EP4017859A4 - Alkylquarternäre ammoniumtryptamine und ihre therapeutischen verwendungen - Google Patents

Alkylquarternäre ammoniumtryptamine und ihre therapeutischen verwendungen Download PDF

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Publication number
EP4017859A4
EP4017859A4 EP20858480.5A EP20858480A EP4017859A4 EP 4017859 A4 EP4017859 A4 EP 4017859A4 EP 20858480 A EP20858480 A EP 20858480A EP 4017859 A4 EP4017859 A4 EP 4017859A4
Authority
EP
European Patent Office
Prior art keywords
tryptamines
therapeutic uses
quarternary ammonium
alkyl quarternary
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20858480.5A
Other languages
English (en)
French (fr)
Other versions
EP4017859A1 (de
Inventor
Andrew R. Chadeayne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Caamtech Inc
Original Assignee
Caamtech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caamtech Inc filed Critical Caamtech Inc
Publication of EP4017859A1 publication Critical patent/EP4017859A1/de
Publication of EP4017859A4 publication Critical patent/EP4017859A4/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP20858480.5A 2019-08-25 2020-08-25 Alkylquarternäre ammoniumtryptamine und ihre therapeutischen verwendungen Pending EP4017859A4 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962891388P 2019-08-25 2019-08-25
US202063007653P 2020-04-09 2020-04-09
US202063053976P 2020-07-20 2020-07-20
PCT/US2020/047791 WO2021041407A1 (en) 2019-08-25 2020-08-25 Alkyl quarternary ammonium tryptamines and their therapeutic uses

Publications (2)

Publication Number Publication Date
EP4017859A1 EP4017859A1 (de) 2022-06-29
EP4017859A4 true EP4017859A4 (de) 2023-08-23

Family

ID=74684268

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20858480.5A Pending EP4017859A4 (de) 2019-08-25 2020-08-25 Alkylquarternäre ammoniumtryptamine und ihre therapeutischen verwendungen

Country Status (4)

Country Link
EP (1) EP4017859A4 (de)
AU (1) AU2020337903A1 (de)
CA (1) CA3149602A1 (de)
WO (1) WO2021041407A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11701348B1 (en) 2016-07-23 2023-07-18 Turtle Bear Holdings, Llc Psilocybin compositions
US20210069170A1 (en) 2016-07-23 2021-03-11 Paul Edward Stamets Tryptamine compositions for enhancing neurite outgrowth
US20180021326A1 (en) 2016-07-23 2018-01-25 Paul Edward Stamets Compositions and methods for enhancing neuroregeneration and cognition by combining mushroom extracts containing active ingredients psilocin or psilocybin with erinacines or hericenones enhanced with niacin
AU2020386445B2 (en) 2019-11-19 2025-12-18 Paul Edward Stamets Tryptamine compositions for enhancing neurite outgrowth
CA3169783C (en) 2020-03-19 2025-12-02 Caamtech, Inc. Crystalline psilacetin derivatives
AU2021267859B9 (en) 2020-05-04 2023-07-27 Caamtech, Inc. Crystalline dimethyl tryptamine analogues
EP4146198A4 (de) 2020-05-08 2024-05-15 Psilera Inc. Neue stoffzusammensetzungen und pharmazeutische zusammensetzungen
US12240813B2 (en) 2020-05-19 2025-03-04 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
KR20230024378A (ko) 2020-06-12 2023-02-20 벡클리 싸이테크 리미티드 5-메톡시-n, n-디메틸트립타민의 벤조에이트 염을 포함하는 조성물
US12534441B2 (en) 2021-01-15 2026-01-27 Beckley Psytech Limited Tryptamine analogues
KR20240058859A (ko) 2021-08-12 2024-05-03 쿨레온 엘엘씨 환각성 및 비환각성 세로토닌 수용체 작용제 및 이의 제조 및 사용 방법
WO2023023298A1 (en) * 2021-08-20 2023-02-23 Psilosterics, Llc Hallucinogenic and non-hallucinogenic compounds and methods of making and using the same
CA3235016A1 (en) * 2021-10-15 2023-04-20 Andrew R. Chadeayne Crystalline tryptamine compounds
EP4457214A4 (de) * 2021-12-30 2025-12-03 Atai Therapeutics Inc Dimethyltryptamin-analoga als stickoxid-abgabemittel
EP4486448A1 (de) 2022-03-04 2025-01-08 Reset Pharmaceuticals, Inc. Co-kristalle oder salze mit psilocin
WO2023173196A1 (en) 2022-03-18 2023-09-21 Enveric Biosciences Canada Inc. C4-carboxylic acid-substituted tryptamine derivatives and methods of using
EP4493543A1 (de) * 2022-03-18 2025-01-22 Enveric Biosciences Canada Inc. C4-substituierte tryptaminderivate und verfahren zu ihrer verwendung
WO2023205768A2 (en) * 2022-04-21 2023-10-26 Caamtech, Inc. Crystalline quaternary salts of 4-substituted tryptamines
US20250171401A1 (en) * 2022-06-24 2025-05-29 Caamtech, Inc. Tryptamine derivatives
AU2023315935A1 (en) * 2022-07-25 2025-03-06 Caamtech, Inc. Methyl substituted quaternary tryptamine derivatives
GB202212116D0 (en) 2022-08-19 2022-10-05 Beckley Psytech Ltd Pharmaceutically acceptable salts and Compositions thereof
US12264131B2 (en) 2022-08-19 2025-04-01 Beckley Psytech Limited Pharmaceutically acceptable salts and compositions thereof
US12396981B2 (en) 2023-03-09 2025-08-26 William Shulman Methods of using DMT
US12246005B2 (en) 2023-06-13 2025-03-11 Beckley Psytech Limited 5-methoxy-n,n-dimethyltryptamine (5-MeO-DMT) formulations
CN118496144A (zh) * 2024-05-17 2024-08-16 南京效真生物科技有限公司 蟾蜍色胺衍生物及其在镇痛、抗抑郁药物中的应用

