EP2552388A2 - Préparations microbiologiquement stables d'utilisation aisée - Google Patents

Préparations microbiologiquement stables d'utilisation aisée

Info

Publication number
EP2552388A2
EP2552388A2 EP10757713A EP10757713A EP2552388A2 EP 2552388 A2 EP2552388 A2 EP 2552388A2 EP 10757713 A EP10757713 A EP 10757713A EP 10757713 A EP10757713 A EP 10757713A EP 2552388 A2 EP2552388 A2 EP 2552388A2
Authority
EP
European Patent Office
Prior art keywords
benzethonium chloride
methylisothiazolinone
pct
peg
cosmetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP10757713A
Other languages
German (de)
English (en)
Inventor
Manuela Köhler
Jens Schulz
Alexander Filbry
Rainer Kröpke
Lara Terstegen
Anke Pilzner
Horst Argembeaux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of EP2552388A2 publication Critical patent/EP2552388A2/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/524—Preservatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners

Definitions

  • the invention encompasses benzethonium chloride, methylisothiazolinone, piroctonolamine and / or lauroylethylarginate in cosmetic or dermatological preparations which comprise no further preservatives with phenol groups, in particular free from
  • the packaging could have a preservative effect, but this type of preservation is very expensive.
  • Some manufacturers refuse plastic tubes, because they attract after pressing out the contents of air and thus germs. However, the small opening of a tube is less inviting to germs than the large surface of a crucible. Some companies therefore use aluminum tubes because this prevents air from being drawn. Cosmetics are increasingly being filled into dispensers because they are particularly hygienic due to their construction.
  • Bacteria and yeasts need water and a neutral environment to multiply. Massage oils or soaps with their high pH value therefore need not be preserved. If, however, water is at the top of the ingredients list for a cream, lotion or shower gel, it usually requires adequate preservation.
  • the essential oils of numerous medicinal plants such as thyme, cloves or rosemary act against bacteria.
  • the art is to add the oils for each product
  • CONFIRMATION COPY Preservatives are responsible for killing bacteria, yeasts and fungi.
  • Known allergens are formaldehyde and substances that release formaldehyde in the product.
  • the organohalogen compounds which include many preservatives, also have great allergic potential.
  • Cosmetic preparations must be formulated long-term stable against microbial contamination and still have a very good skin compatibility.
  • parabens in particular 4-hydroxybenzoic acid and its esters, methylparaben, ethylparaben, propylparaben, isopropylparaben, butylparaben, isobutylparaben, phenylparaben.
  • Phenoxetol ® known for the preservation of cosmetic products.
  • auxiliaries for microbial stabilization are benzethonium chloride, lauroylethylarginate, octopirox and methylisothiazolinone.
  • Benzethonium chloride benzyl-dimethyl- (4- ⁇ 2- [4- (1, 1, 3,3-tetramethylbutyl) -phenoxy] -ethoxy ⁇ -ethyl) -ammonium chloride, of the structure
  • Grapefruit seed extracts can be used in cleaning agents but also in medicines (spermicides, lozenges against angina). Grapefruit seed extracts can be used in cleaning agents but also in medicines (spermicides, lozenges against angina). Grapefruit seed extracts can be used in cleaning agents but also in medicines (spermicides, lozenges against angina). Grapefruit seed extracts can be used in cleaning agents but also in medicines (spermicides, lozenges against angina). Grapefruit seed extracts can
  • PCT 209-092 + 2010-041 In cosmetics, the use of benzethonium chloride is known, as described, for example, in WO 2007015243 A1, WO 2004034964 A1, EP 1310234 A1, WO 2002008377 A1.
  • Preservative used in cosmetic preparations are preferservative used in cosmetic preparations.
  • Aminate-G (INCI: glycerol and ethyl lauroyl arginate HCl) shows a large antimicrobial spectrum and is useful i.a. as an additive in food FDA tested (see for example WO
  • Piroctone Olamine 1-hydroxy-4-methyl-6- (2,4,4-trimethylpentyl) -2 (1 / -) -pyridone, also referred to as octopirox, is an antimicrobial used as a preservative and has e.g. B. is used in shampoos as anti-dandruff. Octopirox is good
  • Methylisothiazolinone (2-methyl-2H-isothiazol-3-one (MIT)) is a class of compounds with high microbicidal activity, which is mainly used for the preservation of technical products and only a few cosmetic products.
  • methylisothiazolinone is described, for example, in US Pat. No. 6,511,673 or EP 1,488,699 A1 in combination with parabens or phenoxyethanol.
  • PCT 209-092 + 2010-041 Furthermore, a simple replacement or avoidance of parabens and / or phenoxyethanol is not readily possible without sacrificing stability and performance.
  • biofilm-forming Staphylococcus epidermidis strains on implants in medicine are particularly problematic. These infections are difficult to treat with conventional antibiotics.
