EP3625263A4 - Anticorps anti-galectine-9 et leurs utilisations - Google Patents

Anticorps anti-galectine-9 et leurs utilisations Download PDF

Info

Publication number
EP3625263A4
EP3625263A4 EP18870270.8A EP18870270A EP3625263A4 EP 3625263 A4 EP3625263 A4 EP 3625263A4 EP 18870270 A EP18870270 A EP 18870270A EP 3625263 A4 EP3625263 A4 EP 3625263A4
Authority
EP
European Patent Office
Prior art keywords
galectin
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP18870270.8A
Other languages
German (de)
English (en)
Other versions
EP3625263A1 (fr
EP3625263B8 (fr
EP3625263B1 (fr
Inventor
Shohei Koide
George Miller
Akiko Koide
Linxiao CHEN
Aleksandra Filipovic
Eric Elenko
Joseph BOLEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York University
Puretech LYT Inc
Original Assignee
New York University
Puretech Health LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=66246040&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP3625263(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by New York University, Puretech Health LLC filed Critical New York University
Priority to EP25168928.7A priority Critical patent/EP4597112A3/fr
Publication of EP3625263A1 publication Critical patent/EP3625263A1/fr
Publication of EP3625263A4 publication Critical patent/EP3625263A4/fr
Application granted granted Critical
Publication of EP3625263B1 publication Critical patent/EP3625263B1/fr
Publication of EP3625263B8 publication Critical patent/EP3625263B8/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
EP18870270.8A 2017-10-27 2018-10-29 Anticorps anti-galectine-9 et leurs utilisations Active EP3625263B8 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP25168928.7A EP4597112A3 (fr) 2017-10-27 2018-10-29 Anticorps anti-galectine-9 et leurs utilisations

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762578111P 2017-10-27 2017-10-27
US201862665175P 2018-05-01 2018-05-01
US201862736317P 2018-09-25 2018-09-25
PCT/US2018/058028 WO2019084553A1 (fr) 2017-10-27 2018-10-29 Anticorps anti-galectine-9 et leurs utilisations

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP25168928.7A Division EP4597112A3 (fr) 2017-10-27 2018-10-29 Anticorps anti-galectine-9 et leurs utilisations
EP25168928.7A Division-Into EP4597112A3 (fr) 2017-10-27 2018-10-29 Anticorps anti-galectine-9 et leurs utilisations

Publications (4)

Publication Number Publication Date
EP3625263A1 EP3625263A1 (fr) 2020-03-25
EP3625263A4 true EP3625263A4 (fr) 2021-05-05
EP3625263B1 EP3625263B1 (fr) 2025-04-09
EP3625263B8 EP3625263B8 (fr) 2025-05-28

Family

ID=66246040

Family Applications (2)

Application Number Title Priority Date Filing Date
EP25168928.7A Pending EP4597112A3 (fr) 2017-10-27 2018-10-29 Anticorps anti-galectine-9 et leurs utilisations
EP18870270.8A Active EP3625263B8 (fr) 2017-10-27 2018-10-29 Anticorps anti-galectine-9 et leurs utilisations

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP25168928.7A Pending EP4597112A3 (fr) 2017-10-27 2018-10-29 Anticorps anti-galectine-9 et leurs utilisations

Country Status (14)

