer zu halten und betriebsfähig ist, um das leitfähige Ultraschallgel in einem gleichzeitigen direkten Kontakt mit dem Subjekt und mit mindestens einem Abschnitt der vorderen Ultraschall emittierenden Oberfläche des Niedrigprofilultraschallwandlers zu halten und
    wobei die fortlaufende Seitenwand konfiguriert ist, dass wenn die Ultraschallkopplungsvorrichtung zusammen mit dem Niedrigprofilultraschallwandler und dem leitfähigen Ultraschallgel wirkgekoppelt ist, und wenn das erste Ende der fortlaufenden Seitenwand mit dem Subjekt in Kontakt steht, das erste Ende der fortlaufenden Seitenwand geeignet ist, um eine Menge des leitfähigen Ultraschallgels innerhalb der Kammer zu halten.
  2. Ultraschallkopplungsvorrichtung (100) nach Anspruch 1, wobei die Kammer (210) ein zweites Ende (212) gegenüber dem ersten Ende (211) aufweist, das zweite Ende umfassend eine Barriere, die wirksam ist, um einen Hohlraumbereich innerhalb der Kammer zwischen dem zweiten Ende der Kammer und dem Niedrigprofilultraschallwandler (50) auszubilden.
  3. Ultraschallkopplungsvorrichtung (100) nach Anspruch 1, wobei die fortlaufende Seitenwand (300) ferner eine Öffnung (300b) umfasst, die konfiguriert ist, um einem mit dem Niedrigprofilultraschallwandler (50) verbundenen Kabel (51) zu ermöglichen, sich außerhalb der Kammer (210) zu erstrecken.
  4. Ultraschallkopplungsvorrichtung (100) nach Anspruch 3, wobei die Öffnung (300b) eine Kabelstützverlängerung (400) umfasst, die sich von der fortlaufenden Seitenwand (300) nach außen erstreckt und einen Durchgang (410) für das Kabel (51) beinhaltet.
  5. Ultraschallkopplungsvorrichtung (100) nach Anspruch 1, wobei mindestens ein Abschnitt des Flanschbereichs (500) ein Klebematerial umfasst, das wirksam ist, um die Kopplungsvorrichtung auf der Oberfläche (111) des Subjekts (110) an Ort und Stelle zu halten.
  6. Ultraschallkopplungsvorrichtung (100) nach Anspruch 1, ferner umfassend:
    eine Kabelstützverlängerung (400), die sich entlang des Flanschbereichs (500) erstreckt.
  7. Ultraschallkopplungsvorrichtung (100) nach Anspruch 1, wobei mindestens ein Abschnitt der fortlaufenden Seitenwand (300) der Kammer (210) konfiguriert ist, um zu ermöglichen, dass der Niedrigprofilultraschallwandler (50) in die Kammer durch den mindestens einen Abschnitt hindurch eingeführt wird und nicht durch das erste Ende (211) oder das zweite Ende (212) der Kammer hindurch.
  8. Tragbare, transportierbare therapeutische Ultraschalleinrichtung (800), umfassend:
    mindestens einen Niedrigprofilultraschallwandler (50); und
    mindestens eine Ultraschallkopplungsvorrichtung (100) nach Anspruch 1,
    wobei die mindestens eine Ultraschallkopplungsvorrichtung mit dem mindestens einen Niedrigprofilultraschallwandler wirkgekoppelt ist, wobei dadurch eine Wandler-/Kopplungsvorrichtungseinheit (600) ausgebildet wird.
  9. Einrichtung (800) nach Anspruch 8, ferner umfassend:
    eine Haltekomponente (900), die konfiguriert ist, um die Wandler-/Kopplungsvorrichtungseinheit (600) auf einer Oberfläche (111) eines Subjekts (110) an Ort und Stelle zu halten.
  10. Einrichtung (800) nach Anspruch 9, wobei die Haltekomponente (900) konfiguriert ist, um eine oder mehrere Wandler-/Kopplungsvorrichtungseinheiten (600) auf einer Oberfläche (111) eines Subjekts (110) an Ort und Stelle zu halten.
  11. Einrichtung (800) nach Anspruch 9, wobei die Haltekomponente als eine Umhüllung konfiguriert ist.
  12. Tragbares, transportierbares therapeutisches Ultraschall-Kit, umfassend:
    mindestens einen Niedrigprofilultraschallwandler (50); und
    mindestens eine Ultraschallkopplungsvorrichtung (100) nach Anspruch 1,
    wobei die mindestens eine Ultraschallkopplungsvorrichtung konfiguriert ist, um mit dem mindestens einen Niedrigprofilultraschallwandler wirkgekoppelt zu werden, wobei dadurch eine Wandler-/Kopplungsvorrichtungseinheit ausgebildet wird.
  13. Kit nach Anspruch 12, ferner umfassend:
    mindestens eine Haltekomponente (900), die betriebsfähig ist, um die mindestens eine Ultraschallkopplungsvorrichtung (100) auf einer Oberfläche (111) eines Subjekts (110) an Ort und Stelle zu halten, wobei die mindestens eine Ultraschallkopplungsvorrichtung mit dem mindestens einen NiedrigprofilUltraschallwandler (50) wirkgekoppelt ist.
  14. Kit nach Anspruch 13, wobei die mindestens eine Haltekomponente (900) konfiguriert ist, um eine oder mehrere Wandler-/Kopplungsvorrichtungseinheiten (600) auf der Oberfläche (111) des Subjekts (110) an Ort und Stelle zu halten.
EP11728550.2A 2009-12-31 2011-01-03 Ultraschall-kopplungsvorrichtung Active EP2519322B1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29173209P 2009-12-31 2009-12-31
US29180409P 2009-12-31 2009-12-31
US29177909P 2009-12-31 2009-12-31
PCT/US2011/020052 WO2011082402A2 (en) 2009-12-31 2011-01-03 Ultrasound coupling device