  • a biofilm dissolving and / or inhibiting effect in addition to antimicrobial efficacy significantly enhances the efficiency of a preservative.
  • the object is therefore to provide cosmetic or dermatological preparations which have sufficient microbiological long-term stability. Additional object is that these preparations are formulated skin, hair and user-friendly and have a low skin irritation potential
  • the invention encompasses benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate in cosmetic or dermatological preparations which comprise no further preservatives, in particular no compositions with
  • Phenol groups include, in particular free of parabens and / or phenoxyethanol.
  • the proportion of benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate is preferably in the range of 0.01 to 5 wt.%, In particular in the range of 0.1 to 2 wt.%, Based on the total mass of the preparation to choose.
  • Benzethonium chloride, methylisothiazolinone, Piroctone olamine and / or Lauroylethylarginat be included.
  • benzethonium chloride and / or Lauroylethylarginat included.
  • Lauroylethylarginat instead of parabens and / or phenoyethanol have sufficient microbial stability.
  • Microplate scale examined. The measurement results of the active substances investigated are related to the positive control (PK1). Neither ethylparaben nor methylparaben showed efficacy. In comparison, benzethonium chloride,
  • Methylisothiazolinone Piroctone Olamine and Lauroylethylarginat a very good biofilm-inhibiting activity.
  • benzethonium chloride for benzethonium chloride
  • the conventional antibacterial agents distinguishes the bacteriostatic and the bactericidal effect. In the latter, the bacteria are killed by the drug. The bacteriostatic effect, however, prevents the proliferation of bacteria.
  • the preservatives used in cosmetic formulations to prevent bacterial contamination are usually among the bactericidal agents.
  • the use of classic antimicrobial agents affects the skin flora and, on the other hand, resistance developments are increasingly being observed in recent years.
  • the anti-biofilm agents do not directly interfere with the bacterial metabolism, but merely prevent or dissolve the formation of the bacteria-protecting biofilm.
  • Staphylococcus epidermidis (syn., Staphylococcus albus, Micrococcus epidermidis, Staphylococcus saprophyticus) is a gram-positive, plasma-coagulase-negative, saprophagic bacterium that colonizes human skin and mucous membranes. Furthermore, it is found on foods and also settles on polymeric surfaces (e.g., packaging). But in
  • PCT 209-092 + 2010-041 S. epidermidis has a wide spectrum of antibiotic resistance. This is especially true against penicillin and ethicillin. The proportion of resistant strains is now 70%.
  • the preparations according to the invention are preferably paraben and / or
  • Phenoxyethanolza still have sufficient microbial stability.
  • Paraben-free or phenoxyethanol-free means that the proportion of parabens and / or phenoxyethanol is less than 1% by weight, based on the total mass of the preparation.
  • the proportion of parabens and phenoxyethanol is 0% by weight.
  • the cosmetic preparations according to the invention may further cosmetic
  • Excipients and other active ingredients such as are commonly used in such preparations, for.
  • substances for preventing the foaming, dyes and color pigments, thickeners, moisturizing and / or moisturizing substances fats, oils, waxes or other conventional constituents of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives provided that the additive does not impair the required properties in terms of microbiological stability and skin and hair compatibility.
  • the preparations according to the invention can advantageously be in the form of aqueous gels, aqueous-alcoholic solutions, O / W or W / O emulsions of soft, semi-soft or solid consistency, microemulsions, W / O / W or O / W / O emulsions.
  • ideal aqueous gels, aqueous-alcoholic solutions, O / W or W / O emulsions of soft, semi-soft or solid consistency, microemulsions, W / O / W or O / W / O emulsions.
  • Forms of application in this context are face creams, serums, make-up, foundation, body lotions, body milks, hand cream, deodorant scooter, deodorant stick, deodorant aerosol, deodorant sprayer.
  • rinse-off products such as shampoos, shower gels or hand wash gels are also preferred.
  • PCT 209-092 + 2010-041 The following examples show inventive cosmetic preparations with good microbial stability.
  • the numbers are parts by weight based on the total mass of the preparation. W / O emulsions,
  • PCT 209-092 + 2010-041 Glycerin 5.0 7.5 10.0 3.0 1, 0
  • PCT 209-092 + 2010-041 Carbomer - - 0.2 - 0.1
  • Titanium dioxide 2.5 1, 2 0.15 -
  • Glyceryl stearate citrate 1.0 0.75 0.1 0.5 0.3
  • PCT 209-092 + 2010-041 Dicaprylyl ether 0 0 0 10 0
  • Citric acid 0.0050 0 0 0 0 0
  • Polyglyceryl-10 Stearate 0.7 0 1, 8 1 1
  • Phenylbenzimidazolesulfonic acid 0 0 0 0 2
  • Polyquaternium 7 0.4 0.3
  • PEG-3 distearates 1, 5 1, 5 1, 5 1, 5 1, 5 1, 5 1, 5 1, 5 1, 5

