EP4031095A1 - Produit de soin cutané contenant de l'acide hyaluronique (ou un sel de celui-ci) et un extrait de cellules souches végétales - Google Patents

Produit de soin cutané contenant de l'acide hyaluronique (ou un sel de celui-ci) et un extrait de cellules souches végétales

Info

Publication number
EP4031095A1
EP4031095A1 EP19773070.8A EP19773070A EP4031095A1 EP 4031095 A1 EP4031095 A1 EP 4031095A1 EP 19773070 A EP19773070 A EP 19773070A EP 4031095 A1 EP4031095 A1 EP 4031095A1
Authority
EP
European Patent Office
Prior art keywords
weight
skin
composition
composition according
mask
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19773070.8A
Other languages
German (de)
English (en)
Inventor
Rolf Sorg
Horst Meinhardt
Karina HERZ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PM International AG
Original Assignee
PM International AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PM International AG filed Critical PM International AG
Publication of EP4031095A1 publication Critical patent/EP4031095A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212—Face masks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention is in the field of cosmetics and relates to a skin care product, in particular a composition for a mask or skin cream and the mask or skin cream.
  • compositions are offered as skin care products to counteract the aging of the skin and to moisturize the skin. It is particularly desirable with such products that the moisture (supply) of the skin is improved, the number of wrinkles (skin folds) reduced, the elasticity of the skin increased, the skin's suppleness increased, the skin's radiance increased, the skin's freshness increased, the complexion is refined, any existing feeling of tension is reduced and / or reddening of the skin is reduced.
  • compositions of masks and skin creams are at least partially aqueous, so that there is a breeding ground for microbial infestation.
  • the microbial infestation can be remedied with preservatives.
  • preservatives it is increasingly preferred to reduce the use of preservatives or to do without them entirely, among other things because preservatives can cause intolerance.
  • preservatives can cause intolerance.
  • compositions in particular in the form of a mask or skin cream, which has at least one effect selected from i) improving the moisture (supply) of the skin, ii) reducing wrinkles in the skin (skin folds), iii) increase the elasticity of the skin, iv) increase the suppleness of the skin, v) increase the radiance of the skin, vi) increase the freshness of the skin, vii) refine the skin's appearance, viii) reduce the feeling of tension and ix) reduce the redness of the Causes skin and is preferably low in preservatives.
  • the composition preferably contains a natural solubilizer or a natural surfactant.
  • At least one of the objects mentioned is achieved by a composition according to a first aspect of the invention, a mask according to a second aspect of the invention, a kit according to a third aspect of the invention, a skin cream according to a fourth aspect of the invention, a method according to a fifth aspect of the Invention, a use according to a sixth aspect of the invention and / or a method according to a seventh aspect of the invention.
  • the invention comprises a composition containing 0.03 to 3.0% by weight of hyaluronic acids and / or salts thereof,
  • composition The sum to 100% by weight of the composition is preferably formed in all embodiments of the invention by water and optionally by further ingredients.
  • the composition shows surprisingly good effects on the skin and is well tolerated.
  • the basic building block of hyaluronic acid is an aminodisaccharide built up from D-glucuronic acid and N-acetyl-D-glucosamine alternating in (1 -> 3) - (1 -> 4) -ß-glycosidic bonds.
  • sodium salts of hyaluronic acid are preferably used as hyaluronic acids and / or salts thereof.
  • Short- and / or long-chain, in particular short- and long-chain, hyaluronic acid are preferably used.
  • An anti-glycation agent is a compound that inhibits glycation. Glycation plays a role in aging and changes in the collagen and laminin of the extracellular matrix. Glycation is the non-enzymatic reaction of glucose and other reducing sugars with proteins to form glycoproteins. In aldoses, glycation usually proceeds with condensation with free amino groups of the protein to form the Schiff base and subsequent Amadori rearrangement to the 1-deoxyketosyl derivative of the protein. In the further course, dehydration and crosslinking of proteins lead to "advanced glycation end products" (AGE).
  • AGE "advanced glycation end products"
  • preferred anti-glycation agents are polyphenols and, in particular, isoquercetin Composition in addition to the one anti-glycation agent, preferably polyphenol, particularly preferably isoquercetin, contain another or further anti-glycation agent (in total then also more than 1.5 wt .-% anti-glycation agent).
  • Plant stem cell extracts and their production are known to the person skilled in the art, e.g. from Daniela, Lulli et al. "Anti-Inflammatory Effects of Concentrated Ethanol Extracts of Edelweiss (Leontopodium alpinum Cass.) Cal lus Cultures towards Human Keratinocytes and Endothelial Cells” (Mediators of inflammation vol. 2012 (2012): 498373) known.
