EP2563479A2 - Préparation microbiologiquement stable et d'utilisation aisée, contenant des épaississants - Google Patents

Préparation microbiologiquement stable et d'utilisation aisée, contenant des épaississants

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Publication number
EP2563479A2
EP2563479A2 EP10757714A EP10757714A EP2563479A2 EP 2563479 A2 EP2563479 A2 EP 2563479A2 EP 10757714 A EP10757714 A EP 10757714A EP 10757714 A EP10757714 A EP 10757714A EP 2563479 A2 EP2563479 A2 EP 2563479A2
Authority
EP
European Patent Office
Prior art keywords
benzethonium chloride
preparations
methylisothiazolinone
preparation
cosmetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP10757714A
Other languages
German (de)
English (en)
Inventor
Manuela Köhler
Jens Schulz
Alexander Filbry
Rainer Kröpke
Horst Argembeaux
Anke Pilzner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of EP2563479A2 publication Critical patent/EP2563479A2/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/48—Thickener, Thickening system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Definitions

  • the invention includes cosmetic or dermatological preparations with
  • Benzethonium chloride methylisothiazolinone, Piroctone olamine and / or lauroylethylarginate and one or more thickening substances.
  • Multi-component systems such as solutions, emulsions or suspensions are frequently adjusted or thickened to higher viscosities for reasons of economy or performance or for reasons of stability.
  • e.g. can be achieved by increasing the viscosity of the external or internal phase of emulsions or suspensions that the time to demixing of the components of such a system can be significantly extended, which manifests itself in an extension of the storage time.
  • the temperature behavior of the polymers is an important property.
  • polymers exhibit high viscosity at low temperatures and low viscosity at high temperatures.
  • such polymers are often desirable which thicken above certain temperatures but remain pumpable and processible at low temperatures in solution, i. are also easy to use.
  • thickeners are, for example, cellulose ethers and others
  • Cellulose derivatives e.g., carboxymethyl cellulose, hydroxyethyl cellulose
  • gelatin starch and starch derivatives
  • sodium alginates e.g., fatty acid polyethylene glycol esters, agar-agar, tragacanth or dextrins.
  • the thickeners mentioned show a variety of disadvantages in the application.
  • fatty acid polyethylene glycol ester tends to be in the presence of water
  • Thickening agents of natural origin for example agar-agar or tragacanth
  • agar-agar or tragacanth have, depending on their origin, highly fluctuating composition, so that a
  • Cosmetic or dermatological preparations can be easily characterized with regard to these sensor criteria.
  • 0.4 g of a formulation stored at 25 ° C is applied between thumb and forefinger.
  • the formulation is gently squeezed and the fingers apart.
  • the process is performed 3 times at a speed of 2 movements per second.
  • the length of the tip or the length of the product thread formed is evaluated.
  • Spray application for clogging the spray devices
  • preservatives are the compounds known as parabens, in particular 4-hydroxybenzoic acid and its esters, methylparaben, ethylparaben, propylparaben, isopropylparaben, butylparaben, isobutylparaben, phenylparaben.
  • Phenoxetol ® known for the preservation of cosmetic products.
  • auxiliaries for microbial stabilization are benzethonium chloride, lauroiethyiarginate, octopirox and methylisothiazolinone.
  • Benzethonium chloride benzyl-dimethyl- (4- ⁇ 2- [4- (1, 1, 3,3-tetramethylbutyl) -phenoxy] -ethoxy ⁇ -ethyl) -ammonium chloride, of the structure
  • Grapefruit seed extracts can be used in cleaning agents but also in medicines (spermicides, lozenges against angina). Grapefruit seed extracts can be used in cleaning agents but also in medicines (spermicides, lozenges against angina). Grapefruit seed extracts can be used in cleaning agents but also in medicines (spermicides, lozenges against angina). Grapefruit seed extracts can be used in cleaning agents but also in medicines (spermicides, lozenges against angina). Grapefruit seed extracts can
  • benzethonium chloride is known, as described, for example, in WO 2007015243 A1, WO 2004034964 A1, EP 1310234 A1, WO 2002008377 A1.
  • Preservative used in cosmetic preparations are preferservative used in cosmetic preparations.
  • Aminate-G (INCI: glycerol and ethyl lauroyl arginate HCl) shows a large antimicrobial spectrum and is among others. as an additive in food FDA tested (see for example WO
  • Piroctone Olamine 1-Hydroxy-4-methyl-6- (2,4,4-trimethylpentyl) -2 (1 / - /) - pyridone, also known as octopirox, is an antimicrobial that is used as a preservative and z.
  • B. is used in shampoos as anti-dandruff.
  • Octopirox is well tolerated by the skin and physiologically indifferent.
  • Methylisothiazolinone (2-methyl-2H-isothiazol-3-one (MIT)) is a class of compounds with high microbicidal activity, which is mainly used for the preservation of technical products and only a few cosmetic products.
  • methylisothiazolinone is described, for example, in US Pat. No. 6,511,673 or EP 1,488,699 A1 in combination with parabens or phenoxyethanol.
