EP3853354A4 - Aus einkernigen zellen abgeleitete nk-zellen - Google Patents

Aus einkernigen zellen abgeleitete nk-zellen Download PDF

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Publication number
EP3853354A4
EP3853354A4 EP19936966.1A EP19936966A EP3853354A4 EP 3853354 A4 EP3853354 A4 EP 3853354A4 EP 19936966 A EP19936966 A EP 19936966A EP 3853354 A4 EP3853354 A4 EP 3853354A4
Authority
EP
European Patent Office
Prior art keywords
cells
cell derived
mononuclear cell
mononuclear
derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19936966.1A
Other languages
English (en)
French (fr)
Other versions
EP3853354A1 (de
Inventor
Rohit Duggal
Ranjeet SINHA
Wenzhao Li
Jason ISAACSON
Karl MARQUEZ
Patrick Soon-Shiong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunitybio Inc
Original Assignee
Immunitybio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunitybio Inc filed Critical Immunitybio Inc
Publication of EP3853354A1 publication Critical patent/EP3853354A1/de
Publication of EP3853354A4 publication Critical patent/EP3853354A4/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2315—Interleukin-15 (IL-15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
EP19936966.1A 2019-07-08 2019-07-08 Aus einkernigen zellen abgeleitete nk-zellen Pending EP3853354A4 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2019/040867 WO2021006875A1 (en) 2019-07-08 2019-07-08 Mononuclear cell derived nk cells

Publications (2)

Publication Number Publication Date
EP3853354A1 EP3853354A1 (de) 2021-07-28
EP3853354A4 true EP3853354A4 (de) 2022-04-20

Family

ID=74114919

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19936966.1A Pending EP3853354A4 (de) 2019-07-08 2019-07-08 Aus einkernigen zellen abgeleitete nk-zellen

Country Status (8)

Country Link
EP (1) EP3853354A4 (de)
JP (2) JP7213976B2 (de)
KR (1) KR102755940B1 (de)
CN (1) CN113166726A (de)
AU (1) AU2019456283B2 (de)
IL (1) IL283998A (de)
SG (1) SG11202104339WA (de)
WO (1) WO2021006875A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7792426B2 (ja) * 2021-03-03 2025-12-25 イミュニティバイオ，インコーポレーテッド 極めて強力なｍ－ｃｅｎｋ細胞及び方法
WO2022216992A1 (en) * 2021-04-08 2022-10-13 Board Of Regents, The University Of Texas System Methods for activation and expansion of natural killer cells and combinations with bispecific antibodies

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180355317A1 (en) * 2016-02-15 2018-12-13 Dong Hyuk Shin Method of culturing nk cells and kits containing medium addtions therefore

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102428173B (zh) * 2009-03-26 2014-07-30 细胞维护北欧制药公司 Nk细胞的扩增
CA3080368A1 (en) 2009-12-04 2011-06-09 Stem Cell & Regenerative Medicine International, Inc. Method of generating natural killer cells and dendritic cells from human embryonic stem cell-derived hemangioblasts
US20130059379A1 (en) 2010-02-24 2013-03-07 Ingo Schmidt-Wolf Method for the generation of a cik cell and nk cell population
US8507222B2 (en) 2010-09-21 2013-08-13 Altor Bioscience Corporation Multimeric IL-15 soluble fusion molecules and methods of making and using same
WO2012099093A1 (ja) 2011-01-21 2012-07-26 株式会社日本バイオセラピー研究所 Nk細胞強化型血液製剤の製造方法
WO2012128622A1 (en) 2011-03-18 2012-09-27 Ipd-Therapeutics B.V. Generation of nk cells and nk-cell progenitors
DK2812011T3 (da) 2012-02-08 2020-02-24 Glycostem Therapeutics B V Differentiering ex vivo af nk-celler fra cd34+ hæmatopoietiske celler
CN102988415B (zh) 2012-08-15 2014-11-19 中航（宁夏）生物有限责任公司 人异基因有核细胞工业化制备自然杀伤性细胞(nk)及注射液
JP5997296B2 (ja) * 2013-01-15 2016-09-28 阿部　博幸 免疫細胞含有組成物の製造方法及び癌治療用組成物
WO2015154012A1 (en) * 2014-04-03 2015-10-08 Memorial Sloan-Kettering Cancer Center Clonogenic natural killer (nk) cell populations and methods of producing and using such populations
CN106232801A (zh) 2014-04-28 2016-12-14 维瓦生物细胞股份公司 自动化细胞培养和收获装置
US12186342B2 (en) * 2016-09-23 2025-01-07 The Regents Of The University Of California Autologous irradiated whole cell tumor vaccines lentivirally engineered to express CD80, IL-15 and IL-15 receptor alpha
MY203000A (en) 2016-10-14 2024-06-01 Xencor Inc Il15/il15r� heterodimeric fc-fusion proteins
AU2018226526B2 (en) * 2017-02-28 2025-03-13 Affimed Gmbh Combination of an anti-CD16A antibody with a cytokine
KR102867975B1 (ko) 2017-03-06 2025-10-14 알토 바이오사이언스 엘엘씨 Il-12 및 il-18로의 il-15-기반 융합
AU2018265534A1 (en) * 2017-05-11 2019-10-31 Nantkwest, Inc. Anti-EGFR/high affinity NK-cells compositions and methods for chordoma treatment
EP3634437A4 (de) * 2017-05-19 2020-11-18 Case Western Reserve University Zusammensetzungen und verfahren zur ex-vivo-expansion natürlicher killerzellen und deren therapeutische verwendungen
CN108070556A (zh) * 2017-07-26 2018-05-25 深圳市北科生物科技有限公司 用于免疫细胞培养的方法和组合物
JP2020533971A (ja) * 2017-08-28 2020-11-26 アルター・バイオサイエンス・コーポレーション Ｉｌ−１５をベースとするｉｌ−７及びｉｌ−２１への融合物
CN109666640B (zh) * 2019-01-14 2020-06-16 武汉睿健医药科技有限公司 自然杀伤细胞体外纯培养的方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180355317A1 (en) * 2016-02-15 2018-12-13 Dong Hyuk Shin Method of culturing nk cells and kits containing medium addtions therefore

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HONG-RAE LEE ET AL: "Expansion of cytotoxic natural killer cells using irradiated autologous peripheral blood mononuclear cells and anti-CD16 antibody", SCIENTIFIC REPORTS, vol. 7, no. 1, 11 September 2017 (2017-09-11), XP055762396, DOI: 10.1038/s41598-017-09259-1 *

Also Published As

Publication number Publication date
JP7213976B2 (ja) 2023-01-27
JP2022513614A (ja) 2022-02-09
IL283998A (en) 2021-07-29
WO2021006875A1 (en) 2021-01-14
EP3853354A1 (de) 2021-07-28
SG11202104339WA (en) 2021-05-28
AU2019456283A1 (en) 2021-05-20
JP2023040184A (ja) 2023-03-22
KR102755940B1 (ko) 2025-01-15
CA3120695A1 (en) 2021-01-14
AU2019456283B2 (en) 2023-06-08
CN113166726A (zh) 2021-07-23
KR20210080566A (ko) 2021-06-30

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