  • the composition is preferably a liquid composition at room temperature (25 ° C).
  • the composition is preferably a liquid (at room temperature (25 ° C)).
  • the composition contains 0.05 to 2.0% by weight, preferably 0.1 to 1.0% by weight, hylauronic acids and salts thereof, 0.03 to 0.5% by weight, preferably 0.04 to 0.1% by weight, anti-glycation agent and 0.05 to 2.0% by weight, preferably 0.1 to 1.0% by weight, of a plant stem cell extract.
  • the composition contains
  • Lecithin is a natural solubilizer or a natural surfactant.
  • the composition of this embodiment surprisingly forms a physically stable single or multiphase system. A phase separation, in particular the formation of droplets due to oily or greasy compounds, or sedimentation or precipitation, is not observed. This is important for one stable, effective and attractive product. Furthermore, this special composition helps with preservation, ie microbial stabilization.
  • Lecithins are preferably derived from soy, sunflower, rapeseed, fish, milk and / or eggs, non-animal sources such as soy, sunflower and / or rapeseed being preferred.
  • de-oiled lecithin fractions can be used. This means that the lecithins are essentially free of non-polar lipids such as fatty acids and triglycerides. The content of non-polar lipids such as fatty acids and triglycerides is then less than 3% by weight.
  • the lecithins preferably contain a proportion of polar lipids (acetone-insoluble substance) of 90 to 100% by weight.
  • the lecithins preferably comprise de-oiled fractions with a preferred content of phosphatidylcholine of 30% by weight to 100% by weight.
  • At least one gelling agent selected from the group consisting of alginic acid, alginates, agar-agar, carrageenan, locust bean gum, guar gum, guar hydroxypropyltrimonium chloride, tragacanth, gum arabic, karaya gum, tara gum, gellan, xanthan gum and sclerotium gum can be selected.
  • At least one gelling agent selected from the group consisting of gellan, xanthan, sclerotium gum and guar hydroxypropyltrimonium chloride is particularly preferred.
  • the composition particularly preferably contains the three gelling agents gellan, xanthan and sclerotium gum.
  • Glycerol, ethanol, propylene glycol and / or pentylene glycol are particularly preferred as monohydric, dihydric and trihydric alcohols having 2 to 6 carbon atoms.
  • the ethanol is preferably undenatured.
  • the composition contains as one alcohol or more alcohols selected from monohydric, dihydric and trihydric alcohols having 2 to 6 carbon atoms,
  • the composition is liquid, transparent and has one or more phases. Due to the special composition, the composition is liquid, transparent and single or multi-phase.
  • the plant stem cell extract contains an extract from a callus culture of edelweiss (Leontopodium alpinum).
  • the extract from the callus culture of edelweiss (Leontopodium alpinum) preferably contains leontopodic acid (leontopodic acid).
  • the extract from the callus culture of edelweiss (Leontopodium alpinum) preferably contains a defined and reproducible amount of leontopodic acid (leontopodic acid).
  • the extract from the callus culture of edelweiss is a glycerol-based extract.
  • the extract from a callus culture of edelweiss is the crude extract or ECC55 from Daniela, Lulli et al.
  • "Anti-Inflammatory Effects of Concentrated Ethanol Extracts of Edelweiss (Leontopodium alpinum Cass.) Callus Cultures towards Human Keratinocytes and Endothelial Cells” Mediators of inflammation vol. 2012 (2012): 498373).
  • the composition contains as one alcohol or more alcohols selected from monohydric, dihydric and trihydric alcohols having 2 to 6 carbon atoms, preferably 1 to 5% by weight propylene glycol, 1 to 5% by weight pentylene glycol and b) 1 to 5% by weight of ethanol and 1 to 5% by weight of glycerine.
  • alcohols selected from monohydric, dihydric and trihydric alcohols having 2 to 6 carbon atoms, preferably 1 to 5% by weight propylene glycol, 1 to 5% by weight pentylene glycol and b) 1 to 5% by weight of ethanol and 1 to 5% by weight of glycerine.
  • the plant stem cell extract contains an extract from a callus culture of the lotus flower (Nelumbo nucifera).
  • the composition preferably contains a bleaching agent.
  • the composition contains, in a preferred embodiment, 0.1 to 1% by weight of an extract from the fruit of the pear (Pyrus communis) and / or 0.1 to 1% by weight of an extract from the real root Licorice (Glycyrrhiza glabra).
  • the composition contains as one alcohol or more alcohols selected from monohydric, dihydric and trihydric alcohols having 2 to 6 carbon atoms, preferably 1 to 5% by weight propylene glycol, 1 to 5% by weight pentylene glycol and a) 5 up to 10% by weight of ethanol.
  • the extract from the root of real liquorice preferably contains a defined and reproducible amount of glabridin.
  • the extract from the root of real liquorice preferably contains at least 50% by weight of glabridin.
  • Glabridin is used in cosmetics as a bleaching agent against pigment spots and for skin lightening.
  • the extract from the root of real liquorice (Glycyrrhiza glabra) or glabridin is a bleaching agent in the sense of the alternative embodiment according to the invention.
