EP2931922A4 - Personalisierte biomarker für krebs - Google Patents

Personalisierte biomarker für krebs

Info

Publication number
EP2931922A4
EP2931922A4 EP13863107.2A EP13863107A EP2931922A4 EP 2931922 A4 EP2931922 A4 EP 2931922A4 EP 13863107 A EP13863107 A EP 13863107A EP 2931922 A4 EP2931922 A4 EP 2931922A4
Authority
EP
European Patent Office
Prior art keywords
biomarkers
custom
cancer
custom biomarkers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13863107.2A
Other languages
English (en)
French (fr)
Other versions
EP2931922B1 (de
EP2931922A1 (de
Inventor
Ekkehard Schütz
Julia Beck
Howard Urnovitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chronix Biomedical Inc
Original Assignee
Chronix Biomedical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chronix Biomedical Inc filed Critical Chronix Biomedical Inc
Priority to PL13863107T priority Critical patent/PL2931922T3/pl
Publication of EP2931922A1 publication Critical patent/EP2931922A1/de
Publication of EP2931922A4 publication Critical patent/EP2931922A4/de
Application granted granted Critical
Publication of EP2931922B1 publication Critical patent/EP2931922B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP13863107.2A 2012-12-14 2013-12-13 Personalisierte biomarker für krebs Active EP2931922B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL13863107T PL2931922T3 (pl) 2012-12-14 2013-12-13 Personalizowane biomarkery nowotworu

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261737626P 2012-12-14 2012-12-14
PCT/US2013/075015 WO2014093825A1 (en) 2012-12-14 2013-12-13 Personalized biomarkers for cancer

Publications (3)

Publication Number Publication Date
EP2931922A1 EP2931922A1 (de) 2015-10-21
EP2931922A4 true EP2931922A4 (de) 2016-07-27
EP2931922B1 EP2931922B1 (de) 2018-10-17

Family

ID=50934991

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13863107.2A Active EP2931922B1 (de) 2012-12-14 2013-12-13 Personalisierte biomarker für krebs

Country Status (5)

Country Link
US (1) US9909186B2 (de)
EP (1) EP2931922B1 (de)
ES (1) ES2703764T3 (de)
PL (1) PL2931922T3 (de)
WO (1) WO2014093825A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111254500B (zh) 2012-12-10 2024-01-23 分析生物科学有限公司 靶向基因组分析的方法
EP4414990A3 (de) 2013-01-17 2024-11-06 Personalis, Inc. Verfahren und systeme zur genetischen analyse
WO2015031689A1 (en) 2013-08-30 2015-03-05 Personalis, Inc. Methods and systems for genomic analysis
WO2015051275A1 (en) 2013-10-03 2015-04-09 Personalis, Inc. Methods for analyzing genotypes
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
JP7441584B6 (ja) * 2014-08-22 2024-03-15 レゾリューション バイオサイエンス， インコーポレイテッド 無細胞ＤＮＡ（ｃｆＤＮＡ）の定量的遺伝子解析のための方法
US10125399B2 (en) 2014-10-30 2018-11-13 Personalis, Inc. Methods for using mosaicism in nucleic acids sampled distal to their origin
WO2017066785A1 (en) * 2015-10-16 2017-04-20 The Regents Of The University Of California, A California Corporation Repetitive element (re)-based genome analysis and dynamic genetics surveillance systems
JP6913089B2 (ja) 2015-11-11 2021-08-04 レゾリューション バイオサイエンス， インコーポレイテッド Ｄｎａライブラリーの高効率構築
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
US11319594B2 (en) 2016-08-25 2022-05-03 Resolution Bioscience, Inc. Methods for the detection of genomic copy changes in DNA samples
EP3541950A4 (de) * 2016-11-16 2020-06-03 Progenity, Inc. Multimodaler test zum nachweis von nukleinsäureaberrationen
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US20210381035A1 (en) * 2019-02-15 2021-12-09 Takara Bio Usa, Inc. Methods of Preparing and Analyzing Nucleic Acid Libraries
CN109825583B (zh) * 2019-03-01 2021-08-17 清华大学 人重复元件dna甲基化作为肝癌早期诊断的标记物及其应用
JP7470787B2 (ja) 2019-11-05 2024-04-18 パーソナリス，インコーポレイティド 単一試料からの腫瘍純度の推定
WO2022046635A1 (en) * 2020-08-24 2022-03-03 Dana-Farber Cancer Institute, Inc. Enhanced sequencing following random dna ligation and repeat element amplification
WO2023059654A1 (en) 2021-10-05 2023-04-13 Personalis, Inc. Customized assays for personalized cancer monitoring
WO2025059176A1 (en) * 2023-09-15 2025-03-20 The Johns Hopkins University Assessing and treating cancer