Publications (3)

Publication Number Publication Date
EP2519322A2 EP2519322A2 (de) 2012-11-07
EP2519322A4 EP2519322A4 (de) 2017-10-11
EP2519322B1 true EP2519322B1 (de) 2022-09-21

Family

ID=44227176

Family Applications (3)

Application Number Title Priority Date Filing Date
EP11728554.4A Active EP2519323B1 (de) 2009-12-31 2011-01-03 Tragbares ultraschallsystem
EP11728550.2A Active EP2519322B1 (de) 2009-12-31 2011-01-03 Ultraschall-kopplungsvorrichtung
EP11728555.1A Active EP2520101B1 (de) 2009-12-31 2011-01-03 Ultraschallwandler mit niedrigem profil

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP11728554.4A Active EP2519323B1 (de) 2009-12-31 2011-01-03 Tragbares ultraschallsystem

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP11728555.1A Active EP2520101B1 (de) 2009-12-31 2011-01-03 Ultraschallwandler mit niedrigem profil

Country Status (7)

Country Link
US (3) US9199096B2 (de)
EP (3) EP2519323B1 (de)
CN (3) CN102907117B (de)
BR (3) BR112012016325A2 (de)
ES (1) ES2928669T3 (de)
IN (3) IN2012DN06605A (de)
WO (3) WO2011082407A2 (de)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8585601B2 (en) * 2010-10-18 2013-11-19 CardioSonic Ltd. Ultrasound transducer
US9566456B2 (en) 2010-10-18 2017-02-14 CardioSonic Ltd. Ultrasound transceiver and cooling thereof
EP2661304A1 (de) 2010-10-18 2013-11-13 Cardiosonic Ltd. Therapeutika-reservoir
US9028417B2 (en) 2010-10-18 2015-05-12 CardioSonic Ltd. Ultrasound emission element
US20130060143A1 (en) * 2011-09-07 2013-03-07 Vasamed, Inc. Doppler probe placement device and method of use
CN103153196B (zh) * 2011-09-22 2016-10-26 东芝医疗系统株式会社 超声波诊断装置
US9877699B2 (en) 2012-03-26 2018-01-30 Teratech Corporation Tablet ultrasound system
US10667790B2 (en) 2012-03-26 2020-06-02 Teratech Corporation Tablet ultrasound system
WO2013157011A2 (en) 2012-04-18 2013-10-24 CardioSonic Ltd. Tissue treatment
CN104363959A (zh) * 2012-05-11 2015-02-18 加利福尼亚大学董事会 在现场启动并监视中风患者治疗的便携式设备
US11357447B2 (en) 2012-05-31 2022-06-14 Sonivie Ltd. Method and/or apparatus for measuring renal denervation effectiveness
US20140073899A1 (en) * 2012-09-12 2014-03-13 Nellcor Puritan Bennett LLC. Photoacoustic sensor system
US20140257108A1 (en) * 2013-02-15 2014-09-11 G. Chad MORGAN Preconfigured ultrasound conductive medium
US9050053B2 (en) * 2013-02-15 2015-06-09 Naimco, Inc. Ultrasound device with cavity for conductive medium
CN103099643B (zh) * 2013-03-01 2014-12-24 上海海事大学 一种肌肉围度测量装置
US9398880B2 (en) * 2013-03-20 2016-07-26 Kelly Annette Vanscoy Barnett Plurality of lamination for soft tissue compression support, protection and bracing; intelligent textile for equine and equestrian sports or activities
EP2999411B1 (de) 2013-05-23 2020-10-07 Cardiosonic Ltd. Vorrichtungen zur renalen denervierung und bewertung davon
ES2899159T3 (es) * 2013-06-24 2022-03-10 Zetroz Systems Llc Dispositivo portátil de ultrasonido
WO2015023820A2 (en) 2013-08-15 2015-02-19 University Of Maryland College Park Systems, methods, and devices for health monitoring of an energy storage device
WO2015095734A1 (en) * 2013-12-20 2015-06-25 Naimco, Inc. Ultrasound conductive medium with locking element
USD733321S1 (en) 2014-01-10 2015-06-30 Celleration, Inc. Ultrasonic treatment device
USD733319S1 (en) 2014-01-10 2015-06-30 Celleration, Inc. Ultrasonic treatment wand
JP5771293B2 (ja) * 2014-01-23 2015-08-26 日立アロカメディカル株式会社 超音波診断装置
CN105939655A (zh) 2014-01-30 2016-09-14 小利兰斯坦福大学托管委员会 治疗阴道萎缩的装置和方法
US20190269943A1 (en) * 2014-02-25 2019-09-05 Zetroz Systems Llc Limited use ultrasonic coupling device
CN103784166B (zh) * 2014-03-03 2015-08-19 哈尔滨工业大学 多功能一体化数字超声诊断系统
WO2015187968A1 (en) * 2014-06-04 2015-12-10 Sonescence, Inc. Systems and methods for therapeutic agent delivery