  • the composition contains 0.001 to 1.0% by weight, preferably 0.01 to 0.1% by weight, glycyrrhizic acid and / or a salt thereof, 0.001 to 0.5% by weight, preferably 0 , 01 to 0.1% by weight, squalane,
  • the compound glycyrrhizic acid or a salt thereof also includes glycyrrhizate, preferably dipotassium glycyrrhizate.
  • the composition contains no further preservatives in addition to the ingredients mentioned so far, in particular no p-hydroxybenzoic acid esters, benzoic acid and / or salts thereof.
  • the invention in a second aspect, relates to a mask comprising a composition according to the invention and a carrier matrix, the composition according to the invention being arranged on and / or in the carrier matrix.
  • the carrier matrix is (essentially) a mechanical or shaping framework.
  • the function of the carrier matrix is (essentially) to absorb the composition / liquid, transfer it to the skin and release it there again.
  • the carrier matrix is suitable for absorbing the composition / liquid, transferring it to the skin and releasing it to the skin on the skin.
  • the carrier matrix can contain organic and / or inorganic components.
  • the ingredients can be natural and / or synthetic. It is crucial that the carrier matrix absorbs the composition / liquid and releases it on the skin to the skin.
  • the carrier matrix can preferably be sterilized.
  • the mask is a face mask.
  • the carrier matrix is a cloth, a woven fabric or a fleece, in particular a cloth.
  • regenerated fibers and / or cellulose fibers, in particular regenerated cellulose fibers form the carrier matrix and / or the cloth, fabric or fleece.
  • the carrier matrix preferably contains cellulose fibers, in particular regenerated cellulose fibers. Wipes made from regenerated cellulose fibers are preferred and are sold under the name Tencel TM.
  • a cellulose regenerated fiber cloth gives the skin a particularly good feel during use.
  • a cellulose regenerated fiber cloth is more absorbent than cotton and is extremely tear-resistant even when it is impregnated with the composition according to the invention.
  • the mask comprises a carrier matrix impregnated with the composition according to the invention, in particular a cloth impregnated with the composition according to the invention.
  • the mask does not contain any further preservatives in addition to the compounds mentioned above, in particular no p-hydroxybenzoic acid esters, benzoic acid and / or salts thereof.
  • the invention relates to a kit for producing a mask according to the invention, the kit comprising a carrier matrix and a composition according to the invention.
  • the kit preferably contains two compartments and the carrier matrix and the composition according to the invention are each arranged in one compartment in the kit.
  • the kit is a plastic bag with two compartments. Each compartment is tightly sealed.
  • the carrier matrix, in particular the cloth is preferably sterile. In other words, the carrier matrix, in particular the cloth, was preferably sterilized.
  • the composition according to the invention is microbially stable and does not have to (but can in certain embodiments) be sterilized.
  • the composition according to the invention preferably contains no further preservatives.
  • the carrier matrix preferably does not contain any preservatives.
  • the kit is preferably designed in such a way that the two compartments are separated by a pressure-sensitive membrane.
  • Pressure sensitive means that the membrane loses its function (ruptures) when pressure is applied and the separation into two components is abolished.
  • pressure is also applied to the pressure-sensitive membrane, as a result of which the membrane tears and the composition according to the invention is applied to the carrier matrix.
  • the mask is made directly from / in the kit.
  • the consumer can then apply the freshly made mask.
  • the consumer produces the mask by exerting pressure on the composition according to the invention and thus the pressure-sensitive membrane.
  • the invention relates to a skin cream.
  • the composition according to the invention is a skin cream.
  • the skin cream is, in particular, a face cream.
  • it is necessary to increase the viscosity of the composition according to the invention and, if necessary, to add fats.
  • the skin cream contains
  • the anti-glycation agent is a polyphenol, particularly preferably isoquercetin.
  • the skin cream contains 0.05 to 2.0% by weight, preferably 0.1 to 1.0% by weight, hylauronic acids and salts thereof, 0.03 to 0.5% by weight, preferably 0.04 to 0.1% by weight, anti-glycation agent and 0.05 to 2.0% by weight, preferably 0.1 to 1.0% by weight, of a plant stem cell extract.
  • the plant stem cell extract contains an extract from a callus culture of edelweiss (Leontopodium alpinum).
  • the plant stem cell extract contains an extract from a callus culture of the lotus flower (Nelumbo nucifera).
  • the composition preferably contains a bleaching agent.
  • the composition contains, in a preferred embodiment, 0.1 to 1% by weight of an extract from the fruit of the pear (Pyrus communis) and / or 0.1 to 1% by weight of an extract from the real root Licorice (Glycyrrhiza glabra).
  • the extract from the root of real liquorice preferably contains a defined and reproducible amount of glabridin.
