EP2623206A1 - Centrifugeuse - Google Patents

Centrifugeuse Download PDF

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Publication number
EP2623206A1
EP2623206A1 EP12153515.7A EP12153515A EP2623206A1 EP 2623206 A1 EP2623206 A1 EP 2623206A1 EP 12153515 A EP12153515 A EP 12153515A EP 2623206 A1 EP2623206 A1 EP 2623206A1
Authority
EP
European Patent Office
Prior art keywords
sensor
medium
centrifuge
transponder
transmitting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12153515.7A
Other languages
German (de)
English (en)
Inventor
Michael Weigel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baumer Electric AG
Original Assignee
Baumer Electric AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baumer Electric AG filed Critical Baumer Electric AG
Priority to EP12153515.7A priority Critical patent/EP2623206A1/fr
Publication of EP2623206A1 publication Critical patent/EP2623206A1/fr
Withdrawn legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B13/00—Control arrangements specially designed for centrifuges; Program control of centrifuges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0414—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0414—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes
    • B04B5/0421—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes pivotably mounted

Definitions

  • the present invention relates to a centrifuge according to the preamble of claim 1 and a method for operating a centrifuge according to the preamble of claim 11.
  • centrifuges are used to separate media or mixtures. Due to centrifugal forces, media or mixtures with components of different density can be separated. Also in medical technology, z. As in medical diagnostics and for the recovery of blood components, centrifuges are used. In determining the hematocrit value, d. H. the volume fraction of erythrocytes in the blood, the centrifugation is used as a reference method. In addition, the red blood cells can also be separated from plasma residues in washing processes.
  • centrifuges or sedimentation centrifuges mixtures of components with different densities can be separated and separated into separate phases. To avoid an unnecessarily long centrifugation period, it is necessary to determine during the centrifuging the time when sufficient separation into the components has occurred.
  • the time duration for a specific mixture is determined empirically. Due to deviations in the composition of the mixture and different environmental conditions, eg. As temperature, the actual time may be subject to strong fluctuations, so that the empirically determined period of time with a sufficiently large Security surcharge is to be provided. This requires centrifugation for a long period of time. By way of derogation, centrifugation may be visually monitored by a person or may be checked by sampling to stop centrifugation if sufficiently separated. However, this is very complicated and expensive. Moreover, it is known with optical systems, for example the image recognition or a transmission spectrum, to recognize the layers or phases of the separation in a sample holder. However, such optical systems are technically complicated and expensive.
  • the DE 41 26 341 C1 shows a separation device for the separation of blood into its components in the context of an in vivo blood processing.
  • the hematocrit value of the supplied blood is determined photoelectrically or by means of conductivity measurement.
  • the GB 1 517 874 shows a continuous centrifuge for separation of blood.
  • the plasma content and the red and white blood cells are detected with conductivity.
  • the object of the present invention is to provide a centrifuge and a method for operating a centrifuge, in which the separation process of the medium can be detected easily and reliably with little technical effort.
  • a centrifuge in particular a sedimentation centrifuge, comprising a rotor with at least one separation space for receiving and separating a medium, wherein the separation space follows a rotational movement of the rotor, at least one sensor for detecting at least one physical property of the medium during the separation process, in which the at least one sensor is arranged in the separation space such that it is in direct contact with the medium during the separation process and means are provided for wirelessly transmitting the physical properties of the medium detected by the at least one sensor to a transmitting and receiving unit.
  • the at least one sensor is in direct contact with the medium during the separation process within the separation space, so that a technically very simple sensor for detecting physical properties of the medium can be used.
  • the wireless data transmission is much easier and cheaper than a data transmission with a data line due to the rotational movement of the at least one sensor.
  • the at least one separation space is delimited by a separation container, preferably a sample container or a test tube.
  • the at least one sensor can be arranged on the inside on a wall of the at least one separation container.
  • the at least one sensor may advantageously be arranged on a shell of a capsule within the at least one separation space.