US10390755B2 (en) 2014-07-17 2019-08-27 Elwha Llc Monitoring body movement or condition according to motion regimen with conformal electronics
US10279200B2 (en) 2014-07-17 2019-05-07 Elwha Llc Monitoring and treating pain with epidermal electronics
US10279201B2 (en) 2014-07-17 2019-05-07 Elwha Llc Monitoring and treating pain with epidermal electronics
US10383550B2 (en) 2014-07-17 2019-08-20 Elwha Llc Monitoring body movement or condition according to motion regimen with conformal electronics
US9621973B2 (en) * 2014-09-22 2017-04-11 Samsung Electronics Company, Ltd Wearable audio device
CN107106869A (zh) * 2014-11-14 2017-08-29 皇家飞利浦有限公司 用于超声溶栓治疗的超声设备
US10507008B2 (en) * 2015-01-08 2019-12-17 Casey K. Scully Ultrasound probe couplers and related methods
US10980510B2 (en) 2015-01-08 2021-04-20 Casey K. Scully Ultrasound probe couplers and related methods
EP3261548B1 (de) * 2015-02-25 2021-09-08 Decision Sciences Medical Company, LLC Akustische signalübertragungskopplungsmittel und kopplungsmedien
CA2982175A1 (en) 2015-04-08 2016-10-13 Carl Magnus SCHOELLHAMMER Systems, apparatus, and assembling method thereof for administering a substance
JP6421277B2 (ja) * 2015-05-15 2018-11-07 ハジッチ、アドミル 超音波プローブカバー及び使用方法
US9586062B2 (en) 2015-07-06 2017-03-07 Eurocomponents, Inc. Low frequency ultrasound device with computer-controlled monitoring
WO2017083088A1 (en) 2015-11-09 2017-05-18 Healthcare Evolution, Llc Ultrashield devices and methods for use in ultrasonic procedures
US10018113B2 (en) * 2015-11-11 2018-07-10 General Electric Company Ultrasonic cleaning system and method
US10987085B2 (en) 2015-12-10 2021-04-27 1929803 Ontario Corp Systems and methods for automated fluid response measurement
CN108778146B (zh) 2015-12-10 2022-03-11 1929803安大略Dba Ke2科技公司 用于自动流体响应测量的系统及方法
US10252066B2 (en) 2016-05-05 2019-04-09 Piezo Energy Technologies Llc Miniaturized wireless ultrasound energy transfer system for powering a bio-implantable medical device
JP6808759B2 (ja) 2016-06-17 2021-01-06 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 規則的なパターンの開口を有する柔軟なカバーを備えた超音波ヘッド
CN106264603A (zh) * 2016-07-26 2017-01-04 麦克思商务咨询(深圳)有限公司 超声波感测贴片以及使用该超声波感测贴片的感测装置
EP3525883A4 (de) * 2016-10-16 2020-12-02 Vibrato Medical, Inc. Extrakorporaler therapeutischer ultraschall zur förderung der angiogenese
EP3326573A1 (de) 2016-11-25 2018-05-30 RWTH Aachen University Intraorale schnittstellenstruktur für eine intraorale abtastungsvorrichtung
CN106684982A (zh) * 2016-12-21 2017-05-17 天津力神特种电源科技股份公司 锂离子电池输出控制电路
US11793487B2 (en) * 2017-01-26 2023-10-24 Annamarie Saarinen Transducer array device, method and system for cardiac conditions
CN110505900A (zh) 2017-03-20 2019-11-26 索尼伟业有限公司 用于通过改善患者的射血分数来治疗心力衰竭的方法
US10945706B2 (en) 2017-05-05 2021-03-16 Biim Ultrasound As Hand held ultrasound probe
US11129661B2 (en) * 2017-05-22 2021-09-28 Cilag Gmbh International Combination ultrasonic and electrosurgical system having EEPROM and ASIC components
WO2018222658A1 (en) 2017-05-30 2018-12-06 Titan Advanced Energy Solutions, Inc. Battery life assessment and capacity restoration
JP7362593B2 (ja) 2017-08-08 2023-10-17 コーニンクレッカ フィリップス エヌ ヴェ ウェアラブル超音波パッチ及びそのようなパッチの貼付方法
EP3456268A1 (de) 2017-09-19 2019-03-20 Koninklijke Philips N.V. Am körper tragbarer ultraschallpatch und anbringungsverfahren solch eines patches
EP3459464A1 (de) 2017-09-20 2019-03-27 Koninklijke Philips N.V. Am körper tragbarer ultraschallpatch und anbringungsverfahren solch eines patches
US20190175201A1 (en) * 2017-12-08 2019-06-13 I3Ventures Llc Acoustic gel container
WO2019169508A1 (en) 2018-03-09 2019-09-12 1929803 Ontario Corp. D/B/A Flosonics Medical Dynamically controllable patient fluid control device
CN109420262B (zh) * 2018-05-21 2025-05-02 杭州光学精密机械研究所 一种痛风及疼痛治疗装置
