EP3810228A1 - Ressort pour un dispositif d'injection - Google Patents

Ressort pour un dispositif d'injection

Info

Publication number
EP3810228A1
EP3810228A1 EP19732119.3A EP19732119A EP3810228A1 EP 3810228 A1 EP3810228 A1 EP 3810228A1 EP 19732119 A EP19732119 A EP 19732119A EP 3810228 A1 EP3810228 A1 EP 3810228A1
Authority
EP
European Patent Office
Prior art keywords
coil spring
spring
turns
injection device
winding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19732119.3A
Other languages
German (de)
English (en)
Inventor
Peter Stettler
Benjamin LORETZ
Lorenzo NOTARO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ypsomed AG
Original Assignee
Ypsomed AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ypsomed AG filed Critical Ypsomed AG
Publication of EP3810228A1 publication Critical patent/EP3810228A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/3245—Constructional features thereof, e.g. to improve manipulation or functioning
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F1/00—Springs
    • F16F1/02—Springs made of steel or other material having low internal friction; Wound, torsion, leaf, cup, ring or the like springs, the material of the spring not being relevant
    • F16F1/04—Wound springs
    • F16F1/06—Wound springs with turns lying in cylindrical surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F1/00—Springs
    • F16F1/02—Springs made of steel or other material having low internal friction; Wound, torsion, leaf, cup, ring or the like springs, the material of the spring not being relevant
    • F16F1/04—Wound springs
    • F16F1/12—Attachments or mountings
    • F16F1/122—Attachments or mountings where coils, e.g. end coils, of the spring are rigidly clamped or similarly fixed
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F2226/00—Manufacturing; Treatments
    • F16F2226/04—Assembly or fixing methods; methods to form or fashion parts
    • F16F2226/048—Welding
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F2228/00—Functional characteristics, e.g. variability, frequency-dependence
    • F16F2228/001—Specific functional characteristics in numerical form or in the form of equations
    • F16F2228/005—Material properties, e.g. moduli
    • F16F2228/007—Material properties, e.g. moduli of solids, e.g. hardness
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F2238/00—Type of springs or dampers
    • F16F2238/02—Springs
    • F16F2238/026—Springs wound- or coil-like