  • the capsule is preferably designed to be freely movable in the separating space. The capsule itself can be made fluid-tight.
  • the centrifuge is a discontinuous centrifuge.
  • a continuous centrifuge there is generally at least one channel in the rotor as the separation space through which the medium is continuously passed.
  • the transmitting and receiving unit includes a Evaluation unit, wherein the evaluation unit preferably with a control unit and / or a power unit of Centrifuge communicates.
  • the evaluation unit may be formed inside or outside a housing and / or as a separate component to the rest of the centrifuge.
  • a chemical, in particular electrochemical, reaction can be detected with the at least one sensor.
  • the at least one physical property of the medium is an electrical conductivity, an impedance, a permittivity or a viscous and / or an elastic property of the medium.
  • the sensor may be designed as two electrodes, with which direct current is passed through the medium and thus the conductivity of the medium can be determined.
  • the at least one sensor is designed as a vibration generator and a vibration detector. With the vibration generator and the vibration detector viscous and / or elastic properties of the medium can be determined.
  • the physical properties of the medium detected by the at least one sensor are wireless, in particular with the means (10, 18) of a radio link or with an induction, from which at least one sensor can be transmitted to the transmitting and receiving unit.
  • the means for wireless transmission of the at least one detected physical property of the medium may advantageously comprise a transponder, which is in operative electrical connection with the at least one sensor, so that the physical properties of the medium detected by the at least one sensor from the sensor wirelessly transmittable to the transponder and from this to the transmitting and receiving unit and preferably from the transponder data from the transmitting and receiving unit can be received.
  • the transponder can preferably be designed passive transponder.
  • the transponder is generally connected to at least one data or power line with the at least one sensor.
  • the data acquired by the at least one sensor can be routed through the data or power line to the transponder, and then the data is routed wirelessly from the transponder to the evaluation unit.
  • the current conducted by the electrodes can be regarded as a date.
  • the data can be conducted in a particularly simple manner to a stationary evaluation unit on account of the rotating at least one sensor.
  • the evaluation unit which generally also functions as a control unit, can end the separation process from a predetermined threshold value of the data or a predetermined other criterion.
  • the transponder and / or the transmitting and receiving unit comprises an energy store and / or a microcontroller and preferably the centrifuge, in particular arranged on the rotor or separation container, comprises an antenna and the antenna is in operative connection, in particular in electrical connection, with the transponder.
  • the energy storage is z.
  • Microcontroller is a calculator and can evaluate signals or data.
  • control unit and / or the evaluation unit comprise a computer and preferably a data memory.
  • the transponder is arranged inside the capsule.
  • the sensor is in this case provided on the outside of the shell of the capsule. The capsule can thus be easily inserted into the separation tank.
  • the transponder and the transmitting and receiving unit may each comprise an antenna for the wireless transmission of data, wherein the antenna of the transmitting and receiving unit is preferably arranged on the rotor.
  • the centrifuge may be a centrifuge for separating blood.
  • the separation process can be stopped when a predetermined criterion, preferably a threshold value of at least one physical property of the medium detected by the at least one sensor, is reached.
  • the data is transmitted from the at least one sensor to a transponder, in particular with at least one electrical line, and the data is transmitted from the transponder to a transmitting and receiving unit wirelessly, preferably by means of a radio link or by means of induction received from the transponder data from the transmitting and receiving unit.
  • the transponder and preferably the sensor is supplied with power wirelessly. This is preferably done by the energy unit of the centrifuge.
  • the medium in particular blood
  • at least one separation vessel for example a sample vessel or test tube
  • the separation container is placed in a rotational movement, so that a centrifugal force is applied to the medium in the separation vessel and thereby the medium is separated into its components of different density.
  • a discontinuous centrifuge 1 is shown.
  • the centrifuge 1 can z. B. are used for separating blood.
  • a rotor 2 with a bearing, not shown, is set by a trained as an electric motor 5 motor 4 in a rotational movement.
  • the rotor 2 is mechanically connected to a shaft 3 with the electric motor 5.
  • On the rotor 2 a plurality of sample containers 15 designed as a separating container 14 are attached.
  • a wall 16 of the sample container 15 thus delimits a separation space 13.
