EP3784265A4 - Modulateurs du récepteur de l'amyline de peptide cyclique thioéther - Google Patents

Modulateurs du récepteur de l'amyline de peptide cyclique thioéther Download PDF

Info

Publication number
EP3784265A4
EP3784265A4 EP19791705.7A EP19791705A EP3784265A4 EP 3784265 A4 EP3784265 A4 EP 3784265A4 EP 19791705 A EP19791705 A EP 19791705A EP 3784265 A4 EP3784265 A4 EP 3784265A4
Authority
EP
European Patent Office
Prior art keywords
amylin
receptor modulators
thioether peptide
cyclic
cyclic receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19791705.7A
Other languages
German (de)
English (en)
Other versions
EP3784265A2 (fr
Inventor
Wenying Jian
Raymond Patch
Rui Zhang
Songmao ZHENG
Simon Hinke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of EP3784265A2 publication Critical patent/EP3784265A2/fr
Publication of EP3784265A4 publication Critical patent/EP3784265A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP19791705.7A 2018-04-25 2019-04-17 Modulateurs du récepteur de l'amyline de peptide cyclique thioéther Withdrawn EP3784265A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862662492P 2018-04-25 2018-04-25
PCT/IB2019/053194 WO2019207427A2 (fr) 2018-04-25 2019-04-17 Modulateurs du récepteur de l'amyline de peptide cyclique thioéther

Publications (2)

Publication Number Publication Date
EP3784265A2 EP3784265A2 (fr) 2021-03-03
EP3784265A4 true EP3784265A4 (fr) 2022-06-22

Family

ID=68293854

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19791705.7A Withdrawn EP3784265A4 (fr) 2018-04-25 2019-04-17 Modulateurs du récepteur de l'amyline de peptide cyclique thioéther

Country Status (5)

Country Link
EP (1) EP3784265A4 (fr)
JP (1) JP2021522231A (fr)
CN (1) CN112074289A (fr)
CA (1) CA3097812A1 (fr)
WO (1) WO2019207427A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240118914A (ko) 2021-01-20 2024-08-05 바이킹 테라퓨틱스 인코포레이티드 대사 및 간 질환 치료를 위한 조성물 및 방법
CA3231953A1 (fr) 2021-09-15 2023-03-23 Brian Lian Compositions et methodes de traitement de troubles metaboliques et hepatiques
CN114057862A (zh) * 2021-12-14 2022-02-18 安徽省国平药业有限公司 一种glp-1(1-37)多肽的合成方法
CN120040558B (zh) * 2024-03-19 2026-07-21 深圳湾实验室 多肽或其类似物及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998050059A1 (fr) * 1997-05-06 1998-11-12 Amylin Pharmaceuticals, Inc. Procedes de prevention de la gastrite au moyen d'amyline ou d'agonistes d'amyline
WO2005115437A2 (fr) * 2004-05-20 2005-12-08 Amylin Pharmaceuticals, Inc. Methodes permettant de modifier la composition du corps
WO2016011208A1 (fr) * 2014-07-17 2016-01-21 Protagonist Therapeutics, Inc. Peptides inhibiteurs par voie orale du récepteur de l'interleukine-23 et leur utilisation dans le traitement des maladies inflammatoires de l'intestin

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101400698A (zh) * 2006-03-15 2009-04-01 诺沃-诺迪斯克有限公司 胰岛淀粉样多肽衍生物
EP2036923A1 (fr) * 2007-09-11 2009-03-18 Novo Nordisk A/S Dérivés d'amyline améliorés
WO2010144508A1 (fr) * 2009-06-08 2010-12-16 Amunix Operating Inc. Polypeptides de régulation du glucose et leurs procédés de production et d'utilisation
WO2011050008A2 (fr) * 2009-10-19 2011-04-28 Amylin Pharmaceuticals, Inc. Polythérapie comprenant l'administration d'un amylinomimétique et d'un peptidomimétique de pyy pour obtenir une perte de poids et pour traiter l'obésité et les états pathologiques et les troubles métaboliques associés
US20110312881A1 (en) * 2009-12-21 2011-12-22 Amunix, Inc. Bifunctional polypeptide compositions and methods for treatment of metabolic and cardiovascular diseases
JP2014516049A (ja) * 2011-05-25 2014-07-07 アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー アミリンペプチドおよび誘導体ならびにそれらの使用
WO2013059336A1 (fr) * 2011-10-18 2013-04-25 Amylin Pharmaceuticals, Llc Peptides chimériques d'amyline-calcitonines conjugués à des radicaux augmentant la durée de l'activité biologique
EP3024847A1 (fr) * 2013-07-25 2016-06-01 Novartis AG Polypeptides cyclique disulfure pour le traitement de l'insuffisance cardiaque
AR097701A1 (es) * 2013-09-19 2016-04-13 Zealand Pharma As Análogos de amilina
CN108473547A (zh) * 2015-10-28 2018-08-31 塔夫茨大学 具有改良的蛋白质分解安定性的新颖多肽，以及制备与使用该新颖多肽的方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998050059A1 (fr) * 1997-05-06 1998-11-12 Amylin Pharmaceuticals, Inc. Procedes de prevention de la gastrite au moyen d'amyline ou d'agonistes d'amyline
WO2005115437A2 (fr) * 2004-05-20 2005-12-08 Amylin Pharmaceuticals, Inc. Methodes permettant de modifier la composition du corps
WO2016011208A1 (fr) * 2014-07-17 2016-01-21 Protagonist Therapeutics, Inc. Peptides inhibiteurs par voie orale du récepteur de l'interleukine-23 et leur utilisation dans le traitement des maladies inflammatoires de l'intestin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MOLL G N ET AL: "A biological stabilization technology for peptide drugs: enzymatic introduction of thioether-bridges", DRUG DISCOVERY TODAY: TECHNOLOGIES, ELSEVIER, AMSTERDAM, NL, vol. 6, no. 1-4, January 2009 (2009-01-01), pages e13 - e18, XP027503974, ISSN: 1740-6749, [retrieved on 20090419], DOI: 10.1016/J.DDTEC.2009.03.001 *

Also Published As

Publication number Publication date
JP2021522231A (ja) 2021-08-30
EP3784265A2 (fr) 2021-03-03
WO2019207427A3 (fr) 2020-01-02
CN112074289A (zh) 2020-12-11
CA3097812A1 (fr) 2019-10-31
WO2019207427A2 (fr) 2019-10-31

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