EP3146455A4 - Signatures moléculaires pour distinguer des rejets de greffe hépatique ou des lésions hépatiques - Google Patents

Signatures moléculaires pour distinguer des rejets de greffe hépatique ou des lésions hépatiques Download PDF

Info

Publication number
EP3146455A4
EP3146455A4 EP15795453.8A EP15795453A EP3146455A4 EP 3146455 A4 EP3146455 A4 EP 3146455A4 EP 15795453 A EP15795453 A EP 15795453A EP 3146455 A4 EP3146455 A4 EP 3146455A4
Authority
EP
European Patent Office
Prior art keywords
injuries
liver transplant
molecular signatures
transplant rejections
distinguishing liver
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP15795453.8A
Other languages
German (de)
English (en)
Other versions
EP3146455A2 (fr
Inventor
Daniel R. Salomon
Josh LEVITSKY
Sunil KURIAN
Michael Abecassis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Northwestern University
Original Assignee
Scripps Research Institute
Northwestern University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2014/054735 external-priority patent/WO2015035367A1/fr
Application filed by Scripps Research Institute, Northwestern University filed Critical Scripps Research Institute
Priority to EP20193129.2A priority Critical patent/EP3825418A3/fr
Publication of EP3146455A2 publication Critical patent/EP3146455A2/fr
Publication of EP3146455A4 publication Critical patent/EP3146455A4/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP15795453.8A 2014-05-22 2015-05-22 Signatures moléculaires pour distinguer des rejets de greffe hépatique ou des lésions hépatiques Ceased EP3146455A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20193129.2A EP3825418A3 (fr) 2014-05-22 2015-05-22 Signatures moléculaires pour distinguer des rejets de greffe hépatique ou des lésions hépatiques

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462001889P 2014-05-22 2014-05-22
US201462001909P 2014-05-22 2014-05-22
US201462001902P 2014-05-22 2014-05-22
US201462029038P 2014-07-25 2014-07-25
PCT/US2014/054735 WO2015035367A1 (fr) 2013-09-09 2014-09-09 Méthodes et systèmes permettant l'analyse d'une transplantation d'organes
US14/481,167 US20150167085A1 (en) 2013-09-09 2014-09-09 Methods and Systems for Analysis of Organ Transplantation
PCT/US2015/032191 WO2015179771A2 (fr) 2014-05-22 2015-05-22 Signatures moléculaires pour distinguer des rejets de greffe hépatique ou des lésions hépatiques

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP20193129.2A Division EP3825418A3 (fr) 2014-05-22 2015-05-22 Signatures moléculaires pour distinguer des rejets de greffe hépatique ou des lésions hépatiques

Publications (2)

Publication Number Publication Date
EP3146455A2 EP3146455A2 (fr) 2017-03-29
EP3146455A4 true EP3146455A4 (fr) 2018-05-02

Family

ID=54554839

Family Applications (2)

Application Number Title Priority Date Filing Date
EP15795453.8A Ceased EP3146455A4 (fr) 2014-05-22 2015-05-22 Signatures moléculaires pour distinguer des rejets de greffe hépatique ou des lésions hépatiques
EP20193129.2A Pending EP3825418A3 (fr) 2014-05-22 2015-05-22 Signatures moléculaires pour distinguer des rejets de greffe hépatique ou des lésions hépatiques

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP20193129.2A Pending EP3825418A3 (fr) 2014-05-22 2015-05-22 Signatures moléculaires pour distinguer des rejets de greffe hépatique ou des lésions hépatiques

Country Status (6)

Country Link
EP (2) EP3146455A4 (fr)
CN (1) CN106661628A (fr)
AU (2) AU2015263998A1 (fr)
CA (2) CA2949959A1 (fr)
GB (1) GB2538006A (fr)
WO (1) WO2015179771A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
DE102020205364B4 (de) * 2020-04-28 2022-01-20 Universität Rostock Verfahren zur Überwachung des Verlaufs einer Kardiomyozyten-Transplantation und Methode zur Bestimmung, ob ein Proband für einer Kardiomyozyten-Transplantation geeignet ist