Country Link
US (5) US10344091B2 (fr)
EP (2) EP4597112A3 (fr)
JP (6) JP6873445B2 (fr)
KR (1) KR102162129B1 (fr)
CN (2) CN115261392B (fr)
AU (3) AU2018355588C1 (fr)
CA (1) CA3080120C (fr)
DK (1) DK3625263T3 (fr)
ES (1) ES3032734T3 (fr)
IL (4) IL312910B2 (fr)
PT (1) PT3625263T (fr)
SG (1) SG11202003652QA (fr)
WO (1) WO2019084553A1 (fr)
ZA (3) ZA202002246B (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019084553A1 (fr) 2017-10-27 2019-05-02 New York University Anticorps anti-galectine-9 et leurs utilisations
CN111256416B (zh) * 2018-11-30 2025-09-09 海尔智家股份有限公司 风冷冰箱
CA3134942A1 (fr) * 2019-03-25 2020-10-01 New York University Anticorps anti-galectine-9 et leurs utilisations
CN119033928A (zh) * 2019-05-01 2024-11-29 纽约大学 抗半乳糖凝集素-9抗体及其用途
SG11202113222PA (en) * 2019-05-31 2021-12-30 Council Queensland Inst Medical Res Activating anti-gal9 binding molecules
JP2022538278A (ja) * 2019-06-24 2022-09-01 ユー ピー エム キュンメネ コーポレーション ナノフィブリルセルロースヒドロゲル中に真核細胞を含む移植可能な細胞組成物、その調製方法、及びナノフィブリルセルロースの使用
US12559559B2 (en) 2019-07-11 2026-02-24 Dana-Farber Cancer Institute, Inc. Targeting Galectin-9 as a therapeutic strategy for T-cell exhaustion in T-cell acute lymphoblastic leukemia
WO2021022256A1 (fr) * 2019-08-01 2021-02-04 New York University Polythérapie anticancéreuse d'anticorps anti-galectine-9 et d'agents chimiothérapeutiques
US20230183336A1 (en) * 2019-08-14 2023-06-15 Modmab Therapeutics Inc. Antibodies that bind to lrp5 proteins and methods of use
AU2021205143A1 (en) 2020-01-07 2022-07-28 Hifibio, Inc. Anti-Galectin-9 antibody and uses thereof
WO2022020745A1 (fr) * 2020-07-23 2022-01-27 Emory University Agents de liaison spécifiques de la galectine-9 destinés à être utilisés dans le traitement du cancer
AU2021322114A1 (en) * 2020-08-04 2023-03-02 Exelixis, Inc. Multispecific binding agents and uses thereof
CA3187850A1 (fr) 2020-08-04 2022-02-10 Bryan Glaser Agents de liaison a pd-l1 et leurs utilisations
CA3187837A1 (fr) * 2020-08-04 2022-02-10 Exelixis, Inc. Agents de liaison a cd47 et leurs utilisations
CN116782934A (zh) * 2020-10-26 2023-09-19 纯技术Lyt股份有限公司 抗半乳糖凝集素9抗体及其在治疗眼部黑素瘤中的用途
WO2022109302A1 (fr) * 2020-11-20 2022-05-27 New York University Anticorps anti-galectine-9 et leurs utilisations thérapeutiques
US20240109968A1 (en) * 2020-11-20 2024-04-04 New York University Anti-galectin-9 antibodies and therapeutic uses thereof
JP2024513651A (ja) * 2021-02-26 2024-03-27 ニューヨーク ユニバーシティ 共有結合性ペプチドコンジュゲートに結合する抗体を含む組成物及び方法
EP4329808A4 (fr) * 2021-04-30 2025-03-12 PureTech LYT, Inc. Combinaison d'anticorps anti-galectine-9 et d'agents chimiothérapeutiques destinée à être utilisée dans le traitement du cancer
AU2022266821A1 (en) * 2021-04-30 2023-11-09 Puretech Lyt, Inc. Anti-galectin-9 antibodies and therapeutic uses thereof
US20240279331A1 (en) * 2021-06-11 2024-08-22 The Regents Of The University Of California Antibodies that stimulate nk cell-mediated cytotoxicity
WO2023056461A1 (fr) * 2021-10-01 2023-04-06 Puretech Lyt, Inc. Anticorps anti-galectine-9 et leurs utilisations thérapeutiques
US20250018038A1 (en) * 2021-10-06 2025-01-16 The University Of Chicago Survivin targeting polypeptides for detection and treatment of cancer
US20250057873A1 (en) * 2021-12-16 2025-02-20 Tokyo University Of Science Foundation Intestinal Tumor Suppressor, PGE2 Production Inhibitor, and IL-22BP Production Promoter
WO2023245021A2 (fr) * 2022-06-14 2023-12-21 Invenra Inc. Agents de liaison multispécifiques qui ciblent cd25 et/ou ctla4 et leurs utilisations
KR20250029919A (ko) * 2022-06-29 2025-03-05 퓨어테크 엘와이티, 아이엔씨. 갈렉틴-9를 억제하는 항체를 사용한 혈액학적 악성종양의 치료
US12599209B2 (en) * 2023-02-16 2026-04-14 Dongguan Casekey Industry Co., Ltd Card fixation assembly for card holder and card holder
CN121399157A (zh) 2023-06-12 2026-01-23 美国安进公司 淋巴毒素β受体激动剂结合蛋白
WO2025014933A1 (fr) * 2023-07-10 2025-01-16 Northwestern University Ciblage de tim-3 dans un gliome induit par mapk
WO2025085792A1 (fr) * 2023-10-19 2025-04-24 Puretech Lyt, Inc. Traitement de malignités hématologiques avec des anticorps inhibant la galectine-9
AU2024404840A1 (en) * 2023-12-22 2026-07-02 Commonwealth Scientific And Industrial Research Organisation Identifying sequence functionality

