EP3139818A2 - Capteur de pression sanguine - Google Patents

Capteur de pression sanguine

Info

Publication number
EP3139818A2
EP3139818A2 EP15723833.8A EP15723833A EP3139818A2 EP 3139818 A2 EP3139818 A2 EP 3139818A2 EP 15723833 A EP15723833 A EP 15723833A EP 3139818 A2 EP3139818 A2 EP 3139818A2
Authority
EP
European Patent Office
Prior art keywords
sensor
blood pressure
data
physiological parameter
sensors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15723833.8A
Other languages
German (de)
English (en)
Inventor
Hans Ehm
Dirk Hammerschmidt
Kristina VAUPEL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Infineon Technologies AG
Original Assignee
Infineon Technologies AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infineon Technologies AG filed Critical Infineon Technologies AG
Publication of EP3139818A2 publication Critical patent/EP3139818A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/0024—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system for multiple sensor units attached to the patient, e.g. using a body or personal area network
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0031—Implanted circuitry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6876—Blood vessel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/40—Animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0204—Operational features of power management
    • A61B2560/0209—Operational features of power management adapted for power saving
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0204—Operational features of power management
    • A61B2560/0214—Operational features of power management of power generation or supply
    • A61B2560/0219—Operational features of power management of power generation or supply of externally powered implanted units