  • blood 12 is stored as a medium 11 to be separated.
  • the electric motor 5 is fixed to a bottom plate 7 as a foot and the electric motor 5, the shaft 3, the rotor 2 and the sample container 15 are surrounded by a housing 6.
  • the housing 6 can be removed from the bottom plate 7.
  • the empty sample containers 15 with blood 12 must first be filled up or the already filled sample containers 15 inserted into the centrifuge. Subsequently, the electric motor 5 is turned on, d. H. the sample containers 15 are set in a rotational movement, so that a large centrifugal force acts on the blood 12.
  • the blood is in its components, eg. As plasma, hematocrit and an aqueous solution.
  • the components of the blood 12 have different physical properties.
  • an unseparated, mixed blood has different physical properties than the separated components of the blood.
  • FIGS. 2 and 3 a first embodiment of the sensors 8 and the sample container 15 is shown.
  • a transponder 10 is enveloped by a sleeve 19 of a capsule 20 fluid-tight.
  • the sheath 19 is made of a chemically inert material, such as glass.
  • the capsule 20 has the shape of an ellipsoid or a sphere (not shown).
  • four electrodes 9 are attached as sensors 8.
  • the electrodes 9 have on the outside a coating of a chemically intertem material, such as gold.
  • the electrodes 9 are electrically connected to data and power lines 17 to the transponder 10.
  • an evaluation unit 21 is arranged, which also functions as a transmitting and receiving unit 22, as a control unit 23 and as an energy unit 24.
  • the electrical energy for operating the transponder 10 and the electrodes 9 is transmitted to the transponder 10 by an electromagnetic field emitted by the transmitting and receiving unit 22 and the energy unit 24.
  • antennas 18 are included, which are in communication with the transponder 10. To adapt to different Measuring conditions, the transponder 10 single of the four electrodes 9 switch on and off.
  • the capsule 20 is inserted.
  • the electrical conductivity of the blood 12 can be measured as a physical property of the blood 12, since the electrodes 12 are in direct contact with the blood 12.
  • With the electrical conductivity of the hematocrit or the concentration of hematocrit in the blood 12 can be determined.
  • different layers or phases of the constituents of the blood 12 are formed in the separation space, whose dividing lines in Fig. 3 are indicated by dashed lines.
  • the detected by the electrodes 9 during the separation process electrical conductivity or impedance of the blood 12 is sent from the transponder 10 due to the voltage applied to the electrodes 9 and the current flowing through the electrodes 9 as a data signal to the transmitting and receiving unit 22.
  • the transmission of the data signal from the transponder 10 takes place with the antennas 18 by means of radio to the transmitting and receiving unit 22.
  • the evaluation unit 21 evaluates these data signals. From a predetermined threshold value of the electrical conductivity of the blood 12, the separation process is terminated by the control unit 23 of the centrifuge 1.
  • the threshold value is stored in the evaluation unit 21 and can be input and changed by means not shown input organs, such as buttons and a screen. In this case, the threshold value is entered so that the separation process is terminated with a sufficient separation of the constituents of the blood 12.
  • the control unit 23 is not in Fig. 1 shown power and control lines connected to the electric motor 5 and the electric motor 5 on and off and control the speed of the electric motor 5 and / or regulate.
  • a second embodiment of the transponder 10 and the sensors 9 is shown.
  • the transponder 10, the antenna 18 and the data and power lines 17 are inserted into the wall 16 of the separation vessel 14.
  • eight electrodes 5 are fixed, which are connected to the data and power lines 17 to the transponder 10.
  • the electrical conductivity of the blood 12 can also be detected in four different layers and phases of the blood 12 separated into its components.
  • different threshold values of the conductivity are stored or stored in the evaluation unit 21, and when one or more of the threshold values for the different layers is reached, the separation process is interrupted by the control unit.
  • the transmitting and receiving unit 22 is not stationary in the evaluation and control unit 21, 23 integrated, but is arranged on the rotor 2, so that the transmitting and receiving unit 22 carries out the rotational movement.
  • the transmitting and receiving unit 22 is provided with an energy store and the energy for the transmitting and receiving unit 22 is transmitted wirelessly, for example by means of radio or electrical induction, from the energy unit 24 to the transmitting and receiving unit 22.
  • the process progress of the separation process can be technically simple with an electrical conductivity measurement be determined during the separation process, so that it can be terminated with sufficient separation of the components of the blood 12 of the separation process. This unnecessarily long Zentrifugiervortician can be avoided.
  • the separation process can be detected reliably.