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne des préparations cosmétiques ou dermatologiques présentant, par ajout de chlorure de benzéthonium, de méthylisothiazolinone, de piroctone olamine et/ou d'éthyl lauroyl arginate, une qualité sensorielle améliorée et une stabilité microbiologique suffisante, les préparations cosmétiques ou dermatologiques ne contenant aucun agent conservateur, et étant notamment exemptes de parabène et/ou de phénoxyethanol.
EP10757713A 2010-03-29 2010-09-02 Préparations microbiologiquement stables d'utilisation aisée Ceased EP2552388A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010013274A DE102010013274A1 (de) 2010-03-29 2010-03-29 Mikrobiologisch stabile anwendungsfreundliche Zubereitungen
PCT/EP2010/005375 WO2011124241A2 (fr) 2010-03-29 2010-09-02 Préparations microbiologiquement stables d'utilisation aisée

Publications (1)

Publication Number Publication Date
EP2552388A2 true EP2552388A2 (fr) 2013-02-06

Family

ID=44624862

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10757713A Ceased EP2552388A2 (fr) 2010-03-29 2010-09-02 Préparations microbiologiquement stables d'utilisation aisée

Country Status (7)

Country Link
US (1) US20130059929A1 (fr)
EP (1) EP2552388A2 (fr)
JP (1) JP2013518831A (fr)
CN (1) CN102821744A (fr)
BR (1) BR112012023903A2 (fr)
DE (1) DE102010013274A1 (fr)
WO (1) WO2011124241A2 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101801521B (zh) 2007-05-14 2015-06-17 纽约州立大学研究基金会 生物膜中细菌细胞内的生理学分散响应诱导
DE102010055768A1 (de) * 2010-12-23 2012-06-28 Beiersdorf Ag Wirkstoffkombinationen aus Glucosylglyceriden und einem oder mehreren Konservierungsmitteln
EP2717968A2 (fr) * 2011-06-07 2014-04-16 Beiersdorf AG Compositions cosmétiques ou dermatologiques sous forme d'émulsions et ayant une libération de parfum améliorée
EP2717970A2 (fr) * 2011-06-07 2014-04-16 Beiersdorf AG Compositions cosmétiques ou dermatologiques exemptes de polyéthylène glycol
DE102011077045A1 (de) * 2011-06-07 2012-12-13 Beiersdorf Ag Kosmetische oder dermatologische Zubereitungen mit verbesserter mikrobiologischer Stabilität
DE102011077028A1 (de) * 2011-06-07 2012-12-13 Beiersdorf Ag Kosmetische oder dermatologische Zubereitungen mit verbesserten rheologischen Eigenschaften
US9232790B2 (en) * 2011-08-02 2016-01-12 Kimberly-Clark Worldwide, Inc. Antimicrobial cleansing compositions
CN110075310A (zh) 2011-12-20 2019-08-02 维奥姆治疗有限公司 用于治疗真菌感染的局部油组合物
AU2014392626B2 (en) 2014-04-30 2020-07-02 Kimberly-Clark Worldwide, Inc. Topical compositions for stimulating adipogenesis and lipogenesis to reduce the signs of skin aging
BR112016023890B1 (pt) 2014-04-30 2020-12-01 Kimberly-Clark Worldwide, Inc métodos para reduzir sinais de envelhecimento da pele, para aumentar a adipogênese da face e do corpo e para aumentar a lipogênese da face e do corpo