Definitions

  • the present invention relates to the field of medical injection devices for the administration of liquid substances, in particular medicaments or medical substances such as insulin and hormone preparations.
  • the invention relates to an injection device with a coil spring and to a method for producing the coil spring.
  • injection devices for administering liquid, medical substances are known from the prior art.
  • Injection devices referred to as auto-injectors
  • auto-injectors enable the medical substance to be automatically dispensed by means of a prestressed dispensing spring which presses a stopper into a syringe via a piston rod.
  • Such autoinjectors usually have a needle protection sleeve which can be displaced in a longitudinal direction between a proximal and a distal position by means of a helical spring relative to the housing of the autoinjector. After the injection, the needle protective sleeve is moved by the pre-tensioned coil spring to the distal position, in which it surrounds and shields the needle laterally. The needle protection sleeve thereby ensures that the user is not injured by the needle after the injection.
  • Spiral springs can be used in injection devices as torsion springs to drive the distribution.
  • tension or compression springs are preferred.
  • the object is achieved by an injection device with a coil spring and by a coil spring with two interconnected windings in accordance with the independent claims.
  • the injection device comprises a helical spring which has a winding which extends in an axial direction and has at least three turns, of which two adjacent turns are permanently connected at one point by a laser-welded connection in the axial direction.
  • the invention further relates to a method for connecting two turns of a helical spring for an injection device.
  • the method comprises the steps: providing a helical spring which has a winding which extends in an axial direction and has at least three turns and connecting two adjacent turns by laser welding at one point.
  • the turns can be quickly and reliably permanently connected to one another in the axial direction.
  • the connection process of the two adjacent windings can take place in less than five seconds. As a result, large quantities of the coil spring according to the invention can be produced efficiently.
  • the term “medicament” or “medical substance” encompasses any flowable medical formulation which is suitable for controlled administration by means of a cannula or hollow needle, for example a liquid, a solution, a gel or a fine suspension containing one or more medicinal active substances ,
  • a medicament can therefore be a composition with a single active ingredient or a premixed or co-formulated composition with several active ingredients from a single container.
  • the term includes in particular medicaments such as peptides (eg insulin, medication containing insulin, preparations containing GLP-1 and derived or analog preparations), proteins and hormones, biologically obtained or active substances, substances based on Hormones or genes, nutritional formulations, enzymes and other substances both in solid (suspended) or liquid form.
  • the term also includes polysaccharides, vaccines, DNA or RNA or oligonucleotides, antibodies or parts of antibodies, as well as suitable base, auxiliary and carrier substances.
  • injection device or “injector” mean a device in which the injection needle is removed from the patient's tissue after the medicinal substance has been dispensed.
  • the injection needle does not remain in the patient permanently or over a longer period of several hours.
  • a coil spring includes a winding with a plurality of turns extending in an axial direction.
  • the coil spring is formed by a helically wound elongated material, which is referred to below as a wire. It is not essential that the wire has a circular cross section. The cross section can equally well be rectangular, polygonal or elliptical.
  • the helical spring can be compressed or expanded by a linear movement along its longitudinal axis or in the axial direction.
  • the coil spring differs fundamentally from a spiral spring. The latter is formed by a band wound in a plane in a helical line, the spiral spring being able to be tensioned or relaxed by rotating one end thereof.
  • turn is understood to mean a section of the helical winding which extends through an angle equal to or less than 360 °.
  • a turn begins where a previous turn ends at an angle of 360 ° or where the elongated material begins. Accordingly, one turn ends at an angle of 360 ° or where the elongated material ends.
  • the two outermost turns of the coil spring winding extend through an angle equal to or less than 360 ° and the inner turns between the two outermost turns each extend through an angle of 360 °.
  • the term “distal” in the present description refers to a direction towards the one-sided end of the injection device.
  • proximal relates to a direction toward the rear end of the injection device, which is opposite the insertion end.
  • the injection device preferably comprises a housing and a needle protection sleeve, the needle protection sleeve being movable in the distal direction relative to the housing by means of the helical spring.
  • the coil spring can preferably be tensioned by a movement of the needle protection sleeve.
  • the coil spring can be implemented as a compression spring (tension of the coil spring by compression) or as a tension spring (tension of the coil spring by expansion).
  • the coil spring is tensioned when the needle guard is in a proximal position in which the needle tip is not shielded by the needle guard. If, on the other hand, the needle protection sleeve is in a distal position in which the needle tip is shielded by the needle protection sleeve, the coil spring is preferably relaxed or less tensioned. This significantly reduces the risk of injury from the injection needle.
  • the helical spring moves other elements of the injection device, such as, for example, a drive device for dispensing the medical substance from the syringe or a movable display or setting element.
  • the injection device comprises a spring receiving volume with an annular cross section, in which the coil spring is at least partially located.
  • the annular cross section can also be referred to as an annular channel or as a spring chamber formed by two concentrically arranged circular cylindrical surfaces.
  • the annular cross section of the spring receiving volume has, at least in sections, a cross-sectional width that is greater than 1.3 times the outer dimension of a wire of the helical spring.
  • the invention further relates to a helical spring for an injection device described above, the helical spring having a winding which extends in an axial direction and has at least three turns, two turns being inseparably connected to one another by a laser-welded connection.
  • An outermost and an adjacent or second outermost turn of the winding are advantageously connected to one another by the laser-welded connection, since the spring end or the end of the wire of the coil spring tends to tend to radially outwards or inwards when the coil spring is compressed or expanded to postpone.
  • the spring ends can be stabilized by this connection, so that a correct and complete axial compression or expansion of the coil spring is possible.
  • the outermost and the outermost turn of the winding are preferably connected to one another at both ends of the helical spring by the connection.
  • the coil spring is symmetrical, which simplifies its handling.