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4777127A (en) 1985-09-30 1988-10-11 Labsystems Oy Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4704692A (en) 1986-09-02 1987-11-03 Ladner Robert C Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
GB8702816D0 (en) 1987-02-07 1987-03-11 Al Sumidaie A M K Obtaining retrovirus-containing fraction
US5219740A (en) 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
US5422120A (en) 1988-05-30 1995-06-06 Depotech Corporation Heterovesicular liposomes
AP129A (en) 1988-06-03 1991-04-17 Smithkline Biologicals S A Expression of retrovirus gag protein eukaryotic cells
DE68927933T2 (de) 1988-09-02 1997-08-14 Dyax Corp Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
EP0832980B1 (fr) 1989-01-23 2002-06-19 Chiron Corporation Thérapie recombinante des infections et désordres hyperprolifératifs
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
DK0737750T3 (da) 1989-03-21 2003-09-01 Vical Inc Ekspression af exogene polynucleotidsekvenser i vertebrater
EP1001032A3 (fr) 1989-08-18 2005-02-23 Chiron Corporation Rétrovirus de recombinaison apportant des constructions de vecteur à des cellules cibles
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
ZA911974B (en) 1990-03-21 1994-08-22 Res Dev Foundation Heterovesicular liposomes
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
ES2139598T3 (es) 1990-07-10 2000-02-16 Medical Res Council Procedimientos para la produccion de miembros de parejas de union especifica.
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DE69129154T2 (de) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
DE69233697T2 (de) 1991-03-01 2008-01-24 Dyax Corp., Cambridge Verfahren zur Entwicklung von bindenden Mikroproteinen
PT100379B (pt) 1991-04-10 1999-01-29 Scripps Research Inst Bibliotecas de receptores heterodimericos usando fagomideos
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
ATE237694T1 (de) 1991-08-20 2003-05-15 Us Gov Health & Human Serv Adenovirus vermittelter gentransfer in den gastrointestinaltrakt
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
WO1993010218A1 (fr) 1991-11-14 1993-05-27 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Vecteurs comprenant des genes etrangers et des marqueurs selectifs negatifs
GB9125623D0 (en) 1991-12-02 1992-01-29 Dynal As Cell modification
EP0552108B1 (fr) 1992-01-17 1999-11-10 Lakowicz, Joseph R. Essai fluoro-immunologique impliquant un transfert d'énergie par phase-modulation
FR2688514A1 (fr) 1992-03-16 1993-09-17 Centre Nat Rech Scient Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
EP0650370A4 (fr) 1992-06-08 1995-11-22 Univ California Procedes et compositions permettant de cibler des tissus specifiques.
EP0644946A4 (fr) 1992-06-10 1997-03-12 Us Health Particules vecteurs resistantes a l'inactivation par le serum humain.
SE9201984D0 (sv) 1992-06-29 1992-06-29 Pharmacia Biosensor Ab Improvement in optical assays
GB2269175A (en) 1992-07-31 1994-02-02 Imperial College Retroviral vectors
EP0673431A1 (fr) 1992-12-03 1995-09-27 Genzyme Corporation Therapie genique de la fibrose kystique
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
AU6818094A (en) 1993-04-22 1994-11-08 Depotech Corporation Cyclodextrin liposomes encapsulating pharmacologic compounds and methods for their use
EP0705344B8 (fr) 1993-06-24 2006-05-10 Advec Inc. Vecteurs a base d'adenovirus destines a la therapie genique
WO1995007994A2 (fr) 1993-09-15 1995-03-23 Viagene, Inc. Vecteurs composes d'alphavirus recombinants
US6015686A (en) 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
