EP2714932A4 - In autismus dysregulierte gene als biomarker und ziele für therapeutische pfade - Google Patents

In autismus dysregulierte gene als biomarker und ziele für therapeutische pfade

Info

Publication number
EP2714932A4
EP2714932A4 EP12789082.0A EP12789082A EP2714932A4 EP 2714932 A4 EP2714932 A4 EP 2714932A4 EP 12789082 A EP12789082 A EP 12789082A EP 2714932 A4 EP2714932 A4 EP 2714932A4
Authority
EP
European Patent Office
Prior art keywords
degregated
autism
biomarkers
genes
targets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12789082.0A
Other languages
English (en)
French (fr)
Other versions
EP2714932A2 (de
Inventor
Daniel H Geschwind
Irina Voineagu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley
Publication of EP2714932A2 publication Critical patent/EP2714932A2/de
Publication of EP2714932A4 publication Critical patent/EP2714932A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP12789082.0A 2011-05-24 2012-05-24 In autismus dysregulierte gene als biomarker und ziele für therapeutische pfade Withdrawn EP2714932A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161489471P 2011-05-24 2011-05-24
PCT/US2012/039269 WO2012162460A2 (en) 2011-05-24 2012-05-24 Genes dysregulated in autism as biomarkers and targets for therapeutic pathways

Publications (2)

Publication Number Publication Date
EP2714932A2 EP2714932A2 (de) 2014-04-09
EP2714932A4 true EP2714932A4 (de) 2015-06-10

Family

ID=47218068

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12789082.0A Withdrawn EP2714932A4 (de) 2011-05-24 2012-05-24 In autismus dysregulierte gene als biomarker und ziele für therapeutische pfade

Country Status (3)

Country Link
US (1) US20140194310A1 (de)
EP (1) EP2714932A4 (de)
WO (1) WO2012162460A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3057493B1 (de) * 2013-10-20 2020-06-24 Massachusetts Institute Of Technology Verwendung einer korrelationsstruktur von sprachdynamik zum nachweis von neurologischen veränderungen
US12522871B2 (en) * 2018-07-12 2026-01-13 The Regents Of The University Of California Expression-based diagnosis, prognosis and treatment of complex diseases
EP3880801B1 (de) * 2018-11-13 2026-04-15 Memorial Sloan-Kettering Cancer Center Auf stammzellen basierende multiplexverfahren
WO2020198556A2 (en) * 2019-03-27 2020-10-01 Phoenix Tissue Repair, Inc. Systems and methods for producing collagen 7 compositions
AU2024244976A1 (en) * 2023-03-24 2025-09-25 Board Of Regents, The University Of Texas System Engineered natural killer cells with enhanced antitumor memory responses

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060257903A1 (en) * 2005-03-31 2006-11-16 Huda Akil Compositions and methods for diagnosing and treating neuropsychiatric disorders
WO2010056982A2 (en) * 2008-11-17 2010-05-20 The George Washington University Compositions and methods for identifying autism spectrum disorders
US20100125042A1 (en) * 2008-05-15 2010-05-20 The Regents Of The University Of California Peripheral gene expression biomarkers for autism
WO2011035249A2 (en) * 2009-09-18 2011-03-24 Bahou Wadie F Methods for detecting thrombocytosis using biomarkers

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
ES2264239T3 (es) 1990-06-27 2006-12-16 Princeton University Complejo de proteinas p53/p90'.
US5733731A (en) 1991-10-16 1998-03-31 Affymax Technologies N.V. Peptide library and screening method
CH686982A5 (fr) 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
US6228582B1 (en) 1997-06-17 2001-05-08 University Of Rochester Genetic polymorphisms which are associated with autism spectrum disorders
AU2003209127A1 (en) 2002-02-11 2003-09-04 Auburn University High-sensitivity real-time polymerase chain reaction for detection of nucleic acids
US7629123B2 (en) 2003-07-03 2009-12-08 University Of Medicine And Dentistry Of New Jersey Compositions and methods for diagnosing autism
AU2004267247B2 (en) 2003-08-22 2010-02-18 Integragen Human autism susceptibility gene and uses thereof
US20060051787A1 (en) 2004-06-28 2006-03-09 Hyesook Kim Quantitative PCR for analysis of DNA damage induced by PGHS-2 (COX-2) or other factors
US7587279B2 (en) 2004-07-06 2009-09-08 Genomic Health Method for quantitative PCR data analysis system (QDAS)
US7405044B2 (en) 2004-10-08 2008-07-29 Reliagene Technologies Inc. Multiplex PCR for simultaneous quantitation of human nuclear, mitochondrial, and male Y-chromosome DNA
CA2598081A1 (en) 2005-02-17 2006-08-24 Integragen Uses of human autism susceptibility gene encoding a kinase
US7835871B2 (en) 2007-01-26 2010-11-16 Illumina, Inc. Nucleic acid sequencing system and method
US20090117562A1 (en) * 2007-04-09 2009-05-07 Valerie Wailin Hu Method and kit for diagnosing Autism using gene expression profiling
US20100286143A1 (en) * 2009-04-24 2010-11-11 Dora Dias-Santagata Methods and materials for genetic analysis of tumors
US20130123124A1 (en) * 2010-03-12 2013-05-16 Children's Medical Center Corporation Methods and compositions for characterizing autism spectrum disorder based on gene expression patterns

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060257903A1 (en) * 2005-03-31 2006-11-16 Huda Akil Compositions and methods for diagnosing and treating neuropsychiatric disorders
US20100125042A1 (en) * 2008-05-15 2010-05-20 The Regents Of The University Of California Peripheral gene expression biomarkers for autism
WO2010056982A2 (en) * 2008-11-17 2010-05-20 The George Washington University Compositions and methods for identifying autism spectrum disorders
WO2011035249A2 (en) * 2009-09-18 2011-03-24 Bahou Wadie F Methods for detecting thrombocytosis using biomarkers

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
IRINA VOINEAGU ET AL: "Transcriptomic analysis of autistic brain reveals convergent molecular pathology - Supplementary figures", NATURE, 25 May 2011 (2011-05-25), pages 1 - 10, XP055160448 *
IRINA VOINEAGU ET AL: "Transcriptomic analysis of autistic brain reveals convergent molecular pathology - Supplementary tables", NATURE, 25 May 2011 (2011-05-25), pages 1 - 23, XP055160449 *
IRINA VOINEAGU ET AL: "Transcriptomic analysis of autistic brain reveals convergent molecular pathology", NATURE, vol. 474, no. 7351, 25 May 2011 (2011-05-25), pages 380 - 384, XP055038194, ISSN: 0028-0836, DOI: 10.1038/nature10110 *
S. E. SWANBERG ET AL: "Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism", HUMAN MOLECULAR GENETICS, vol. 18, no. 3, 7 November 2008 (2008-11-07), pages 525 - 534, XP055160444, ISSN: 0964-6906, DOI: 10.1093/hmg/ddn380 *
See also references of WO2012162460A2 *

Also Published As

Publication number Publication date
US20140194310A1 (en) 2014-07-10
WO2012162460A3 (en) 2013-07-04
WO2012162460A2 (en) 2012-11-29
EP2714932A2 (de) 2014-04-09

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