EP3217809A1 - Procédé de fabrication d'un comprimé effervescent, d'une poudre effervescente ou de granulés effervescents exempts d'ions sodium et à teneur élevée en ions x, x pouvant représenter diverses substances - Google Patents

Procédé de fabrication d'un comprimé effervescent, d'une poudre effervescente ou de granulés effervescents exempts d'ions sodium et à teneur élevée en ions x, x pouvant représenter diverses substances

Info

Publication number
EP3217809A1
EP3217809A1 EP15820259.8A EP15820259A EP3217809A1 EP 3217809 A1 EP3217809 A1 EP 3217809A1 EP 15820259 A EP15820259 A EP 15820259A EP 3217809 A1 EP3217809 A1 EP 3217809A1
Authority
EP
European Patent Office
Prior art keywords
carbonate
effervescent
acid
powder
ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP15820259.8A
Other languages
German (de)
English (en)
Inventor
Hanspeter Strobel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biofar Laboratoires
Original Assignee
Biofar Laboratoires
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biofar Laboratoires filed Critical Biofar Laboratoires
Priority to EP24218693.0A priority Critical patent/EP4516115A3/fr
Publication of EP3217809A1 publication Critical patent/EP3217809A1/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/40—Effervescence-generating compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • This invention relates to a process for preparing a sodium ion-free effervescent tablet or effervescent powder or granules as a supplier of optionally calcium, magnesium, potassium or a mixture of these substances, said effervescent tablet or effervescent powder or granules rapidly and should be completely soluble in water.
  • Nutrient fortification of food products may include additives that are conducive to the overall health of the human body.
  • nutrient enhancement include the addition of vitamins, minerals and similar materials. These additives are either absolutely necessary for human metabolism or they promote the supply of substances that are not available in sufficient quantities in a normal diet.
  • U.S. Patent 5,834,045 discloses calcium fortified acidic beverages. This patent reports that the use of a calcium source containing calcium hydroxide and calcium glycerophosphate with an acidifying agent gives a beverage product with a marked improvement in shelf life.
  • U.S. Patent 5,855,936 (January 5, 1999) describes a mixture of Caicium salts in equilibrium with soluble and insoluble salts stabilized with a source of glucuronic acid. This composition can enhance milk drinks and other milk-based products without coagulation and sedimentation and with improved palatability. The calcium salts must be stabilized with the glucuronic acid source. Other calcium sources could optionally be included. Other calcium fortified beverages are described, for example, in U.S.
  • Patent 4,642,238 (February 10, 1987, Dietetic and Nutritionally Balanced Drinks); U.S. Patent 4,701,329 (October 20, 1987, Milk); U.S. Patent 4,737,375 (April 12, 1988, carbonated and non-carbonated beverages with solubilized calcium and specific amounts.
  • effervescent tablets for supplying calcium as a supplement for the needs of the human and animal body.
  • These calcium effervescent tablets have been known for many decades, but they always use sodium ion (HST) to ensure solubility in water.
  • HST sodium ion
  • Sodium has the negative effect of increasing blood pressure because it retains water in the blood, which can be critical in older people with slower digestion and increases the risk of stroke or thrombosis.
  • the effervescent tablets should therefore not contain any sodium ion or sodium bicarbonate.
  • calcium ion effervescent tablets are administered in calcium deficiency and vitamin D deficiency or also used to combat urinary stones, such as kidney stones, bladder stones or ureteral stones, ie deposits of urinary salts and to solve.
  • a typical composition of such an effervescent tablet contains, for example, with respect to calcium and sodium ion:
  • Object of this invention is to provide a method, as an X lon effervescent tablet or such effervescent powder or granules can be prepared without sodium bicarbonate, and still in water by showering quickly and completely solvable, as well as against this background specify the necessary ingredients of effervescent tablet or effervescent powder.
  • X should be used in particular calcium for the production of calcium-lon effervescent tablets (CaCo3), but the method should also be feasible with magnesium or potassium or a mixture of these substances instead of calcium or X.
  • composition of an effervescent tablet calcium carbonate as the main component serves the following composition:
  • Calcium carbonate is actually nothing more than marble, which is present as a very fine powder. And this powder does not dissolve in the water practically, namely only 0.014 grams of calcium carbonate can be dissolved in one liter of water. With CO2 bubbles in the water but can dissolve up to 16.6 grams of calcium carbonate in one liter of water. It is therefore important to first generate the gas CO2 in the water. And for this purpose, for example, potassium bicarbonate can be used outstandingly, because in small quantities potassium hydrogen carbonate is considered as a food additive and can therefore be safely used for this purpose.
  • calcium carbonate also magnesium carbonate, magnesium bicarbonate, potassium carbonate and potassium bicarbonate either alone or mixtures thereof with calcium carbonate produce the same effects
  • calcium carbonate also magnesium carbonate, magnesium bicarbonate, potassium carbonate and potassium bicarbonate either alone or mixtures thereof with calcium carbonate produce the same effects
  • lactobion to roar and thus and to generate CO2.
  • the resulting CO2 then causes a significant improvement in the water solubility of the calcium carbonate, namely up to 16.6 grams per liter of water.
  • the lactobionate ion ensures a better solubility of the calcium ions.
  • potassium bicarbonate is used in conjunction with the lactobionic acid as a starter for the solubility process for the calcium carbonate.
  • the calcium ion effervescent tablets (CaCo3) thus produced are used for mineral fortification of food and beverage products. They form a stable, pure-tasting Caicium provoke, which is suitable for the Caiciumverstärkung very different food and beverage products. If other substances occur instead of calcium, such as magnesium or potassium or mixtures of all these substances, then further supplements for the body are made available.
  • Lactobionic acid is generally a white crystalline powder. Lactobionic acid can be obtained commercially (e.g., Fairlawn, N.J., Sigma, St. Louis, MO) or prepared by chemical or enzymatic oxidation of lactose or a lactose-containing substrate. The lactobionic acid can be prepared by chemical saccharide oxidation or bioconversion processes (for example, catalytic action of a carbohydrate oxidase enzyme) using lactose or a lactose-containing substrate (for example, whey or whey permeate) as a starting material. In principle, lactobionic acid is a by-product of the dairy industry.
  • Suitable carbohydrate oxidase enzymes are, for example, lactose oxidase, glucose oxidase, hexose oxidase and the like, as well as mixtures thereof. In general, lactose oxidase is preferred. A particularly suitable enzyme for lactose oxidation was developed by Novozymes NS and is described in WO 99/31990.