US11109831B2 (en) 2018-07-17 2021-09-07 1929803 Ontario Corp, (o/a FloSonics Medical) Ultrasound patch for detecting fluid flow
CA3108429A1 (en) * 2018-08-08 2020-02-13 Craniovation, Inc. Tissue treatment with sensitizer and light and/or sound
CN113038987A (zh) * 2018-08-25 2021-06-25 杰拓奥兹系统有限责任公司 柔性可穿戴的长期超声装置
CN111166372A (zh) * 2018-11-12 2020-05-19 深圳迈瑞生物医疗电子股份有限公司 一种便携式超声设备和超声设备
CN109498406A (zh) * 2019-01-09 2019-03-22 珠海泓韵科技有限公司 一种便携式相控阵超声波美容仪
IL285384B2 (en) 2019-02-13 2024-11-01 Alpheus Medical Inc Non-invasive sonodynamic therapy
USD897543S1 (en) 2019-03-01 2020-09-29 Madorra Inc. Disposable component for vaginal ultrasound therapy device
CN109821160A (zh) * 2019-03-26 2019-05-31 张智慧 一种外科多自由度肩部按摩护理医疗器材
US11832872B2 (en) 2019-04-01 2023-12-05 Anya L. Getman Resonating probe with optional sensor, emitter, and/or injection capability
MX2021014512A (es) 2019-05-29 2022-02-11 Sonalasense Inc Sonosensibilizacion.
CN114206440B (zh) 2019-07-19 2024-09-10 玛多拉公司 具有可附接部件的超声装置
US20210275835A1 (en) * 2019-08-29 2021-09-09 Adenocyte Ltd. Device for inducing exfoliation of cells and/or tissue fragments for enhanced cytopathologic cell collection
EP3815616A1 (de) * 2019-10-29 2021-05-05 Koninklijke Philips N.V. Systeme und verfahren zur positionierung von ultraschall-patches
CN110772723A (zh) * 2019-11-08 2020-02-11 昆明医科大学 一种皮肤组织治疗系统
WO2021163056A1 (en) 2020-02-10 2021-08-19 Titan Advanced Energy Solutions Inc. Battery testing systems and methods
US11937976B2 (en) 2020-07-06 2024-03-26 1929803 Ontario Corp Ultrasound patch with integrated flexible transducer assembly
WO2022032283A2 (en) 2020-08-07 2022-02-10 Alpheus Medical, Inc. Ultrasound arrays for enhanced sonodynamic therapy for treating cancer
US20220087948A1 (en) * 2020-09-18 2022-03-24 Nanovibronix, Inc. Transdermal patch of a portable ultrasound-generating system for improved delivery of therapeutic agents and associated methods of treatment
US12446917B2 (en) 2020-09-29 2025-10-21 Bard Access Systems, Inc. Hands-free ultrasound assembly and system
CN113081756A (zh) * 2021-03-10 2021-07-09 北京航空航天大学 基于超声振动的止痛装置
US20220304658A1 (en) * 2021-03-26 2022-09-29 Judith Sene Cordless Ultrasonic Device
US11826197B2 (en) 2021-05-13 2023-11-28 General Electric Company Patient-specific neuromodulation alignment structures
IT202100017267A1 (it) * 2021-06-30 2022-12-30 Scuola Superiore Santanna Dispositivo di posizionamento per sonda ecografica
EP4384108B1 (de) 2021-08-10 2025-08-20 MAKO Surgical Corp. Verfolgungsvorrichtung zur verfolgung einer gliedmasse eines patienten
TWI864322B (zh) * 2021-08-17 2024-12-01 財團法人國家衛生研究院 行動載具控制之穿戴式超音波治療裝置
US20230381352A1 (en) * 2021-12-31 2023-11-30 Nanovibronix, Inc. System, device, and method for mitigating bacterial biofilms associated with indwelling medical devices
WO2024019896A1 (en) 2022-07-18 2024-01-25 Mako Surgical Corp. Pre-operative ultrasound scanning system for patient limbs
WO2024145714A1 (en) * 2023-01-03 2024-07-11 Auge Pierre Portable directional threat detection and alerting device
KR102573109B1 (ko) * 2023-03-27 2023-09-04 (주)일신이앤씨 도로대장 및 도로기반 지하시설물 측정을 위한 회전형 스타프 설치용 측량장치
US12218518B2 (en) 2023-04-14 2025-02-04 Ultrapower, Inc. System and method for powering an implantable device using acoustic energy
DE102023120463B3 (de) 2023-08-01 2024-11-14 Vera Herrmann Ultraschall-Vorrichtung zur lokalen Inhibition der Schmerzleitung
US12491383B2 (en) * 2024-04-18 2025-12-09 Acoustiic Inc. Generating histotripsy therapy pulses using full cycle transmit
US20260041407A1 (en) * 2024-08-12 2026-02-12 GE Precision Healthcare LLC System and method for intelligent ultrasound data acquisition with wearable ultrasound probe having distributed electronics