  • compositions are microbially stable, skin, hair and user-friendly formulated.
  • the invention encompasses cosmetic or dermatological preparations
  • Benzethonium chloride methylisothiazolinone, Piroctone olamine and / or Lauroylethylarginat in combination with one or more thickening substances.
  • the proportion of benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate is preferably in the range of 0.01 to 5 wt.%, In particular in the range of 0.1 to 2 wt.%, Based on the total mass of the preparation to choose.
  • Benzethonium chloride, methylisothiazolinone, Piroctone olamine and / or Lauroylethylarginat be included.
  • benzethonium chloride and / or Lauroylethylarginat included.
  • Thickening substances also called thickeners, are substances or compounds which cause a change in the viscosity of the preparations they contain compared to the same preparation without the thickener.
  • Preferred thickeners are selected from the group of fatty alcohols or
  • Hydroxyfettalkohole having 12 to 22 and preferably 16 to 18 carbon atoms and partial glycerides, fatty acids or hydroxy fatty acids. Preference is given to a combination of these substances with alkyl oligoglucosides and / or fatty acid N-methylglucamides of the same chain length and / or polyglycerol poly-12-hydroxystearates. Suitable thickeners are
  • Aerosil types hydrophilic silicic acids
  • polysaccharides in particular xanthan gum, guar guar, agar agar, carageenan, alginates and tyloses
  • xanthan gum guar guar
  • agar agar agar
  • carageenan alginates and tyloses
  • Carboxymethylcellulose and hydroxyethylcellulose also higher molecular weight polyethylene glycol mono- and diesters of fatty acids, ammonium acryloyldimethyltaurate / VP copolymer, polyacrylates, (eg Carbopols and Pemulen types from Goodrich, Sigma's Synthalene TM, Keltrol grades from Kelco, Sepigel types from Seppic; Salcare types of Allied Colloids), polyacrylamides, polymers, polyvinyl alcohol and polyvinylpyrrolidone.
  • polyacrylates eg Carbopols and Pemulen types from Goodrich, Sigma's Synthalene TM, Keltrol grades from Kelco, Sepigel types from Seppic; Salcare types of Allied Colloids
  • metal salts of fatty acids e.g. Magnesium, aluminum and / or zinc stearate or ricinoleate are preferably used.
  • thickeners for surfactant-containing preparations in particular those which have a proportion of Anionentensiden, fatty acid amides and / or ethoxylated fatty acid esters and / or ethoxylated fatty alcohols can be preferably used.
  • thickeners are suitable cationic polymers, such as cationic cellulose derivatives, such as quaternized hydroxyethyl cellulose, referred to under the name Polymer JR 400 TM available from Amerchol is cationic starch, copolymers of
  • Wheat polypeptides polyethylenimine, cationic silicone polymers, e.g. Amodimethicones, copolymers of adipic acid and dimethylaminohydroxypropyldiethylenetriamine (Cartaretine TM / Sandoz), copolymers of acrylic acid with dimethyldiallylammonium chloride (Merquat TM 550 / Chemviron), polyamino-polyamides, e.g. described in FR 2252840 A and their crosslinked water-soluble polymers, cationic chitin derivatives such as quaternized chitosan, optionally microcrystalline distributed, condensation products of dihaloalkylene, such as.
  • cationic silicone polymers e.g. Amodimethicones, copolymers of adipic acid and dimethylaminohydroxypropyldiethylenetriamine (Cartaretine TM / Sandoz), copolymers of acrylic acid with dimethyldiallylammonium chloride (M
  • Dibromobutane with bis-dialkylamines e.g. Bis-dimethylamino-1, 3-propane, cationic guar gum, e.g. Jaguar TM CBS, Jaguar TM C-17, Jaguar TM C-16 from Celanese, quaternized ammonium salt polymers, e.g. Mirapol TM A-15, Mirapol TM AD-1, Mirapol TM AZ-1 from Miranol.
  • bis-dialkylamines e.g. Bis-dimethylamino-1, 3-propane
  • cationic guar gum e.g. Jaguar TM CBS, Jaguar TM C-17, Jaguar TM C-16 from Celanese
  • quaternized ammonium salt polymers e.g. Mirapol TM A-15, Mirapol TM AD-1, Mirapol TM AZ-1 from Miranol.
  • thickeners are anionic, zwitterionic, amphoteric and nonionic polymers, such as, for example, vinyl acetate / crotonic acid copolymers, vinylpyrrolidone / vinyl acrylate copolymers, vinyl acetate / butyl maleate / isobornyl acrylate copolymers,
  • Methyl vinyl ether / maleic anhydride copolymers and their esters uncrosslinked and polyols crosslinked with polyols, acrylamidopropyltrimethylammonium chloride / acrylate copolymers, octylacrylamide / methyl methacrylate tert.butylaminoethyl methacrylate / 2-hydroxypropyl methacrylate copolymers, polyvinylpyrrolidone, vinylpyrrolidone / vinyl acetate copolymers, vinylpyrrolidone / dimethylaminoethyl methacrylate / vinylcaprolactam Terpolymers and optionally derivatized cellulose ethers; microchstalline cellulose and silicones.
  • Particularly preferred thickeners include xanthan gum, carageenan, alginates and tyloses, carboxymethyl cellulose, microcrystalline cellulose and hydroxyethyl cellulose, polyacrylates (e.g., Carbopols TM and Pemulen types from Noveon).
  • the thickeners can be used in combination with the substances according to the invention, benzethonium chloride, methylisothiazolinone, piroctone olamine and / or