DE69435223D1 (de) 1993-10-25 2009-09-03 Canji Inc Rekombinanter Adenoviren-Vektor und Verfahren zur Verwendung
HUT75162A (en) 1993-11-16 1997-04-28 Depotech Corp Vesicles with controlled release of actives
DE69535669T2 (de) 1994-05-09 2008-12-04 Oxford Biomedica (Uk) Ltd. Retrovirale vektoren mit verminderter rekombinationsrate
WO1996017072A2 (fr) 1994-11-30 1996-06-06 Chiron Viagene, Inc. Vecteurs d'alphavirus de recombinaison
US6265150B1 (en) 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
DE69739286D1 (de) 1996-05-06 2009-04-16 Oxford Biomedica Ltd Rekombinationsunfähige retrovirale vektoren
IL131016A (en) 1997-01-21 2004-12-15 Gen Hospital Corp Selection of proteins using RNA-protein blends
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
WO2000053211A2 (fr) 1999-03-09 2000-09-14 University Of Southern California Methode de stimulation de la proliferation de myocytes et de la reparation des tissus myocardiques
JP3950050B2 (ja) * 2000-11-01 2007-07-25 株式会社ガルファーマ ガン転移能検出剤
US20030186374A1 (en) 2001-10-01 2003-10-02 Hufton Simon E. Multi-chain eukaryotic display vectors and uses thereof
CA2514108A1 (fr) * 2003-01-24 2004-08-05 Galpharma Co., Ltd. Medicaments contenant galectine 9
JP2004244411A (ja) * 2003-01-24 2004-09-02 Galpharma Co Ltd ガレクチン９含有医薬
JP5021309B2 (ja) 2003-10-16 2012-09-05 ステファン ジョン ラルフ 免疫調節性組成物およびその使用方法
ES2396555T3 (es) 2004-12-15 2013-02-22 Janssen Alzheimer Immunotherapy Anticuerpos que reconocen péptido beta amiloide
BRPI0518994A2 (pt) 2004-12-31 2008-12-02 Biogen Idec Inc anticorpos ou polipeptÍdeos que se ligam a br3, seus usos e formulaÇÕes lÍquidas
WO2007064919A2 (fr) 2005-12-02 2007-06-07 Genentech, Inc. Polypeptides de liaison avec des sequences de diversite limitees
WO2015164330A1 (fr) 2014-04-21 2015-10-29 Millennium Pharmaceuticals, Inc. Molécules d'anticorps anti-psyk et leur utilisation pour la thérapie ciblée sur syk
CA2710398A1 (fr) 2008-01-18 2009-10-15 Genentech, Inc. Procedes et compositions pour cibler la polyubiquitine
ES2337224B1 (es) 2008-06-11 2011-02-17 Consejo Superior De Investigaciones Cientificas (Csic) (40%) Anticuerpo anti-dectin-1 humano, hibridoma productor de dicho anticuerpo y sus aplicaciones.
MX2011000655A (es) 2008-07-18 2011-03-21 Oragenics Inc Composiciones para la deteccion y tratamiento de cancer colorrectal.
US9163087B2 (en) 2010-06-18 2015-10-20 The Brigham And Women's Hospital, Inc. Bi-specific antibodies against TIM-3 and PD-1 for immunotherapy in chronic immune conditions
AU2011326564A1 (en) 2010-11-10 2013-05-09 Genentech, Inc. Methods and compositions for neural disease immunotherapy
KR20130103587A (ko) 2010-12-09 2013-09-23 가르파마 컴퍼니 리미티드 갈렉틴 9를 분비하는 세포, 그 제조 방법 및 그 용도
WO2012177788A1 (fr) 2011-06-20 2012-12-27 La Jolla Institute For Allergy And Immunology Modulateurs de 4-1bb et réponses immunitaires
WO2013056352A1 (fr) * 2011-10-19 2013-04-25 University Health Network Anticorps et fragments d'anticorps ciblant sirp-alpha et leur utilisation pour le traitement de cancers hématologiques
US20140378531A1 (en) 2012-02-01 2014-12-25 New York University Inhibition of pattern recognition receptors in pancreatic cancer treatment using tlr inhibitors
US9511046B2 (en) 2013-01-11 2016-12-06 Abraxis Bioscience, Llc Methods of treating pancreatic cancer
WO2015035112A1 (fr) 2013-09-05 2015-03-12 The Johns Hopkins University Thérapie anticancéreuse par l'intermédiaire d'une combinaison de modulation épigénétique et modulation immunitaire
FR3021970B1 (fr) * 2014-06-06 2018-01-26 Universite Sciences Technologies Lille Anticorps dirige contre la galectine 9 et inhibiteur de l'activite suppressive des lymphocytes t regulateurs