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030229331A1 (en) * 1999-11-05 2003-12-11 Pharmasonics, Inc. Methods and apparatus for uniform transcutaneous therapeutic ultrasound
GB2435614A (en) * 2006-03-01 2007-09-05 Samuel George Transducer holder for maintaining signal-receiving contact with a patient's body
US20080200810A1 (en) * 2007-02-16 2008-08-21 Buchalter Neal Ultrasound coupling device
US20090198157A1 (en) * 2008-02-01 2009-08-06 Eilaz Babaev Ultrasound moxibustion method and device

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2728869A (en) 1950-01-06 1955-12-27 Ultraschall A G Piezoelectric oscillator or vibrator for ultrasonic waves, especially as an instrument for therapeutical treatment and diagnosis
US4183249A (en) * 1975-03-07 1980-01-15 Varian Associates, Inc. Lens system for acoustical imaging
US4383529A (en) 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
US4484569A (en) 1981-03-13 1984-11-27 Riverside Research Institute Ultrasonic diagnostic and therapeutic transducer assembly and method for using
JPS5851697A (ja) * 1981-09-22 1983-03-26 Matsushita Electric Ind Co Ltd 超音波送受波器
US4784148A (en) 1986-02-21 1988-11-15 Johnson & Johnson Ultrasonic transducer probe expansion chamber
US4787888A (en) 1987-06-01 1988-11-29 University Of Connecticut Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a)
US5212988A (en) 1988-02-29 1993-05-25 The Reagents Of The University Of California Plate-mode ultrasonic structure including a gel
US5054470A (en) 1988-03-02 1991-10-08 Laboratory Equipment, Corp. Ultrasonic treatment transducer with pressurized acoustic coupling
CN2032047U (zh) * 1988-04-20 1989-02-08 中国人民解放军第四军医大学口腔医院 超声波洁牙机
US5211160A (en) 1988-09-14 1993-05-18 Interpore Orthopaedics, Inc. Ultrasonic orthopedic treatment head and body-mounting means therefor
US5003965A (en) 1988-09-14 1991-04-02 Meditron Corporation Medical device for ultrasonic treatment of living tissue and/or cells
US5435311A (en) 1989-06-27 1995-07-25 Hitachi, Ltd. Ultrasound therapeutic system
JPH074428B2 (ja) 1989-07-31 1995-01-25 俊郎 立花 超音波による薬物投与具
JPH03280939A (ja) 1990-03-29 1991-12-11 Fujitsu Ltd 超音波探触子
EP0533816B1 (de) 1990-06-15 1995-06-14 Cortrak Medical, Inc. Vorrichtung zur abgabe von medikamenten
US5176142A (en) 1991-04-16 1993-01-05 Hewlett-Packard Company Endoscopic ultrasound probe with take-up cable mechanism
US5271406A (en) * 1992-05-22 1993-12-21 Diagnostic Devices Group, Limited Low-profile ultrasonic transducer incorporating static beam steering
US5394877A (en) * 1993-04-01 1995-03-07 Axon Medical, Inc. Ultrasound medical diagnostic device having a coupling medium providing self-adherence to a patient
US5402793A (en) 1993-11-19 1995-04-04 Advanced Technology Laboratories, Inc. Ultrasonic transesophageal probe for the imaging and diagnosis of multiple scan planes
US5492126A (en) 1994-05-02 1996-02-20 Focal Surgery Probe for medical imaging and therapy using ultrasound
US5467779A (en) * 1994-07-18 1995-11-21 General Electric Company Multiplanar probe for ultrasonic imaging
JP3063071B2 (ja) 1995-05-22 2000-07-12 日本製紙株式会社 感熱記録体
US5503152A (en) * 1994-09-28 1996-04-02 Tetrad Corporation Ultrasonic transducer assembly and method for three-dimensional imaging
US5619476A (en) 1994-10-21 1997-04-08 The Board Of Trustees Of The Leland Stanford Jr. Univ. Electrostatic ultrasonic transducer
US5577507A (en) 1994-11-21 1996-11-26 General Electric Company Compound lens for ultrasound transducer probe
US5520612A (en) 1994-12-30 1996-05-28 Exogen, Inc. Acoustic system for bone-fracture therapy
US5626554A (en) 1995-02-21 1997-05-06 Exogen, Inc. Gel containment structure
US5770801A (en) 1995-04-25 1998-06-23 Abbott Laboratories Ultrasound transmissive pad
US5494038A (en) 1995-04-25 1996-02-27 Abbott Laboratories Apparatus for ultrasound testing
US6041253A (en) 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
US5893363A (en) * 1996-06-28 1999-04-13 Sonosight, Inc. Ultrasonic array transducer transceiver for a hand held ultrasonic diagnostic instrument