BR112016023571B1 (pt) 2014-04-30 2020-12-01 Kimberly-Clark Worldwide, Inc. métodos para reduzir os sinais de envelhecimento da pele em um indivíduo, para aumentar a adipogênese da face e do corpo de um indivíduo e para aumentar a lipogênese da face e do corpo de um indivíduo
BR112016022734B1 (pt) 2014-04-30 2020-12-01 Kimberly-Clark Worldwide, Inc. método para redução do estresse oxidativo das células, método para redução da apoptose de células induzida pelo estresse oxidativo e método para redução do fotodano das células
US20160287566A1 (en) * 2015-04-04 2016-10-06 Thomas Lynn Busby Anti-demodectic active agents and topical compositions for the treatment of demodicosis in humans and animals
JP6896381B2 (ja) * 2015-07-10 2021-06-30 花王株式会社 毛髪化粧料
DE102015223821A1 (de) * 2015-12-01 2017-06-01 Henkel Ag & Co. Kgaa "Leistungsstarke Haarbehandlungsmittel mit strukturstärkendem-Effekt"
CN108430444B (zh) 2015-12-31 2021-09-28 高露洁-棕榄公司 清洁条
EP3644950A2 (fr) 2017-06-30 2020-05-06 The Procter and Gamble Company Compositions déodorantes et antitranspirantes
US10543164B2 (en) 2017-06-30 2020-01-28 The Procter & Gamble Company Deodorant compositions
WO2019006233A1 (fr) 2017-06-30 2019-01-03 The Procter & Gamble Company Compositions de soins capillaires comprenant un matériau de type 2-pyridinol-n-oxyde et un chélateur du fer
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
BR112021017148A2 (pt) 2019-03-08 2021-11-09 Colgate Palmolive Co Composições de higiene pessoal
EP4003285A1 (fr) * 2019-07-26 2022-06-01 Unilever Global IP Limited Composition de traitement capillaire
AU2019474692C1 (en) * 2019-11-14 2024-05-09 Colgate-Palmolive Company Personal care compositions for treating odor causing bacteria and methods for the same
US11331253B2 (en) 2019-11-14 2022-05-17 Colgate-Palmolive Company Personal care compositions for treating odor causing bacteria and methods for the same
BR112022012803A2 (pt) 2020-01-17 2022-09-06 Unilever Ip Holdings B V Composição de limpeza pessoal, composição de cuidados pessoais, método não terapêutico de tratamento dos cabelos ou couro cabeludo e uso de um tensoativo de limpeza
WO2021144267A1 (fr) 2020-01-17 2021-07-22 Unilever Ip Holdings B.V. Compositions et procédés de traitement capillaire
CN111789119B (zh) * 2020-08-03 2024-08-30 兰州大学 一种吡啶酮类抗真菌医药在农作物病害防治上的新用途
EP3967291A1 (fr) 2020-09-15 2022-03-16 Unilever Global IP Ltd Composition capillaire
MX2024002382A (es) 2021-09-01 2024-03-14 Colgate Palmolive Co Composiciones para el cuidado personal que contienen mezclas posbioticas para reequilibrar el microbioma de la piel.
EP4376800A1 (fr) 2021-09-03 2024-06-05 Colgate-Palmolive Company Compositions de soins personnels
WO2024096208A1 (fr) * 2022-10-31 2024-05-10 주식회사 우드워드바이오 Composé de sel et composition biocide le comprenant
WO2024099788A1 (fr) 2022-11-09 2024-05-16 Unilever Ip Holdings B.V. Compositions et méthodes de traitement capillaire

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060051385A1 (en) * 2004-09-07 2006-03-09 3M Innovative Properties Company Cationic antiseptic compositions and methods of use