Citations (4)

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Publication number Priority date Publication date Assignee Title
US6306181B1 (en) * 1998-09-21 2001-10-23 L'oreal Cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing
US20160374964A1 (en) * 2014-07-03 2016-12-29 Wisconsin Alumni Research Foundation Antimicrobial compounds, compositions and methods of use thereof
US20180221396A1 (en) * 2017-02-09 2018-08-09 CaaMTech, LLC Compositions and methods comprising a psilocybin derivative
US20190142851A1 (en) * 2017-11-16 2019-05-16 CaaMTech, LLC Compositions comprising a psilocybin derivative and a cannabinoid

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306181B1 (en) * 1998-09-21 2001-10-23 L'oreal Cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing
US20160374964A1 (en) * 2014-07-03 2016-12-29 Wisconsin Alumni Research Foundation Antimicrobial compounds, compositions and methods of use thereof
US20180221396A1 (en) * 2017-02-09 2018-08-09 CaaMTech, LLC Compositions and methods comprising a psilocybin derivative
US20190142851A1 (en) * 2017-11-16 2019-05-16 CaaMTech, LLC Compositions comprising a psilocybin derivative and a cannabinoid

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ANN NEWMAN: "Specialized Solid Form Screening Techniques", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 17, no. 3, 15 March 2013 (2013-03-15), US, pages 457 - 471, XP055399400, ISSN: 1083-6160, DOI: 10.1021/op300241f *
BERGE S M ET AL: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCES,, vol. 66, no. 1, 1 January 1977 (1977-01-01), pages 1 - 19, XP000562636, DOI: 10.1002/JPS.2600660104 *
E.K. OLSEN ET. AL.: "Marine AChE inhibitors isolated from Geodia barretti: Natural compounds and their synthetic analogs.", ORGANIC AND BIOMOLECULAR CHEMISTRY, vol. 14, 1 May 2016 (2016-05-01), pages 1629 - 1640, XP093061966, DOI: 10.1039/c5ob02416a *
GUPTA DEEPAK ET AL: "Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations", MOLECULES, vol. 23, no. 7, 14 July 2018 (2018-07-14), CH, pages 1719, XP093308329, ISSN: 1420-3049, DOI: 10.3390/molecules23071719 *
H. WIELAND ET. AL.: "Die Konstitution von Bufotenin und Bufotenidin .Über Kröten Giftstoffe. VII.", JUSTUS LIEBIGS ANNALEN DER CHEMIE, vol. 513, 1 January 1934 (1934-01-01), pages 1 - 25, XP093062000, DOI: 10.1002/jlac.19345130102 *
L. SERVILLO ET. AL.: "N-Methylated Tryptamine Dervatives in Citrus Genus Plants. Identification of N,N,N-triethyl-Tryptamine in Bergamot", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 60, no. 37, 19 September 2012 (2012-09-19), pages 9512 - 9518, XP055802747, DOI: 10.1021/jf302767e *
R.B. BARLOW ET. AL.: "Actions of some analogues of 5-hydroxy-tryptamine on the isolated rat uterus and the rat fundus strip preparations.", BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, vol. 14, 1 January 1959 (1959-01-01), pages 265 - 266, XP093061989, DOI: 10.1111/j.1476-5381.1959.tb01397.x *
See also references of WO2021041407A1 *

Also Published As

Publication number Publication date
EP4017859A1 (de) 2022-06-29
AU2020337903A1 (en) 2022-03-31
CA3149602A1 (en) 2021-03-04
WO2021041407A1 (en) 2021-03-04

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