US5882300A (en) * 1996-11-07 1999-03-16 Spacelabs Medical, Inc. Wireless patient monitoring apparatus using inductive coupling
US5904659A (en) 1997-02-14 1999-05-18 Exogen, Inc. Ultrasonic treatment for wounds
JP4073967B2 (ja) 1997-04-18 2008-04-09 エキソゲン，インコーポレイティド 超音波による骨治療の装置
US6007499A (en) 1997-10-31 1999-12-28 University Of Washington Method and apparatus for medical procedures using high-intensity focused ultrasound
US6575956B1 (en) 1997-12-31 2003-06-10 Pharmasonics, Inc. Methods and apparatus for uniform transcutaneous therapeutic ultrasound
US20060015058A1 (en) * 1998-01-08 2006-01-19 Kellogg Scott C Agents and methods for enhancement of transdermal transport
US20020055702A1 (en) 1998-02-10 2002-05-09 Anthony Atala Ultrasound-mediated drug delivery
US5997481A (en) 1998-02-17 1999-12-07 Ultra Sound Probe Covers, Llc Probe cover with deformable membrane gel reservoir
JP2002513661A (ja) 1998-05-06 2002-05-14 エクソジェン インコーポレイテッド 超音波包帯
US6552471B1 (en) 1999-01-28 2003-04-22 Parallel Design, Inc. Multi-piezoelectric layer ultrasonic transducer for medical imaging
US6477410B1 (en) 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US6666835B2 (en) * 1999-05-14 2003-12-23 University Of Washington Self-cooled ultrasonic applicator for medical applications
US6217530B1 (en) 1999-05-14 2001-04-17 University Of Washington Ultrasonic applicator for medical applications
CN100342929C (zh) * 1999-05-21 2007-10-17 伊爱克斯奥根公司 用超声波和电磁方法治疗组织的装置和方法
US6210425B1 (en) 1999-07-08 2001-04-03 Light Sciences Corporation Combined imaging and PDT delivery system
US20030078499A1 (en) 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US6251073B1 (en) 1999-08-20 2001-06-26 Novasonics, Inc. Miniaturized ultrasound apparatus and method
CN2460122Y (zh) * 2000-06-19 2001-11-21 翁春晓 一种超声电导透皮给药装置的治疗头
AU2001288383A1 (en) 2000-08-24 2002-03-26 Encapsulation Systems, Inc. Ultrasonically enhanced substance delivery system and device
US6790187B2 (en) * 2000-08-24 2004-09-14 Timi 3 Systems, Inc. Systems and methods for applying ultrasonic energy
US7283874B2 (en) 2000-10-16 2007-10-16 Remon Medical Technologies Ltd. Acoustically powered implantable stimulating device
US6571444B2 (en) * 2001-03-20 2003-06-03 Vermon Method of manufacturing an ultrasonic transducer
EP1377343A1 (de) 2001-03-29 2004-01-07 Sobet AG Handgerät zur schmerzreduktion
DE10136402C2 (de) 2001-07-26 2003-07-31 Fraunhofer Ges Forschung Physikalisch aktives Pflaster und Verfahren zur Herstellung
WO2004052208A1 (en) 2002-01-15 2004-06-24 Redding Bruce K Jr A wearable, portable sonic applicator for inducing the release of bioactive compounds from internal organs
WO2003061756A2 (en) 2002-01-23 2003-07-31 The Regents Of The University Of California Implantable thermal treatment method and apparatus
US6719699B2 (en) * 2002-02-07 2004-04-13 Sonotech, Inc. Adhesive hydrophilic membranes as couplants in ultrasound imaging applications
US7070565B2 (en) * 2002-05-30 2006-07-04 University Of Washington Solid hydrogel coupling for ultrasound imaging and therapy
KR20040022550A (ko) 2002-09-09 2004-03-16 임태영 초음파를 이용한 휴대용 압전진동기기
AU2003273080A1 (en) 2002-10-24 2004-05-13 Healthpia Co., Ltd. Battery pack of a mobile communication terminal and connector for connecting the battery pack with the terminal
US7909782B2 (en) 2002-10-28 2011-03-22 John Perrier Ultrasonic medical device
DE20314667U1 (de) 2003-09-23 2003-12-04 Peter Krauth Gmbh Gerät für die Behandlung von Erkrankungen mit regelbaren Ultraschallwellen im Niederfrequenzbereich
JP4256309B2 (ja) 2003-09-29 2009-04-22 株式会社東芝 超音波プローブおよび超音波診断装置
US20050154308A1 (en) 2003-12-30 2005-07-14 Liposonix, Inc. Disposable transducer seal
EP1711106A2 (de) * 2004-01-20 2006-10-18 Therus Corporation Schnittstelle zur verwendung zwischen medizinischen instrumenten und einem patienten
US7951095B2 (en) 2004-05-20 2011-05-31 Ethicon Endo-Surgery, Inc. Ultrasound medical system