  • the winding is preferably formed by a wire with a circular cross section. This is readily available and the coil spring is particularly easy to wind with a wire with a circular.
  • the wire is preferably made of stainless spring steel and is also electrically conductive. Due to the electrical conductivity, the spring position can be detected, for example with an inductive or a capacitive sensor.
  • the helical spring can, for example, also be formed from a rectangular wire. In this case, however, the production is more complex due to the necessary alignment of the wire. In addition, the raw material for a coil spring made of rectangular wire is difficult to obtain.
  • the diameter of the wire is preferably less than 2 mm and is in particular between 0.3 mm and 1.2 mm.
  • the coil spring is preferably used as a compression spring, which has a spring constant of less than 0.2 N / mm.
  • the two turns are laser-welded to one another at two spaced apart points. As a result, the two turns are connected to one another in a particularly stable manner. In this case, it is also ensured that even if one of the two laser-welded connections is lost, the two turns are still connected to one another.
  • the helical spring preferably comprises at least 5 turns, preferably between 10 and 30 turns.
  • the spring in the unloaded state, when it is neither compressed nor expanded, the spring preferably has a length of less than 200 mm.
  • the outer dimension of the coil spring is preferably between 4 mm and 26 mm and in particular between 9 and 21 mm.
  • the outside dimension of the helical spring perpendicular to the axis is at least 9 mm and the connection is a maximum of 20 mm, preferably a maximum of 5 mm, spaced in the circumferential direction from one end of the wire of the helical spring.
  • the end of the wire is optimally fixed so that it cannot move radially inwards or radially outwards.
  • FIG. 1 shows a perspective view of a coil spring according to the invention
  • Fig. 2a shows a sectional view through the longitudinal axis of an inventive
  • FIG. 2b shows a sectional view of the injection device offset by 90 ° about the longitudinal axis with respect to FIG. 2a;
  • 3a shows a sectional view of the injection device with the helical spring in a compressed state
  • FIG. 3b shows a sectional view of the injection device offset by FIG. 3a by 90 ° about the longitudinal axis.
  • FIG. 1 shows an overall perspective view of a helical spring 10 according to the invention.
  • the helical spring 10 is designed as a compression spring and has a winding with a total of 15 turns extending in the axial direction or in the longitudinal direction of the helical spring 10.
  • the coil spring 10 in unloaded condition a length of 1 14 mm. It also has an outside diameter of 15 mm.
  • the coil spring 10 is made of a wire with a circular cross section, which has a diameter of 0.7 mm.
  • the wire is made of spring steel with a chrome-nickel alloy and is also electrically conductive. As can be seen in FIG. 1, the two outermost turns are connected to one another by selective laser welding.
  • connection points 20a, 20b, 20c 20d The outermost or first turn and the second outermost or second turn of the winding are connected to one another by means of two connection points 20a, 20b, 20c 20d.
  • a first connection point 20a is located approximately 2 mm from one end of the wire, and this distance can also be selected to be larger.
  • a second connection point 20b is spaced 3 mm from the end of the wire or 1 mm from the first connection point.
  • connection points 20a, 20b at a first end of the coil spring corresponds to the arrangement of a third and fourth connection point 20c, 20d at a second end of the coil spring 10.
  • the coil spring 10 thus has a total of 4 connection points 20a, 20b, 20c, 20d.
  • FIGS. 2a, 2b, 3a and 3b each show a sectional view of the injection device according to the invention in the form of an auto injector 1 with a coil spring 10 according to the invention.
  • the section in each case runs through the longitudinal axis of the auto injector 1.
  • the section in FIGS. 2b and 3b is offset by 90 ° about the longitudinal axis in comparison to FIGS. 2a, 3a.
  • the arrangement and the function of the coil spring 10 in the auto-injector 1 are described below with reference to these figures.
  • the auto-injector 1 has a sleeve-shaped, elongated housing 2 with a longitudinal axis L.
  • a product container 13 with the medicament is accommodated in the housing 2.
  • the product container 13 is connected to a hollow injection needle 13a.
  • the auto-injector 1 also has a needle protection sleeve 3, which can be displaced in the proximal direction relative to the housing 2 and along the longitudinal axis L by an actuation stroke HB in an actuated position in order to trigger a product distribution.
  • the switching sleeve 15 lies against a proximal end 3a of the needle protection sleeve 3.
  • the coil spring 10 is aligned in the longitudinal direction in the auto-injector and surrounds it partially the switching sleeve 15 and the locking sleeve 8.
  • the helical spring 10 is supported with its distal end in sections on the switching sleeve 15 in the circumferential direction. A part of the switching sleeve 15 is thus arranged between the needle protection sleeve 3 and the distal end of the coil spring 10.
  • the helical spring 10 with its distal region is located in an annular channel 9a, which is formed by an outer surface of the switching sleeve 15 and an inner wall of the housing 2, as can be seen in FIG. 2a.
  • the helical spring 10 is supported with its proximal end on a protrusion 6e of a holding element 6, as can be seen in FIG. 2b.
  • the holding element 6 engages in the housing 2 in an axially displaceable and non-rotatable manner.
  • the helical spring 10 is also located in an annular channel 9b, which is formed by the outer surface of the holding element 6 and the inner wall of the housing 2.
  • the coil spring 10 is thus supported only at its distal and proximal ends.
  • the annular channels 9a, 9b are significantly wider than the diameter of the wire of the helical spring 10. In sections, the channels 9a, 9b are approximately twice as wide as the wire diameter. As a result, the turns of the coil spring 10 between the two ends of the coil spring 10 hardly touch the walls of the annular channels 9a, 9b.
  • the distal end of the needle protection sleeve 3 protrudes distally beyond the needle tip of the injection needle 13a, so that access to the needle tip is initially prevented.
  • the distal end of the needle protection sleeve 3 is placed at the puncture site of a patient, the housing 2 being displaced towards the puncture site, as a result of which the needle protection sleeve 3 moves relative to the actuation stroke HB in the proximal direction from its starting position moved to the housing 2 in the actuated position.
  • the helical spring 10 is compressed and thus tensioned, the switching sleeve 15 and the locking sleeve 8 being carried along by the needle protection sleeve 3 by the actuation stroke HB. This state can be seen in FIGS. 3a and 3b.
  • engaging members 6b of the holding element 6 are moved out of a recess 8b of the locking sleeve 8. This can make the tense Coil spring 10 partially relax and thereby accelerate the holding element 6 in the proximal direction, whereby an acoustic and / or tactile signal is generated when the holding element 6 strikes an end signal stop 5e.
  • the needle protection sleeve 3 is released for movement in the distal direction, the coil spring 10 relaxes and thereby moves the switching sleeve 15 and the needle protection sleeve 3 from the actuated position to the needle protection position around the needle protection stroke (not in the figures shown).