CA2954678A1 (fr) * 2014-07-14 2016-01-21 The Council Of The Queensland Institute Of Medical Research Immunotherapie par galectine
KR20250007689A (ko) 2014-09-16 2025-01-14 이나뜨 파르마 에스.에이. 림프구에서의 억제 경로의 중화
US10640549B2 (en) * 2014-10-17 2020-05-05 University Of Virginia Patent Foundation Recombinant antibodies that recognize the C-terminal domains of Ebola virus nucleoprotein
AU2015343425A1 (en) 2014-11-04 2017-05-25 Dana-Farber Cancer Institute, Inc. Anti-galectin antibody biomarkers predictive of anti-immune checkpoint and anti-angiogenesis responses
US20160209425A1 (en) 2015-01-16 2016-07-21 New York University Use of dectin-1 activators for treatment of liver disorders
WO2017044308A1 (fr) 2015-09-10 2017-03-16 Albert Einstein College Of Medicine, Inc. Anticorps synthétiques contre bax et leurs utilisations
WO2017202962A1 (fr) 2016-05-24 2017-11-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés et compositions pharmaceutiques pour le traitement du cancer du poumon non à petites cellules (cbnpc) qui coexiste avec la bronchopneumopathie chronique obstructive (bpco)
US20180044422A1 (en) 2016-07-29 2018-02-15 New York University Treating solid tumor by targeting dectin-1 signaling
US11254738B2 (en) 2016-09-07 2022-02-22 The Governing Council Of The University Of Toronto Banting Institute Synthetic antibodies against VEGF and their uses
CA3034105A1 (fr) 2016-09-23 2018-03-29 Csl Limited Proteines de liaison au facteur de coagulation et leurs utilisations
CN111050791A (zh) 2017-06-27 2020-04-21 诺华股份有限公司 用于抗tim-3抗体的给药方案及其用途
US12030940B2 (en) 2017-08-17 2024-07-09 Nektar Therapeutics Immunotherapeutic tumor treatment method
JP2020535119A (ja) 2017-09-13 2020-12-03 ファイヴ プライム セラピューティクス インク 膵臓がんの抗ｃｓｆ１ｒおよび抗ｐｄ−１抗体組合せ併用療法
WO2019084553A1 (fr) 2017-10-27 2019-05-02 New York University Anticorps anti-galectine-9 et leurs utilisations
US20210315909A1 (en) 2018-07-11 2021-10-14 Arrys Therapeutics, Inc. Polymorphic compounds and uses thereof
CA3134942A1 (fr) 2019-03-25 2020-10-01 New York University Anticorps anti-galectine-9 et leurs utilisations
CN119033928A (zh) 2019-05-01 2024-11-29 纽约大学 抗半乳糖凝集素-9抗体及其用途
WO2021022256A1 (fr) 2019-08-01 2021-02-04 New York University Polythérapie anticancéreuse d'anticorps anti-galectine-9 et d'agents chimiothérapeutiques
CN116782934A (zh) 2020-10-26 2023-09-19 纯技术Lyt股份有限公司 抗半乳糖凝集素9抗体及其在治疗眼部黑素瘤中的用途
US20240109968A1 (en) 2020-11-20 2024-04-04 New York University Anti-galectin-9 antibodies and therapeutic uses thereof
WO2022109302A1 (fr) 2020-11-20 2022-05-27 New York University Anticorps anti-galectine-9 et leurs utilisations thérapeutiques
EP4329808A4 (fr) 2021-04-30 2025-03-12 PureTech LYT, Inc. Combinaison d'anticorps anti-galectine-9 et d'agents chimiothérapeutiques destinée à être utilisée dans le traitement du cancer
AU2022266821A1 (en) 2021-04-30 2023-11-09 Puretech Lyt, Inc. Anti-galectin-9 antibodies and therapeutic uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CLÉMENT BARJON ET AL: "A novel monoclonal antibody for detection of galectin-9 in tissue sections: application to human tissues infected by oncogenic viruses", INFECTIOUS AGENTS AND CANCER, BIOMED CENTRAL LTD, LO, vol. 7, no. 1, 17 July 2012 (2012-07-17), pages 16, XP021116920, ISSN: 1750-9378, DOI: 10.1186/1750-9378-7-16 *
See also references of WO2019084553A1 *
TUERECI O ET AL: "MOLECULAR DEFINITION OF A NOVEL HUMAN GALECTIN WHICH IS IMMUNOGENIC IN PATIENTS WITH HODGKIN'S DISEASE", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 272, no. 10, 7 March 1997 (1997-03-07), pages 6416 - 6422, XP002065487, ISSN: 0021-9258, DOI: 10.1074/JBC.272.10.6416 *