WO2006021651A1 (fr) 2004-07-23 2006-03-02 Inserm Dispositif et methode de traitement par ultrasons
WO2006026459A2 (en) 2004-08-26 2006-03-09 Finsterwald P Michael Biological cell acoustic enhancement and stimulation
GB0422525D0 (en) 2004-10-11 2004-11-10 Luebcke Peter Dermatological compositions and methods
US20060184070A1 (en) * 2004-11-12 2006-08-17 Hansmann Douglas R External ultrasonic therapy
CN100506323C (zh) * 2005-01-10 2009-07-01 重庆海扶(Hifu)技术有限公司 一体化超声治疗换能器装置
JP2008532568A (ja) 2005-01-18 2008-08-21 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 電子制御されるカプセル
US20060264751A1 (en) 2005-05-04 2006-11-23 Wendelken Martin E Protective thin film dressing for therapeutic and diagnostic ultrasound
US8075488B2 (en) * 2005-05-12 2011-12-13 Compumedics Medical Innovation Pty. Ltd. Ultrasound diagnosis and treatment apparatus
US7563279B2 (en) * 2005-06-20 2009-07-21 Alfred E. Mann Foundation For Scientific Research Stent having an ultrasonic emitter
US8303510B2 (en) 2005-07-01 2012-11-06 Scimed Life Systems, Inc. Medical imaging device having a forward looking flow detector
US20070066978A1 (en) 2005-09-06 2007-03-22 Schafer Mark E Ultrasound medical devices and related methods
WO2007035529A2 (en) 2005-09-16 2007-03-29 University Of Washington Thin-profile therapeutic ultrasound applicators
US9387515B2 (en) 2005-11-15 2016-07-12 The Brigham And Women's Hospital, Inc. Impedance matching for ultrasound phased array elements
RU2008123883A (ru) * 2005-11-17 2009-12-27 Конинклейке Филипс Электроникс, Н.В. (Nl) Сердечно-легочная реанимация, управляемая посредством измерения сосудистого кровотока
US9028748B2 (en) 2006-02-24 2015-05-12 Nanovibronix Inc System and method for surface acoustic wave treatment of medical devices
US20080039746A1 (en) * 2006-05-25 2008-02-14 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US20080033292A1 (en) 2006-08-02 2008-02-07 Insightec Ltd Ultrasound patient interface device
JP5009301B2 (ja) * 2006-11-08 2012-08-22 株式会社日立メディコ 超音波探触子及びこれを用いた超音波診断装置
US9492686B2 (en) * 2006-12-04 2016-11-15 Koninklijke Philips N.V. Devices and methods for treatment of skin conditions
US20080139944A1 (en) 2006-12-08 2008-06-12 Weymer Raymond F Devices for covering ultrasound probes of ultrasound machines
US20080140026A1 (en) 2006-12-11 2008-06-12 Sliwa John W Acoustically-Aided and/or gel-aided delivery of beneficial gaseous, ionic, unstable, metastable, short-lived or reactive species for medical purposes
US20080195003A1 (en) * 2007-02-08 2008-08-14 Sliwa John W High intensity focused ultrasound transducer with acoustic lens
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
JP5049340B2 (ja) * 2007-03-20 2012-10-17 株式会社日立メディコ 超音波探触子及び超音波診断装置
US20080269648A1 (en) 2007-04-30 2008-10-30 Ultra License Holdings, Inc. Method for increasing saliva and tear production with ultrasound
EP2152167B1 (de) 2007-05-07 2018-09-05 Guided Therapy Systems, L.L.C. Verfahren und systeme zur kopplung und fokussierung von akustischer energie mit einem kopplungselement
US20100132450A1 (en) 2007-09-13 2010-06-03 Pomerantz Andrew E Methods for optimizing petroleum reservoir analysis
US10035027B2 (en) * 2007-10-31 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Device and method for ultrasonic neuromodulation via stereotactic frame based technique
WO2010006293A2 (en) 2008-07-10 2010-01-14 Cornell University Ultrasound wave generating apparatus
CN101362005A (zh) * 2008-09-11 2009-02-11 高春平 智能化超声波治疗方法和装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030229331A1 (en) * 1999-11-05 2003-12-11 Pharmasonics, Inc. Methods and apparatus for uniform transcutaneous therapeutic ultrasound
GB2435614A (en) * 2006-03-01 2007-09-05 Samuel George Transducer holder for maintaining signal-receiving contact with a patient's body
US20080200810A1 (en) * 2007-02-16 2008-08-21 Buchalter Neal Ultrasound coupling device
US20090198157A1 (en) * 2008-02-01 2009-08-06 Eilaz Babaev Ultrasound moxibustion method and device

