EP3083580A4 - Procédé de préparation de succinate de trélagliptine - Google Patents

Procédé de préparation de succinate de trélagliptine Download PDF

Info

Publication number
EP3083580A4
EP3083580A4 EP14871930.5A EP14871930A EP3083580A4 EP 3083580 A4 EP3083580 A4 EP 3083580A4 EP 14871930 A EP14871930 A EP 14871930A EP 3083580 A4 EP3083580 A4 EP 3083580A4
Authority
EP
European Patent Office
Prior art keywords
preparation
trelagliptin succinate
trelagliptin
succinate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14871930.5A
Other languages
German (de)
English (en)
Other versions
EP3083580A1 (fr
Inventor
Vijay Trimbak KADAM
Roshan Ramesh Medhane
Santosh Rambhau GAWALI
Harpreet Singh Minhas
Gurpreet Singh Minhas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harman Finochem Ltd
Original Assignee
Harman Finochem Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harman Finochem Ltd filed Critical Harman Finochem Ltd
Publication of EP3083580A1 publication Critical patent/EP3083580A1/fr
Publication of EP3083580A4 publication Critical patent/EP3083580A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP14871930.5A 2013-12-18 2014-09-01 Procédé de préparation de succinate de trélagliptine Withdrawn EP3083580A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3964MU2013 2013-12-18
PCT/IN2014/000563 WO2015092805A1 (fr) 2013-12-18 2014-09-01 Procédé de préparation de succinate de trélagliptine

Publications (2)

Publication Number Publication Date
EP3083580A1 EP3083580A1 (fr) 2016-10-26
EP3083580A4 true EP3083580A4 (fr) 2017-06-28

Family

ID=53402222

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14871930.5A Withdrawn EP3083580A4 (fr) 2013-12-18 2014-09-01 Procédé de préparation de succinate de trélagliptine

Country Status (2)

Country Link
EP (1) EP3083580A4 (fr)
WO (1) WO2015092805A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105646447A (zh) * 2015-12-25 2016-06-08 北京康立生医药技术开发有限公司 一种二肽基肽酶抑制剂的合成方法
CN105541793B (zh) * 2016-01-04 2018-08-10 河北国龙制药有限公司 曲格列汀的合成方法
CN107434800A (zh) * 2016-05-27 2017-12-05 威海迪素制药有限公司 一种琥珀酸曲格列汀晶型a的制备方法
CN108822080A (zh) * 2018-08-31 2018-11-16 四川新斯顿制药股份有限公司 琥珀酸曲格列汀的制备方法
CN109734673A (zh) * 2019-02-27 2019-05-10 浙江华贝药业有限责任公司 一种化合物的纯化方法
CN109668988B (zh) * 2019-02-27 2021-07-02 浙江华贝药业有限责任公司 一种分析测定琥珀酸曲格列汀中2-(二溴甲基)-4-氟苯腈的方法
CN110483478B (zh) * 2019-08-15 2021-07-06 广东工业大学 一种结晶态曲格列汀及其制备方法和应用、曲格列汀琥珀酸盐晶体及其制备方法
CN115448887A (zh) * 2022-09-05 2022-12-09 河北国龙制药有限公司 一种琥珀酸曲格列汀中间体杂质及其制备方法和应用
CN116143754A (zh) * 2022-10-25 2023-05-23 浙江燎原药业有限公司 一种琥珀酸曲格列汀杂质化合物的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090275750A1 (en) * 2005-09-16 2009-11-05 Jun Feng Dipeptidyl peptidase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA85871C2 (uk) * 2004-03-15 2009-03-10 Такеда Фармасьютікал Компані Лімітед Інгібітори дипептидилпептидази
TW200838536A (en) * 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) * 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
CN103030631B (zh) * 2011-09-28 2014-12-10 正大天晴药业集团股份有限公司 用于制备嘧啶二酮类dpp-iv抑制剂的化合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090275750A1 (en) * 2005-09-16 2009-11-05 Jun Feng Dipeptidyl peptidase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2015092805A1 *

Also Published As

Publication number Publication date
WO2015092805A1 (fr) 2015-06-25
EP3083580A1 (fr) 2016-10-26

Similar Documents

Publication Publication Date Title
EP3006568A4 (fr) Procédé de production de tagatose
EP3083580A4 (fr) Procédé de préparation de succinate de trélagliptine
EP3010883A4 (fr) Procédé pour la préparation de monomères à fonction guanidino
EP3055281A4 (fr) Préparation de dérivés d'hydroxy-benzylbenzène
PL3013801T3 (pl) Sposób stereoselektywnego wytwarzania pirazolo-karboksyamidu
GB2525949B (en) Process for the production of dialkyl succinate
GB2525950B (en) Process for the production of dialkyl succinate
EP3087475A4 (fr) Décompactage générique de binaires de programme
EP3019495A4 (fr) Procédé de préparation de fluoxastrobine
EP3045440A4 (fr) Procédé de préparation d'un benzène substitué par un groupe trichlorométhyle
EP3036211A4 (fr) Procédé de préparation d'isomères de xylène
EP3077525A4 (fr) Procédé de préparation d'ester de succinate
EP3080139A4 (fr) Procédé de préparation de régadénoson
EP3085232A4 (fr) Procédé de production de co-cristaux
EP3016935A4 (fr) Procédé pour la préparation d'intermédiaire de dolutégravir
EP3052616A4 (fr) Procédé de production d'exosomes
IL239697A0 (en) A process for preparing a derivative of fluorolactone
EP3039004A4 (fr) Procédé de préparation de cétone insaturée
EP3047028A4 (fr) Procédé de fermentation
EP3027622B8 (fr) Procede pour la preparation de oxymorphone
EP2835194A3 (fr) Procédé de support d'une pièce
EP3089959A4 (fr) Procédé de préparation d'éthanolamines
EP3089960A4 (fr) Procédé de production d'éthanolamines
EP3036227A4 (fr) Procédé pour préparer un composé
EP2786402B8 (fr) Procédé de fabrication mécanosynthétique

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20160701

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20170526

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 401/04 20060101AFI20170519BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20180103