Also Published As

Publication number Publication date
KR102162129B1 (ko) 2020-10-06
ES3032734T3 (en) 2025-07-24
US20200010551A1 (en) 2020-01-09
CN111511765A (zh) 2020-08-07
US10344091B2 (en) 2019-07-09
JP6873445B2 (ja) 2021-05-19
PT3625263T (pt) 2025-06-20
AU2018355588B2 (en) 2020-10-15
US12624108B2 (en) 2026-05-12
JP2023116789A (ja) 2023-08-22
US20190127472A1 (en) 2019-05-02
US10450374B2 (en) 2019-10-22
JP2021501120A (ja) 2021-01-14
IL312910B1 (en) 2026-02-01
IL280648A (en) 2021-03-25
US20220340666A1 (en) 2022-10-27
US11629191B2 (en) 2023-04-18
US20190256604A1 (en) 2019-08-22
AU2018355588C1 (en) 2023-04-27
CN115261392A (zh) 2022-11-01
JP7800872B2 (ja) 2026-01-16
JP7092317B2 (ja) 2022-06-28
AU2020294364B2 (en) 2023-09-21
EP4597112A3 (fr) 2026-04-01
IL312910A (en) 2024-07-01
CN115261392B (zh) 2025-05-13
IL274152B (en) 2021-02-28
AU2023285898A1 (en) 2024-01-18
EP3625263A1 (fr) 2020-03-25
ZA202303412B (en) 2024-09-25
AU2018355588A1 (en) 2020-06-11
JP7307443B2 (ja) 2023-07-12
SG11202003652QA (en) 2020-05-28
IL280648B2 (en) 2024-10-01
JP2026062750A (ja) 2026-04-10
ZA202102905B (en) 2023-04-26
EP3625263B8 (fr) 2025-05-28
WO2019084553A1 (fr) 2019-05-02
CA3080120C (fr) 2023-11-21
KR20200064150A (ko) 2020-06-05
AU2020294364A1 (en) 2021-02-18
IL274152A (en) 2020-06-30
DK3625263T3 (da) 2025-06-30
JP2021153585A (ja) 2021-10-07
JP2022116325A (ja) 2022-08-09
IL325804A (en) 2026-03-01
NZ764590A (en) 2020-12-18
ZA202002246B (en) 2025-04-30
CA3080120A1 (fr) 2019-05-02
IL280648B1 (en) 2024-06-01
US11414492B2 (en) 2022-08-16
KR102162129B9 (ko) 2023-02-08
EP4597112A2 (fr) 2025-08-06
JP2024133590A (ja) 2024-10-02
CN111511765B (zh) 2022-05-27
EP3625263B1 (fr) 2025-04-09
JP7523084B2 (ja) 2024-07-26
US20220332830A1 (en) 2022-10-20
IL312910B2 (en) 2026-06-01

Similar Documents

Publication Publication Date Title
EP3891183A4 (fr) Anticorps anti-claudine et leurs utilisations
EP3759143A4 (fr) Anticorps anti-tigit et leurs utilisations
EP3383916A4 (fr) Anticorps anti-cd73 et leurs utilisations
MA47789A (fr) Anticorps anti-phf-tau et leurs utilisations
EP3389702A4 (fr) Anticorps anti-lag-3 et leurs utilisations
MA49683A (fr) Anticorps anti-cd8 et leurs utilisations
EP3504243A4 (fr) Anticorps anti-tim-3 et leurs utilisations
EP3661965A4 (fr) Anticorps anti-cd47 et leurs utilisations
MA49687A (fr) Anticorps anti-ctla-4 et leurs utilisations
MA46704A (fr) Anticorps anti-pyroglutamate- amyloïde-beta et leurs utilisations
EP3426288A4 (fr) Anticorps anti-pacap et leurs utilisations
MA49886A (fr) Anticorps anti-par2 et leurs utilisations
MA46708A (fr) Anticorps anti-pd1 et leurs utilisations
MA49537A (fr) Anticorps anti-lag3 et leurs utilisations
MA45235A (fr) Anticorps anti-c5 et leurs utilisations
MA53184A (fr) Anticorps anti-ox40 et leurs utilisations
MA45125A (fr) Anticorps anti-alpha-synucléine et leurs utilisations
EP3283517A4 (fr) Anticorps anti-pacap et leurs utilisations
EP3645563A4 (fr) Anticorps anti-fam19a5 et leurs utilisations
EP3790586A4 (fr) Anticorps anti-dll3 et leurs utilisations
MA45233A (fr) Anticorps anti-gitr et leurs utilisations
EP3733702A4 (fr) Anticorps anti-lag-3 et utilisations associées
EP3672987A4 (fr) Anticorps anti-apéline et leurs utilisations
EP3661555A4 (fr) Anticorps bispécifiques et leurs utilisations
EP3894440A4 (fr) Anticorps anti-il-27 et leurs utilisations