Citations (1)

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Publication number Priority date Publication date Assignee Title
US5773649A (en) * 1996-06-10 1998-06-30 Centre De Recherche De L'hopital Sainte-Justine DNA markers to detect cancer cells expressing a mutator phenotype and method of diagnosis of cancer cells

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US5955589A (en) 1991-12-24 1999-09-21 Isis Pharmaceuticals Inc. Gapped 2' modified oligonucleotides
YU187991A (sh) 1990-12-11 1994-09-09 Hoechst Aktiengesellschaft 3-(2)-amino-ali tiol-modifikovani, s fluorescentnom bojom vezani nukleozidi, nukleotidi i oligonukleotidi, postupak za njihovo dobijanje i njihova upotreba
US5652099A (en) 1992-02-12 1997-07-29 Conrad; Michael J. Probes comprising fluorescent nucleosides and uses thereof
US5446137B1 (en) 1993-12-09 1998-10-06 Behringwerke Ag Oligonucleotides containing 4'-substituted nucleotides
DE4415370A1 (de) 1994-05-02 1995-11-09 Hoechst Ag Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
DE4438918A1 (de) 1994-11-04 1996-05-09 Hoechst Ag Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
EP0960210A4 (de) * 1996-10-04 2004-06-09 Chronix Biomedical Diagnostische nukleinsäure-detektion
EP0866071B1 (de) 1997-03-20 2004-10-20 F. Hoffmann-La Roche Ag Modifizierte Primer
USH2191H1 (en) * 2000-10-24 2007-06-05 Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
WO2007111937A1 (en) * 2006-03-23 2007-10-04 Applera Corporation Directed enrichment of genomic dna for high-throughput sequencing
WO2010117817A2 (en) * 2009-03-30 2010-10-14 Life Technologies Corporation Methods for generating target specific probes for solution based capture
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US5773649A (en) * 1996-06-10 1998-06-30 Centre De Recherche De L'hopital Sainte-Justine DNA markers to detect cancer cells expressing a mutator phenotype and method of diagnosis of cancer cells

Non-Patent Citations (5)

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Title
EIJI SUNAMI A ET AL: "Quantification of LINE1 in Circulating DNA as a Molecular Biomarker of Breast Cancer", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, US, 1 January 2008 (2008-01-01), pages 171 - 174, XP009123306, ISSN: 0077-8923, DOI: 10.1196/ANNALS.1448.011 *
I A KOZERETSKA ET AL: "MOBILE GENETIC ELEMENTS AND CANCER. FROM MUTATIONS TO GENE THERAPY Dedicated to Kyiv and Kyiv region clinical oncologists", EXPERIMENTAL ONCOLOGY, vol. 33, 1 December 2011 (2011-12-01), pages 198 - 205, XP055280341 *
PETER J CAMPBELL ET AL: "Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing", NATURE GENETICS, NATURE PUBLISHING GROUP, US, vol. 40, no. 6, 1 June 2008 (2008-06-01), pages 722 - 729, XP002622046, ISSN: 1546-1718, [retrieved on 20080427], DOI: 10.1038/NG.128 *
See also references of WO2014093825A1 *
WENSHENG ZHANG ET AL: "Alu distribution and mutation types of cancer genes", BMC GENOMICS, BIOMED CENTRAL LTD, LONDON, UK, vol. 12, no. 1, 23 March 2011 (2011-03-23), pages 157, XP021096395, ISSN: 1471-2164, DOI: 10.1186/1471-2164-12-157 *

Also Published As

Publication number Publication date
ES2703764T3 (es) 2019-03-12
EP2931922B1 (de) 2018-10-17
US20160053328A1 (en) 2016-02-25
PL2931922T3 (pl) 2019-04-30
US9909186B2 (en) 2018-03-06
EP2931922A1 (de) 2015-10-21
WO2014093825A1 (en) 2014-06-19

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