EP2855658A4 - Integriertes system zur echtzeitüberwachung mikrofluidischer reaktionen - Google Patents

Integriertes system zur echtzeitüberwachung mikrofluidischer reaktionen

Info

Publication number
EP2855658A4
EP2855658A4 EP13797711.2A EP13797711A EP2855658A4 EP 2855658 A4 EP2855658 A4 EP 2855658A4 EP 13797711 A EP13797711 A EP 13797711A EP 2855658 A4 EP2855658 A4 EP 2855658A4
Authority
EP
European Patent Office
Prior art keywords
real
time monitoring
integrated system
microfluidic reactions
microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP13797711.2A
Other languages
English (en)
French (fr)
Other versions
EP2855658A1 (de
Inventor
Jiang Zhu
Hongju Guo
Danyang Mei
Xiumei Song
Dong Wang
Jing Cheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tsinghua University
CapitalBio Technology Co Ltd
Original Assignee
Tsinghua University
CapitalBio Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tsinghua University, CapitalBio Corp filed Critical Tsinghua University
Publication of EP2855658A1 publication Critical patent/EP2855658A1/de
Publication of EP2855658A4 publication Critical patent/EP2855658A4/de
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP13797711.2A 2012-05-31 2013-05-31 Integriertes system zur echtzeitüberwachung mikrofluidischer reaktionen Pending EP2855658A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201210177086.6A CN102719357B (zh) 2012-05-31 2012-05-31 一种实时监控微阵列芯片分析过程的杂交系统
PCT/CN2013/000647 WO2013177953A1 (en) 2012-05-31 2013-05-31 Integrated system for real-time monitoring of microfluidic reactions

Publications (2)

Publication Number Publication Date
EP2855658A1 EP2855658A1 (de) 2015-04-08
EP2855658A4 true EP2855658A4 (de) 2016-02-24

Family

ID=46945234

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13797711.2A Pending EP2855658A4 (de) 2012-05-31 2013-05-31 Integriertes system zur echtzeitüberwachung mikrofluidischer reaktionen

Country Status (3)

Country Link
EP (1) EP2855658A4 (de)
CN (1) CN102719357B (de)
WO (1) WO2013177953A1 (de)

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CN102719357B (zh) * 2012-05-31 2014-07-09 博奥生物集团有限公司 一种实时监控微阵列芯片分析过程的杂交系统
CN104226384B (zh) * 2013-06-06 2015-12-02 博奥生物集团有限公司 液体导流装置
TWI513508B (zh) * 2013-09-06 2015-12-21 Ind Tech Res Inst 微流體檢測裝置
US9341639B2 (en) 2013-07-26 2016-05-17 Industrial Technology Research Institute Apparatus for microfluid detection
CN104437702B (zh) * 2014-11-21 2016-04-06 陈永欣 多通道过滤装置
CN105733936B (zh) * 2014-12-12 2017-11-17 深圳华大基因研究院 基因测序仪
US10519493B2 (en) 2015-06-22 2019-12-31 Fluxergy, Llc Apparatus and method for image analysis of a fluid sample undergoing a polymerase chain reaction (PCR)
US11371091B2 (en) 2015-06-22 2022-06-28 Fluxergy, Inc. Device for analyzing a fluid sample and use of test card with same
WO2016209731A1 (en) 2015-06-22 2016-12-29 Fluxergy, Llc Test card for assay and method of manufacturing same
CN105521841B (zh) * 2016-02-04 2017-06-23 龙岩市九健生物芯片有限公司 一种生物芯片杂交盒
WO2017216270A1 (de) 2016-06-15 2017-12-21 Grabmayr Heinrich Einzelmolekülnachweis bzw. -quantifizierung durch dna-nanotechnologie
CN208224274U (zh) * 2018-04-27 2018-12-11 广州万孚生物技术股份有限公司 一种微流控芯片及具有该微流控芯片的分析仪器
DE102018213026A1 (de) * 2018-08-03 2020-02-06 Robert Bosch Gmbh Verfahren zur Durchführung einer Echtzeit-PCR
CN110904274A (zh) * 2019-12-13 2020-03-24 福建工程学院 一种流控式的hpv基因分型芯片检测方法
EP4078151A4 (de) * 2019-12-17 2024-01-03 Applied Materials, Inc. System und verfahren zur erfassung und verarbeitung multiplexierter fluoreszenz-in-situ-hybridisierungsbilder
CN111397660B (zh) * 2020-04-03 2022-03-15 天津大学 一种多功能光子芯片检测系统
CN111504941B (zh) * 2020-05-14 2021-01-01 中国人民解放军陆军军医大学第一附属医院 一种无标记评估响应性水凝胶响应特征的太赫兹衰减全反射技术平台
CN111595633B (zh) * 2020-06-22 2025-07-08 海南核电有限公司 一种移动式油中微量水分监测装置及其监测方法
CN112175820B (zh) * 2020-10-10 2022-09-02 上海世艾生物科技有限公司 一种核酸提取和pcr一体化装置及其工作方法
KR20230127225A (ko) * 2020-12-31 2023-08-31 플럭서지 인크. 다중모드 시험 카드
CN116254374A (zh) * 2023-03-14 2023-06-13 广东凯普科技智造有限公司 一种杂交反应仪参数的调节方法及装置
CN120349856B (zh) * 2025-06-23 2025-10-17 杭州智灵龙生物科技有限公司 一种储压式样本制备装置及方法