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20191219

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

RIN1 Information on inventor provided before grant (corrected)

Inventor name: KOIDE, AKIKO

Inventor name: ELENKO, ERIC

Inventor name: BOLEN, JOSEPH

Inventor name: FILIPOVIC, ALEKSANDRA

Inventor name: CHEN, LINXIAO

Inventor name: MILLER, GEORGE

Inventor name: KOIDE, SHOHEI

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40027176

Country of ref document: HK

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20210401

RIC1 Information provided on ipc code assigned before grant

Ipc: C07K 16/28 20060101AFI20210326BHEP

Ipc: A61K 39/395 20060101ALI20210326BHEP

Ipc: G01N 33/574 20060101ALI20210326BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20221027

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230512

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20241209

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: CH

Ref legal event code: PK

Free format text: BERICHTIGUNG B8

Ref country code: DE

Ref legal event code: R096

Ref document number: 602018081030

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

RAP2 Party data changed (patent owner data changed or rights of a patent transferred)

Owner name: PURETECH LYT, INC.

Owner name: NEW YORK UNIVERSITY

REG Reference to a national code

Ref country code: DE

Ref legal event code: R081

Ref document number: 602018081030

Country of ref document: DE

Owner name: PURETECH LYT, INC., BOSTON, US

Free format text: FORMER OWNERS: NEW YORK UNIVERSITY, NEW YORK, NY, US; PURETECH HEALTH LLC, BOSTON, MA, US

Ref country code: DE

Ref legal event code: R081

Ref document number: 602018081030

Country of ref document: DE

Owner name: NEW YORK UNIVERSITY, NEW YORK, US

Free format text: FORMER OWNERS: NEW YORK UNIVERSITY, NEW YORK, NY, US; PURETECH HEALTH LLC, BOSTON, MA, US

REG Reference to a national code

Ref country code: PT

Ref legal event code: SC4A

Ref document number: 3625263

Country of ref document: PT

Date of ref document: 20250620

Kind code of ref document: T

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 20250612

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

Effective date: 20250623

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: NL

Ref legal event code: FP

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 3032734

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20250724

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250409

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG9D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250710

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250409

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20250912

Year of fee payment: 8

Ref country code: IT

Payment date: 20250922

Year of fee payment: 8

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250409

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20250917

Year of fee payment: 8

Ref country code: GB

Payment date: 20250904

Year of fee payment: 8

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250409

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20250908

Year of fee payment: 8

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 20250910

Year of fee payment: 8

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250709

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IE

Payment date: 20250909

Year of fee payment: 8

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250809

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250409

REG Reference to a national code

Ref country code: CH

Ref legal event code: U11

Free format text: ST27 STATUS EVENT CODE: U-0-0-U10-U11 (AS PROVIDED BY THE NATIONAL OFFICE)

Effective date: 20251101

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: LU

Payment date: 20251016

Year of fee payment: 8

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PT

Payment date: 20251024

Year of fee payment: 8

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20250902

Year of fee payment: 8

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NO

Payment date: 20251009

Year of fee payment: 8

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602018081030

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250409

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: AT

Payment date: 20250925

Year of fee payment: 8

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DK

Payment date: 20251014

Year of fee payment: 8

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20251101

Year of fee payment: 8

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250409

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250409

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250409

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20251105

Year of fee payment: 8

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

REG Reference to a national code

Ref country code: CH

Ref legal event code: L10

Free format text: ST27 STATUS EVENT CODE: U-0-0-L10-L00 (AS PROVIDED BY THE NATIONAL OFFICE)

Effective date: 20260218

26N No opposition filed

Effective date: 20260112

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250409

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250409