EP3134102A4 - Superagonistes, agonistes et antagonistes partiels de l'interleukine-2 - Google Patents
Superagonistes, agonistes et antagonistes partiels de l'interleukine-2 Download PDFInfo
- Publication number
- EP3134102A4 EP3134102A4 EP15782644.7A EP15782644A EP3134102A4 EP 3134102 A4 EP3134102 A4 EP 3134102A4 EP 15782644 A EP15782644 A EP 15782644A EP 3134102 A4 EP3134102 A4 EP 3134102A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- superagonists
- interleukin
- antagonists
- partial agonists
- agonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461983973P | 2014-04-24 | 2014-04-24 | |
| PCT/US2015/027635 WO2015164815A1 (fr) | 2014-04-24 | 2015-04-24 | Superagonistes, agonistes et antagonistes partiels de l'interleukine-2 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP3134102A1 EP3134102A1 (fr) | 2017-03-01 |
| EP3134102A4 true EP3134102A4 (fr) | 2017-11-15 |
| EP3134102B1 EP3134102B1 (fr) | 2019-07-03 |
Family
ID=54333315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP15782644.7A Active EP3134102B1 (fr) | 2014-04-24 | 2015-04-24 | Superagonistes, agonistes et antagonistes partiels de l'interleukine-2 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US10150802B2 (fr) |
| EP (1) | EP3134102B1 (fr) |
| JP (4) | JP6592505B2 (fr) |
| CN (1) | CN106659757B (fr) |
| WO (1) | WO2015164815A1 (fr) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10696723B2 (en) | 2018-05-14 | 2020-06-30 | Werewolf Therapeutics, Inc. | Activatable interleukin 12 polypeptides |
| US10696724B2 (en) | 2018-05-14 | 2020-06-30 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides |
| US11739132B2 (en) | 2019-05-14 | 2023-08-29 | Werewolf Therapeutics, Inc. | Separation moieties and methods of use thereof |
| US12036266B2 (en) | 2019-11-14 | 2024-07-16 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9428567B2 (en) | 2010-12-22 | 2016-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Antagonists of interleukin-2 receptor |
| EP3640375A3 (fr) | 2012-12-11 | 2020-07-29 | Albert Einstein College of Medicine | Procédés pour identification de récepteur/ligand à rendement élevé |
| CN105722860A (zh) | 2013-09-24 | 2016-06-29 | 梅迪塞纳医疗股份有限公司 | 白介素-2融合蛋白及其应用 |
| WO2015164815A1 (fr) | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonistes, agonistes et antagonistes partiels de l'interleukine-2 |
| WO2016025385A1 (fr) | 2014-08-11 | 2016-02-18 | Delinia, Inc. | Variants d'il-2 modifiés qui activent sélectivement les cellules t régulatrices pour le traitement de maladies auto-immunes |
| WO2017096262A1 (fr) | 2015-12-04 | 2017-06-08 | Jomoco, Corp. | Compositions et procédés pour atténuer ou prévenir une réponse immunitaire à une molécule thérapeutique immunogène chez des primates non humains |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| WO2017165464A1 (fr) * | 2016-03-21 | 2017-09-28 | Elstar Therapeutics, Inc. | Molécules multispécifiques et multifonctionnelles et leurs utilisations |
| KR20190044029A (ko) | 2016-05-18 | 2019-04-29 | 알버트 아인슈타인 컬리지 오브 메디슨, 인크. | 변이체 pd-l1 폴리펩타이드, t-세포 조절 다량체 폴리펩타이드 및 이들의 사용 방법 |
| CA3019005A1 (fr) | 2016-05-18 | 2017-11-23 | Cue Biopharma, Inc. | Polypeptides multimeres modulateurs des lymphocytes t et leurs procede d'utilisation |
| KR102379464B1 (ko) | 2016-06-20 | 2022-03-29 | 키맵 리미티드 | 항-pd-l1 항체 |
| AU2017335771A1 (en) | 2016-09-28 | 2019-02-28 | Musc Foundation For Research Development | Antibodies that bind interleukin-2 and uses thereof |
| US11077172B2 (en) | 2016-11-08 | 2021-08-03 | Delinia, Inc. | IL-2 variants for the treatment of psoriasis |
| CN116970059A (zh) | 2016-12-22 | 2023-10-31 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
| US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| BR112019018915A2 (pt) | 2017-03-15 | 2020-04-14 | Pandion Therapeutics Inc | imunotolerância direcionada |
| IL269000B2 (en) | 2017-03-15 | 2024-06-01 | Cue Biopharma Inc | Methods for modulating an immune response |
| JP2020521452A (ja) | 2017-05-24 | 2020-07-27 | パンディオン・セラピューティクス・インコーポレイテッド | 標的化免疫寛容 |
| WO2019112852A1 (fr) * | 2017-12-06 | 2019-06-13 | Pandion Therapeutics, Inc. | Immunotolérance ciblée |
| AU2018287317B2 (en) * | 2017-06-19 | 2024-06-20 | Medicenna Therapeutics Inc. | Uses and methods for IL-2 superagonists, agonists, and fusions thereof |
| AU2018300069C1 (en) | 2017-07-11 | 2025-11-20 | Synthorx, Inc. | Incorporation of unnatural nucleotides and methods thereof |