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental & Geological Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un dispositif d'injection (1) pour administrer une substance médicamenteuse, le dispositif d'injection (1) comprenant un ressort hélicoïdal (10) qui présente un enroulement s'étendant dans une direction axiale et muni d'au moins trois spires, deux spires adjacentes étant mutuellement reliées, dans la direction axiale, de manière fixe en un point grâce à une liaison (20a) par soudure au laser. L'invention concerne également un ressort hélicoïdal (10) de ce type et un procédé pour relier deux spires du ressort hélicoïdal (10).
EP19732119.3A 2018-06-19 2019-05-08 Ressort pour un dispositif d'injection Pending EP3810228A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH00773/18A CH715110A2 (de) 2018-06-19 2018-06-19 Injektionsvorrichtung zum Verabreichen einer medizinischen Substanz, umfassend eine Schraubenfeder, sowie eine solche Schraubenfeder.
PCT/IB2019/053762 WO2019243908A1 (fr) 2018-06-19 2019-05-08 Ressort pour un dispositif d'injection

Publications (1)

Publication Number Publication Date
EP3810228A1 true EP3810228A1 (fr) 2021-04-28

Family

ID=66998455

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19732119.3A Pending EP3810228A1 (fr) 2018-06-19 2019-05-08 Ressort pour un dispositif d'injection

Country Status (5)

Country Link
US (1) US20210100955A1 (fr)
EP (1) EP3810228A1 (fr)
CN (1) CN112672775A (fr)
CH (1) CH715110A2 (fr)
WO (1) WO2019243908A1 (fr)

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USD1007676S1 (en) 2021-11-16 2023-12-12 Regeneron Pharmaceuticals, Inc. Wearable autoinjector
WO2025214783A1 (fr) * 2024-04-12 2025-10-16 Shl Medical Ag Unité de surveillance pour un dispositif d'administration de médicament entraîné par un ressort de torsion

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