  • the inventive method allows the production of effervescent tablets or effervescent granules, which not only have excellent storage stability, but also in their quality are always consistent, since the reproducibility of the process is ensured by controlling a number of reaction parameters at any time.
  • the process for producing effervescent tablets or processable effervescent granules is carried out by heat treatment at 30 ° C. to 100 ° C. from acid and bicarbonate and / or carbonate together with the granulating liquid as essential effervescing constituents.
  • the pulverulent or granular mixture is treated in a closed system in a partial vacuum, wherein the acid (a metered amount of up to 7% by mass, based on the mass of the mixture, lactobionic acid) with the necessary amount of bicarbonate and / or carbonate is mixed and then added to this mixture with a polar solvent such as water, alcohol, methanol, or mixtures thereof and granulated.
  • a polar solvent such as water, alcohol, methanol, or mixtures thereof and granulated.
  • the pressure in the vacuum vessel initially increases, up to max. 1000 mbar (atmospheric pressure). From the pressure difference to the initial value of, for example, 10 mbar in a vacuum vessel, the volume and mass of the released CO2 can be determined.
  • the heat treatment in each case after the rapid vacuum drying of the mixture can be repeated until it indicates the end of the surface roughening by significant slowing down of the reaction or reduced evolution of gas.
  • the aggregates obtained are then comminuted to a desired particle size, optionally provided with the desired additives and then tableted by means of a tablet press to effervescent tablets.
  • the temperature at which the process of the invention is carried out is not critical and is best between 40 and 80 ° C.
  • the initial partial vacuum may have a pressure of, for example, 10 mbar.
  • the polar solvent is preferably water used in an amount of 0.2 to 2% by mass based on the weight of the mixture to be treated.
  • the released amount of CO2 is determined, one can determine in the course of simple stoichiometric calculations how much bicarbonate is consumed or how much salt was formed with the lactobionic acid. It is now possible by suitable parameters such as the stirring speed, the amount of moisture used, for example, water and alcohol, to determine the grain size of the lactobionic acid used, and how much lactobionic acid has been converted at the surface thereof to the acid salt.
  • the free space between the mass and the contents of the vessel will be about 50 l. If the vessel has been evacuated before the reaction, then this 50 l free space will be virtually gas-free. If a quantity of moisture is allowed to flow into the mass with simultaneous stirring, then the corresponding carbon dioxide will fill the supernatant space of 50 liters. This filling of the room can be easily checked with a good gauge. Thus, if the initial partial vacuum has reached 10 mbar and the pressure in the vacuum vessel has risen to atmospheric pressure, for example, then this means that about 50 l of carbon dioxide have been generated.
  • the contact surfaces of the reactants form a buffer zone, which are formed by various alkali or alkaline earth metal salts of the corresponding acid.
  • these buffer zones will be formed depending on the surface of the individual crystals and the reactivity.
  • the reaction time is about 4 min.
  • the treated material is dried and vacuum-treated, repeated under the same conditions and using 300 ml of water.
  • the pressure in the vacuum vessel is then allowed to rise again to 1000 mbar, corresponding to a volume of 50 liters or a mass of 81 grams of CO2. Due to the partial flushing of the surface layer by the lactobionic acid achieved in the first treatment, the reaction time is much longer this time and is about 10 to 30 minutes.
  • the treated material is again dried and subjected to a third vacuum treatment, wherein only a slight increase in pressure is measured because the lactobionic acid is used up, so that essentially no more CO2 production takes place.
  • the surface of the acid crystals is largely roughened or has been passivated, meaning that no further reaction takes place.
  • the product is then dried and the resulting agglomerates can be comminuted to the desired particle size and can be added with the desired additives such as flavorings, vitamins, sweeteners and the like.
  • an acid is added in a conventional manner, preferably citric acid, but other acids such as malic acid, succinic acid, fumaric acid, tartaric acid or ascorbic acid as well as mixtures of these acids function.
  • this effervescent granulate can be pressed into effervescent tablets in a known manner by means of tablet presses.
  • the product obtained in this way has an excellent shelf life over long periods even at tropical temperatures.
  • the showering is accelerated by the described pretreatment by means of lactobionic acid and deeply effective, because all powder particles are "burred", the means they offer a much larger surface for later reaction with the added acid, for example citric acid, as soon as the effervescent tablet comes into contact with water.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un procédé de fabrication d'une poudre effervescente, de granulés effervescents ou de comprimés effervescents de X-carbonate ou d'hydrocarbonate exempts d'ions sodium. Les substances actives X, au moins du carbonate de calcium, humidifiées avec une faible quantité d'alcool et d'eau, sont mélangées sous forme de poudre avec une faible quantité d'acide lactobionique dans une enceinte à vide avec pompage constant pour maintenir un vide partiel. Le sel de calcium (CaCO3) du calcium dans la couche superficielle des particules de poudre réagit ainsi avec l'acide lactobionique, entre en effervescence et dégage une faible quantité de CO2. Il s'ensuit une augmentation de la pression dans l'enceinte à vide et, à la fin de la réaction d'effervescence, la pression interne dans l'enceinte à vide redescend à la valeur initiale sous l'effet du pompage constant. Il en résulte un dessèchement de la poudre. À la sortie du pot à vide, un acide, de préférence de l'acide citrique est ajouté comme agent d'effervescence, puis la poudre est éventuellement transformée en comprimés par compression. Le comprimé effervescent de carbonate de calcium exempt d'ions sodium ainsi obtenu contient donc au moins du carbonate de calcium et de l'acide citrique comme agent d'effervescence, les particules comprimées étant amenées à l'effervescence au moyen de l'acide lactobionique dans leur couche superficielle.
EP15820259.8A 2014-11-12 2015-11-12 Procédé de fabrication d'un comprimé effervescent, d'une poudre effervescente ou de granulés effervescents exempts d'ions sodium et à teneur élevée en ions x, x pouvant représenter diverses substances Ceased EP3217809A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP24218693.0A EP4516115A3 (fr) 2014-11-12 2015-11-12 Procédé de fabrication d'un comprimé effervescent exempt d'ions sodium ou d'une telle poudre ou granulé effervescent à haute teneur en x-ion, où x peut être différentes substances

