EP3083580A4 - Verfahren zur herstellung von trelagliptinsuccinat - Google Patents

Verfahren zur herstellung von trelagliptinsuccinat Download PDF

Info

Publication number
EP3083580A4
EP3083580A4 EP14871930.5A EP14871930A EP3083580A4 EP 3083580 A4 EP3083580 A4 EP 3083580A4 EP 14871930 A EP14871930 A EP 14871930A EP 3083580 A4 EP3083580 A4 EP 3083580A4
Authority
EP
European Patent Office
Prior art keywords
preparation
trelagliptin succinate
trelagliptin
succinate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14871930.5A
Other languages
English (en)
French (fr)
Other versions
EP3083580A1 (de
Inventor
Vijay Trimbak KADAM
Roshan Ramesh Medhane
Santosh Rambhau GAWALI
Harpreet Singh Minhas
Gurpreet Singh Minhas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harman Finochem Ltd
Original Assignee
Harman Finochem Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harman Finochem Ltd filed Critical Harman Finochem Ltd
Publication of EP3083580A1 publication Critical patent/EP3083580A1/de
Publication of EP3083580A4 publication Critical patent/EP3083580A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP14871930.5A 2013-12-18 2014-09-01 Verfahren zur herstellung von trelagliptinsuccinat Withdrawn EP3083580A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3964MU2013 2013-12-18
PCT/IN2014/000563 WO2015092805A1 (en) 2013-12-18 2014-09-01 A process for preparation of trelagliptin succinate

Publications (2)

Publication Number Publication Date
EP3083580A1 EP3083580A1 (de) 2016-10-26
EP3083580A4 true EP3083580A4 (de) 2017-06-28

Family

ID=53402222

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14871930.5A Withdrawn EP3083580A4 (de) 2013-12-18 2014-09-01 Verfahren zur herstellung von trelagliptinsuccinat

Country Status (2)

Country Link
EP (1) EP3083580A4 (de)
WO (1) WO2015092805A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105646447A (zh) * 2015-12-25 2016-06-08 北京康立生医药技术开发有限公司 一种二肽基肽酶抑制剂的合成方法
CN105541793B (zh) * 2016-01-04 2018-08-10 河北国龙制药有限公司 曲格列汀的合成方法
CN107434800A (zh) * 2016-05-27 2017-12-05 威海迪素制药有限公司 一种琥珀酸曲格列汀晶型a的制备方法
CN108822080A (zh) * 2018-08-31 2018-11-16 四川新斯顿制药股份有限公司 琥珀酸曲格列汀的制备方法
CN109734673A (zh) * 2019-02-27 2019-05-10 浙江华贝药业有限责任公司 一种化合物的纯化方法
CN109668988B (zh) * 2019-02-27 2021-07-02 浙江华贝药业有限责任公司 一种分析测定琥珀酸曲格列汀中2-(二溴甲基)-4-氟苯腈的方法
CN110483478B (zh) * 2019-08-15 2021-07-06 广东工业大学 一种结晶态曲格列汀及其制备方法和应用、曲格列汀琥珀酸盐晶体及其制备方法
CN115448887A (zh) * 2022-09-05 2022-12-09 河北国龙制药有限公司 一种琥珀酸曲格列汀中间体杂质及其制备方法和应用
CN116143754A (zh) * 2022-10-25 2023-05-23 浙江燎原药业有限公司 一种琥珀酸曲格列汀杂质化合物的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090275750A1 (en) * 2005-09-16 2009-11-05 Jun Feng Dipeptidyl peptidase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA013427B1 (ru) * 2004-03-15 2010-04-30 Такеда Фармасьютикал Компани Лимитед Ингибиторы дипептидилпептидазы
TW200838536A (en) * 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) * 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
CN103030631B (zh) * 2011-09-28 2014-12-10 正大天晴药业集团股份有限公司 用于制备嘧啶二酮类dpp-iv抑制剂的化合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090275750A1 (en) * 2005-09-16 2009-11-05 Jun Feng Dipeptidyl peptidase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2015092805A1 *

Also Published As

Publication number Publication date
WO2015092805A1 (en) 2015-06-25
EP3083580A1 (de) 2016-10-26

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