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3061512A (en) * 1959-06-25 1962-10-30 Borden Co Dermatological preparation
US4574081A (en) * 1984-09-25 1986-03-04 Colgate-Palmolive Co. Antiplaque dentifrice having improved flavor
US5997893A (en) * 1998-01-20 1999-12-07 Ethicon, Inc. Alcohol based anti-microbial compositions with cosmetic appearance
US6372230B1 (en) * 1999-04-28 2002-04-16 Nick Joseph Schincaglia Skin care composition, its use and apparatus for the application thereof
EP1259115A1 (fr) * 2000-02-25 2002-11-27 BetzDearborn Inc Procede permettant d'accentuer l'activite biocide
US6511673B1 (en) 2000-05-10 2003-01-28 Rohm And Haas Company Microbicidal composition
CA2346626A1 (fr) * 2000-05-11 2001-11-11 Unilever Plc Composition et serviette nettoyantes antimicrobiennes
WO2002008377A1 (fr) 2000-07-21 2002-01-31 Novozymes A/S Compositions antimicrobiennes
TW201002201A (en) * 2001-03-01 2010-01-16 Lonza Ag Preservative blends containing quaternary ammonium compounds
AU2001254819A1 (en) * 2001-04-28 2002-11-11 Lamirsa (Laboratorios Miret, S.A.) Antimicrobial composition comprising potassium sorbate and lae
MXPA04001169A (es) * 2001-08-09 2005-02-17 Miret Lab Nuevos sistemas de conservacion y su uso en preparaciones cosmeticas.
US6652842B2 (en) 2001-11-13 2003-11-25 Noville, Inc. Deodorant compositions comprising diglycerol
EP1332675B2 (fr) 2002-01-31 2012-11-07 Rohm And Haas Company Association microbicide synergique
AU2003301240A1 (en) * 2002-05-20 2004-05-04 William O. Kling Skin cleanser compositions and methods of use
US8361450B2 (en) * 2002-06-04 2013-01-29 The Procter & Gamble Company Shampoo containing a gel network and a non-guar galactomannan polymer derivative
US20040016608A1 (en) * 2002-06-20 2004-01-29 Vladyslaw Gutowski Brake backing plate and method and apparatus for making same
US20060051430A1 (en) * 2004-09-07 2006-03-09 Arata Andrew B Silver dihydrogen citrate compositions
EA015815B1 (ru) 2005-08-02 2011-12-30 Сол-Джел Текнолоджиз Лтд. Покрытие из оксида металла для водонерастворимых ингредиентов
CN101394898A (zh) * 2005-11-30 2009-03-25 西巴控股公司 葡聚糖组合物
JP4743704B2 (ja) * 2006-01-16 2011-08-10 株式会社マンダム 腋臭菌用抗菌剤、並びに該抗菌剤を含有する腋臭防止剤及び皮膚外用剤
DE102006029879A1 (de) * 2006-06-28 2008-01-03 Clariant International Limited Kosmetische Mittel enthaltend nanopartikuläres Korund
US9555167B2 (en) 2006-12-11 2017-01-31 3M Innovative Properties Company Biocompatible antimicrobial compositions
JP2008156288A (ja) * 2006-12-25 2008-07-10 Lion Corp 口腔用組成物
DE102007045241A1 (de) * 2007-04-20 2008-10-23 Beiersdorf Ag Stabilisierte kosmetische Zubereitungen mit Piroctone Olamine
ES2675045T3 (es) * 2007-05-04 2018-07-06 Symrise Ag Preparaciones activas sinérgicas que comprenden 1,2-decanodiol y además compuestos activos antimicrobianos
JP4944844B2 (ja) * 2007-07-18 2012-06-06 ローム アンド ハース カンパニー 殺微生物組成物
JP5043588B2 (ja) * 2007-10-12 2012-10-10 花王株式会社 液体口腔用組成物
AR070271A1 (es) * 2008-02-13 2010-03-25 Miret Lab Uso de tensioactivos cationicos para la proteccion contra la erosion dental y composicion para uso oral
EP2153813A1 (fr) * 2008-08-15 2010-02-17 Lonza, Inc. Mélanges synergiques de conservateurs
DE102009014877A1 (de) * 2009-03-25 2009-09-24 Clariant International Ltd. Polymere auf Basis von Acryl-, Methacryl- oder Ethacrylamidoalkylsulfonsäure oder -salzen und Carboxyalkylacrylat, -methacrylat oder -ethacrylat oder Oligomeren dieser Carboxy-Verbindungen
JP2010241693A (ja) * 2009-04-01 2010-10-28 Lion Corp 口腔用組成物
TWM373127U (en) * 2009-08-06 2010-02-01 Liang-Yang Lin disassembleable warm-keeping clothing set formed of solar nano-carbon balls composite material

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060051385A1 (en) * 2004-09-07 2006-03-09 3M Innovative Properties Company Cationic antiseptic compositions and methods of use

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JP2013518831A (ja) 2013-05-23
DE102010013274A1 (de) 2011-11-17
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US20130059929A1 (en) 2013-03-07
WO2011124241A2 (fr) 2011-10-13
WO2011124241A3 (fr) 2012-07-05

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