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH01758/14A CH710361B1 (de) 2014-11-12 2014-11-12 Natrium-Ion-freie Brausetablette oder Brausepulver mit hohem Calcium-Ion-Gehalt (CaCO3).
PCT/IB2015/058756 WO2016075655A1 (fr) 2014-11-12 2015-11-12 Procédé de fabrication d'un comprimé effervescent, d'une poudre effervescente ou de granulés effervescents exempts d'ions sodium et à teneur élevée en ions x, x pouvant représenter diverses substances

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP24218693.0A Division EP4516115A3 (fr) 2014-11-12 2015-11-12 Procédé de fabrication d'un comprimé effervescent exempt d'ions sodium ou d'une telle poudre ou granulé effervescent à haute teneur en x-ion, où x peut être différentes substances

Publications (1)

Publication Number Publication Date
EP3217809A1 true EP3217809A1 (fr) 2017-09-20

Family

ID=55069915

Family Applications (2)

Application Number Title Priority Date Filing Date
EP15820259.8A Ceased EP3217809A1 (fr) 2014-11-12 2015-11-12 Procédé de fabrication d'un comprimé effervescent, d'une poudre effervescente ou de granulés effervescents exempts d'ions sodium et à teneur élevée en ions x, x pouvant représenter diverses substances
EP24218693.0A Pending EP4516115A3 (fr) 2014-11-12 2015-11-12 Procédé de fabrication d'un comprimé effervescent exempt d'ions sodium ou d'une telle poudre ou granulé effervescent à haute teneur en x-ion, où x peut être différentes substances