  • the extract from the root of real liquorice preferably contains at least 50% by weight of glabridin.
  • Glabridin is used in cosmetics as a bleaching agent against pigment spots and for skin lightening.
  • the extract from the root of real liquorice (Glycyrrhiza glabra) or glabridin is a bleaching agent in the sense of the alternative embodiment according to the invention.
  • the composition contains 0.001 to 1.0% by weight, preferably 0.01 to 0.1% by weight, glycyrrhizic acid and / or a salt thereof, 0.001 to 0.5% by weight, preferably 0 , 01 to 0.1% by weight, squalane,
  • the compound glycyrrhizic acid or a salt thereof also includes glycyrrhizate, preferably dipotassium glycyrrhizate.
  • the invention relates to a method for anti-aging treatment of the skin, in particular the facial skin, wherein a composition according to the invention, a mask according to the invention and / or a skin cream according to the invention is applied to the skin, in particular facial skin.
  • the method is preferably a non-medical and / or cosmetic method.
  • the composition according to the invention, the mask according to the invention and / or the skin cream according to the invention is applied at least once a week, preferably once a week, for at least four weeks.
  • the method is in particular a method for reducing wrinkles in the skin (skin folds) and / or for Increase in skin radiance.
  • the invention relates to a method for producing a mask according to the invention, comprising
  • the application of the composition according to the invention to the carrier matrix comprises soaking the carrier matrix, preferably a cloth, in the composition according to the invention.
  • the production is preferably carried out using the kit according to the invention, preferably wherein the kit contains two compartments and the carrier matrix and the composition according to the invention are each arranged in one compartment.
  • the two compartments are separated by a pressure sensitive membrane.
  • the application of the composition according to the invention to the carrier matrix preferably comprises exerting pressure on the compartment that contains the composition according to the invention in such a way that the pressure-sensitive membrane loses its function (tears) and the separation into two components is abolished.
  • the composition according to the invention is pressed into the compartment which contains the carrier matrix.
  • the composition according to the invention is applied to the carrier matrix.
  • the mask is therefore preferably produced directly from / in the kit.
  • the consumer can then apply the freshly made mask.
  • the consumer makes the mask by applying pressure to the pressure sensitive membrane.
  • Stored soaked wipes require increased microbial stabilization through increased use of preservatives.
  • the microbial stability of the product is increased and preservatives can be dispensed with.
  • test persons tested a face mask according to the invention with a composition according to the invention The subjects used the mask once a week for about 15 minutes for four weeks. During the test phase, the subjects did not change their usual skin care routine. The subjects rated the product after the first and fourth use.
  • the test subjects each received the masks as a kit.
  • the kit is a plastic bag with two compartments, each compartment being tightly sealed. The two compartments are separated by a pressure sensitive membrane.
  • One compartment contains a sterilized regenerated cellulose fiber cloth (Tencel TM) as a carrier matrix and the other compartment contains the composition according to the invention (“serum”).
  • the mask is made from the kit by the user.
  • the serum is applied to the regenerated cellulose fiber cloth by manually exerting pressure on the compartment containing the serum. This tears the pressure-sensitive membrane and the serum is pressed into the compartment that contains the regenerated cellulose fiber cloth. The serum is thus applied to the regenerated cellulose fiber cloth. If necessary, the user can manually support the soaking of the regenerated cellulose fiber cloth in the serum, e.g. by kneading or applying further pressure. Then the user opens the plastic bag, removes the mask and applies it to his face.
  • the microbial stability of the product is increased and preservatives can be dispensed with.
  • the serum does not contain any further preservatives, in particular no p-hydroxybenzoic acid esters, benzoic acid and / or salts thereof.
  • the serum is physically and microbially stable.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition contenant de 0,03 à 3,0 % en poids d'acides hyaluroniques et/ou de sels de ceux-ci, de 0,01 à 1,5 % en poids d'un agent anti-glycation et de 0,03 à 3,0 % en poids d'un extrait de cellules souches végétales.
EP19773070.8A 2019-09-19 2019-09-19 Produit de soin cutané contenant de l'acide hyaluronique (ou un sel de celui-ci) et un extrait de cellules souches végétales Pending EP4031095A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2019/075255 WO2021052597A1 (fr) 2019-09-19 2019-09-19 Produit de soin cutané contenant de l'acide hyaluronique (ou un sel de celui-ci) et un extrait de cellules souches végétales

