EP3720493C0 - Kombinationen von ripk1 und ikk-hemmern zur vorbeugung und behandlung von immunerkrankungen - Google Patents

Kombinationen von ripk1 und ikk-hemmern zur vorbeugung und behandlung von immunerkrankungen

Info

Publication number: EP3720493C0
Authority: EP; European Patent Office
Prior art keywords: ripk1; prevention; combinations; treatment; immune diseases
Prior art date: 2017-12-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

EP18826203.4A

Other languages

English (en)

French (fr)

Other versions

EP3720493B1 (de

EP3720493A1 (de

Inventor

Manolis Pasparakis

Nikos Oikonomou

Apostolos Polykratis

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Universitaet zu Koeln

Original Assignee

Universitaet zu Koeln

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-12-07

Filing date

2018-12-07

Publication date

2024-07-24

2018-12-07 Application filed by Universitaet zu Koeln filed Critical Universitaet zu Koeln

2020-10-14 Publication of EP3720493A1 publication Critical patent/EP3720493A1/de

2024-07-24 Application granted granted Critical

2024-07-24 Publication of EP3720493B1 publication Critical patent/EP3720493B1/de

2024-07-24 Publication of EP3720493C0 publication Critical patent/EP3720493C0/de

Status Active legal-status Critical Current

2038-12-07 Anticipated expiration legal-status Critical

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

EP18826203.4A 2017-12-07 2018-12-07 Kombinationen von ripk1 und ikk-hemmern zur vorbeugung und behandlung von immunerkrankungen Active EP3720493B1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP17205864.6A EP3494994A1 (de)	2017-12-07	2017-12-07	Kombinationen von ripk1 und ikk-hemmern zur vorbeugung und behandlung von immunerkrankungen
PCT/EP2018/084055 WO2019110832A1 (en)	2017-12-07	2018-12-07	Combinations of ripk1- and ikk-inhibitors for the prevention or treatment of immune diseases

Publications (3)

Publication Number	Publication Date
EP3720493A1 EP3720493A1 (de)	2020-10-14
EP3720493B1 EP3720493B1 (de)	2024-07-24
EP3720493C0 true EP3720493C0 (de)	2024-07-24

Family

ID=60629504

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
EP17205864.6A Withdrawn EP3494994A1 (de)	2017-12-07	2017-12-07	Kombinationen von ripk1 und ikk-hemmern zur vorbeugung und behandlung von immunerkrankungen
EP18826203.4A Active EP3720493B1 (de)	2017-12-07	2018-12-07	Kombinationen von ripk1 und ikk-hemmern zur vorbeugung und behandlung von immunerkrankungen

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
EP17205864.6A Withdrawn EP3494994A1 (de)	2017-12-07	2017-12-07	Kombinationen von ripk1 und ikk-hemmern zur vorbeugung und behandlung von immunerkrankungen

Country Status (7)

Country	Link
US (1)	US20200383995A1 (de)
EP (2)	EP3494994A1 (de)
JP (1)	JP7527639B2 (de)
CN (1)	CN111670049A (de)
CA (1)	CA3103847A1 (de)
MX (1)	MX2020007036A (de)
WO (1)	WO2019110832A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2021046515A1 (en) *	2019-09-06	2021-03-11	Board Of Regents, The University Of Texas System	Inhibitors of receptor interacting protein kinase i for the treatment of disease
IL291665B2 (en)	2019-09-27	2025-07-01	Univ Texas	Inhibitors of receptor interacting protein kinase i for the treatment of disease
JP2023502514A (ja)	2019-11-26	2023-01-24	ボードオブレジェンツ，ザユニバーシティオブテキサスシステム	疾患の処置のための受容体相互作用プロテインキナーゼｉの阻害剤
EP4209213A1 (de)	2022-01-05	2023-07-12	Universität zu Köln	Kombinationen von signalweginhibitoren zur verwendung in der behandlung von krebserkrankungen
EP4665334A1 (de)	2023-02-17	2025-12-24	Universität zu Köln	Dreifachkinasehemmung zur behandlung von erkrankungen im zusammenhang mit typ-i-interferon-reaktion
CN119064582B (zh) *	2024-09-02	2025-05-27	南方医科大学南方医院	RIPK1 O-GlcNAc糖基化抑制剂在制备增强肾细胞癌舒尼替尼敏感性药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL364111A1 (en)	2001-02-01	2004-12-13	Bristol-Myers Squibb Company	Methods of treating inflammatory and immune diseases using inhibitors of ikappab kinase (ikk)
US7592353B2 (en) *	2006-06-06	2009-09-22	Boehringer Ingelheim International Gmbh	Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
ES2555160B1 (es) *	2014-06-24	2016-10-25	Aptus Biotech, S.L.	Aptámeros específicos de TLR-4 y usos de los mismos
EP3017825A1 (de) *	2014-11-06	2016-05-11	Ludwig-Maximilians-Universität München	Inhibitor des RIPK1-abhängigen Nekrosepfades und pharmazeutische Zusammensetzung damit

2017
- 2017-12-07 EP EP17205864.6A patent/EP3494994A1/de not_active Withdrawn
2018
- 2018-12-07 CA CA3103847A patent/CA3103847A1/en active Pending
- 2018-12-07 MX MX2020007036A patent/MX2020007036A/es unknown
- 2018-12-07 US US16/769,972 patent/US20200383995A1/en active Pending
- 2018-12-07 CN CN201880088634.3A patent/CN111670049A/zh active Pending
- 2018-12-07 JP JP2020531104A patent/JP7527639B2/ja active Active
- 2018-12-07 WO PCT/EP2018/084055 patent/WO2019110832A1/en not_active Ceased
- 2018-12-07 EP EP18826203.4A patent/EP3720493B1/de active Active

Also Published As

Publication number	Publication date
JP7527639B2 (ja)	2024-08-05
JP2021505611A (ja)	2021-02-18
EP3494994A1 (de)	2019-06-12
WO2019110832A1 (en)	2019-06-13
US20200383995A1 (en)	2020-12-10
EP3720493B1 (de)	2024-07-24
CA3103847A1 (en)	2019-06-13
EP3720493A1 (de)	2020-10-14
MX2020007036A (es)	2020-12-03
CN111670049A (zh)	2020-09-15

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