Definitions

  • Sensor devices and a method and system for monitoring physiological parameters.
  • the description refers to the monitoring of the
  • the present description proposes a system
  • a method and apparatus for measuring at least one vital parameter such as blood pressure according to any one of the independent claims. Further examples and
  • the device comprises a sensor device for detecting the at least one physiological parameter, a
  • Memory device for the electronic storage of data in connection with the at least one physiological
  • Transmission device is inductive with an external
  • Fig. 1 shows how a measuring device of the present
  • Fig. 2 shows the points at which a blood pressure sensor can be advantageously arranged on a heart or a blood vessel close to the heart;
  • FIG. 3 shows a measuring device of the description in more detail
  • Fig. 4 shows a block diagram of a measuring device
  • FIGS. 5a and b show a system for using the
  • Measuring device in a cage Measuring device in a cage.
  • the present disclosure discloses a measuring device for measuring or determining a
  • the physiological parameter may be blood pressure. Additionally or alternatively, other physiological parameters such as body temperature, heart rate, blood glucose, volume change, pH and other physiological parameters may be measured.
  • the measuring device comprises a
  • Sensor device with e.g. a pressure sensor, which
  • the sensor device can be implanted and placed in or on a bloodstream.
  • the sensor device can be arranged inside or outside on a vessel wall or in the heart.
  • the description relates to a system for determining the at least one physiological parameter.
  • Fig. 1 shows an example of how a measuring device of the present description can be used.
  • Measuring device comprises a carrier unit 30. Die
  • Carrier unit for example, a housing, a
  • Carrier film a PCB (printed circuit board) or the like which is attached to the back of a mouse 1 preferably under the skin and / or subcutaneously and is carried by the latter without hindrance or restriction in freedom of movement.
  • the carrier or the housing could also be fastened to the mouse in the form of a backpack or a stomach bandage.
  • various electronic components are arranged, as described below.
  • Carrier device 30 a sensor device 20 is connected to an electrical cable 23.
  • the electrical cable 23 may be a microwire and may also be made of the material of the carrier film.
  • the sensor device 20 of FIG. 1 comprises one or more blood pressure sensors and is implanted in a bloodstream of the mouse 1.
  • FIG. 2 shows a heart 2 in which the locations at which the sensor device 20 can be arranged or implanted in a particularly favorable manner are marked with crosses.
  • the sensor device 20 can be arranged in the left ventricle or at the aorta to allow a particularly reliable and accurate determination of the blood pressure.
  • the exact location can also be chosen by the implanting person depending on the situation and requirement, eg in the carotid artery. It is also possible to arrange a plurality of blood pressure sensors or mutually different sensor devices at different locations in or on the heart 2 or on different vessels.
  • the blood pressure or another physiological parameter can be determined not only at one point, but also differences or distributions, such as, for example Blood pressure differences or distributions at single or multiple sites, independently, in groups or in groups.
  • a blood pressure sensor on the aorta and another blood pressure sensor on the vena cava can be arranged and / or arranged at different points of the heart.
  • Each of the sensor devices 20 or each blood pressure sensor can then be connected to the carrier device 30 via a separate flexible microcable 23.
  • the attachment or anchoring of the sensor device 20 to the blood vessel can take place, for example, via a tissue adhesive or another adhesive which is known and available per se. It is also possible to anchor or sewn the sensor device 20 in tissue pockets. It is possible to combine several of these mounting options. It is also possible to have one sensor, several sensors, several sensors, several sensors, several adhesives, etc.
  • FIG. 3 shows schematically a measuring device 3 of a
  • Sensor device 20 is, as also shown in FIG. 1, connected to carrier device 30 via flexible microcable 23.
  • carrier device 30 is a
  • Transmission device with a transponder 40 and a resonator in the form of a coil 50 is arranged as an antenna.
  • the transponder 40 may be designed for NFC (near field communication) or for another wireless transmission technology.
  • the coil 50 may, for example, be printed on a flexible film.
  • an energy storage 60 is also arranged, which has a
  • the energy storage 60 may be in the form of a battery and may be configured as a primary or secondary battery.
  • a secondary battery may be charged by a current induced in coil 50.
  • a battery in a flat design e.g. a silicon battery of similar thickness as the ICs used.
  • the battery 60 may also be integrated in the foil of the coil 50.
  • the transponder 40 and the battery 60 disposed on the coil 50 for example, provided with a protective layer to attach directly to the mouse 1 or to implant under her coat.
  • the sensor unit 20 can be so from the space requirements
  • FIG. 4 shows a block diagram of the measuring device 3.
  • the measuring device comprises a sensor device with four sensors 200, 201, 202, 203.
  • a temperature sensor 201 an ECG (electrocardiograph) probe can be provided 202 and an electrical stimulator 203 may be provided as an example, which are collectively referred to as sensors 200, 201, 202, 203 here.
  • sensors 200, 201, 202, 203 are just examples and other sensors can be used depending on the situation. Non-exhaustive examples include pH sensors, ion-specific sensors, blood glucose sensors, expansion or volume sensors, resistance measuring devices or other biosensors. It is also possible to connect several blood pressure sensors to determine the blood pressure in different places or a combination of blood pressure and other sensors.
  • a network or array of sensors For example, a network or array of sensors
  • an array of heart-mounted sensors can detect failures or sub-functions of certain regions of the heart, thereby detecting heart attacks or spikes in ventricular fibrillation. It is also possible to attach an array of sensors to different parts of the body and so on
  • All sensors may be blood pressure sensors or a combination of
  • sensors In addition to sensors can also use actuators
  • Drug delivery devices drug delivery devices, stimulators or
  • Defibrillators can be arranged individually or in arrays. These can be controlled analogously to the sensors or via a separate control.
  • the sensors 200, 201, 202, 203 can be arranged at different locations on the mouse.
  • the temperature sensor 201 may, for example, with the
  • Blood pressure sensor 200 in one unit or on one
  • the temperature sensor 201 can also be arranged at another location, for example at the transponder 40.
  • the electronics of the sensors can also be partially or completely integrated in the same chip as the transponder 40.
  • each of the sensors 200, 201, 202, 203 is assigned a data processing or sensor control 210, 211, 212, 213, which controls the respective sensor and possibly processes the signals detected by the sensor for further processing.
  • the sensors 200, 201, 202, 203 and the data conditioning or sensor controllers 210, 211, 212, 213 are above respective ones
  • Ports 280, 281, 282, 283 are connected to a sample interface 820.
  • the sample interface 820 may be part of the
  • Sensor device 20 is connected to a processor 800.
  • the sample interface 820 can also be integrated in the processor 800, which controls the measurements and, if necessary, processes the measured data, for example compressed.
  • the processor 800 is connected to a data memory 700, which stores the data in the
  • the data memory 700 may be a RAM or flash memory.
  • 212, 213 may also be constructed as a grid, array or network, wherein sensors 200, 201, 202, 203 may be arranged at different locations in and / or on the body, for example.
  • Each data processing or sensor controllers 210, 211, 212, 213 can have an interface and communicate directly or via the processor 800 with sensor controllers 210, 211, 212, 213 of other sensors.
  • a first sensor after measuring a certain value, the measurement at other locations or the measurement request other parameters or activate actuators.
  • the grid or network can consist of sensors of the same type
  • a system monitor 610 with, for example, a voltage regulator, an energy and / or
  • Time control and a control processor be provided. With the wake-up timer or the time control can be provided.
  • system monitor with the wake-up timer activates the sensors, the processor, and the data memory at the predetermined times or intervals, and the measurement is initiated and remains active until the measured data is stored in the memory 700.
  • the energy management or the time control are constantly supplied with energy. All other units are switched on or off according to need and operating condition. Possible operating states include
  • a need can be, for example, measuring, compressing
  • the transponder 400 and the antenna 500 are not or only for certain aspects
  • the transponder 400 can be supplied with power when the antenna 500 is within range of a near field reader 90.
  • a voltage can be inductively coupled, which the
  • the transponder remains passive in contrast, as long as it is not powered via the antenna 500 with power or a voltage and is activated only by the coupled voltage. This has the advantage that the battery is not for the
  • Position of the mouse can be performed and the battery life and thus the total measurement time can be significantly increased and / or the battery can be made correspondingly smaller and thus lighter, to restrict the animal less.
  • the transponder can also be used to
  • the near-field reader 90 can be designed not only for reading the data, but also as a transceiver for transmitting data.
  • the energy management or wake-up function can be reconfigured and other measurement intervals or times or other control sequences programmed and set.
  • One or more parameters for the sensors and / or the measurements can also be reconfigured.
  • the inductively coupled voltage / or. the inductively injected current may also be used to charge the battery 600 if it is a rechargeable
  • FIG. 5a shows the arrangement of the carrier device 30 with transponder 40, antenna 50 and battery 60 on the mouse 1.
  • FIG. 5b shows the mouse 1 with the carrier device 30 of the measuring device in a cage 8, wherein the
  • Carrier device 30 can also be wrapped, packaged or executed as a housing. This can be a laboratory cage, as is customary for the keeping of laboratory mice.
  • a feeding point and / or watering 9 is arranged, on which the mouse 1 can drink or eat, as is common also in laboratory cages.
  • the near field reader 90 is arranged. If the mouse with the measuring device and thus with the antenna 50 for eating or drinking and thus within reach of the near field reader 90, a data transmission to and from the transponder 40 is activated via the near field reader 90 and the measured data and stored Data is transferred. At the same time, if desired, the measuring device can be reconfigured or programmed, allowing bidirectional exchange of data between the near field reader 90 and the transponder.
  • the near-field reader 90 supplies the transponder 40 with power inductively and thus serves the power supply for the
  • a usual residence time of the mouse 1 at the feeding place and / or drinking trough 9 is sufficient for the data transmission without more out. However, this time may be too short to charge the battery efficiently. It can therefore be provided for charging a separate charging device 7G. This can be provided for example in the vicinity of the sleep bib, so that the charging process can be done during sleep. Furthermore, it is possible to attach the loading device 70 to one of the inner cage walls or to the upper cage lid. Furthermore, the loading device can protrude into the cage or swing on the lid. Also, it is possible the
  • the entire system hardly or not at all affects the mouse, since no cable connections are required.
  • the mouse can move undisturbed.
  • each measuring device 3 or even each sensor unit 20 can have a unique identification
  • assign in the form of an ID code which is transmitted in the data transmission.
  • This ID code can already be written into a chip during production.
  • the identification code can also be readably attached to a housing of the carrier device from the outside. This allows the animals to be identified simultaneously by visual inspection.
  • Animals can also be used with wildlife.
  • Reading device is brought.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Pulmonology (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

