EP3334820A4 - Cellules souches pluripotentes étendues et induites, procédés de fabrication et d'utilisation - Google Patents

Cellules souches pluripotentes étendues et induites, procédés de fabrication et d'utilisation Download PDF

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Publication number
EP3334820A4
EP3334820A4 EP16834685.6A EP16834685A EP3334820A4 EP 3334820 A4 EP3334820 A4 EP 3334820A4 EP 16834685 A EP16834685 A EP 16834685A EP 3334820 A4 EP3334820 A4 EP 3334820A4
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EP
European Patent Office
Prior art keywords
making
methods
stem cells
pluripotent stem
extended pluripotent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16834685.6A
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German (de)
English (en)
Other versions
EP3334820A1 (fr
EP3334820B1 (fr
EP3334820C0 (fr
Inventor
Hongkui Deng
Yang Yang
Bei LIU
Jun Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hong Guan Ltd
Peking University
Beihao Stem Cell and Regenerative Medicine Research Institute Co Ltd
Original Assignee
Hong Guan Ltd
Peking University
Beihao Stem Cell and Regenerative Medicine Research Institute Co Ltd
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Publication of EP3334820A1 publication Critical patent/EP3334820A1/fr
Publication of EP3334820A4 publication Critical patent/EP3334820A4/fr
Application granted granted Critical
Publication of EP3334820B1 publication Critical patent/EP3334820B1/fr
Publication of EP3334820C0 publication Critical patent/EP3334820C0/fr
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    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
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    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/20—Cytokines; Chemokines
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EP16834685.6A 2015-08-13 2016-08-12 Cellules souches pluripotentes étendues et induites, procédés de fabrication et d'utilisation Active EP3334820B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2015086854 2015-08-13
PCT/CN2016/094828 WO2017025061A1 (fr) 2015-08-13 2016-08-12 Cellules souches pluripotentes étendues et induites, procédés de fabrication et d'utilisation

Publications (4)

Publication Number Publication Date
EP3334820A1 EP3334820A1 (fr) 2018-06-20
EP3334820A4 true EP3334820A4 (fr) 2019-01-02
EP3334820B1 EP3334820B1 (fr) 2024-05-15
EP3334820C0 EP3334820C0 (fr) 2024-05-15

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EP16834685.6A Active EP3334820B1 (fr) 2015-08-13 2016-08-12 Cellules souches pluripotentes étendues et induites, procédés de fabrication et d'utilisation

Country Status (8)

Country Link
US (1) US11028369B2 (fr)
EP (1) EP3334820B1 (fr)
JP (1) JP6780870B2 (fr)
KR (1) KR102142364B1 (fr)
CN (1) CN108884436B (fr)
AU (1) AU2016305705B2 (fr)
CA (1) CA2994192C (fr)
WO (1) WO2017025061A1 (fr)

