EP3459933A3 - Feste formen einer pharmazeutisch aktiven verbindung - Google Patents

Feste formen einer pharmazeutisch aktiven verbindung Download PDF

Info

Publication number
EP3459933A3
EP3459933A3 EP18200578.5A EP18200578A EP3459933A3 EP 3459933 A3 EP3459933 A3 EP 3459933A3 EP 18200578 A EP18200578 A EP 18200578A EP 3459933 A3 EP3459933 A3 EP 3459933A3
Authority
EP
European Patent Office
Prior art keywords
solid forms
active compound
pharmaceutically active
compound
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP18200578.5A
Other languages
English (en)
French (fr)
Other versions
EP3459933A2 (de
EP3459933B1 (de
Inventor
Rudolf Benz
Ralph Diodone
Zhongjiang JIA
Bharat Patel
Urs Schwitter
Duk Soon Choi
Ningxin YAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of EP3459933A2 publication Critical patent/EP3459933A2/de
Publication of EP3459933A3 publication Critical patent/EP3459933A3/de
Application granted granted Critical
Publication of EP3459933B1 publication Critical patent/EP3459933B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP18200578.5A 2014-04-15 2015-04-13 Feste formen einer pharmazeutisch aktiven verbindung Active EP3459933B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461979649P 2014-04-15 2014-04-15
PCT/EP2015/057937 WO2015158648A1 (en) 2014-04-15 2015-04-13 Solid forms of a pharmaceutically active compound
EP15714843.8A EP3131878A1 (de) 2014-04-15 2015-04-13 Feste formen einer pharmazeutisch aktiven verbindung

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP15714843.8A Division EP3131878A1 (de) 2014-04-15 2015-04-13 Feste formen einer pharmazeutisch aktiven verbindung

Publications (3)

Publication Number Publication Date
EP3459933A2 EP3459933A2 (de) 2019-03-27
EP3459933A3 true EP3459933A3 (de) 2019-05-29
EP3459933B1 EP3459933B1 (de) 2022-08-24

Family

ID=52815005

Family Applications (2)

Application Number Title Priority Date Filing Date
EP15714843.8A Withdrawn EP3131878A1 (de) 2014-04-15 2015-04-13 Feste formen einer pharmazeutisch aktiven verbindung
EP18200578.5A Active EP3459933B1 (de) 2014-04-15 2015-04-13 Feste formen einer pharmazeutisch aktiven verbindung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP15714843.8A Withdrawn EP3131878A1 (de) 2014-04-15 2015-04-13 Feste formen einer pharmazeutisch aktiven verbindung

Country Status (18)

Country Link
US (1) US10227298B2 (de)
EP (2) EP3131878A1 (de)
JP (2) JP6621761B2 (de)
KR (1) KR20160138307A (de)
CN (1) CN106458886A (de)
AR (1) AR100095A1 (de)
AU (1) AU2015249018A1 (de)
BR (1) BR112016023767A2 (de)
CA (1) CA2943571A1 (de)
ES (1) ES2928706T3 (de)
IL (1) IL247974A0 (de)
MA (1) MA39877A (de)
MX (1) MX2016013439A (de)
PL (1) PL3459933T3 (de)
RU (1) RU2016144187A (de)
SG (1) SG11201608559QA (de)
WO (1) WO2015158648A1 (de)
ZA (1) ZA201606653B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118436801A (zh) 2016-05-20 2024-08-06 豪夫迈·罗氏有限公司 Protac抗体缀合物及其使用方法
WO2019213106A1 (en) 2018-04-30 2019-11-07 Teva Pharmaceuticals International Gmbh Solid state forms of idasanutlin
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
WO2024240858A1 (en) 2023-05-23 2024-11-28 Valerio Therapeutics Protac molecules directed against dna damage repair system and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8354444B2 (en) * 2008-09-18 2013-01-15 Hoffmann-La Roche Inc. Substituted pyrrolidine-2-carboxamides
US20130244958A1 (en) * 2012-03-15 2013-09-19 Hoffmann-La Roche Inc. Substituted pyrrolidine-2-carboxamides
US20130245089A1 (en) * 2012-03-19 2013-09-19 Hoffmann-La Roche Inc. Method for administration
WO2014114575A1 (en) * 2013-01-22 2014-07-31 F. Hoffmann-La Roche Ag Pharmaceutical composition with improved bioavailability

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9216170B2 (en) * 2012-03-19 2015-12-22 Hoffmann-La Roche Inc. Combination therapy for proliferative disorders
BR112014029530A2 (pt) * 2012-05-30 2017-06-27 Hoffmann La Roche compostos, composição farmacêutica e uso de um composto
EP2958893B1 (de) 2013-02-21 2017-05-03 F. Hoffmann-La Roche AG Asymmetrische synthese eines substituierten pyrrolidine-2-carboxamids

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8354444B2 (en) * 2008-09-18 2013-01-15 Hoffmann-La Roche Inc. Substituted pyrrolidine-2-carboxamides
US20130244958A1 (en) * 2012-03-15 2013-09-19 Hoffmann-La Roche Inc. Substituted pyrrolidine-2-carboxamides
US20130245089A1 (en) * 2012-03-19 2013-09-19 Hoffmann-La Roche Inc. Method for administration
WO2014114575A1 (en) * 2013-01-22 2014-07-31 F. Hoffmann-La Roche Ag Pharmaceutical composition with improved bioavailability

Also Published As

Publication number Publication date
CN106458886A (zh) 2017-02-22
AR100095A1 (es) 2016-09-07
JP2019055960A (ja) 2019-04-11
ZA201606653B (en) 2018-05-30
KR20160138307A (ko) 2016-12-02
JP2017511362A (ja) 2017-04-20
JP6887980B2 (ja) 2021-06-16
BR112016023767A2 (pt) 2017-08-15
ES2928706T3 (es) 2022-11-22
MX2016013439A (es) 2016-11-17
EP3459933A2 (de) 2019-03-27
US10227298B2 (en) 2019-03-12
RU2016144187A (ru) 2018-05-16
AU2015249018A1 (en) 2016-10-06
PL3459933T3 (pl) 2023-01-23
WO2015158648A1 (en) 2015-10-22
JP6621761B2 (ja) 2019-12-18
MA39877A (fr) 2017-02-22
IL247974A0 (en) 2016-11-30
RU2016144187A3 (de) 2018-11-13
CA2943571A1 (en) 2015-10-22
SG11201608559QA (en) 2016-11-29
EP3131878A1 (de) 2017-02-22
EP3459933B1 (de) 2022-08-24
US20170037005A1 (en) 2017-02-09

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