L'invention concerne un système destiné à la surveillance d'au moins un paramètre physiologique. Le système comprend un dispositif de mesure, constitué d'un ensemble capteur (20) destiné à acquérir ledit au moins un paramètre physiologique et d'un dispositif de transmission (40, 50; 400, 500), et un dispositif de lecture (90) pour la réception de données en rapport avec ledit au moins un paramètre physiologique. Le dispositif de transmission est activé lorsque le dispositif de mesure se trouve dans la portée du dispositif de lecture (90).
EP15723833.8A 2014-05-08 2015-05-07 Capteur de pression sanguine Withdrawn EP3139818A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102014006726.2A DE102014006726A1 (de) 2014-05-08 2014-05-08 Blutdrucksensor
PCT/EP2015/000928 WO2015169444A2 (fr) 2014-05-08 2015-05-07 Capteur de pression sanguine

Publications (1)

Publication Number Publication Date
EP3139818A2 true EP3139818A2 (fr) 2017-03-15

Family

ID=53199922

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15723833.8A Withdrawn EP3139818A2 (fr) 2014-05-08 2015-05-07 Capteur de pression sanguine

Country Status (4)

Country Link
US (1) US20170164843A1 (fr)
EP (1) EP3139818A2 (fr)
DE (1) DE102014006726A1 (fr)
WO (1) WO2015169444A2 (fr)

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CN112304366A (zh) * 2020-10-19 2021-02-02 上海飞域实验室设备有限公司 一种实验室环境监测系统及其监测方法
US11786133B2 (en) 2020-12-18 2023-10-17 Movano Inc. System for monitoring a health parameter of a person utilizing a pulse wave signal
US11883134B2 (en) 2020-12-18 2024-01-30 Movano Inc. System for monitoring a physiological parameter in a person that involves coherently combining data generated from an RF-based sensor system
US11832919B2 (en) 2020-12-18 2023-12-05 Movano Inc. Method for generating training data for use in monitoring the blood pressure of a person that utilizes a pulse wave signal generated from radio frequency scanning
US12121336B2 (en) 2020-12-18 2024-10-22 Movano Inc. Method for monitoring a physiological parameter in a person that involves coherently combining data generated from an RF-based sensor system
US11864861B2 (en) 2020-12-18 2024-01-09 Movano Inc. Method for monitoring a physiological parameter in a person that involves spectral agility
MX2024005504A (es) * 2021-11-11 2024-05-23 Hills Pet Nutrition Inc Sistemas y metodos para determinar el movimiento o la ubicacion del animal.

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Also Published As

Publication number Publication date
DE102014006726A1 (de) 2015-11-12
WO2015169444A2 (fr) 2015-11-12
WO2015169444A3 (fr) 2015-12-30
US20170164843A1 (en) 2017-06-15

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