  • Lauroylethylarginat use in the preparation without this to the lengthiness, i. pull to the strings that leads to formulations.
  • Methylisothiazolinone, Piroctone Olamine and / or Lauroylethylarginat enabled are examples of agents which are not actually known to have a viscosity or tackiness.
  • agents which are not actually known to have a viscosity or tackiness affect the sliding properties of the entire formulation in such a way that the adhesion of the compositions containing them to surfaces is positively influenced.
  • the adhesion to the surfaces in the dispenser systems is positively influenced, so that a pumpability can be ensured over a wide temperature range.
  • Vitamin E acetate 1, 0 1, 0
  • the "threading” is to be classified in the preparation B according to the invention as "not pulling threads”.
  • benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate can advantageously be used in cosmetic or dermatological preparations comprising one or more thickening substances for improving the
  • sensory properties of the preparation can be used.
  • Lauroylethylarginat instead of parabens and / or phenoyethanol have sufficient microbial stability.
  • biofilm inhibition at 0h as well as the biofilm-dissolving effect at 24h by a color reaction in the
  • Microplate scale examined. The measurement results of the active substances investigated are related to the positive control (PK1). Neither ethylparaben nor methylparaben showed efficacy. In comparison, benzethonium chloride,
  • Methylisothiazolinone Piroctone Olamine and Lauroylethylarginat a very good biofilm-inhibiting activity.
  • benzethonium chloride for benzethonium chloride
  • the conventional antibacterial agents distinguishes the bacteriostatic and the bactericidal effect. In the latter, the bacteria are killed by the drug. The bacteriostatic effect, however, prevents the proliferation of bacteria.
  • the preservatives used in cosmetic formulations to prevent bacterial contamination are usually among the bactericidal agents.
  • the use of classic antimicrobial agents affects the skin flora and, on the other hand, resistance developments are increasingly being observed in recent years.
  • the anti-biofilm agents do not directly interfere with the bacterial metabolism, but merely prevent or dissolve the formation of the bacteria-protecting biofilm. Resistance development is therefore excluded.
  • Staphylococcus epidermidis (syn., Staphylococcus albus, Micrococcus epidermidis, Staphylococcus saprophyticus) is a gram-positive, plasma-coagulase-negative, saprophagic bacterium that colonizes human skin and mucous membranes. Furthermore, it is found on foods and also settles on polymeric surfaces (e.g., packaging). But in
  • S. epidermidis has a wide spectrum of antibiotic resistance. This is especially true against penicillin and methicilfin. The proportion of resistant strains is now 70%.
  • preparations according to the invention are preferably paraben and / or
  • Phenoxyethanolza still have sufficient microbial stability.
  • Paraben-free or phenoxyethanol-free means that the proportion of parabens and / or phenoxyethanol is less than 1% by weight, based on the total mass of the preparation.
  • the proportion of parabens and phenoxyethanol is 0% by weight.
  • the cosmetic preparations according to the invention may further cosmetic
  • Excipients and other active ingredients such as are commonly used in such preparations, for.
  • substances for preventing foaming, dyes and color pigments, thickeners, moisturizing and / or moisturizing substances fats, oils, waxes or other conventional ingredients of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives provided that the additive does not impair the required properties in terms of microbiological stability and skin and hair compatibility.
  • the preparations according to the invention may advantageously be in the form of aqueous gels, aqueous-alcoholic solutions, O / W or W / O emulsions of soft, semi-soft or solid consistency, microemulsions, W / O / W or O / W / O emulsions.
  • ideal aqueous gels, aqueous-alcoholic solutions, O / W or W / O emulsions of soft, semi-soft or solid consistency, microemulsions, W / O / W or O / W / O emulsions.
  • Forms of application in this context are face creams, serums, make-up, foundation, body lotions, body milks, hand cream, deodorant scooter, deodorant stick, deodorant aerosol, deodorant sprayer.
  • rinse-off products such as shampoos, shower gels or hand wash gels are also preferred.
  • the numbers are parts by weight based on the total mass of the preparation.
  • Triglycerol diisostearate 1 0 0.5 0.25 2.0 3.0
  • PEG-30 dipolyhydroxystearate - 0.5 0.25 - 3.0
  • cyclic silicone oil (cyclomethicone) 12.5 15 22.0 20.0 15.5 linear silicone oil (dimethicone) 5.0 13.0 5.0 12.0 15.0 hydrogenated polyisobutene 0.5 0.75 1, 0 2 , 0 0.25
  • cyclic silicone oil 12.5 15 8.0 20.0 17.5 linear silicone oil (dimethicone) 5.0 13.0 5.0 12.0 15.0 hydrogenated polyisobutene 0.5 0.75 1, 0 2 , 0 0.25
  • cyclic silicone oil 12.5 15 25.0 10.0 7.5 linear silicone oil (dimethicone) 5.0 15.0 5.0 12.0 15.0
  • Glyceryl sterate citrate 1 0 1, 5 1, 5 0.5 0.25
  • Cetyl stearyl alcohol 2.5 5 0.5 2.0 1, 5
  • Titanium dioxide 2.5 1, 2 0.15 ⁇