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  • External Artificial Organs (AREA)
  • Centrifugal Separators (AREA)
EP12153515.7A 2012-02-01 2012-02-01 Centrifugeuse Withdrawn EP2623206A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP12153515.7A EP2623206A1 (fr) 2012-02-01 2012-02-01 Centrifugeuse

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12153515.7A EP2623206A1 (fr) 2012-02-01 2012-02-01 Centrifugeuse

Publications (1)

Publication Number Publication Date
EP2623206A1 true EP2623206A1 (fr) 2013-08-07

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EP12153515.7A Withdrawn EP2623206A1 (fr) 2012-02-01 2012-02-01 Centrifugeuse

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EP (1) EP2623206A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3501660A1 (fr) * 2017-12-19 2019-06-26 Antonio Pinto Procédé et dispositif de séparation de substances par centrifugation
EP3560592A3 (fr) * 2018-03-28 2020-02-12 Sigma Laborzentrifugen GmbH Centrifuge de laboratoire, récipient centrifuge pour une centrifuge de laboratoire et procédé de fonctionnement d'un récipient centrifuge
WO2021148831A1 (fr) * 2020-01-23 2021-07-29 Total Se Rotor centrifuge pour centrifugation d'un échantillon, centrifugeuse associée et procédé de mesure
CN114728297A (zh) * 2019-08-09 2022-07-08 安德烈亚斯·海蒂诗两合公司 离心机
US12194478B2 (en) 2019-08-19 2025-01-14 Alfa Laval Corporate Ab Centrifugal separation system and method of operating a centrifugal separator

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004061633A1 (de) * 2004-12-17 2006-06-29 Lossau, Harald, Dr. Behälter mit Transponder
DE102006019642A1 (de) * 2005-04-28 2006-11-02 Martin Christ Gefriertrocknungsanlagen Gmbh Vorrichtung zur Konzentrierung von Lösungen
US20070173397A1 (en) * 2005-12-09 2007-07-26 Hinman Jeffrey M Biofuel centrifuge

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004061633A1 (de) * 2004-12-17 2006-06-29 Lossau, Harald, Dr. Behälter mit Transponder
DE102006019642A1 (de) * 2005-04-28 2006-11-02 Martin Christ Gefriertrocknungsanlagen Gmbh Vorrichtung zur Konzentrierung von Lösungen
US20070173397A1 (en) * 2005-12-09 2007-07-26 Hinman Jeffrey M Biofuel centrifuge

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3501660A1 (fr) * 2017-12-19 2019-06-26 Antonio Pinto Procédé et dispositif de séparation de substances par centrifugation
EP3560592A3 (fr) * 2018-03-28 2020-02-12 Sigma Laborzentrifugen GmbH Centrifuge de laboratoire, récipient centrifuge pour une centrifuge de laboratoire et procédé de fonctionnement d'un récipient centrifuge
EP3560592B1 (fr) 2018-03-28 2023-02-15 Sigma Laborzentrifugen GmbH Centrifuge de laboratoire, récipient centrifuge pour une centrifuge de laboratoire et procédé de fonctionnement d'un récipient centrifuge
CN114728297A (zh) * 2019-08-09 2022-07-08 安德烈亚斯·海蒂诗两合公司 离心机
CN114728297B (zh) * 2019-08-09 2023-11-03 安德烈亚斯·海蒂诗两合公司 离心机
US12194478B2 (en) 2019-08-19 2025-01-14 Alfa Laval Corporate Ab Centrifugal separation system and method of operating a centrifugal separator
WO2021148831A1 (fr) * 2020-01-23 2021-07-29 Total Se Rotor centrifuge pour centrifugation d'un échantillon, centrifugeuse associée et procédé de mesure
US12085492B2 (en) 2020-01-23 2024-09-10 Totalenergies Onetech Centrifuge rotor for centrifuging a sample, related centrifuge and measurement method

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