EP3744845A4 - T-zellen-rezeptor - Google Patents
T-zellen-rezeptor Download PDFInfo
- Publication number
- EP3744845A4 EP3744845A4 EP19743810.4A EP19743810A EP3744845A4 EP 3744845 A4 EP3744845 A4 EP 3744845A4 EP 19743810 A EP19743810 A EP 19743810A EP 3744845 A4 EP3744845 A4 EP 3744845A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- lymphocyte receptor
- lymphocyte
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/32—T-cell receptors [TCR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/46—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57505—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018008947A JP7181517B2 (ja) | 2018-01-23 | 2018-01-23 | T細胞レセプター |
| PCT/JP2019/001182 WO2019146477A1 (ja) | 2018-01-23 | 2019-01-17 | T細胞レセプター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP3744845A1 EP3744845A1 (de) | 2020-12-02 |
| EP3744845A4 true EP3744845A4 (de) | 2021-11-03 |
Family
ID=67394780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP19743810.4A Pending EP3744845A4 (de) | 2018-01-23 | 2019-01-17 | T-zellen-rezeptor |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12479901B2 (de) |
| EP (1) | EP3744845A4 (de) |
| JP (1) | JP7181517B2 (de) |
| CN (1) | CN111655721B (de) |
| BR (1) | BR112020014529A2 (de) |
| WO (1) | WO2019146477A1 (de) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999060120A2 (en) | 1998-05-19 | 1999-11-25 | Avidex Limited | Soluble t cell receptor |
| US7435592B2 (en) * | 2003-05-13 | 2008-10-14 | Immunovative Therapies, Ltd. | Compositions for allogeneic cell therapy |
| DK1910521T3 (da) * | 2005-08-05 | 2011-02-07 | Helmholtz Zentrum Muenchen | Generering af allo-begrænsede, antigenspecifikke T-celler |
| FR2957799B1 (fr) * | 2010-03-26 | 2012-08-17 | Inst Des Vaisseaux Et Du Sang | Compositions proangiogeniques, leur procede de preparation et leurs utilisations |
| JP6126804B2 (ja) | 2012-07-25 | 2017-05-10 | 国立大学法人富山大学 | T細胞受容体のクローニング方法 |
| KR102499753B1 (ko) | 2012-07-27 | 2023-02-16 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | T 세포 수용체 조작 |
| KR102415259B1 (ko) | 2013-11-22 | 2022-06-30 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 조작된 고-친화도의 인간 t 세포 수용체 |
| EP3475706B1 (de) * | 2016-06-27 | 2021-08-11 | Juno Therapeutics, Inc. | Mhc-e-beschränkte epitopen, bindungsmoleküle, und zugehörige verfahren und verwendungen |
-
2018
- 2018-01-23 JP JP2018008947A patent/JP7181517B2/ja active Active
-
2019
- 2019-01-17 CN CN201980009889.0A patent/CN111655721B/zh active Active
- 2019-01-17 US US16/961,409 patent/US12479901B2/en active Active
- 2019-01-17 BR BR112020014529-7A patent/BR112020014529A2/pt unknown
- 2019-01-17 WO PCT/JP2019/001182 patent/WO2019146477A1/ja not_active Ceased
- 2019-01-17 EP EP19743810.4A patent/EP3744845A4/de active Pending
Non-Patent Citations (7)
| Title |
|---|
| ISHIHARA YUKO ET AL: "A Unique T-Cell Receptor Amino Acid Sequence Selected by Human T-Cell Lymphotropic Virus Type 1 Tax301-309- Specific Cytotoxic T Cells in HLA-A24:02- Positive Asymptomatic Carriers and Adult T-Cell Leukemia/Lymphoma Patients", vol. 91, no. 19, 12 September 2017 (2017-09-12), US, XP055842811, ISSN: 0022-538X, Retrieved from the Internet <URL:https://journals.asm.org/doi/pdf/10.1128/JVI.00974-17> DOI: 10.1128/JVI 00974-17 * |