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des préparations cosmétiques ou dermatologiques contenant au moins une substance épaississante, présentant par l'ajout de chlorure de benzéthonium, de méthylisothiazolinone, de piroctone Olamine et/ou d'éthyl lauroyl arginate, une qualité sensorielle améliorée et une stabilité microbiologique suffisante.
EP10757714A 2010-03-29 2010-09-02 Préparation microbiologiquement stable et d'utilisation aisée, contenant des épaississants Ceased EP2563479A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010013272A DE102010013272A1 (de) 2010-03-29 2010-03-29 Mikrobiologisch stabile anwendungsfreundliche Zubereitung mit Verdickern
PCT/EP2010/005377 WO2011124243A2 (fr) 2010-03-29 2010-09-02 Préparation microbiologiquement stable et d'utilisation aisée, contenant des épaississants

Publications (1)

Publication Number Publication Date
EP2563479A2 true EP2563479A2 (fr) 2013-03-06

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EP10757714A Ceased EP2563479A2 (fr) 2010-03-29 2010-09-02 Préparation microbiologiquement stable et d'utilisation aisée, contenant des épaississants

Country Status (3)

Country Link
EP (1) EP2563479A2 (fr)
DE (1) DE102010013272A1 (fr)
WO (1) WO2011124243A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010007958A1 (de) * 2010-02-12 2011-08-18 Beiersdorf AG, 20253 Wirkstoffkombinationen aus Acylarginaten und quaternären Ammoniumverbindungen
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DE102012219641A1 (de) * 2012-10-26 2014-04-30 Beiersdorf Ag Zweiphasen Produkt
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