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010083121A1 (fr) * 2009-01-15 2010-07-22 The Board Of Trustees Of The Leland Stanford Junior University Panel de biomarqueurs pour le diagnostic et la prédiction d'un rejet de greffon

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1063603A (en) 1907-08-01 1913-06-03 Gen Electric Governing mechanism for turbines.
US5028535A (en) 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
US5939272A (en) 1989-01-10 1999-08-17 Biosite Diagnostics Incorporated Non-competitive threshold ligand-receptor assays
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5922615A (en) 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
CA2072758A1 (fr) 1990-09-14 1992-03-15 Kenneth Francis Buechler Anticorps liant aux complexes de recepteurs de ligands et de ligands et leur utilite dans les tests ligand-recepteur
CA2107894C (fr) 1991-04-10 2003-10-14 Kenneth F. Buechler Subtances inhibitrices
EP0579767B1 (fr) 1991-04-11 2000-08-23 Biosite Diagnostics Inc. Nouveaux conjugues et dosages destines a la detection simultanee de ligands multiples
US6143576A (en) 1992-05-21 2000-11-07 Biosite Diagnostics, Inc. Non-porous diagnostic devices for the controlled movement of reagents
US5458852A (en) 1992-05-21 1995-10-17 Biosite Diagnostics, Inc. Diagnostic devices for the controlled movement of reagents without membranes
US6019944A (en) 1992-05-21 2000-02-01 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US5824799A (en) 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
WO1997027317A1 (fr) 1996-01-23 1997-07-31 Affymetrix, Inc. Evaluation rapide de difference d'abondance d'acides nucleiques, avec un systeme d'oligonucleotides haute densite
US6113855A (en) 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
US5947124A (en) 1997-03-11 1999-09-07 Biosite Diagnostics Incorporated Diagnostic for determining the time of a heart attack
US5863736A (en) 1997-05-23 1999-01-26 Becton, Dickinson And Company Method, apparatus and computer program products for determining quantities of nucleic acid sequences in samples
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US20040126767A1 (en) 2002-12-27 2004-07-01 Biosite Incorporated Method and system for disease detection using marker combinations
DE10238922A1 (de) * 2002-08-22 2004-03-04 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Immunmarker zur Diagnostik und Therapie im Zusammenhang mit Transplantat-Reaktionen
JP2006526140A (ja) 2002-12-24 2006-11-16 バイオサイト インコーポレイテッド 鑑別診断のためのマーカーおよびその使用方法
GB0419728D0 (en) * 2004-09-06 2004-10-06 Novartis Ag Organic compounds
GB0607943D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Biomarkers for chronic transplant dysfunction
US20110143953A1 (en) 2006-10-16 2011-06-16 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Synthetic Antibodies
US20110189680A1 (en) * 2008-05-30 2011-08-04 The University Of British Columbia Methods of Diagnosing Rejection of a Kidney Allograft Using Genomic or Proteomic Expression Profiling
EP2131200A1 (fr) * 2008-06-04 2009-12-09 BRAHMS Aktiengesellschaft Marqueur pour le rejet de greffe et la mortalité
WO2011006119A2 (fr) * 2009-07-09 2011-01-13 The Scripps Research Institute Profils d'expression génique associés à une néphropathie chronique de l'allogreffe
WO2011119980A1 (fr) * 2010-03-25 2011-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biomarqueurs protéiques et génétiques pour le rejet de greffes d'organes
GB201009798D0 (en) * 2010-06-11 2010-07-21 Immunovia Ab Method,array and use thereof
CN102854305B (zh) * 2011-12-23 2013-08-07 中国人民解放军第三〇九医院 移植肾排斥反应预警试剂盒及其使用方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010083121A1 (fr) * 2009-01-15 2010-07-22 The Board Of Trustees Of The Leland Stanford Junior University Panel de biomarqueurs pour le diagnostic et la prédiction d'un rejet de greffon