| K. D. BOURCIER ET AL: "Conserved CDR3 Regions in T-Cell Receptor (TCR) CD8+ T Cells That Recognize the Tax11-19/HLA-A*0201 Complex in a Subject Infected with Human T-Cell Leukemia Virus Type 1: Relationship of T-Cell Fine Specificity and Major Histocompatibility Complex/Peptide/TCR Crystal Structure", JOURNAL OF VIROLOGY, vol. 75, no. 20, 15 October 2001 (2001-10-15), US, pages 9836 - 9843, XP055627123, ISSN: 0022-538X, DOI: 10.1128/JVI.75.20.9836-9843.2001 * |
| MINEKI SAITO ET AL: "Molecular Analysis of T Cell Clonotypes in Muscle-Infiltrating Lymphocytes from Patients with Human T Lymphotropic Virus Type 1 Polymyositis", JOURNAL OF INFECTIOUS DISEASES, vol. 186, no. 9, 1 November 2002 (2002-11-01), US, pages 1231 - 1241, XP055627121, ISSN: 0022-1899, DOI: 10.1086/344315 * |
| See also references of WO2019146477A1 * |
| UTZ U ET AL: "Analysis of the T-cell receptor repertoire of human T-cell leukemia virus type 1 (HTLV-1) tax-specific CD8+ cytotoxic T lymphocytes from patients with HTLV-1-associated disease: Evidence for oligoclonal expansion", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 70, no. 2, 1 January 1996 (1996-01-01), pages 843 - 851, XP002287145, ISSN: 0022-538X * |
| Y. TANAKA ET AL: "Single-Cell Analysis of T-Cell Receptor Repertoire of HTLV-1 Tax-Specific Cytotoxic T Cells in Allogeneic Transplant Recipients with Adult T-Cell Leukemia/Lymphoma", CANCER RESEARCH, vol. 70, no. 15, 1 August 2010 (2010-08-01), pages 6181 - 6192, XP055075777, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-10-0678 * |
| YUKIE TANAKA ET AL: "Long-Term Persistence of Limited HTLV-I Tax-specific Cytotoxic T Cell Clones in a Patient with Adult T Cell Leukemia/Lymphoma after Allogeneic Stem Cell Transplantation", JOURNAL OF CLINICAL IMMUNOLOGY, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 32, no. 6, 5 July 2012 (2012-07-05), pages 1340 - 1352, XP035153741, ISSN: 1573-2592, DOI: 10.1007/S10875-012-9729-5 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20200360435A1 (en) | 2020-11-19 |
| JP2019126276A (ja) | 2019-08-01 |
| EP3744845A1 (de) | 2020-12-02 |
| CN111655721A (zh) | 2020-09-11 |
| WO2019146477A1 (ja) | 2019-08-01 |
| JP7181517B2 (ja) | 2022-12-01 |
| US12479901B2 (en) | 2025-11-25 |
| CN111655721B (zh) | 2023-05-05 |
| BR112020014529A2 (pt) | 2020-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
| 17P | Request for examination filed |
Effective date: 20200820 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| AX | Request for extension of the european patent |
Extension state: BA ME |
|
| RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: FUJII, KEISUKE Inventor name: SHIKU, HIROSHI Inventor name: KISHI, HIROYUKI Inventor name: JO, TATSURO Inventor name: MIYAHARA, YOSHIHIRO |
|
| DAV | Request for validation of the european patent (deleted) | ||
| DAX | Request for extension of the european patent (deleted) | ||
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20211006 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 5/0783 20100101ALI20210930BHEP Ipc: G01N 33/68 20060101ALI20210930BHEP Ipc: G01N 33/574 20060101ALI20210930BHEP Ipc: G01N 33/569 20060101ALI20210930BHEP Ipc: C12Q 1/02 20060101ALI20210930BHEP Ipc: C07K 14/725 20060101ALI20210930BHEP Ipc: A61P 35/02 20060101ALI20210930BHEP Ipc: A61P 31/14 20060101ALI20210930BHEP Ipc: A61K 48/00 20060101ALI20210930BHEP Ipc: A61K 35/76 20150101ALI20210930BHEP Ipc: A61K 35/17 20150101ALI20210930BHEP Ipc: C12N 15/12 20060101AFI20210930BHEP |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
| 17Q | First examination report despatched |
Effective date: 20250422 |
|
| R17C | First examination report despatched (corrected) |
Effective date: 20250422 |