Also Published As

Publication number Publication date
WO2011082407A2 (en) 2011-07-07
WO2011082402A3 (en) 2011-12-22
CN102869409A (zh) 2013-01-09
EP2520101A4 (de) 2017-09-20
CN102907117B (zh) 2015-09-23
EP2519322A2 (de) 2012-11-07
EP2519322A4 (de) 2017-10-11
EP2520101A2 (de) 2012-11-07
CN102907117A (zh) 2013-01-30
WO2011082407A3 (en) 2011-11-17
WO2011082402A2 (en) 2011-07-07
WO2011082408A3 (en) 2011-11-17
EP2520101B1 (de) 2021-03-17
BR112012016316A2 (pt) 2016-08-23
US20130006153A1 (en) 2013-01-03
BR112012016325A2 (pt) 2016-08-23
IN2012DN06605A (de) 2015-10-23
EP2519323A4 (de) 2018-01-03
US20120277640A1 (en) 2012-11-01
CN103096976B (zh) 2016-04-27
EP2519323A2 (de) 2012-11-07
CN103096976A (zh) 2013-05-08
ES2928669T3 (es) 2022-11-22
US20120283605A1 (en) 2012-11-08
US9480863B2 (en) 2016-11-01
EP2519323B1 (de) 2024-12-18
IN2012DN06598A (de) 2015-10-23
WO2011082408A2 (en) 2011-07-07
US9492687B2 (en) 2016-11-15
BR112012016312A2 (pt) 2016-08-23
IN2012DN06597A (de) 2015-10-23
US9199096B2 (en) 2015-12-01

Similar Documents

Publication Publication Date Title
EP2519322B1 (de) Ultraschall-kopplungsvorrichtung
CN101195059B (zh) 超声波装置
US6273864B1 (en) Ultrasonic treatment for wounds
JP4122055B2 (ja) ゲル封入構造
CN104244899B (zh) 大面积美体塑形的帖敷器
JP2018522640A (ja) 光治療包帯システム
RU2478001C2 (ru) Ультразвуковой пластырь с медикаментом
MXPA05008900A (es) Tratamiento salino ultrasonicamente mejorado para piel danada por quemadura.
CN115177875A (zh) 治疗阴道萎缩的装置和方法
US8105248B2 (en) Medical plaster
US20150073311A1 (en) Method and device for treating pathological conditions associated with bone and musculoskeletal environments
US11691026B2 (en) Pain relief utilizing polymer based materials or a combination of LED bulbs and polymer based materials to create a near field accelerator
KR20170001425A (ko) 초음파 진동 점착 패드
JP2011062373A (ja) 超音波発振ユニット及び超音波発振システム
WO2015016396A1 (ko) 가슴 확대 및 성형을 위한 장치
CN221831521U (zh) 一种可对声带病灶进行超声理疗及药雾治疗装置
KR101965611B1 (ko) 초음파 진동기능이 부가된 부목
CN118142071A (zh) 一种穿戴式超声治疗贴膏
MXPA97006256A (en) Containment structure of

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20120727

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: ZETROZ, INC.

A4 Supplementary search report drawn up and despatched

Effective date: 20170913

RIC1 Information provided on ipc code assigned before grant

Ipc: A61N 7/00 20060101AFI20170907BHEP

Ipc: A61B 8/00 20060101ALI20170907BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20181019

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20211117

GRAJ Information related to disapproval of communication of intention to grant by the applicant or resumption of examination proceedings by the epo deleted

Free format text: ORIGINAL CODE: EPIDOSDIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: ZETROZ SYSTEMS, LLC

INTC Intention to grant announced (deleted)
INTG Intention to grant announced

Effective date: 20220411

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

RIN1 Information on inventor provided before grant (corrected)

Inventor name: GUFFEY, BRYANT

Inventor name: LEWIS JR., GEORGE K.

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602011073304

Country of ref document: DE

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1519666

Country of ref document: AT

Kind code of ref document: T

Effective date: 20221015

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2928669

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20221122

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG9D

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20220921

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20221221

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1519666

Country of ref document: AT

Kind code of ref document: T

Effective date: 20220921

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20221222

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20230123

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20230121

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602011073304

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

26N No opposition filed

Effective date: 20230622

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230103

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20230131

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230131

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230131

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230131

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20110103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20110103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220921

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20251204

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20251208

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20260206

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20251203

Year of fee payment: 16