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
OMAR MASSOUD ET AL: "Noninvasive diagnosis of acute cellular rejection in liver transplant recipients: A proteomic signature validated by enzyme-linked immunosorbent assay", LIVER TRANSPLANTATION, vol. 17, no. 6, June 2011 (2011-06-01), US, pages 723 - 732, XP055429735, ISSN: 1527-6465, DOI: 10.1002/lt.22266 *
RICARDO GEHRAU ET AL: "Molecular Pathways Differentiate Hepatitis C Virus (HCV) Recurrence from Acute Cellular Rejection in HCV Liver Recipients", MOLECULAR MEDICINE, vol. 17, no. 7-8, 2011, WASHINGTON, DC; US, pages 1, XP055429673, ISSN: 1076-1551, DOI: 10.2119/molmed.2011.00072 *
V. DEFAMIE ET AL: "Gene Expression Profiling of Human Liver Transplants Identifies an Early Transcriptional Signature Associated with Initial Poor Graft Function", AMERICAN JOURNAL OF TRANSPLANTATION, vol. 8, no. 6, June 2008 (2008-06-01), DK, pages 1221 - 1236, XP055429716, ISSN: 1600-6135, DOI: 10.1111/j.1600-6143.2008.02249.x *
WAQAR R. R. FARID ET AL: "Hepatocyte-derived microRNAs as serum biomarkers of hepatic injury and rejection after liver transplantation", LIVER TRANSPLANTATION, vol. 18, no. 3, March 2012 (2012-03-01), US, pages 290 - 297, XP055429767, ISSN: 1527-6465, DOI: 10.1002/lt.22438 *

Also Published As

Publication number Publication date
CA2949959A1 (fr) 2015-11-26
AU2021221905A1 (en) 2021-09-23
EP3146455A2 (fr) 2017-03-29
CN106661628A (zh) 2017-05-10
AU2015263998A1 (en) 2016-12-08
WO2015179771A2 (fr) 2015-11-26
AU2021221905B2 (en) 2024-06-27
WO2015179771A3 (fr) 2016-01-14
CA3297753A1 (en) 2026-03-02
EP3825418A3 (fr) 2021-09-15
GB2538006A (en) 2016-11-02
EP3825418A2 (fr) 2021-05-26
GB201609984D0 (en) 2016-07-20

Similar Documents

Publication Publication Date Title
EP3689984B8 (fr) Encres moléculaires
EP3162853A4 (fr) Composition de résine de copolycarbonate
EP3187548A4 (fr) Composition de résine
EP3162818A4 (fr) Résine méthacrylique ou composition de résine méthacrylique
EP3211989A4 (fr) Procédés améliorés de sélection moléculaire
EP3135727A4 (fr) Composition de résine de polycarbonate
EP3120314A4 (fr) Tableau de bord de plateforme
EP3202796A4 (fr) Composition de résine durcissable
EP3130627A4 (fr) Composition de résine de polyamide
EP3106493A4 (fr) Composition de résine de polycarbonate
EP3231684A4 (fr) Véhicule ferroviaire
EP3170870A4 (fr) Composition de résine absorbant l'oxygène
EP3152579A4 (fr) Mammographie moléculaire
EP3159371A4 (fr) Composition de résine renforcée de fibres
EP3122568B8 (fr) Livret de sécurité
EP3112423A4 (fr) Composition de résine
EP3146077A4 (fr) Signatures moléculaires de tissu de rejets de transplantation hépatique
EP3106494A4 (fr) Composition de résine durcissable
GB201401854D0 (en) Molecular recognition
EP3113876A4 (fr) Système d'addition ou d'injection temporaire
EP3135315A4 (fr) Polymère stratifié
EP3123752A4 (fr) Identification de livres basée sur la localisation
GB2538589B (en) Molecular motor
EP3210794A4 (fr) Article polymère multicouches, comme un document d'identité
EP3208311A4 (fr) Composition de résine polymère

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20161124

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: C12Q 1/68 20180101AFI20171219BHEP

Ipc: G01N 33/68 20060101ALI20171219BHEP

Ipc: G01N 33/53 20060101ALI20171219BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20180405

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 33/68 20060101ALI20180329BHEP

Ipc: C12Q 1/68 20060101AFI20180329BHEP

Ipc: G01N 33/53 20060101ALI20180329BHEP

17Q First examination report despatched

Effective date: 20190502

REG Reference to a national code

Ref country code: DE

Ref legal event code: R003

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20201023