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP24218693.0A Pending EP4516115A3 (fr) 2014-11-12 2015-11-12 Procédé de fabrication d'un comprimé effervescent exempt d'ions sodium ou d'une telle poudre ou granulé effervescent à haute teneur en x-ion, où x peut être différentes substances

Country Status (4)

Country Link
US (1) US10485754B2 (fr)
EP (2) EP3217809A1 (fr)
CH (1) CH710361B1 (fr)
WO (1) WO2016075655A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH710361B1 (de) * 2014-11-12 2018-12-28 Laboratoires Biofar Sarl Natrium-Ion-freie Brausetablette oder Brausepulver mit hohem Calcium-Ion-Gehalt (CaCO3).
CN111517519A (zh) * 2020-05-08 2020-08-11 欣格瑞（山东）环境科技有限公司 一种柠檬酸清洗废液的处理方法
EP4115741B1 (fr) * 2021-11-16 2024-09-25 Pompadour Ibérica S.A. Boisson pour infusion dans un liquide froid à effervescence contrôlée

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0948961A2 (fr) * 1998-03-31 1999-10-13 HERMES Fabrik pharmazeutischer Präparate Franz Gradinger GmbH & Co. Comprimé effervescent comprenant du calcium avec un antihistaminique comme principe actif
US10485754B2 (en) * 2014-11-12 2019-11-26 Biofar Laboratories Method for the production of a sodium ion-free effervescent tablet, powder or granulate having a high X ion content, where X can be a variety of substances

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3165572D1 (en) * 1981-10-06 1984-09-20 Gergely Gerhard Process for manufacturing effervescent granules which may be transformed, when required, into effervescent tablets
FR2552308B1 (fr) * 1983-09-28 1991-07-05 Gergely Gerhard Melange effervescent convenant en particulier pour des comprimes effervescents, comprimes effervescents prepares a l'aide de ce melange et procede pour sa preparation
US4678661A (en) * 1983-09-28 1987-07-07 Gerhard Gergely Effervescent composition and method of making same
US4737375A (en) 1985-12-26 1988-04-12 The Procter & Gamble Company Beverages and beverage concentrates nutritionally supplemented with calcium
US4642238A (en) 1986-02-03 1987-02-10 Ralston Purina Company Process for the production of a mineral fortified protein composition
US4701329A (en) 1986-02-10 1987-10-20 Borden, Inc. Calcium-fortified milk
US4784871A (en) 1986-04-29 1988-11-15 Marigold Foods, Inc. Method for producing calcium fortified yogurt
HU217125B (hu) * 1993-03-10 1999-11-29 Béres Rt. Cukor- és nátriummentes pezsgőtabletta és -granulátum és eljárás azok előállítására
US5449523A (en) 1993-04-20 1995-09-12 The Ohio State University Research Foundation Process for the manufacture of a calcium fortified yogurt with improved heat stability
US5478587A (en) 1993-08-20 1995-12-26 Henry G. Kohlmann Dessert composition
RU2153330C2 (ru) * 1993-09-09 2000-07-27 Гергели Герхард Шипучий гранулят и способ его получения
US5500232A (en) 1994-10-06 1996-03-19 Bristol-Myers Squibb Company Calcium fortified beverages
US5855936A (en) 1997-03-21 1999-01-05 Nestec S.A. Food fortification
US5820903A (en) 1997-06-30 1998-10-13 General Mills, Inc. Calcium fortified yogurt and methods of preparation
DE69829878T2 (de) 1997-12-22 2006-03-02 Novozymes A/S Kohlenhydratoxidase sowie verwendung derselben beim backen
US20040170724A1 (en) * 2003-02-28 2004-09-02 Kraft Foods Holdings, Inc. Mineral complexes of lactobionic acid and method of using for mineral fortification of food products

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0948961A2 (fr) * 1998-03-31 1999-10-13 HERMES Fabrik pharmazeutischer Präparate Franz Gradinger GmbH & Co. Comprimé effervescent comprenant du calcium avec un antihistaminique comme principe actif
US10485754B2 (en) * 2014-11-12 2019-11-26 Biofar Laboratories Method for the production of a sodium ion-free effervescent tablet, powder or granulate having a high X ion content, where X can be a variety of substances

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2016075655A1 *

Also Published As

Publication number Publication date
EP4516115A3 (fr) 2025-05-28
US20170319471A1 (en) 2017-11-09
US10485754B2 (en) 2019-11-26
CH710361A2 (de) 2016-05-13
WO2016075655A1 (fr) 2016-05-19
CH710361B1 (de) 2018-12-28
EP4516115A2 (fr) 2025-03-05

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