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US7314718B1 (en) * 2001-04-03 2008-01-01 Bioarray Solutions Ltd. Method and apparatus for maintaining multiple planar fluid flows
US20110048951A1 (en) * 2007-06-27 2011-03-03 Digital Biosystems Digital microfluidics based apparatus for heat-exchanging chemical processes
US20110111968A1 (en) * 2008-06-25 2011-05-12 Real-Time Genomics, Llc Method and Apparatus for Melting Curve Analysis of Nucleic Acids in Microarray Format
US20120040470A1 (en) * 2009-04-09 2012-02-16 Bayer Technology Services Gmbh Single-use microfluidic test cartridge for the bioassay of analytes
US20140011707A1 (en) * 2011-03-22 2014-01-09 Tsinghua University Biological chip hybridization system

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CN1330154A (zh) * 2000-06-27 2002-01-09 南京益来基因医学有限公司 细胞微阵列芯片及其制备方法
CN2485313Y (zh) * 2001-06-21 2002-04-10 张家洵 多功能分子杂交仪
JP3691837B2 (ja) * 2002-08-16 2005-09-07 株式会社林創研 バイオチップ分析装置
CN1289904C (zh) * 2003-08-01 2006-12-13 博奥生物有限公司 一种微阵列反应装置及其应用
ES2284087T3 (es) * 2005-01-18 2007-11-01 F. Hoffmann-La Roche Ag Generacion de imagenes de señales de fluorescencia mediante opticas telecentricas de excitacion y de generacion de imagenes.
CN100417931C (zh) * 2005-04-06 2008-09-10 博奥生物有限公司 微阵列芯片检测系统
US7615758B2 (en) * 2005-06-02 2009-11-10 Capitalbio Corporation Laser confocal microarray scanner
CN101199197B (zh) * 2005-06-02 2010-08-11 博奥生物有限公司 一种微阵列扫描仪的扫描运动平台
CN101203790A (zh) * 2005-06-03 2008-06-18 博奥生物有限公司 一种微阵列芯片激光扫描仪光学系统
US7715001B2 (en) * 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
EP2023127B1 (de) * 2006-05-31 2017-12-20 Olympus Corporation Verfahren und vorrichtung zur abbildung einer biologischen probe
EP2017354A1 (de) * 2007-07-20 2009-01-21 Eppendorf Ag Erkennung und/oder Quantifizierung von Zielmolekülen auf einem festen Träger
CN100535644C (zh) * 2007-09-21 2009-09-02 博奥生物有限公司 一种微纳升体系流体芯片的检测系统及检测方法
CN102010817B (zh) * 2010-08-06 2013-05-22 博奥生物有限公司 一种微阵列芯片扫描仪的芯片自动装载装置
CN102206573B (zh) * 2011-03-22 2014-12-31 博奥生物有限公司 用于微阵列芯片的自动进样装置及自动进样杂交微阵列芯片
CN102719357B (zh) * 2012-05-31 2014-07-09 博奥生物集团有限公司 一种实时监控微阵列芯片分析过程的杂交系统

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7314718B1 (en) * 2001-04-03 2008-01-01 Bioarray Solutions Ltd. Method and apparatus for maintaining multiple planar fluid flows
US20110048951A1 (en) * 2007-06-27 2011-03-03 Digital Biosystems Digital microfluidics based apparatus for heat-exchanging chemical processes
US20110111968A1 (en) * 2008-06-25 2011-05-12 Real-Time Genomics, Llc Method and Apparatus for Melting Curve Analysis of Nucleic Acids in Microarray Format
US20120040470A1 (en) * 2009-04-09 2012-02-16 Bayer Technology Services Gmbh Single-use microfluidic test cartridge for the bioassay of analytes
US20140011707A1 (en) * 2011-03-22 2014-01-09 Tsinghua University Biological chip hybridization system

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MARTIN JENSEN SØE ET AL: "HistoFlex-a microfluidic device providing uniform flow conditions enabling highly sensitive, reproducible and quantitative in situ hybridizations", LAB ON A CHIP, vol. 11, no. 22, 1 January 2011 (2011-01-01), GB, pages 3896, XP055238751, ISSN: 1473-0197, DOI: 10.1039/c1lc20748b *
See also references of WO2013177953A1 *
TYRRELL E ET AL: "Development of a micro-fluidic manifold for copper monitoring utilising chemiluminescence detection", LAB ON A CHIP, ROYAL SOCIETY OF CHEMISTRY - CAMBRIDGE, GB, vol. 4, no. 4, 1 August 2004 (2004-08-01), pages 384 - 390, XP002584852, ISSN: 1473-0197, [retrieved on 20040426], DOI: 10.1039/B400805G *

Also Published As

Publication number Publication date
EP2855658A1 (de) 2015-04-08
WO2013177953A1 (en) 2013-12-05
CN102719357A (zh) 2012-10-10
CN102719357B (zh) 2014-07-09

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Owner name: TSINGHUA UNIVERSITY

Owner name: CAPITALBIO TECHNOLOGY CORPORATION