Publications (1)

Publication Number Publication Date
EP4031095A1 true EP4031095A1 (fr) 2022-07-27

Family

ID=67999668

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19773070.8A Pending EP4031095A1 (fr) 2019-09-19 2019-09-19 Produit de soin cutané contenant de l'acide hyaluronique (ou un sel de celui-ci) et un extrait de cellules souches végétales

Country Status (2)

Country Link
EP (1) EP4031095A1 (fr)
WO (1) WO2021052597A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116650347B (zh) * 2023-06-20 2023-12-01 康柏利科技（苏州）有限公司 一种含粉红微藻和千日菊精粹的抗皱精油面膜及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10478391B2 (en) * 2015-06-08 2019-11-19 Maryam Ershadi Skin-care formulation for treating anti-aging and wrinkle reduction
US20210275495A1 (en) * 2017-06-23 2021-09-09 Vivier Canada Inc. Putrescine topical formulations
CN107982200A (zh) * 2017-12-05 2018-05-04 广州赛莱拉干细胞科技股份有限公司 一种含有枸杞干细胞提取物的祛皱护肤品及其制备方法
CN108379218A (zh) * 2018-05-21 2018-08-10 佛山市三水区嘉华化学研究院（普通合伙） 一种抗衰老美容霜及其制备方法

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