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WO2017007994A1 (fr) 2015-07-08 2017-01-12 American Gene Technologies International Inc. Pré-immunisation et immunothérapie du vih
CN111569090A (zh) 2016-01-15 2020-08-25 美国基因技术国际有限公司 用于活化γ-δ T细胞的方法和组合物
JP7153332B2 (ja) 2016-02-08 2022-10-14 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド Ｈｉｖワクチン接種および免疫療法
ES2911448T3 (es) 2016-03-09 2022-05-19 American Gene Tech Int Inc Vectores combinados y métodos para el tratamiento del cáncer
US11976292B2 (en) 2016-06-08 2024-05-07 American Gene Technologies International Inc. Non-integrating viral delivery system and methods related thereto
EP3481418A4 (fr) 2016-07-08 2020-03-11 American Gene Technologies International Inc. Pré-immunisation et immunothérapie du vih
US11583562B2 (en) * 2016-07-21 2023-02-21 American Gene Technologies International Inc. Viral vectors for treating Parkinson's disease
JP2020512815A (ja) 2017-04-03 2020-04-30 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド フェニルケトン尿症を処置するための組成物および方法
WO2018232359A1 (fr) 2017-06-16 2018-12-20 American Gene Technologies International Inc. Méthodes et compositions pour l'activation de la cytoxicité tumorale par le biais de lymphocytes t gamma-delta humains
WO2018235583A1 (fr) * 2017-06-19 2018-12-27 公益財団法人神戸医療産業都市推進機構 Procédé de prévision de capacité de différenciation de cellules souches pluripotentes, et réactif associé
US12570956B2 (en) 2018-01-12 2026-03-10 The Regents Of The University Of California Efficient derivation of stable pluripotent bovine embryonic stem cells
WO2019204530A1 (fr) * 2018-04-17 2019-10-24 University Of Maryland, College Park Génération d'organes endodermiques humains dans un modèle de cochon à l'aide de précurseurs endodermiques à lignée restreinte
US11547440B2 (en) 2018-11-26 2023-01-10 International Business Machines Corporation Cranial access device
CN109439617A (zh) * 2018-12-25 2019-03-08 成都赋智健康科技有限公司 一种干细胞无血清培养基及其制作方法
WO2020203538A1 (fr) * 2019-03-29 2020-10-08 株式会社カネカ Population de cellules comprenant des cellules souches pluripotentes et son procédé de production
SG10201905939WA (en) * 2019-06-26 2021-01-28 Cell Mogrify Australia Pty Ltd Cell culture methods and compositions
WO2021037142A1 (fr) * 2019-08-27 2021-03-04 The Third Hospital Of Hebei Medical University Cellules progénitrices d'articulation multipotentes, compositions et procédés associés
US20230115640A1 (en) * 2019-10-03 2023-04-13 Salk Institute For Biological Studies Blastocyst-like structures from extended pluripotent stem cells
WO2021087354A1 (fr) * 2019-10-30 2021-05-06 The General Hospital Corporation Culture à haut débit de cellules alvéolaires dérivées d'ipsc
CA3156095A1 (fr) * 2019-11-25 2021-06-03 Lonza Walkersville, Inc. Plate-forme integrale pour la fabrication de cellules souches pluripotentes humaines
CN111243671A (zh) * 2020-01-07 2020-06-05 广州基迪奥生物科技有限公司 一种动态交互的单细胞测序数据质控分析平台及方法
CN111269878B (zh) * 2020-01-19 2022-02-11 深圳市北科生物科技有限公司 一种人多能干细胞转化为扩展多能干细胞的专用培养基及其应用
CN113151147B (zh) * 2020-01-23 2023-07-25 北京大学 功能性肝实质细胞及其制备方法
JP7339192B2 (ja) * 2020-03-11 2023-09-05 株式会社日立製作所 細胞培養方法および自動細胞培養装置
WO2022039279A1 (fr) * 2020-08-18 2022-02-24 国立大学法人京都大学 Procédé de maintien et d'amplification de cellules germinales primordiales humaines/cellules du type cellules germinales primordiales humaines
CN112760225A (zh) * 2021-01-27 2021-05-07 西北农林科技大学 一种牛胚胎体外早期着床培养体系
CN114836372B (zh) * 2021-02-01 2024-02-02 内蒙古大学 小鼠上胚层干细胞向新型多能干细胞转化的培养方法
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AU2016305705A1 (en) 2018-02-01
CN108884436A (zh) 2018-11-23
CA2994192C (fr) 2020-06-16
JP6780870B2 (ja) 2020-11-04
KR102142364B1 (ko) 2020-08-07
EP3334820B1 (fr) 2024-05-15
KR20180052612A (ko) 2018-05-18
AU2016305705B2 (en) 2019-06-13
CN108884436B (zh) 2021-11-05
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EP3334820C0 (fr) 2024-05-15
JP2018527024A (ja) 2018-09-20

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