| WO2019028419A1 (fr) | 2017-08-03 | 2019-02-07 | Synthorx, Inc. | Conjugués de cytokine destinés au traitement de maladies prolifératives et infectieuses |
| US20200299349A1 (en) * | 2017-11-21 | 2020-09-24 | The Board Of Trustees Of The Leland Stanford Junior University | Partial agonists of interleukin-2 |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| EP3737692A4 (fr) | 2018-01-09 | 2021-09-29 | Elstar Therapeutics, Inc. | Constructions de liaison à la calréticuline et lymphocytes t modifiés pour le traitement de maladies |
| WO2019139896A1 (fr) | 2018-01-09 | 2019-07-18 | Cue Biopharma, Inc. | Polypeptides multimères modulateurs de lymphocytes t et leurs procédés d'utilisation |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| EP3768698B1 (fr) | 2018-03-19 | 2025-02-12 | MultiVir Inc. | Procédés et compositions comprenant une thérapie génique suppressive de tumeur et des agonistes de cd122/cd132 pour le traitement du cancer |
| JP7637415B2 (ja) * | 2018-06-22 | 2025-02-28 | キュージーン インコーポレイテッド | インターロイキン－２バリアントおよびその使用方法 |
| EP3810640A1 (fr) | 2018-06-25 | 2021-04-28 | University of Washington | Conception de novo de mimétiques d'interleukine puissants et sélectifs |
| EP3818083A2 (fr) | 2018-07-03 | 2021-05-12 | Elstar Therapeutics, Inc. | Molécules d'anticorps anti-tcr et leurs utilisations |
| MX2021000801A (es) * | 2018-07-24 | 2021-04-12 | BioNTech SE | Agonistas de il2. |
| MX2021001493A (es) | 2018-08-06 | 2021-07-15 | Medikine Inc | Compuestos de fijación al receptor de il-2. |
| HRP20240016T1 (hr) * | 2018-09-11 | 2024-03-29 | Ambrx, Inc. | Konjugati polipeptida interleukina-2 i njihove uporabe |
| WO2020057646A1 (fr) | 2018-09-21 | 2020-03-26 | 信达生物制药(苏州)有限公司 | Nouvelle interleukine 2 et utilisation associée |
| EP3854805A4 (fr) | 2018-09-21 | 2022-08-24 | Innovent Biologics (Suzhou) Co., Ltd. | Nouvelle interleukine 2 et son utilisation |
| EP3883956A1 (fr) * | 2018-11-20 | 2021-09-29 | University of Washington | Mimétiques d'interleukine divisés et leur utilisation |
| KR20260039812A (ko) | 2019-02-06 | 2026-03-20 | 신톡스, 인크. | Il-2 콘쥬게이트 및 이의 사용 방법 |
| JP7710373B2 (ja) | 2019-02-21 | 2025-07-18 | マレンゴ・セラピューティクス，インコーポレーテッド | Ｔ細胞関連のがん細胞に結合する多機能性分子およびその使用 |
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| US10696723B2 (en) | 2018-05-14 | 2020-06-30 | Werewolf Therapeutics, Inc. | Activatable interleukin 12 polypeptides |
| US10696724B2 (en) | 2018-05-14 | 2020-06-30 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides |
| US11352403B2 (en) | 2018-05-14 | 2022-06-07 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
| US11453710B2 (en) | 2018-05-14 | 2022-09-27 | Werewolf Therapeutics, Inc. | Activatable interleukin 12 polypeptides and methods of use thereof |
| US11535658B2 (en) | 2018-05-14 | 2022-12-27 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
| US11981716B2 (en) | 2018-05-14 | 2024-05-14 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
| US12275769B2 (en) | 2018-05-14 | 2025-04-15 | Werewolf Therapeutics, Inc. | Activatable interleukin 12 polypeptides and methods of use thereof |
| US12534505B2 (en) | 2018-05-14 | 2026-01-27 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
| US11739132B2 (en) | 2019-05-14 | 2023-08-29 | Werewolf Therapeutics, Inc. | Separation moieties and methods of use thereof |
| US12036266B2 (en) | 2019-11-14 | 2024-07-16 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| US12076371B2 (en) | 2019-11-14 | 2024-09-03 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2020023506A (ja) | 2020-02-13 |
| JP2024113005A (ja) | 2024-08-21 |
| JP2022046693A (ja) | 2022-03-23 |
| JP7307919B2 (ja) | 2023-07-13 |
| US12202873B2 (en) | 2025-01-21 |
| US10150802B2 (en) | 2018-12-11 |
| CN106659757B (zh) | 2022-01-28 |
| JP7729570B2 (ja) | 2025-08-26 |
| EP3134102A1 (fr) | 2017-03-01 |
| CN106659757A (zh) | 2017-05-10 |
| US20190119346A1 (en) | 2019-04-25 |
| WO2015164815A1 (fr) | 2015-10-29 |
| US11384131B2 (en) | 2022-07-12 |
| JP7503794B2 (ja) | 2024-06-21 |
| US20210079055A1 (en) | 2021-03-18 |
| JP6592505B2 (ja) | 2019-10-16 |
| CN106659757A8 (zh) | 2017-07-07 |
| US20230002467A1 (en) | 2023-01-05 |
| EP3134102B1 (fr) | 2019-07-03 |
| CA2946398A1 (fr) | 2015-10-29 |
| US10654905B2 (en) | 2020-05-19 |
| JP2017518361A (ja) | 2017-07-06 |
| US20170044229A1 (en) | 2017-02-16 |
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